1. Academic Medical Center at the University of Amsterdam

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    1. Mentioned In 156 Articles

    2. From sample structure to optical properties and back : A theoretical framework for quantitative OCT and its clinical application (Thesis)

      From sample structure to optical properties and back : A theoretical framework for quantitative OCT and its clinical application (Thesis)
      The aim of this thesis is to provide a methodology to extract quantitative parameters from optical coherence tomography (OCT) images and to relate these parameters to sample properties such as structure, organization and flow. OCT uses near-infrared light to acquire 3D images of biological tissue, with a resolution around 5-15 m and an imaging depth of approximately 2 mm. OCT can be a useful clinical tool for minimally-invasive, high-resolution imaging ...
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    3. Acute Airway Effects of Bronchial Thermoplasty Assessed by Optical Coherence Tomography (OCT)

      Acute Airway Effects of Bronchial Thermoplasty Assessed by Optical Coherence Tomography (OCT)
      Background: Bronchial Thermoplasty (BT) is an endoscopic treatment for severe asthma targeting airway smooth muscle (ASM) with thermal energy. The extent of treatment effect is largely unknown. Optical coherence tomography (OCT) is a high resolution imaging technique, using near-infrared light, that generates near-histology cross sectional images of the airway wall. Aim: Assess the extent of acute airway wall effects of BT with OCT and compare these to the untreated right ...
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    4. Optical Coherence Tomography in Urologic Oncology: a Comprehensive Review

      Optical Coherence Tomography in Urologic Oncology: a Comprehensive Review
      Introduction Optical coherence tomography (OCT) is being investigated in urologic oncology for optical diagnosis. This comprehensive review analyzes the current state of development of OCT for bladder, upper urinary tract, kidney, prostate, testis, and penis cancer. Also, the potential role of OCT with regard to the current diagnostic pathways is critically appraised to guide future developments. Methods Embase and Pubmed were systematically searched for English and German articles on OCT ...
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    5. 5‐Year clinical follow‐up of the COBRA (complex coronary bifurcation lesions: Randomized comparison of a strategy using a dedicated self‐expanding biolimus A9‐eluting stent vs. a culotte strategy using everolimus‐eluting stents) study

      5‐Year clinical follow‐up of the COBRA (complex coronary bifurcation lesions: Randomized comparison of a strategy using a dedicated self‐expanding biolimus A9‐eluting stent vs. a culotte strategy using everolimus‐eluting stents) study
      Objectives We evaluated healing responses with optical coherence tomography, and long‐term clinical outcomes after treatment with a dedicated stent versus a conventional culotte technique. Background Dedicated bifurcation stents have been proposed as an alternative treatment for coronary bifurcation lesions. The long‐term performance of dedicated stents versus conventional dual‐stent techniques for the treatment of complex coronary bifurcation lesions is unknown. Methods Forty patients with true coronary bifurcation lesions ...
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    6. One‐to‐one registration of en‐face optical coherence tomography attenuation coefficients with histology of a prostatectomy specimen

      One‐to‐one registration of en‐face optical coherence tomography attenuation coefficients with histology of a prostatectomy specimen
      Optical coherence tomography (OCT), enables high‐resolution 3D imaging of the morphology of light scattering tissues. From the OCT signal, parameters can be extracted and related to tissue structures. One of the quantitative parameters is the attenuation coefficient; the rate at which the intensity of detected light decays in depth. To couple the quantitative parameters with the histology one‐to‐one registration is needed. The primary aim of this study ...
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    7. Decreasing the Size of a Spectral Domain Optical Coherence Tomography System with Cascaded Arrayed Waveguide Gratings in a Photonic Integrated Circuit

      Decreasing the Size of a Spectral Domain Optical Coherence Tomography System with Cascaded Arrayed Waveguide Gratings in a Photonic Integrated Circuit
      This paper describes a proof-of-concept of a miniaturized spectral-domain optical coherence tomography system, based on photonic integrated circuit (PIC) technology. The integrated optics 512-channel spectrometer consists of cascaded arrayed waveguide gratings (AWG) with the output waveguides directly attached to a CCD detector. The spectrometer has a center wavelength of 850 nm and a spectral sampling interval of 0.22 nm. The PIC has a footprint of 2.0x2.7 cm2 ...
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    8. The role of optical coherence tomography and infrared oculography in assessing the visual pathway and CNS in multiple sclerosis

      The role of optical coherence tomography and infrared oculography in assessing the visual pathway and CNS in multiple sclerosis
      In this review, a current overview is provided of how optical coherence tomography and infrared oculography can aid in assessing the visual system and CNS in multiple sclerosis (MS). Both afferent and efferent visual disorders are common in MS and visual complaints can have a tremendous impact on daily functioning. Optical coherence tomography and infrared oculography can detect and quantify visual disorders with high accuracy, but could also serve as ...
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    9. Correlation between redefined optical coherence tomography parameters and best-corrected visual acuity in non-resolving central serous chorioretinopathy treated with half-dose photodynamic therapy

      Correlation between redefined optical coherence tomography parameters and best-corrected visual acuity in non-resolving central serous chorioretinopathy treated with half-dose photodynamic therapy
      Purpose To assess parameters on optical coherence tomography (OCT), and their correlation with best-corrected visual acuity (BCVA) in patients with non-resolving central serous chorioretinopathy (CSC). Methods For 25 non-resolving CSC patients treated with photodynamic therapy (PDT), the thickness of retinal layers was assessed on the foveal spectral-domain (SD) OCT scan. Evaluated OCT parameters included the central retinal thickness (CRT), defined as the internal limiting membrane (ILM) to ellipsoid zone (EZ ...
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    10. Bronchial Thermoplasty-Induced Acute Airway Effects Assessed with Optical Coherence Tomography in Severe Asthma

      Bronchial Thermoplasty-Induced Acute Airway Effects Assessed with Optical Coherence Tomography in Severe Asthma
      Background: Bronchial thermoplasty (BT) is an endoscopic treatment for severe asthma targeting airway smooth muscle (ASM) with radiofrequent energy. Although implemented worldwide, the effect of BT treatment on the airways is unclear. Optical coherence tomography (OCT) is a novel imaging technique, based on near-infrared light, that generates high-resolution cross-sectional airway wall images. Objective: To assess the safety and feasibility of OCT in severe asthma patients and determine acute airway effects ...
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    11. Feasibility of using optical coherence tomography to detect radiation-induced fibrosis and residual cancer extent after neoadjuvant chemo-radiation therapy: an ex vivo study

      Feasibility of using optical coherence tomography to detect radiation-induced fibrosis and residual cancer extent after neoadjuvant chemo-radiation therapy: an ex vivo study
      Treatment of resectable esophageal cancer includes neoadjuvant chemo-radiation therapy (nCRT) followed by esophagectomy in operable patients. High-risk surgery may have been avoided in patients with a pathological complete response (pCR). We investigated the feasibility of optical coherence tomography (OCT) to detect residual cancer and radiation-induced fibrosis in 10 esophageal cancer patients that underwent nCRT followed by esophagectomy. We compared our OCT findings with histopathology. Overall, OCT was able to differentiate ...
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    12. Needle-based optical coherence tomography for the detection of prostate cancer: a visual and quantitative analysis in 20 patients

      Needle-based optical coherence tomography for the detection of prostate cancer: a visual and quantitative analysis in 20 patients
      iagnostic accuracy of needle-based optical coherence tomography (OCT) for prostate cancer detection by visual and quantitative analysis is defined. 106 three-dimensional (3-D)-OCT data sets were acquired in 20 prostates after radical prostatectomy and precisely matched with pathology. OCT images were grouped per histological category. Two reviewers performed blind assessments of the OCT images. Sensitivity and specificity for malignancy detection were calculated. Quantitative analyses by automated optical attenuation coefficient calculation ...
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    13. Focal Prostate Imaging With CLE and OCT (FPI)

      Focal Prostate Imaging With CLE and OCT (FPI)
      The current limitations in prostate cancer diagnostics lead to over- and undertreatment for a significant fraction of patients. Confocal Laser Endomicroscopy (CLE) and Optical Coherence Tomography (OCT) are focal imaging modalities with potential for in-vivo prostate imaging. The investigators anticipate that integrating focal imaging with MRI/TRUS fusion will further improve prostate cancer detection and provides a real-time histopathological threedimensional representation of the tumor lesions. This is an investigator-initiated, prospective ...
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    14. Confocal Laser Endomicroscopy and Optical Coherence Tomography for the Diagnosis of Prostate Cancer: A Needle-Based, In Vivo Feasibility Study Protocol (IDEAL Phase 2A)

      Confocal Laser Endomicroscopy and Optical Coherence Tomography for the Diagnosis of Prostate Cancer: A Needle-Based, In Vivo Feasibility Study Protocol (IDEAL Phase 2A)
      Background: Focal therapy for prostate cancer has been proposed as an alternative treatment to whole-gland therapies in selected men to diminish side effects in localized prostate cancer. As nowadays imaging cannot offer complete prostate cancer disease characterization, multicore systematic biopsies are recommended (transrectal or transperineal). Optical imaging techniques such as confocal laser endomicroscopy and optical coherence tomography allow in vivo, high-resolution imaging. Moreover, they can provide real-time visualization and analysis ...
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    15. Feasibility of Optical Coherence Tomography (OCT) for Intra-Operative Detection of Blood Flow during Gastric Tube Reconstruction

      Feasibility of Optical Coherence Tomography (OCT) for Intra-Operative Detection of Blood Flow during Gastric Tube Reconstruction
      In this study; an OCT-based intra-operative imaging method for blood flow detection during esophagectomy with gastric tube reconstruction is investigated. Change in perfusion of the gastric tube tissue can lead to ischemia; with a high morbidity and mortality as a result. Anastomotic leakage (incidence 520%) is one of the most severe complications after esophagectomy with gastric tube reconstruction. Optical imaging techniques provide for minimal-invasive and real-time visualization tools that can ...
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    16. Feasibility of using optical coherence tomography to detect acute radiation-induced esophageal damage in small animal models

      Feasibility of using optical coherence tomography to detect acute radiation-induced esophageal damage in small animal models
      Lung cancer survival is poor, and radiation therapy patients often suffer serious treatment side effects. The esophagus is particularly sensitive leading to acute radiation-induced esophageal damage (ARIED). We investigated the feasibility of optical coherence tomography (OCT) for minimally invasive imaging of the esophagus with high resolution (10m) to detect ARIED in mice. Thirty mice underwent cone-beam computed tomography imaging for initial setup assessment and dose planning followed by a single-dose ...
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  2. About Academic Medical Center at the University of Amsterdam

    Academic Medical Center at the University of Amsterdam

    Academic Medical Center at the University of Amsterdam.  The Academic Medical Center (AMC) is the most prominent medical center in the Netherlands and one of the largest hospitals. The AMC complex houses the university hospital and the medical faculty of the University of Amsterdam, as well the Netherlands Institute for Neuroscience and the medical department of the Royal Tropical Institute. Also a number of biotech companies – partly AMC spin-offs - are located on the premises. This concentration of expertise makes the AMC ‘more than just a university hospital’ and provides a breeding ground for fruitful scientific collaboration.