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Academic Medical Center at the University of Amsterdam

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1. Mentioned In 191 Articles
2. Normative Data and Conversion Equation for Spectral-Domain Optical Coherence Tomography in an International Healthy Control Cohort
  
  Explore LWW Online Sep 2 2022 Ophthalmology
  
  Background: Spectral-domain (SD-) optical coherence tomography (OCT) can reliably measure axonal (peripapillary retinal nerve fiber layer [pRNFL]) and neuronal (macular ganglion cell + inner plexiform layer [GCIPL]) thinning in the retina. Measurements from 2 commonly used SD-OCT devices are often pooled together in multiple sclerosis (MS) studies and clinical trials despite software and segmentation algorithm differences; however, individual pRNFL and GCIPL thickness measurements are not interchangeable between devices. In some circumstances ...
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  Mentions: University College London Oregon Health & Science University Academic Medical Center at the University of Amsterdam
3. Bronchoscopic Journey of in vivo Real-Time Microscopic Imaging in ILD: A Case Series
  
  Explore Karger Publishers Sep 1 2022 Pulmonology
  
  Background: Patients with interstitial lung diseases (ILDs) frequently present with nondiagnostic high-resolution CT (HRCT) scan and bronchoalveolar lavage (BAL) results, resulting in the need for invasive surgical or cryo-lung biopsy that is associated with significant morbidity. Confocal laser endomicroscopy (CLE) and optical coherence tomography (OCT) are high-resolution laser and light-based techniques that provide real-time imaging of the alveolar compartment during bronchoscopy with a different depth and field of view. Objectives ...
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  Mentions: Academic Medical Center at the University of Amsterdam
4. Precision of attenuation coefficient measurements by optical coherence tomography
  
  Explore SPIE Digital Library Aug 10 2022
  
  Significance: Optical coherence tomography (OCT) is an interferometric imaging modality, which provides tomographic information on the microscopic scale. Furthermore, OCT signal analysis facilitates quantification of tissue optical properties (e.g., the attenuation coefficient), which provides information regarding the structure and organization of tissue. However, a rigorous and standardized measure of the precision of the OCT-derived optical properties, to date, is missing. Aim: We present a robust theoretical framework, which provides ...
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  Mentions: Academic Medical Center at the University of Amsterdam
5. Sodium-Iodate Injection Can Replicate Retinal Degenerative Disease Stages in Pigmented Mice and Rats: Non-Invasive Follow-Up Using OCT and ERG
  
  Explore MDPI Open Access Journals Platform Mar 26 2022 Ophthalmology
  
  Purpose: The lack of suitable animal models for (dry) age-related macular degeneration (AMD) has hampered therapeutic research into the disease, so far. In this study, pigmented rats and mice were systematically injected with various doses of sodium iodate (SI). After injection, the retinal structure and visual function were non-invasively characterized over time to obtain in-depth data on the suitability of these models for studying experimental therapies for retinal degenerative diseases ...
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  Mentions: National Institutes of Health Academic Medical Center at the University of Amsterdam University of Bonn
6. Detection of Vulnerable Coronary Plaques Using Invasive and Non-Invasive Imaging Modalities
  
  Explore MDPI Open Access Journals Platform Mar 11 2022 Cardiology
  
  Acute coronary syndrome (ACS) mostly arises from so-called vulnerable coronary plaques, particularly prone for rupture. Vulnerable plaques comprise a specific type of plaque, called the thin-cap fibroatheroma (TFCA). A TCFA is characterized by a large lipid-rich necrotic core, a thin fibrous cap, inflammation, neovascularization, intraplaque hemorrhage, microcalcifications or spotty calcifications, and positive remodeling. Vulnerable plaques are often not visible during coronary angiography. However, different plaque features can be visualized with ...
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  Mentions: Academic Medical Center at the University of Amsterdam
7. Endobronchial Optical Coherence Tomography: Shining New Light on Diagnosing UIP?
  
  Explore Home (thoracic) Feb 12 2022 Pulmonology
  
  To the editor: In 15-30% of patients with a fibrotic interstitial lung disease (ILD) tissue acquisition is indicated as the diagnostic confidence based on clinical and radiological investigations does not justify a specific treatment allocation [1]. However, surgical lung biopsy and transbronchial cryobiopsy are associated with considerable risks of morbidity and even mortality [2]. Minimally invasive imaging techniques have the potential to obviate the need for tissue biopsy in at ...
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  Mentions: Academic Medical Center at the University of Amsterdam VU University Amsterdam
8. Polarization Sensitive Optical Coherence Tomography for Bronchoscopic Airway Smooth Muscle Detection in Bronchial Thermoplasty-Treated Patients With Asthma
  
  Explore ScienceDirect Sep 1 2021 Pulmonology
  
  Asthma is a chronic inflammatory disease characterized by airway remodeling (AR), including thickening of airway smooth muscle (ASM) as a key element of this alteration. 1 Patients with severe asthma may benefit from bronchial thermoplasty (BT), an endoscopic treatment that targets structural AR and induces ASM reduction. 2 Assessment of AR is critical to evaluate the impact of BT and might provide a tool for patient selection for BT. Polarization ...
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  Mentions: Academic Medical Center at the University of Amsterdam VU University Amsterdam
9. Optical coherence tomography (OCT) and irreversible electroporation (IRE) in the diagnosis and treatment of renal masses
  
  Explore UvA DARE Jun 3 2021 Student Theses
  
  The first aim of this thesis is to investigate the diagnostic value of needle-based, percutaneous optical coherence tomography (OCT) in the differentiation of renal masses. Secondly, the feasibility and safety of percutaneous, irreversible electroporation (IRE) are assessed for the treatment of SRMs.
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  Mentions: Academic Medical Center at the University of Amsterdam
10. Optical coherence tomography to measure the progression of myelopathy in adrenoleukodystrophy
  
  Explore Wiley Online Library Apr 1 2021 Ophthalmology
  
  Objective: To prospectively determine the value of optical coherence tomography (OCT) as a surrogate outcome measure for the progression of myelopathy in males with adrenoleukodystrophy. Methods: Retinal nerve fiber layer (RNFL) and ganglion cell layer (GCL) thickness were measured at baseline, 1- and 2-year follow-up in patients and age-matched controls. We assessed the severity of myelopathy with clinical parameters: Expanded Disability Status Scale (EDSS), Severity Scoring system for Progressive Myelopathy ...
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  Mentions: Academic Medical Center at the University of Amsterdam
11. Polarization sensitive optical coherence tomography (PS-OCT) for bronchoscopic airway smooth muscle detection in bronchial thermoplasty treated asthma patients
  
  Explore CHEST Apr 1 2021 Pulmonology
  
  To the editor, 79 Asthma is a chronic inflammatory disease characterized by airway remodeling (AR), 80 including thickening of airway smooth muscle (ASM) as a key element of this alteration (1). 81 Severe asthma patients may benefit from bronchial thermoplasty (BT), an endoscopic 82 treatment that targets structural AR and induces ASM reduction (2). Assessment of AR is 83 critical to evaluate the impact of BT and might provide a ...
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  Mentions: Academic Medical Center at the University of Amsterdam VU University Amsterdam
12. Optical Coherence Tomography-Guided PCI With Single-Antiplatelet Therapy
  
  Explore Home - ClinicalTrials.gov Feb 23 2021 Cardiology , Clinical Trials
  
  Rationale: Dual antiplatelet therapy (DAPT), consisting of aspirin and a P2Y12-inhibitor, reduces the risk of stent thrombosis, myocardial infarction and stroke after coronary stent implantation. Inevitably, it is also associated with a higher risk of (major) bleeding. Given the advances in stent properties, stenting implantation technique and pharmacology, it may be possible to treat patients with a single antiplatelet strategy using a potent P2Y12- inhibitor such as prasugrel. Objective: This ...
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  Mentions: Academic Medical Center at the University of Amsterdam
13. Single-chip optical coherence tomography device
  
  Explore uspto.gov Feb 2 2021 Patents
  
  A high-performance single-chip, integrated-optics-based OCT system is disclosed, where the length of the reference arm is digitally variable. The reference arm includes a plurality of switch stages comprising a 2.times.2 tunable wavelength-independent waveguide switch that can direct an input light signal onto either of two different-length output waveguides. In some embodiments, the directional couplers are thermo-optic based. Some embodiments include a solid-state scanning system for scanning a sample ...
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  Mentions: Academic Medical Center at the University of Amsterdam
14. Bayesian analysis of depth resolved OCT attenuation coefficients
  
  Explore Nature Publishing Group Jan 26 2021
  
  Biomedical engineering Abstract Optical coherence tomography (OCT) is an optical technique which allows for volumetric visualization of the internal structures of translucent materials. Additional information can be gained by measuring the rate of signal attenuation in depth. Techniques have been developed to estimate the rate of attenuation on a voxel by voxel basis. This depth resolved attenuation analysis gives insight into tissue structure and organization in a spatially resolved way.
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  Mentions: Academic Medical Center at the University of Amsterdam
15. In vivo characterization of chick embryo mesoderm by optical coherence tomography‐assisted microindentation
  
  Explore faseb.onlinelibrary.wiley.com Jan 9 2021
  
  Embryos are growing organisms with highly heterogeneous properties in space and time. Understanding the mechanical properties is a crucial prerequisite for the investigation of morphogenesis. During the last 10 years, new techniques have been developed to evaluate the mechanical properties of biological tissues in vivo. To address this need, we employed a new instrument that, via the combination of micro‐indentation with Optical Coherence Tomography (OCT), allows us to determine ...
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  Mentions: Academic Medical Center at the University of Amsterdam
16. Quantification of key retinal features in early and late age-related macular degeneration using deep learning
  
  Explore American Journal of Ophthalmology Jan 7 2021 Ophthalmology
  
  Purpose To develop and validate a deep learning model for segmentation of 13 features associated with neovascular and atrophic age-related macular degeneration (AMD). Design Development and validation of a deep-learning model for feature segmentation Methods Data for model development were obtained from 307 optical coherence tomography volumes. Eight experienced graders manually delineated all abnormalities in 2,712 B-scans. A deep neural network was trained with this data to perform voxel-level ...
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  Mentions: Academic Medical Center at the University of Amsterdam Erasmus University
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