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Academic Medical Center at the University of Amsterdam

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2. Simple and robust calibration procedure for k-linearization and dispersion compensation in optical coherence tomography
  
  Explore SPIE Digital Library May 23 2019
  
  In Fourier-domain optical coherence tomography (FD-OCT), proper signal sampling and dispersion compensation are essential steps to achieve optimal axial resolution. These calibration steps can be performed through numerical signal processing, but require calibration information about the system that may require lengthy and complex measurement protocols. We report a highly robust calibration procedure that can simultaneously determine correction vectors for nonlinear wavenumber sampling and dispersion compensation. The proposed method requires only ...
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  Mentions: Academic Medical Center at the University of Amsterdam Polytechnique Montreal Dirk J. Faber
3. Optical coherence tomography to detect acute esophageal radiation-induced damage in mice: a validation study
  
  Explore Wiley Online Library May 14 2019 Gastroenterology
  
  Radiation therapy for patients with non-small-cell lung cancer is hampered by acute radiation-induced toxicity in the esophagus. This study aims to validate that optical coherence tomography (OCT), a minimally invasive imaging technique with high resolution (~10 m), is able to visualize and monitor acute radiation-induced esophageal damage (ARIED) in mice. We compare our findings with histopathology as the gold standard. Irradiated mice receive a single dose of 40 Gy at ...
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  Mentions: Johannes F. de Boer Academic Medical Center at the University of Amsterdam VU University Amsterdam
4. Decreasing the Size of a Spectral Domain Optical Coherence Tomography System With Cascaded ...
  
  Explore IEEE Xplore Apr 18 2019 Ophthalmology
  
  This paper describes a proof-of-concept of a miniaturized spectral-domain optical coherence tomography system, based on photonic integrated circuit (PIC) technology. The integrated optics 512-channel spectrometer consists of cascaded arrayed waveguide gratings (AWG) with the output waveguides directly attached to a CCD detector. The spectrometer has a center wavelength of 850 nm and a spectral sampling interval of 0.22 nm. The PIC has a footprint of 2.0 2.7 ...
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  Mentions: Academic Medical Center at the University of Amsterdam Dirk J. Faber Ton G. van Leeuwen
5. Micro-indentation and optical coherence tomography for the mechanical characterization of embryos: Experimental setup and measurements on fixed chicken embryos.
  
  Explore bioRxiv.org Feb 28 2019 Developmental Biology
  
  The investigation of the mechanical properties of embryos is expected to provide valuable information on the phenomenology of morphogenesis. It is thus believed that, by mapping the viscoelastic features of an embryo at different stages of growth, it may be possible to shed light on the role of mechanics in embryonic development. To contribute to this field, we present a new instrument that can determine spatiotemporal distributions of mechanical properties ...
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  Mentions: Academic Medical Center at the University of Amsterdam VU University Amsterdam University Medical Center Utrecht
6. From sample structure to optical properties and back : A theoretical framework for quantitative OCT and its clinical application (Thesis)
  
  Explore NARCIS > Home Dec 6 2018 Student Theses
  
  The aim of this thesis is to provide a methodology to extract quantitative parameters from optical coherence tomography (OCT) images and to relate these parameters to sample properties such as structure, organization and flow. OCT uses near-infrared light to acquire 3D images of biological tissue, with a resolution around 5-15 m and an imaging depth of approximately 2 mm. OCT can be a useful clinical tool for minimally-invasive, high-resolution imaging ...
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  Mentions: Academic Medical Center at the University of Amsterdam Dirk J. Faber Ton G. van Leeuwen
7. Acute Airway Effects of Bronchial Thermoplasty Assessed by Optical Coherence Tomography (OCT)
  
  Explore European Respiratory Journal Nov 27 2018 Pulmonology
  
  Background: Bronchial Thermoplasty (BT) is an endoscopic treatment for severe asthma targeting airway smooth muscle (ASM) with thermal energy. The extent of treatment effect is largely unknown. Optical coherence tomography (OCT) is a high resolution imaging technique, using near-infrared light, that generates near-histology cross sectional images of the airway wall. Aim: Assess the extent of acute airway wall effects of BT with OCT and compare these to the untreated right ...
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  Mentions: Academic Medical Center at the University of Amsterdam Daniël M. de Bruin
8. Optical Coherence Tomography in Urologic Oncology: a Comprehensive Review
  
  Explore Home - Springer Nov 27 2018 Urology
  
  Introduction Optical coherence tomography (OCT) is being investigated in urologic oncology for optical diagnosis. This comprehensive review analyzes the current state of development of OCT for bladder, upper urinary tract, kidney, prostate, testis, and penis cancer. Also, the potential role of OCT with regard to the current diagnostic pathways is critically appraised to guide future developments. Methods Embase and Pubmed were systematically searched for English and German articles on OCT ...
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  Mentions: Academic Medical Center at the University of Amsterdam Ton G. van Leeuwen Daniël M. de Bruin
9. 5‐Year clinical follow‐up of the COBRA (complex coronary bifurcation lesions: Randomized comparison of a strategy using a dedicated self‐expanding biolimus A9‐eluting stent vs. a culotte strategy using everolimus‐eluting stents) study
  
  Explore Wiley Online Library Nov 26 2018 Cardiology
  
  Objectives We evaluated healing responses with optical coherence tomography, and long‐term clinical outcomes after treatment with a dedicated stent versus a conventional culotte technique. Background Dedicated bifurcation stents have been proposed as an alternative treatment for coronary bifurcation lesions. The long‐term performance of dedicated stents versus conventional dual‐stent techniques for the treatment of complex coronary bifurcation lesions is unknown. Methods Forty patients with true coronary bifurcation lesions ...
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  Mentions: Arnaud Dubois Academic Medical Center at the University of Amsterdam Walter Desmet
10. One‐to‐one registration of en‐face optical coherence tomography attenuation coefficients with histology of a prostatectomy specimen
  
  Explore Wiley Online Library Nov 22 2018 Urology
  
  Optical coherence tomography (OCT), enables high‐resolution 3D imaging of the morphology of light scattering tissues. From the OCT signal, parameters can be extracted and related to tissue structures. One of the quantitative parameters is the attenuation coefficient; the rate at which the intensity of detected light decays in depth. To couple the quantitative parameters with the histology one‐to‐one registration is needed. The primary aim of this study ...
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  Mentions: Academic Medical Center at the University of Amsterdam Dirk J. Faber Ton G. van Leeuwen
11. Decreasing the Size of a Spectral Domain Optical Coherence Tomography System with Cascaded Arrayed Waveguide Gratings in a Photonic Integrated Circuit
  
  Explore IEEE Xplore Oct 9 2018
  
  This paper describes a proof-of-concept of a miniaturized spectral-domain optical coherence tomography system, based on photonic integrated circuit (PIC) technology. The integrated optics 512-channel spectrometer consists of cascaded arrayed waveguide gratings (AWG) with the output waveguides directly attached to a CCD detector. The spectrometer has a center wavelength of 850 nm and a spectral sampling interval of 0.22 nm. The PIC has a footprint of 2.0x2.7 cm2 ...
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  Mentions: Academic Medical Center at the University of Amsterdam Dirk J. Faber Ton G. van Leeuwen
12. The role of optical coherence tomography and infrared oculography in assessing the visual pathway and CNS in multiple sclerosis
  
  Explore futuremedicine.com Oct 2 2018 Ophthalmology
  
  In this review, a current overview is provided of how optical coherence tomography and infrared oculography can aid in assessing the visual system and CNS in multiple sclerosis (MS). Both afferent and efferent visual disorders are common in MS and visual complaints can have a tremendous impact on daily functioning. Optical coherence tomography and infrared oculography can detect and quantify visual disorders with high accuracy, but could also serve as ...
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  Mentions: Academic Medical Center at the University of Amsterdam Axel Petzold
13. Correlation between redefined optical coherence tomography parameters and best-corrected visual acuity in non-resolving central serous chorioretinopathy treated with half-dose photodynamic therapy
  
  Explore Journals | PLOS Aug 24 2018 Ophthalmology
  
  Purpose To assess parameters on optical coherence tomography (OCT), and their correlation with best-corrected visual acuity (BCVA) in patients with non-resolving central serous chorioretinopathy (CSC). Methods For 25 non-resolving CSC patients treated with photodynamic therapy (PDT), the thickness of retinal layers was assessed on the foveal spectral-domain (SD) OCT scan. Evaluated OCT parameters included the central retinal thickness (CRT), defined as the internal limiting membrane (ILM) to ellipsoid zone (EZ ...
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  Mentions: Heidelberg Engineering Leiden University Academic Medical Center at the University of Amsterdam
14. Bronchial Thermoplasty-Induced Acute Airway Effects Assessed with Optical Coherence Tomography in Severe Asthma
  
  Explore Karger Publishers Aug 21 2018 Pulmonology
  
  Background: Bronchial thermoplasty (BT) is an endoscopic treatment for severe asthma targeting airway smooth muscle (ASM) with radiofrequent energy. Although implemented worldwide, the effect of BT treatment on the airways is unclear. Optical coherence tomography (OCT) is a novel imaging technique, based on near-infrared light, that generates high-resolution cross-sectional airway wall images. Objective: To assess the safety and feasibility of OCT in severe asthma patients and determine acute airway effects ...
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  Mentions: Academic Medical Center at the University of Amsterdam Daniël M. de Bruin Jan D'hooge
15. Feasibility of using optical coherence tomography to detect radiation-induced fibrosis and residual cancer extent after neoadjuvant chemo-radiation therapy: an ex vivo study
  
  Explore OSA | OSA Publishing Aug 20 2018 Gastroenterology
  
  Treatment of resectable esophageal cancer includes neoadjuvant chemo-radiation therapy (nCRT) followed by esophagectomy in operable patients. High-risk surgery may have been avoided in patients with a pathological complete response (pCR). We investigated the feasibility of optical coherence tomography (OCT) to detect residual cancer and radiation-induced fibrosis in 10 esophageal cancer patients that underwent nCRT followed by esophagectomy. We compared our OCT findings with histopathology. Overall, OCT was able to differentiate ...
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  Mentions: Johannes F. de Boer Academic Medical Center at the University of Amsterdam VU University Amsterdam
16. Needle-based optical coherence tomography for the detection of prostate cancer: a visual and quantitative analysis in 20 patients
  
  Explore SPIE Digital Library Aug 15 2018
  
  iagnostic accuracy of needle-based optical coherence tomography (OCT) for prostate cancer detection by visual and quantitative analysis is defined. 106 three-dimensional (3-D)-OCT data sets were acquired in 20 prostates after radical prostatectomy and precisely matched with pathology. OCT images were grouped per histological category. Two reviewers performed blind assessments of the OCT images. Sensitivity and specificity for malignancy detection were calculated. Quantitative analyses by automated optical attenuation coefficient calculation ...
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  Mentions: Academic Medical Center at the University of Amsterdam Dirk J. Faber Ton G. van Leeuwen
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