1. Articles mentioning both Zhongping Chen and Matthew Brenner

    1-24 of 24
    1. Endoscopic Optical Coherence Tomography for Assessing Inhalation Airway Injury: A Technical Review

      Endoscopic Optical Coherence Tomography for Assessing Inhalation Airway Injury: A Technical Review
      Diagnosis of inhalation injury has been clinically challenging. Currently, assessment of inhalation injury relies on subjective clinical exams and bronchoscopy, which provides little understanding of tissue conditions and results in limited prognostics. Endoscopic Optical coherence tomography (OCT) technology has been recently utilized in the airway for direct assessment of respiratory tract disorders and injuries. Endoscopic OCT is capable of capturing highresolution images of tissue morphology 1-3 mm beneath the surface ...
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    2. Automatic Proximal Airway Volume Segmentation Using Optical Coherence Tomography for Assessment of Inhalation Injury

      Automatic Proximal Airway Volume Segmentation Using Optical Coherence Tomography for Assessment of Inhalation Injury
      Background Acute respiratory distress syndrome (ARDS) is a severe form of acute lung injury with a mortality rate of up to 40%. Early management of ARDS has been difficult due to the lack of sensitive imaging tools and robust analysis software. We previously designed an optical coherence tomography (OCT) system to evaluate mucosa thickness (MT) post smoke inhalation, but the analysis relied on manual segmentation. The aim of this study ...
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    3. Point-of-care endoscopic optical coherence tomography detects changes in mucosal thickness in ARDS due to smoke inhalation and burns

      Point-of-care endoscopic optical coherence tomography detects changes in mucosal thickness in ARDS due to smoke inhalation and burns
      Background The prevalence of acute respiratory distress syndrome (ARDS) in mechanically ventilated burn patients is 33%, with mortality varying from 1146% depending on ARDS severity. Despite the new Berlin definition for ARDS, prompt bedside diagnosis is lacking. We developed and tested a bedside technique of fiberoptic-bronchoscopy-based optical coherence tomography (OCT) measurement of airway mucosal thickness (MT) for diagnosis of ARDS following smoke inhalation injury (SII) and burns. Methods 16 female ...
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    4. Optical coherence tomography imaging to analyze biofilm thickness from distal to proximal regions of the endotracheal tubes

      Optical coherence tomography imaging to analyze biofilm thickness from distal to proximal regions of the endotracheal tubes
      The development of nosocomial ventilator-associated pneumonia (VAP) has been linked to the presence of specific bacteria found in the biofilm that develops in intubated endotracheal tubes of critical care patients. Presence of biofilm has been difficult to assess clinically. Here, we use Optical coherence tomography (OCT), to visualize the biofilm at both the proximal and distal tips. Ultimately, the goal will be to determine if OCT can be a tool ...
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    5. Visualizing biofilm formation in endotracheal tubes using endoscopic three-dimensional optical coherence tomography

      Visualizing biofilm formation in endotracheal tubes using endoscopic three-dimensional optical coherence tomography
      Biofilm formation has been linked to ventilator-associated pneumonia, which is a prevalent infection in hospital intensive care units. Currently, there is no rapid diagnostic tool to assess the degree of biofilm formation or cellular biofilm composition. Optical coherence tomography (OCT) is a minimally invasive, nonionizing imaging modality that can be used to provide high-resolution cross-sectional images. Biofilm deposited in critical care patients endotracheal tubes was analyzed in vitro . This study ...
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    6. UC Irvine Receives at 2014 NIH Grant for Evaluation of Obstructive Sleep Apnea with Long Range 3D Endoscopic FD-OCT

      UC Irvine Receives at 2014 NIH Grant  for Evaluation of Obstructive Sleep Apnea with Long Range 3D Endoscopic FD-OCT
      ...ablished track record in the development of optical imaging methods and translational research. Co-mentor Dr. Matthew Brenner, Professor and Chief of Pulmonary Medicine at the Lung Center at the University of California ...
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    7. In vivo detection of inhalation injury in large airway using three-dimensional long-range swept-source optical coherence tomography

      In vivo detection of inhalation injury in large airway using three-dimensional long-range swept-source optical coherence tomography
      We report on the feasibility of using long-range swept-source optical coherence tomography (OCT) to detect airway changes following smoke inhalation in a sheep model. The long-range OCT system (with axial imaging range of 25 mm) and probe are capable of rapidly obtaining a series of high-resolution full cross-sectional images and three-dimensional reconstructions covering 20-cm length of tracheal and bronchial airways with airway diameter up to 25 mm, regardless of the ...
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    8. Integrated IVUS-OCT for Real-Time Imaging of Coronary Atherosclerosis

      Integrated IVUS-OCT for Real-Time Imaging of Coronary Atherosclerosis
      Accurate assessment of atherosclerotic plaque characteristics and the subsequent tailoring of optimal therapy holds great promise for preventing acute coronary syndromes (ACS) and life-threatening sequelae 1 . Combined use of optical coherence tomography (OCT) and intravascular ultrasound (IVUS) was proposed as a potential method for accurate assessment of plaque characteristics and vulnerability ( 2 , ). However, significant challenges remain in trying to adapt an integrated OCT-IVUS system for clinical applications. We report here ...
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    9. Endoscopic long range fourier domain optical coherence tomography (LR-FD-OCT)

      Endoscopic long range fourier domain optical coherence tomography (LR-FD-OCT)
      An endoscopic swept-source Fourier Domain optical coherence tomographic system (FDOCT system) for imaging of tissue structure includes a Fourier Domain mode locked (FDML), high speed, narrow line-width, wavelength swept source, an OCT interferometer having a sample arm, a reference arm, a detection arm, and a source arm coupled to the swept source, an endoscopic probe coupled to the sample arm, and a data processing circuit coupled to the detection arm ...
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    10. Integrated intravascular optical coherence tomography (OCT) - ultrasound (US) catheter for characterization of atherosclerotic plaques in vivo

      Integrated intravascular optical coherence tomography (OCT) - ultrasound (US) catheter for characterization of atherosclerotic plaques in vivo
      A miniature integrated intravascular optical coherence tomography (OCT) - ultrasound (US) catheter for real-time imaging of atherosclerotic plaques has been developed, providing high resolution and deep tissue penetration at the same time. This catheter, with an outer diameter of 1.18mm, is suitable for imaging in human coronary arteries. The first in vivo 3D imaging of atherosclerotic microstructure in a rabbit abdominal aorta obtained by an integrated OCT-US catheter is presented ...
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    11. Investigating in vivo airway wall mechanics during tidal breathing with optical coherence tomography

      Investigating in vivo airway wall mechanics during tidal breathing with optical coherence tomography
      Optical coherence tomography (OCT) is a nondestructive imaging technique offering high temporal and spatial resolution, which makes it a natural choice for assessing tissue mechanical properties. We have developed methods to mechanically analyze the compliance of the rabbit trachea in vivo using tissue deformations induced by tidal breathing, offering a unique tool to assess the behavior of the airways during their normal function. Four-hundred images were acquired during tidal breathing ...
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    12. Recent advances in optical coherence tomography for the diagnoses of lung disorders

      Recent advances in optical coherence tomography for the diagnoses of lung disorders
      There have been many advances in the field of diagnostic and therapeutic pulmonary medicine in the past several years, with major progress in the field of imaging. Optical coherence tomography (OCT) is a high-resolution (micron level) imaging modality currently being advanced with the potential to image airway wall structures in real time and at higher resolution than previously possible. OCT has the potential to increase the sensitivity and specificity of ...
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    13. UC Irvine Receives NIH Award for Evaluation of Obstructive Sleep Apnea with Long Range 3D Endoscopic Fourier Domain OCT

      UC Irvine Receives NIH Award for Evaluation of Obstructive Sleep Apnea with Long Range 3D Endoscopic Fourier Domain OCT
      ...ablished track record in the development of optical imaging methods and translational research. Co-mentor Dr. Matthew Brenner, Professor and Chief of Pulmonary Medicine at the Lung Center at the University of California ...
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    14. Novel combined miniature optical coherence tomography ultrasound probe for in vivo intravascular imaging

      Novel combined miniature optical coherence tomography ultrasound probe for in vivo intravascular imaging
      We have developed a miniature integrated optical coherence tomography (OCT) ultrasound (US) probing system for intravascular imaging applications. In the OCT probe, the light coming out of a single mode fiber is focused by a gradient-index lens and then reflected by a right-angle prism from the side of the probe into the sample. It was combined with a 35 MHz PMN-PT side-viewing ultrasound transducer to obtain the ultrasound image as ...
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    15. Detection and monitoring of early airway injury effects of half-mustard (2-chloroethylethylsulfide) exposure using high-resolution optical coherence tomography

      Optical coherence tomography (OCT) is a noninvasive, high-resolution imaging technology capable of delivering real-time, near-histologic images of tissues. Mustard gas is a vesicant-blistering agent that can cause severe and lethal damage to airway and lungs. The ability to detect and assess airway injury in the clinical setting of mustard exposure is currently limited. The purpose of this study is to assess the ability to detect and monitor progression of half-mustard ...
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    16. Optical coherent tomographic (OCT) imaging apparatus and method using a fiber bundle

      Comment "Since 2004, Moptim imaging technical Ltd has cooperated with Graduate school at shenzhen Tsinghua University of China in OCT (optical ..." - John Sibney
      A fiber-optic bundle based optical coherence tomography (OCT) probe method is demonstrated in a multimode optical fiber bundle based OCT system. The system can achieve a lateral resolution of 12 .mu.m and an axial resolution of 10 .mu.m using a super-luminescent diode source. This imaging approach eliminates any moving parts in the probe and has a primary advantage for use in extremely compact and safe OCT endoscopes to ...
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    17. Advances in oral cancer detection using optical coherence tomography

      Advances in oral cancer detection using optical coherence tomography
      Optical coherence tomography (OCT) is a new modality capable of cross sectional imaging of biological tissue. Due to its many technical advantages such as high image resolution, fast acquisition time, and noninvasive capabilities, OCT is potentially useful in various medical applications. Because OCT systems can function with a fiber optic probe, they are applicable to almost any anatomic structures accessible either directly, or by endoscopy. OCT has the potential to ...
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  2. Organizations in the News

    1. (23 articles) UC Irvine
    2. (4 articles) University of Southern California
    3. (2 articles) National Institutes of Health
    4. (1 articles) University of South Florida
    5. (1 articles) Washington University in St. Louis
    6. (1 articles) University of Western Australia
  3. People in the News

    1. (7 articles) Jun Zhang
    2. (4 articles) Joseph C. Jing
    3. (4 articles) Jiechen Yin
    4. (4 articles) Gangjun Liu
    5. (4 articles) Qifa Zhou
    6. (4 articles) K. Kirk Shung
    7. (4 articles) Xiang Li
    8. (3 articles) Jiawen Li
    9. (2 articles) Steven C. George
    10. (2 articles) Sang-Won Lee
    11. (2 articles) Jagat Narula
    12. (1 articles) David D. Sampson
  4. OCT Companies in the News

    1. (1 articles) OCT Medical Imaging Inc