1. Academic Medical Center at the University of Amsterdam

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    1. Mentioned In 188 Articles

    2. Sodium-Iodate Injection Can Replicate Retinal Degenerative Disease Stages in Pigmented Mice and Rats: Non-Invasive Follow-Up Using OCT and ERG

      Sodium-Iodate Injection Can Replicate Retinal Degenerative Disease Stages in Pigmented Mice and Rats: Non-Invasive Follow-Up Using OCT and ERG
      Purpose: The lack of suitable animal models for (dry) age-related macular degeneration (AMD) has hampered therapeutic research into the disease, so far. In this study, pigmented rats and mice were systematically injected with various doses of sodium iodate (SI). After injection, the retinal structure and visual function were non-invasively characterized over time to obtain in-depth data on the suitability of these models for studying experimental therapies for retinal degenerative diseases ...
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    3. Detection of Vulnerable Coronary Plaques Using Invasive and Non-Invasive Imaging Modalities

      Detection of Vulnerable Coronary Plaques Using Invasive and Non-Invasive Imaging Modalities
      Acute coronary syndrome (ACS) mostly arises from so-called vulnerable coronary plaques, particularly prone for rupture. Vulnerable plaques comprise a specific type of plaque, called the thin-cap fibroatheroma (TFCA). A TCFA is characterized by a large lipid-rich necrotic core, a thin fibrous cap, inflammation, neovascularization, intraplaque hemorrhage, microcalcifications or spotty calcifications, and positive remodeling. Vulnerable plaques are often not visible during coronary angiography. However, different plaque features can be visualized with ...
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    4. Endobronchial Optical Coherence Tomography: Shining New Light on Diagnosing UIP?

      Endobronchial Optical Coherence Tomography: Shining New Light on Diagnosing UIP?
      To the editor: In 15-30% of patients with a fibrotic interstitial lung disease (ILD) tissue acquisition is indicated as the diagnostic confidence based on clinical and radiological investigations does not justify a specific treatment allocation [1]. However, surgical lung biopsy and transbronchial cryobiopsy are associated with considerable risks of morbidity and even mortality [2]. Minimally invasive imaging techniques have the potential to obviate the need for tissue biopsy in at ...
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    5. Polarization Sensitive Optical Coherence Tomography for Bronchoscopic Airway Smooth Muscle Detection in Bronchial Thermoplasty-Treated Patients With Asthma

      Polarization Sensitive Optical Coherence Tomography for Bronchoscopic Airway Smooth Muscle Detection in Bronchial Thermoplasty-Treated Patients With Asthma
      Asthma is a chronic inflammatory disease characterized by airway remodeling (AR), including thickening of airway smooth muscle (ASM) as a key element of this alteration. 1 Patients with severe asthma may benefit from bronchial thermoplasty (BT), an endoscopic treatment that targets structural AR and induces ASM reduction. 2 Assessment of AR is critical to evaluate the impact of BT and might provide a tool for patient selection for BT. Polarization ...
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    6. Optical coherence tomography (OCT) and irreversible electroporation (IRE) in the diagnosis and treatment of renal masses

      Optical coherence tomography (OCT) and irreversible electroporation (IRE) in the diagnosis and treatment of renal masses
      The first aim of this thesis is to investigate the diagnostic value of needle-based, percutaneous optical coherence tomography (OCT) in the differentiation of renal masses. Secondly, the feasibility and safety of percutaneous, irreversible electroporation (IRE) are assessed for the treatment of SRMs.
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    7. Optical coherence tomography to measure the progression of myelopathy in adrenoleukodystrophy

      Optical coherence tomography to measure the progression of myelopathy in adrenoleukodystrophy
      Objective: To prospectively determine the value of optical coherence tomography (OCT) as a surrogate outcome measure for the progression of myelopathy in males with adrenoleukodystrophy. Methods: Retinal nerve fiber layer (RNFL) and ganglion cell layer (GCL) thickness were measured at baseline, 1- and 2-year follow-up in patients and age-matched controls. We assessed the severity of myelopathy with clinical parameters: Expanded Disability Status Scale (EDSS), Severity Scoring system for Progressive Myelopathy ...
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    8. Polarization sensitive optical coherence tomography (PS-OCT) for bronchoscopic airway smooth muscle detection in bronchial thermoplasty treated asthma patients

      Polarization sensitive optical coherence tomography (PS-OCT) for bronchoscopic airway smooth muscle detection in bronchial thermoplasty treated asthma patients
      To the editor, 79 Asthma is a chronic inflammatory disease characterized by airway remodeling (AR), 80 including thickening of airway smooth muscle (ASM) as a key element of this alteration (1). 81 Severe asthma patients may benefit from bronchial thermoplasty (BT), an endoscopic 82 treatment that targets structural AR and induces ASM reduction (2). Assessment of AR is 83 critical to evaluate the impact of BT and might provide a ...
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    9. Optical Coherence Tomography-Guided PCI With Single-Antiplatelet Therapy

      Optical Coherence Tomography-Guided PCI With Single-Antiplatelet Therapy
      Rationale: Dual antiplatelet therapy (DAPT), consisting of aspirin and a P2Y12-inhibitor, reduces the risk of stent thrombosis, myocardial infarction and stroke after coronary stent implantation. Inevitably, it is also associated with a higher risk of (major) bleeding. Given the advances in stent properties, stenting implantation technique and pharmacology, it may be possible to treat patients with a single antiplatelet strategy using a potent P2Y12- inhibitor such as prasugrel. Objective: This ...
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    10. Single-chip optical coherence tomography device

      Single-chip optical coherence tomography device
      A high-performance single-chip, integrated-optics-based OCT system is disclosed, where the length of the reference arm is digitally variable. The reference arm includes a plurality of switch stages comprising a 2.times.2 tunable wavelength-independent waveguide switch that can direct an input light signal onto either of two different-length output waveguides. In some embodiments, the directional couplers are thermo-optic based. Some embodiments include a solid-state scanning system for scanning a sample ...
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    11. Bayesian analysis of depth resolved OCT attenuation coefficients

      Bayesian analysis of depth resolved OCT attenuation coefficients
      Biomedical engineering Abstract Optical coherence tomography (OCT) is an optical technique which allows for volumetric visualization of the internal structures of translucent materials. Additional information can be gained by measuring the rate of signal attenuation in depth. Techniques have been developed to estimate the rate of attenuation on a voxel by voxel basis. This depth resolved attenuation analysis gives insight into tissue structure and organization in a spatially resolved way.
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    12. In vivo characterization of chick embryo mesoderm by optical coherence tomography‐assisted microindentation

      In vivo characterization of chick embryo mesoderm by optical coherence tomography‐assisted microindentation
      Embryos are growing organisms with highly heterogeneous properties in space and time. Understanding the mechanical properties is a crucial prerequisite for the investigation of morphogenesis. During the last 10 years, new techniques have been developed to evaluate the mechanical properties of biological tissues in vivo. To address this need, we employed a new instrument that, via the combination of micro‐indentation with Optical Coherence Tomography (OCT), allows us to determine ...
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    13. Quantification of key retinal features in early and late age-related macular degeneration using deep learning

      Quantification of key retinal features in early and late age-related macular degeneration using deep learning
      Purpose To develop and validate a deep learning model for segmentation of 13 features associated with neovascular and atrophic age-related macular degeneration (AMD). Design Development and validation of a deep-learning model for feature segmentation Methods Data for model development were obtained from 307 optical coherence tomography volumes. Eight experienced graders manually delineated all abnormalities in 2,712 B-scans. A deep neural network was trained with this data to perform voxel-level ...
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    14. Optical coherence tomography (OCT) in neuro-ophthalmology

      Optical coherence tomography (OCT) in neuro-ophthalmology
      Optical coherence tomography (OCT) is a non-invasive medical imaging technology that is playing an increasing role in the routine assessment and management of patients with neuro-ophthalmic conditions. Its ability to characterise the optic nerve head, peripapillary retinal nerve fibre layer and cellular layers of the macula including the ganglion cell layer enables qualitative and quantitative assessment of optic nerve disease. In this review, we discuss technical features of OCT and ...
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    15. Longitudinal retinal layer changes in preclinical Alzheimer’s disease

      Longitudinal retinal layer changes in preclinical Alzheimer’s disease
      Purpose Several studies found reduced retinal thickness on optical coherence tomography (OCT) in Alzheimers disease (AD), even in preclinical stages, labelling this technique of interest as biomarker. In this study, we examine retinal thickness changes in preclinical AD, as defined by cognitively normal individuals with amyloid‐beta (A) on positron emission tomography (PET). Methods For this monocentre study, 145 cognitively healthy monozygotic twins aged 60 were included from the Netherlands ...
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    16. 3D co-registration algorithm for catheter-based optical coherence tomography

      3D co-registration algorithm for catheter-based optical coherence tomography
      Applications of catheter-based optical coherence tomography (OCT) - originally developed for cardiovascular imaging - have expanded to other organ systems. However, currently available algorithms to co-register 3D OCT data to a second imaging modality were developed for cardiovascular applications and with it, are tailored to small tubular tissue structures. The available algorithms can often not be applied outside the cardiovascular system, e.g. when an OCT probe is introduced into the kidney ...
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  2. About Academic Medical Center at the University of Amsterdam

    Academic Medical Center at the University of Amsterdam

    Academic Medical Center at the University of Amsterdam.  The Academic Medical Center (AMC) is the most prominent medical center in the Netherlands and one of the largest hospitals. The AMC complex houses the university hospital and the medical faculty of the University of Amsterdam, as well the Netherlands Institute for Neuroscience and the medical department of the Royal Tropical Institute. Also a number of biotech companies – partly AMC spin-offs - are located on the premises. This concentration of expertise makes the AMC ‘more than just a university hospital’ and provides a breeding ground for fruitful scientific collaboration.