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Academic Medical Center at the University of Amsterdam

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2. Needle-based optical coherence tomography for the detection of prostate cancer: a visual and quantitative analysis in 20 patients
  
  Explore SPIE Digital Library Aug 15 2018
  
  iagnostic accuracy of needle-based optical coherence tomography (OCT) for prostate cancer detection by visual and quantitative analysis is defined. 106 three-dimensional (3-D)-OCT data sets were acquired in 20 prostates after radical prostatectomy and precisely matched with pathology. OCT images were grouped per histological category. Two reviewers performed blind assessments of the OCT images. Sensitivity and specificity for malignancy detection were calculated. Quantitative analyses by automated optical attenuation coefficient calculation ...
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  Mentions: Academic Medical Center at the University of Amsterdam Dirk J. Faber Ton G. van Leeuwen
3. Focal Prostate Imaging With CLE and OCT (FPI)
  
  Explore Home - ClinicalTrials.gov May 22 2018 Urology , Clinical Trials
  
  The current limitations in prostate cancer diagnostics lead to over- and undertreatment for a significant fraction of patients. Confocal Laser Endomicroscopy (CLE) and Optical Coherence Tomography (OCT) are focal imaging modalities with potential for in-vivo prostate imaging. The investigators anticipate that integrating focal imaging with MRI/TRUS fusion will further improve prostate cancer detection and provides a real-time histopathological threedimensional representation of the tumor lesions. This is an investigator-initiated, prospective ...
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  Mentions: Academic Medical Center at the University of Amsterdam Jean J. M. C. H. de la Rosette
4. Confocal Laser Endomicroscopy and Optical Coherence Tomography for the Diagnosis of Prostate Cancer: A Needle-Based, In Vivo Feasibility Study Protocol (IDEAL Phase 2A)
  
  Explore JRP-JMIR Research Protocols May 22 2018 Urology
  
  Background: Focal therapy for prostate cancer has been proposed as an alternative treatment to whole-gland therapies in selected men to diminish side effects in localized prostate cancer. As nowadays imaging cannot offer complete prostate cancer disease characterization, multicore systematic biopsies are recommended (transrectal or transperineal). Optical imaging techniques such as confocal laser endomicroscopy and optical coherence tomography allow in vivo, high-resolution imaging. Moreover, they can provide real-time visualization and analysis ...
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  Mentions: Academic Medical Center at the University of Amsterdam Ton G. van Leeuwen Daniël M. de Bruin
5. Feasibility of Optical Coherence Tomography (OCT) for Intra-Operative Detection of Blood Flow during Gastric Tube Reconstruction
  
  Explore MDPI Open Access Journals Platform Apr 25 2018 Gastroenterology
  
  In this study; an OCT-based intra-operative imaging method for blood flow detection during esophagectomy with gastric tube reconstruction is investigated. Change in perfusion of the gastric tube tissue can lead to ischemia; with a high morbidity and mortality as a result. Anastomotic leakage (incidence 520%) is one of the most severe complications after esophagectomy with gastric tube reconstruction. Optical imaging techniques provide for minimal-invasive and real-time visualization tools that can ...
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  Mentions: Academic Medical Center at the University of Amsterdam Ton G. van Leeuwen Daniël M. de Bruin
6. Feasibility of using optical coherence tomography to detect acute radiation-induced esophageal damage in small animal models
  
  Explore SPIE Digital Library Apr 16 2018 Gastroenterology
  
  Lung cancer survival is poor, and radiation therapy patients often suffer serious treatment side effects. The esophagus is particularly sensitive leading to acute radiation-induced esophageal damage (ARIED). We investigated the feasibility of optical coherence tomography (OCT) for minimally invasive imaging of the esophagus with high resolution (10m) to detect ARIED in mice. Thirty mice underwent cone-beam computed tomography imaging for initial setup assessment and dose planning followed by a single-dose ...
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  Mentions: Johannes F. de Boer Academic Medical Center at the University of Amsterdam Ton G. van Leeuwen
7. Quality difference of neointima following the implantation of bioresorbable scaffold and metallic stent in patients with ST elevation myocardial infarction: quantitative assessments by light intensity, light attenuation, and backscatter on optical coheren
  
  Explore eurointervention.org Mar 8 2018 Cardiology
  
  Aims: We aimed to assess possible difference of the neointimal quality after everolimus-eluting bioresorbable scaffold (BVS) implantation in comparison with cobalt chromium everolimus-eluting scaffold (CoCr-EES) by optical frequency domain imaging (OFDI). Methods and results: This study is a post-hoc analysis of TROFI II trial assessing neointimal quality 6-month after the implantation of BVS(N=82) and CoCr-EES(N=87) in STEMI patients. Neointimal light property analysis by OFDI full-automatically computed ...
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  Mentions: Imperial College London Leiden University Academic Medical Center at the University of Amsterdam
8. Ex-vivo study in nephroureterectomy specimens defining the role of 3-D upper urinary tract visualization using optical coherence tomography and endoluminal ultrasound
  
  Explore SPIE Digital Library Feb 17 2018 Urology
  
  Minimal invasive endoscopic treatment for upper urinary tract urothelial carcinoma (UUT-UC) is advocated in patients with low-risk disease and limited tumor volume. Diagnostic ureterorenoscopy combined with biopsy is the diagnostic standard. This study aims to evaluate two alternative diagnostic techniques for UUT-UC: optical coherence tomography (OCT) and endoluminal ultrasound (ELUS). Following nephroureterectomy, OCT, ELUS, and computed tomography (CT) were performed of the complete nephroureterectomy specimen. Visualization software (AMIRA) was used ...
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  Mentions: Academic Medical Center at the University of Amsterdam Dirk J. Faber Ton G. van Leeuwen
9. On-chip Mach-Zehnder interferometer for OCT systems
  
  Explore Home Jan 11 2018
  
  By using integrated optics, it is possible to reduce the size and cost of a bulky optical coherence tomography (OCT) system. One of the OCT components that can be implemented on-chip is the interferometer. In this work, we present the design and characterization of a Mach-Zehnder interferometer consisting of the wavelength-independent splitters and an on-chip reference arm. The Si 3 N 4 was chosen as the material platform as it ...
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  Mentions: Academic Medical Center at the University of Amsterdam Ton G. van Leeuwen B. Imran Akca
10. Label-free optical imaging technologies for rapid translation and use during intraoperative surgical and tumor margin assessment
  
  Explore SPIE Digital Library Jan 4 2018
  
  The biannual International Conference on Biophotonics was recently held on April 30 to May 1, 2017, in Fremantle, Western Australia. This continuing conference series brought together key opinion leaders in biophotonics to present their latest results and, importantly, to participate in discussions on the future of the field and what opportunities exist when we collectively work together for using biophotonics for biological discovery and medical applications. One session in this ...
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  Mentions: Stephen A. Boppart University of Illinois at Urbana-Champaign University of Western Australia
11. Special Section Guest Editorial: Commemorating 25 Years of Optical Coherence Tomography: a Perspective on Biomedical Applications
  
  Explore SPIE Digital Library Dec 20 2017
  
  ptical coherence tomography (OCT) has become a major medical imaging technology in the time since its inception now more than 25 years ago. During this time, OCT has become very well established in ophthalmology, and this application area largely dominates the field. Next in importance and stage of development is cardiovascular medicine, also a strongly commercial technology, but at an earlier stage and a slower pace of uptake than ophthalmology ...
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  Mentions: Peter E. Andersen David D. Sampson University of Washington
12. Optical coherence tomography in gastroenterology: a review and future outlook
  
  Explore SPIE Digital Library Dec 19 2017 Gastroenterology
  
  Optical coherence tomography (OCT) is an imaging technique optically analogous to ultrasound that can generate depth-resolved images with micrometer-scale resolution. Advances in fiber optics and miniaturized actuation technologies allow OCT imaging of the human body and further expand OCT utilization in applications including but not limited to cardiology and gastroenterology. This review article provides an overview of current OCT development and its clinical utility in the gastrointestinal tract, including disease ...
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  Mentions: Columbia University Massachusetts General Hospital Harvard University
13. AMC and LioniX International partner on development of OCT modules
  
  Explore optics.org Nov 30 2017
  
  LioniX International (LXI) and Academic Medical Center (AMC) of the University of Amsterdam are collaborating on the development of Photonic Integrated Circuit-based Optical Coherence Tomography modules. The partners say that the implementation of PIC-based technologies in OCT modules will enable miniaturized handheld OCT modules and so broaden the scope and application of OCT-based systems. AMC and LXI have signed a collaboration agreement to accelerate the development of PIC-based OCT modules ...
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  Mentions: Academic Medical Center at the University of Amsterdam Ton G. van Leeuwen
14. Can we predict necrosis intra-operatively? Real-time optical quantitative perfusion imaging in surgery: study protocol for a prospective, observational, in vivo pilot study
  
  Explore Pilot and Feasibility Studies Nov 28 2017
  
  Background Compromised perfusion as a result of surgical intervention causes a reduction of oxygen and nutrients in tissue and therefore decreased tissue vitality. Quantitative imaging of tissue perfusion during reconstructive surgery, therefore, may reduce the incidence of complications. Non-invasive optical techniques allow real-time tissue imaging, with high resolution and high contrast. The objectives of this study are, first, to assess the feasibility and accuracy of optical coherence tomography (OCT), sidestream ...
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  Mentions: Academic Medical Center at the University of Amsterdam Ton G. van Leeuwen Daniël M. de Bruin
15. OCT Amplitude and Speckle Statistics of Discrete Random Media
  
  Explore Nature Publishing Group Nov 15 2017
  
  Speckle, amplitude fluctuations in optical coherence tomography (OCT) images, contains information on sub-resolution structural properties of the imaged sample. Speckle statistics could therefore be utilized in the characterization of biological tissues. However, a rigorous theoretical framework relating OCT speckle statistics to structural tissue properties has yet to be developed. As a first step, we present a theoretical description of OCT speckle, relating the OCT amplitude variance to size and organization ...
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  Mentions: Academic Medical Center at the University of Amsterdam Dirk J. Faber Ton G. van Leeuwen
16. Visibility of Fiducial Markers used for Image-Guided Radiation Therapy on Optical Coherence Tomography for Registration with CT: an Esophageal Phantom Study
  
  Explore Wiley Online Library Oct 18 2017 Gastroenterology
  
  Purpose Optical coherence tomography (OCT) is of interest to visualize microscopic esophageal tumor extensions to improve tumor delineation for radiation therapy (RT) planning. Fiducial marker placement is a common method to ensure target localization during planning and treatment. Visualization of these fiducial markers on OCT permits integrating OCT and computed tomography (CT) images used for RT planning via image registration. We studied the visibility of 13 (8 types) commercially available ...
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  Mentions: Johannes F. de Boer Academic Medical Center at the University of Amsterdam Dirk J. Faber
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