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2. Validation of a semi-automatic software for optical coherence tomography - analysis in heart transplanted patients
  
  Explore Home - Springer Sep 16 2022 Cardiology
  
  Optical Coherence Tomography (OCT) is an intravascular imaging modality enabling detailed evaluation of cardiac allograft vasculopathy (CAV) after heart transplantation (HTx). However, its clinical application remains hampered by time-consuming manual quantitative analysis. We aimed to validate a semi-automated quantitative OCT analysis software (Iowa Coronary Wall Analyzer, ICWA-OCT) to improve OCT-analysis in HTx patients. 23 patients underwent OCT evaluation of all three major coronary arteries at 3 months (3M) and 12 ...
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  Mentions: University of Iowa Aarhus University
3. Optical coherence tomography in coronary atherosclerosis assessment and intervention
  
  Explore Nature Publishing Group Apr 30 2022 Cardiology
  
  Since optical coherence tomography (OCT) was first performed in humans two decades ago, this imaging modality has been widely adopted in research on coronary atherosclerosis and adopted clinically for the optimization of percutaneous coronary intervention. In the past 10 years, substantial advances have been made in the understanding of in vivo vascular biology using OCT. Identification by OCT of culprit plaque pathology could potentially lead to a major shift in ...
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  Mentions: Brigham and Women’s Hospital Johns Hopkins University Massachusetts Institute of Technology
4. Impact of coronary plaque morphology on the precision of computational fractional flow reserve derived from optical coherence tomography imaging
  
  Explore cdn.amegroups.cn Apr 20 2022 Cardiology
  
  $Impact of coronary plaque morphology on the precision of computational fractional flow reserve derived from optical coherence tomography imaging$
  Background: Computational fractional flow reserve (FFR) was recently developed to expand the use of physiology-guided percutaneous coronary intervention (PCI). Nevertheless, current methods do not account for plaque composition. It remains unknown whether the numerical precision of computational FFR is impacted by the plaque composition in the interrogated vessels. Methods: This study is an observational, retrospective, cross-sectional study. Patients who underwent both optical coherence tomography (OCT) and FFR prior to intervention ...
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  Mentions: Fujian Normal University Aarhus University National University of Ireland, Galway
5. Thrombus characteristics evaluated by acute optical coherence tomography in ST elevation myocardial Infarction
  
  Explore Journals | PLOS Apr 11 2022 Cardiology
  
  ...erators discretion. Thrombi were identified in the stored recordings in co-operation with the OCT core lab at Aarhus University Hospital, Skejby, Denmark. After identifying culprit lesion in a coronary artery by angiogra...
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  Mentions: National Institutes of Health Abbott Aarhus University
6. NA-AION Risk Factors: New Perspectives
  
  Explore Home - ClinicalTrials.gov Mar 31 2022 Ophthalmology , Clinical Trials
  
  Non-arteritic anterior ischemic optic neuropathy (NA-AION) is the most common acute optic neuropathy in the middle-aged and elderly population and can also occur in children and young adults. NA-AION leads to irreversible vision loss, and there is currently no effective treatment. In recent years, acellular calcified deposits in the optic nerve head called optic disc drusen (ODD) have been investigated as an important risk factor for NA-AION in patients under ...
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  Mentions: Stanford University University of Copenhagen University of Utah
7. Capillary stall quantification from optical coherence tomography angiogram maximum intensity projections
  
  Explore bioRxiv.org Oct 2 2021 Ophthalmology
  
  Optical coherence tomography (OCT) is applicable to the study of cerebral microvasculature in vivo. Optimised acquisition schemes enable the generation of three-dimensional OCT angiograms, i.e., volumetric images of red blood cell flux in capillary networks, currently at a repetition rate of up to 1/10 seconds. This makes testable a new class of hypotheses that strive to bridge the gap between microscopic phenomena occurring at the spatial scale of ...
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  Mentions: Chinese Academy of Sciences Aarhus University
8. Automatic Characterisation of Human Atherosclerotic Plaque Composition from Intravascular Optical Coherence Tomography Using Artificial Intelligence
  
  Explore eurointervention.pcronline.com Feb 2 2021 Cardiology
  
  Background Intravascular optical coherence tomography (IVOCT) enables detailed plaque characterisation in-vivo, but visual assessment is time-consuming and subjective. Aims This study aims to develop and validate an automatic framework for IVOCT plaque characterisation using artificial intelligence (AI). Methods IVOCT pullbacks from 5 international centres were analysed in a corelab, annotating basic plaque components, inflammatory markers and other structures. A deep convolutional network with encoding-decoding architecture and pseudo-3D input was developed ...
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  Mentions: Cardiovascular Research Foundation Wakayama Medical University Chinese Academy of Sciences
9. Imaging of Cardiac Transplantation: An Overview
  
  Explore ScienceDirect Jan 20 2021 Cardiology
  
  Heart transplantation (HTx) remains the optimal treatment for selected patients with end-stage advanced heart failure. However, survival is limited early by acute rejection and long term by cardiac allograft vasculopathy (CAV). Even though the diagnosis of rejection is based on histology, cardiac imaging provides a pivotal role for early detection and severity assessment of these hazards. The present review focuses on the use and reliability of different invasive and non-invasive ...
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  Mentions: Aarhus University
10. Culprit lesion morphology in patients with ST-segment elevation myocardial infarction assessed by optical coherence tomography
  
  Explore LWW Online Sep 3 2020 Cardiology
  
  Aims This study sought to evaluate the incidence of ruptured plaques and nonruptured plaques (NRP) and to compare patient characteristics and detailed plaque morphology features between the two culprit types in ST-segment elevation myocardial infarction (STEMI) patients, using optical coherence tomography (OCT). Methods and results Using OCT, the culprit lesions in patients with STEMI were assessed prior to stent implantation. The culprit lesion was categorized as ruptured plaques or NRP ...
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  Mentions: Cardiovascular Research Foundation Aarhus University
11. Fractional flow reserve in clinical practice: from wire-based invasive measurement to image-based computation
  
  Explore Journals Dec 30 2019 Cardiology
  
  ...hina (81871460) and by the Program of Shanghai Technology Research Leader. J.W. acknowledges the support from Aarhus University (PhD scholarship). W.W. is the recipient of a Research Professorship Award, by Science Found...
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  Mentions: Leiden University Boston Scientific Abbott
12. First Report of Edge Vascular Response at 12 Months of Magmaris, A Second-Generation Drug-Eluting Resorbable Magnesium Scaffold, Assessed by Grayscale Intravascular Ultrasound, Virtual Histology, and Optical Coherence Tomography. A Biosolve-II Trial Sub-S
  
  Explore ScienceDirect May 23 2019 Cardiology
  
  Introduction and objective The edge vascular response (EVR) remains unknown in second generation drug-eluting Resorbable Magnesium Scaffold (RMS), such as Magmaris. The aim of the study was to evaluate tissue modifications in the RMS edges over time, assessed by different invasive imaging modalities. Methods The patients treated with the device were assessed by optical coherence tomography (OCT), grayscale intravascular ultrasound (IVUS), and virtual histology IVUS at baseline and 12 months ...
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  Mentions: University of São Paulo Universität Rostock University of Lausanne
13. Mechanical performance and healing patterns of the novel sirolimus-eluting bioresorbable Fantom scaffold: 6-month and 9-month follow-up by optical coherence tomography in the FANTOM II study
  
  Explore Open Heart Mar 6 2019 Cardiology
  
  Objectives We aimed to evaluate the mechanical properties and healing patterns 6 and 9 months after implantation of the sirolimus-eluting Fantom bioresorbable scaffold (BRS). Background The Fantom BRS (Reva Medical, San Diego, USA) has differentiating properties including radiopacity, strut thickness of 125 m, high expansion capacity and has demonstrated favourable mid-term clinical and angiographic outcomes. Methods and results FANTOM II was a prospective, single arm study with implantation of the ...
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  Mentions: Leiden University Erasmus University Aarhus University
14. Rational and Design of the European Randomized Optical Coherence Tomography Optimized Bifurcation Event Reduction Trial (OCTOBER)
  
  Explore ScienceDirect Aug 21 2018 Cardiology
  
  Background Percutaneous coronary intervention (PCI) in complex bifurcation lesions is prone to suboptimal implantation results and is associated with increased risk of subsequent clinical events. Angiographic ambiguity is high during bifurcation stenting but it is unknown if procedural guidance by intravascular optical coherence tomography (OCT) improves clinical outcome. Methods and design OCTOBER is a randomized, investigator initiated, multi-center trial aimed to show superiority of OCT guided stent implantation compared to ...
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  Mentions: Tampere University of Technology VU University Amsterdam Aarhus University
15. Plaque Burden Influences Accurate Classification of Fibrous Cap Atheroma by In-Vivo Optical Coherence Tomography in a Porcine Model of Advanced Coronary Atherosclerosis
  
  Explore eurointervention.org Apr 16 2018 Cardiology
  
  Aims: In-vivo validation of coronary optical coherence tomography (OCT) against histology and the effects of plaque burden (PB) on plaque classification remain unreported. We investigated this in a porcine model with human-like coronary atherosclerosis. Methods and results: Five female Yucatan D374Y-PCSK9 transgenic hypercholesterolemic mini-pigs were implanted with a coronary shear-modifying stent to induce advanced atherosclerosis. OCT frames (n=201) were obtained 34 weeks after implantation. Coronary arteries were perfusion-fixed, serially ...
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  Mentions: Imperial College London Royal Brompton Hospital Aarhus University
16. Detection of early changes in the coronary artery microstructure after heart transplantation: A prospective optical coherence tomography study
  
  Explore ScienceDirect Oct 28 2017 Cardiology
  
  Objectives To describe and characterize changes in the coronary artery microstructure during the first year following heart transplantation (HTx) by serial optical coherence tomography (OCT) scans. Background OCT enables in-vivo cardiac allograft vasculopathy (CAV) microstructure characterization. Early coronary artery microstructure changes after HTx may provide important mechanistic information regarding CAV development. Methods Twenty-six patients were enrolled at routine baseline coronary angiography 3 months after HTx. Coronary OCT scans were performed ...
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  Mentions: Leiden University Aarhus University
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