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Academic Medical Center at the University of Amsterdam

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1. Mentioned In 181 Articles
2. Optical Coherence Tomography-Guided PCI With Single-Antiplatelet Therapy
  
  Explore Home - ClinicalTrials.gov Feb 23 2021 Cardiology , Clinical Trials
  
  Rationale: Dual antiplatelet therapy (DAPT), consisting of aspirin and a P2Y12-inhibitor, reduces the risk of stent thrombosis, myocardial infarction and stroke after coronary stent implantation. Inevitably, it is also associated with a higher risk of (major) bleeding. Given the advances in stent properties, stenting implantation technique and pharmacology, it may be possible to treat patients with a single antiplatelet strategy using a potent P2Y12- inhibitor such as prasugrel. Objective: This ...
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  Mentions: Academic Medical Center at the University of Amsterdam
3. Single-chip optical coherence tomography device
  
  Explore uspto.gov Feb 2 2021 Patents
  
  A high-performance single-chip, integrated-optics-based OCT system is disclosed, where the length of the reference arm is digitally variable. The reference arm includes a plurality of switch stages comprising a 2.times.2 tunable wavelength-independent waveguide switch that can direct an input light signal onto either of two different-length output waveguides. In some embodiments, the directional couplers are thermo-optic based. Some embodiments include a solid-state scanning system for scanning a sample ...
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  Mentions: Academic Medical Center at the University of Amsterdam
4. Bayesian analysis of depth resolved OCT attenuation coefficients
  
  Explore Nature Publishing Group Jan 26 2021
  
  Biomedical engineering Abstract Optical coherence tomography (OCT) is an optical technique which allows for volumetric visualization of the internal structures of translucent materials. Additional information can be gained by measuring the rate of signal attenuation in depth. Techniques have been developed to estimate the rate of attenuation on a voxel by voxel basis. This depth resolved attenuation analysis gives insight into tissue structure and organization in a spatially resolved way.
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  Mentions: Academic Medical Center at the University of Amsterdam Dirk J. Faber Ton G. van Leeuwen
5. In vivo characterization of chick embryo mesoderm by optical coherence tomography‐assisted microindentation
  
  Explore faseb.onlinelibrary.wiley.com Jan 9 2021
  
  Embryos are growing organisms with highly heterogeneous properties in space and time. Understanding the mechanical properties is a crucial prerequisite for the investigation of morphogenesis. During the last 10 years, new techniques have been developed to evaluate the mechanical properties of biological tissues in vivo. To address this need, we employed a new instrument that, via the combination of micro‐indentation with Optical Coherence Tomography (OCT), allows us to determine ...
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  Mentions: Academic Medical Center at the University of Amsterdam
6. Quantification of key retinal features in early and late age-related macular degeneration using deep learning
  
  Explore American Journal of Ophthalmology Jan 7 2021 Ophthalmology
  
  Purpose To develop and validate a deep learning model for segmentation of 13 features associated with neovascular and atrophic age-related macular degeneration (AMD). Design Development and validation of a deep-learning model for feature segmentation Methods Data for model development were obtained from 307 optical coherence tomography volumes. Eight experienced graders manually delineated all abnormalities in 2,712 B-scans. A deep neural network was trained with this data to perform voxel-level ...
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  Mentions: Academic Medical Center at the University of Amsterdam Adnan Tufail Erasmus University
7. Optical coherence tomography (OCT) in neuro-ophthalmology
  
  Explore Nature Publishing Group Nov 25 2020 Ophthalmology
  
  Optical coherence tomography (OCT) is a non-invasive medical imaging technology that is playing an increasing role in the routine assessment and management of patients with neuro-ophthalmic conditions. Its ability to characterise the optic nerve head, peripapillary retinal nerve fibre layer and cellular layers of the macula including the ganglion cell layer enables qualitative and quantitative assessment of optic nerve disease. In this review, we discuss technical features of OCT and ...
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  Mentions: University College London Academic Medical Center at the University of Amsterdam Axel Petzold
8. Longitudinal retinal layer changes in preclinical Alzheimer’s disease
  
  Explore Wiley Online Library Oct 21 2020 Neurology , Ophthalmology
  
  Purpose Several studies found reduced retinal thickness on optical coherence tomography (OCT) in Alzheimers disease (AD), even in preclinical stages, labelling this technique of interest as biomarker. In this study, we examine retinal thickness changes in preclinical AD, as defined by cognitively normal individuals with amyloid‐beta (A) on positron emission tomography (PET). Methods For this monocentre study, 145 cognitively healthy monozygotic twins aged 60 were included from the Netherlands ...
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  Mentions: Academic Medical Center at the University of Amsterdam Frank D. Verbraak
9. 3D co-registration algorithm for catheter-based optical coherence tomography
  
  Explore OSA | OSA Publishing Sep 21 2020
  
  Applications of catheter-based optical coherence tomography (OCT) - originally developed for cardiovascular imaging - have expanded to other organ systems. However, currently available algorithms to co-register 3D OCT data to a second imaging modality were developed for cardiovascular applications and with it, are tailored to small tubular tissue structures. The available algorithms can often not be applied outside the cardiovascular system, e.g. when an OCT probe is introduced into the kidney ...
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  Mentions: Academic Medical Center at the University of Amsterdam Dirk J. Faber Ton G. van Leeuwen
10. Advances in IVUS/OCT and Future Clinical Perspective of Novel Hybrid Catheter System in Coronary Imaging
  
  Explore Frontiers Aug 29 2020
  
  Intravascular ultrasound (IVUS) and optical coherence tomography (OCT) have been developed and improved as both diagnostic and guidance tools for interventional procedures over the past three decades. IVUS has a resolution of 100 m with a high tissue penetration and capability of assessing the entire structure of a coronary artery including the external elastic membrane, whereas OCT has a higher resolution of 1020 m to assess endoluminal structures with a ...
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  Mentions: University of Toronto Terumo Corporation Academic Medical Center at the University of Amsterdam
11. Common-path integrated low coherence interferometry system and method therefor
  
  Explore uspto.gov Aug 25 2020 Patents
  
  A low coherence interferometry imaging system comprising a common-path interferometer that is at least partially integrated as part of a planar lightwave circuit is disclosed. Imaging systems in accordance with the present invention are implemented in integrated optics without the inclusion of highly wavelength-sensitive components. As a result, they exhibit less wavelength dependence than PLC-based interferometers of the prior art. Further, the common-path interferometer arrangement of the present invention avoids ...
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  Mentions: Academic Medical Center at the University of Amsterdam Ton G. van Leeuwen
12. Comparison of Optical Imaging Techniques to Quantitatively Assess the Perfusion of the Gastric Conduit during Oesophagectomy
  
  Explore MDPI Open Access Journals Platform Aug 10 2020 Gastroenterology
  
  In this study, four optical techniquesOptical Coherence Tomography, Sidestream Darkfield Microscopy, Laser Speckle Contrast Imaging, and Fluorescence Angiography (FA)were compared on performing an intraoperative quantitative perfusion assessment of the gastric conduit during oesophagectomy. We hypothesised that the quantitative parameters show decreased perfusion towards the fundus in the gastric conduit and in patients with anastomotic leakage. In a prospective study in patients undergoing oesophagectomy with gastric conduit reconstruction, measurements were ...
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  Mentions: Academic Medical Center at the University of Amsterdam Ton G. van Leeuwen Daniël M. de Bruin
13. CLE and OCT in Acute Respiratory Insufficiency
  
  Explore Home - ClinicalTrials.gov Jul 21 2020 Pulmonology , Clinical Trials
  
  Acute respiratory distress syndrome is a severe complication of critical illness. The diagnosis of ARDS is difficult, and it could be important to differentiate ARDS from other causes of acute respiratory failure. Innovative probe-based imaging techniques such as 'Confocal Laser Endomicroscopy' (CLE) and Optical Coherence Tomography (OCT) are high resolution optical techniques that, combined with conventional bronchoscopy, have been found to provide non-invasive, real-time near-histology information about the alveolar compartment ...
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  Mentions: Academic Medical Center at the University of Amsterdam
14. The analysis of prostate tissue by optical coherence tomography (Thesis)
  
  Explore Research Explorer Jul 6 2020 Urology , Student Theses
  
  The prostate is the gland located around the urethra beneath the bladder that produces most of the sperm fluid (figure 1). Prostate cancer (PCa) accounted for almost 1 in 5 new cancer diagnoses in males in the USA in 2017, and 1 in 8 men will develop invasive cancer in the prostate in their lifetime [1]. Prostate cancer is the second most common cancer in men (after skin cancer) and ...
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  Mentions: Academic Medical Center at the University of Amsterdam
15. Illuminating the trapeziometacarpal joint: Dawn for optical coherence tomography in osteoarthritis (Thesis)
  
  Explore UvA DARE Jun 15 2020 Student Theses
  
  Osteoarthritis (OA) is a debilitating degenerative joint disease affecting millions of patients worldwide and is characterized by loss of cartilage thickness and quality in affected joints. OA of the trapeziometacarpal (TMC) joint or thumb base joint especially gives rise to loss of hand function and disability. However, clinical imaging strategies have thus far been unable to accurately assess the thin cartilage layers lining small joints like the TMC joint. Moreover ...
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  Mentions: Academic Medical Center at the University of Amsterdam
16. Optical Coherence Tomography Intensity Correlates with Extracellular Matrix Components in the Airway Wall
  
  Explore Home (thoracic) May 5 2020 Pulmonology
  
  No abstract provided.
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  Mentions: Academic Medical Center at the University of Amsterdam University of Groningen Daniël M. de Bruin
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