1. Academic Medical Center at the University of Amsterdam

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    1. Mentioned In 163 Articles

    2. Optical properties of neonatal skin measured in vivo as a function of age and skin pigmentation

      Optical properties of neonatal skin measured in vivo as a function of age and skin pigmentation
      Knowledge of the optical properties of neonatal skin is invaluable when developing new, or improving existing optical techniques for use at the neonatal intensive care. In this article, we present in vivo measurements of the absorption μa and reduced scattering coefficient μs′ of neonatal skin between 450 and 600 nm and assess the influence of age and skin pigmentation on the optical properties. The optical properties were measured using a ...
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    3. Postdoctoral Associate Position in the Biomedical Engineering Department at Stony Brook University

      Postdoctoral Associate Position in the Biomedical Engineering Department at Stony Brook University
      Campus Description: Stony Brook University, home to many highly ranked graduate research programs, is located 60 miles from New York City on Long Island's scenic North Shore. Our 1,100-acre campus is home to 24,000 undergraduate, graduate, and doctoral students and more than 13,500 faculty and staff. The University is a member of the prestigious Association of American Universities and co-manager of nearby Brookhaven National Laboratory, a ...
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    4. Emerging optical techniques in advanced cystoscopy for bladder cancer diagnosis: A review of the current literature

      Emerging optical techniques in advanced cystoscopy for bladder cancer diagnosis: A review of the current literature
      Background and objective : The current standard for the diagnosis and followup of bladder cancer remains white light cystoscopy, despite its well-known limitations. The aim of this paper is to review the current literature on three optical diagnostics that have been developed to improve the performance of white light cystoscopy: photodynamic diagnosis, narrow-band imaging and optical coherence tomography. Materials and Methods : A PubMed search was performed for all articles on bladder ...
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    5. Biphasic Oxidation of Oxy-Hemoglobin in Bloodstains

      Biphasic Oxidation of Oxy-Hemoglobin in Bloodstains
      Background: In forensic science, age determination of bloodstains can be crucial in reconstructing crimes. Upon exiting the body, bloodstains transit from bright red to dark brown, which is attributed to oxidation of oxy-hemoglobin (HbO2) to methemoglobin (met-Hb) and hemichrome (HC). The fractions of HbO2, met-Hb and HC in a bloodstain can be used for age determination of bloodstains. In this study, we further analyze the conversion of HbO2 to met-Hb ...
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    6. Research Technician Opening at Stony Brook University

      Research Technician Opening at Stony Brook University
      Campus Description: Stony Brook University, home to many highly ranked graduate research programs, is located 60 miles from New York City on Long Island's scenic North Shore. Our 1,100-acre campus is home to 24,000 undergraduate, graduate, and doctoral students and more than 13,500 faculty and staff. The University is a member of the prestigious Association of American Universities and co-manager of nearby Brookhaven National Laboratory, a ...
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    7. NIRS and IVUS for Characterization of Atherosclerosis in Patients Undergoing Coronary Angiography

      NIRS and IVUS for Characterization of Atherosclerosis in Patients Undergoing Coronary Angiography
      Objectives: The aim of this study was to compare the findings of near-infrared spectroscopy (NIRS), intravascular ultrasound (IVUS) virtual histology (VH), and grayscale IVUS obtained in matched coronary vessel segments of patients undergoing coronary angiography. Background: Intravascular ultrasound VH has been developed to add tissue characterization to the grayscale IVUS assessment of coronary plaques. Near-infrared spectroscopy is a new imaging technique able to identify lipid core-containing coronary plaques (LCP). Methods ...
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    8. Feature Of The Week 5/29/11: Researchers at University of Twente and University of Amsterdam Investigate Miniaturization of SD-OCT Systems using Integrated Optics

      Feature Of The Week 5/29/11: Researchers at University of Twente and University of Amsterdam Investigate Miniaturization of SD-OCT Systems using Integrated Optics
      Optical coherence tomography (OCT) is an interferometric imaging technique which has developed rapidly over the last 20 years and has many applications in biomedical optics. Current OCT systems consist of a large number of bulk optical components and are quite expensive. Thus integration of optical components is expected to make OCT systems smaller and more cost efficient.Within the MEMPHIS project (Merging Electronics and Micro & Nano-Photonics in Integrated Systems), researchers ...
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    9. Heartbeat-induced axial motion artifacts in optical coherence tomography measurements of the retina

      Heartbeat-induced axial motion artifacts in optical coherence tomography measurements of the retina
      Purpose: To investigate the cause of axial eye motion artifacts that occur in optical coherence tomography (OCT) imaging of the retina. Understanding the cause of these motions can lead to improved OCT image quality and therefore better diagnosis. Methods: 27 measurements were done on 5 subjects. We collected spectral-domain OCT images at the macula over periods up to 30 seconds. We calculated the axial shift of every average A-scan with ...
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    10. Spectral domain optical coherence tomography imaging with an integrated optics spectrometer

      Spectral domain optical coherence tomography imaging with an integrated optics spectrometer
      We designed and fabricated an arrayed-waveguide grating (AWG) in silicon oxynitride as a spectrometer for spectral domain optical coherence tomography (SD-OCT). The AWG has a footprint of only 3.0 cm×2.5 cm, operates at a center wavelength of 1300 nm, and has 78 nm free spectral range. OCT measurements are performed that demonstrate imaging up to a maximum depth of 1 mm with an axial resolution of 19 ...
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    11. Determination of the scattering anisotropy with optical coherence tomography

      Determination of the scattering anisotropy with optical coherence tomography
      In this work we demonstrate measurements with optical coherence tomography (OCT) of the scattering phase function in the backward direction and the scattering anisotropy parameter g. Measurements of the OCT attenuation coefficient and the backscattering amplitude are performed on calibrated polystyrene microspheres with a time-domain OCT system. From these measurements the phase function in the backward direction is determined. The measurements are described by the single scattering model and match ...
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    12. A clinical instrument for combined raman spectroscopy-optical coherence tomography of skin cancers

      A clinical instrument for combined raman spectroscopy-optical coherence tomography of skin cancers
      Background and Objective The current standard for diagnosis of skin cancers is visual inspection followed by biopsy and histopathology. This process can be invasive, subjective, time consuming, and costly. Optical techniques, including Optical Coherence Tomography (OCT) and Raman Spectroscopy (RS), have been developed to perform non-invasive characterization of skin lesions based on either morphological or biochemical features of disease. The objective of this work is to report a clinical instrument ...
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    13. Feature Of The Week 2/6/11: Investigation into using Optical Coherence Tomography for Grading Urothelial Carcinoma - Recent Work from Academic Medical Center Amsterdam and University of Twente

      Feature Of The Week 2/6/11: Investigation into using Optical Coherence Tomography for Grading Urothelial Carcinoma - Recent Work from Academic Medical Center Amsterdam and University of Twente
      Feature Of The Week 2/6/11: Achieving the goal of a real-time in-situ high-resolution optical biopsy using OCT would be a tremendous boost to medicine and mankind. However is it quite a complex and difficult challenge that has not been fully realized to date. Many people believe this challenge will be realized in the not too distant future as understanding, approaches, and technology is improved due to progress at ...
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    14. Overview of Optical and Thermal Laser-Tissue Interaction and Nomenclature

      Overview of Optical and Thermal Laser-Tissue Interaction and Nomenclature
      The development of a unified theory for the optical and thermal response of tissue to laser radiation is no longer in its infancy, though it is still not fully developed. This book describes our current understanding of the physical events that can occur when light interacts with tissue, particularly the sequence of formulations that estimate the optical and thermal responses of tissue to laser radiation. This overview is followed by ...
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    15. Integrated system for combined Raman spectroscopy–spectral domain optical coherence tomography

      Integrated system for combined Raman spectroscopy–spectral domain optical coherence tomography
      Raman spectroscopy (RS) and optical coherence tomography (OCT) are powerful tools for optical analysis of tissues with mutually complementary strengths and limitations. OCT excels at visualizing tissue microstructure but lacks molecular specificity, while RS can relay tissue biochemical composition but typically cannot relate microstructure. Previous implementations of combined RS-OCT have utilized a common sample arm while maintaining independent RS and OCT detection arms. We present the design and application of ...
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    16. Quantitative measurement of attenuation coefficients of bladder biopsies using optical coherence tomography for grading urothelial carcinoma of the bladder

      Quantitative measurement of attenuation coefficients of bladder biopsies using optical coherence tomography for grading urothelial carcinoma of the bladder
      Real-time grading of bladder urothelial carcinoma (UC) is clinically important, but the current standard for grading (histopathology) cannot provide this information. Based on optical coherence tomography (OCT)-measured optical attenuation (µt), the grade of bladder UC could potentially be assessed in real time. We evaluate ex vivo whether µt differs between different grades of UC and benign bladder tissue. Human bladder tissue specimens are examined ex vivo by 850-nm OCT ...
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  2. About Academic Medical Center at the University of Amsterdam

    Academic Medical Center at the University of Amsterdam

    Academic Medical Center at the University of Amsterdam.  The Academic Medical Center (AMC) is the most prominent medical center in the Netherlands and one of the largest hospitals. The AMC complex houses the university hospital and the medical faculty of the University of Amsterdam, as well the Netherlands Institute for Neuroscience and the medical department of the Royal Tropical Institute. Also a number of biotech companies – partly AMC spin-offs - are located on the premises. This concentration of expertise makes the AMC ‘more than just a university hospital’ and provides a breeding ground for fruitful scientific collaboration.