1. Common detector for combined raman spectroscopy-optical coherence tomography

      Common detector for combined raman spectroscopy-optical coherence tomography
      An apparatus includes first and second light sources for respectively generating broadband and monochromatic lights, a beamsplitter optically coupled to the first light source for splitting the broadband light into a reference light and a sample light, a reference arm optically coupled to the beamsplitter for receiving the reference light and returning the received reference light into the beamsplitter, a sample arm optically coupled to the beamsplitter and the second ...
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    2. A clinical instrument for combined raman spectroscopy-optical coherence tomography of skin cancers

      A clinical instrument for combined raman spectroscopy-optical coherence tomography of skin cancers
      ...Veterans Affairs Tennessee Valley Healthcare System, Nashville, Tennessee 37212 College of Arts and Sciences, Vanderbilt University, Nashville, Tennessee 37235 Division of Dermatology, Department of Medicine, Vanderbilt ...
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    3. Integrated system for combined Raman spectroscopy–spectral domain optical coherence tomography

      Integrated system for combined Raman spectroscopy–spectral domain optical coherence tomography
      Raman spectroscopy (RS) and optical coherence tomography (OCT) are powerful tools for optical analysis of tissues with mutually complementary strengths and limitations. OCT excels at visualizing tissue microstructure but lacks molecular specificity, while RS can relay tissue biochemical composition but typically cannot relate microstructure. Previous implementations of combined RS-OCT have utilized a common sample arm while maintaining independent RS and OCT detection arms. We present the design and application of ...
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    4. Structural and biochemical characterization of the rat retina with combined Raman spectroscopy-optical coherence tomography (RS-SDOCT)

      Structural and biochemical characterization of the rat retina with combined Raman spectroscopy-optical coherence tomography (RS-SDOCT)
      Raman spectroscopy (RS) and Optical Coherence Tomography (OCT) are powerful tools for optical analysis of tissues with complimentary strengths. OCT excels and visualizing tissue microstructure while RS can relay tissue biochemical composition. Both instruments have significant potential to serve as valuable tools in non-invasive characterization of the rodent models of retinal disease. In this abstract we present the design and application of a common detector combined RS-OCT instrument for evaluating ...
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    5. A clinical probe for combined Raman spectroscopy/optical coherence tomography (RS-OCT) of the skin cancers

      A clinical probe for combined Raman spectroscopy/optical coherence tomography (RS-OCT) of the skin cancers
      Skin cancer is the most commonly occurring cancer, with incidence rates rising annually. Realizing favorable outcomes requires early diagnosis, for which the current standard is biopsy followed by histopathology. This process can be invasive, subjective, time consuming, and costly. Optical techniques, including Optical Coherence Tomography (OCT) and Raman Spectroscopy (RS), have been developed to perform non-invasive characterization of skin lesions, however neither is without limitation. Here, we demonstrate a clinical ...
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    6. Combined Raman spectroscopy and optical coherence tomography device for tissue characterization

      Combined Raman spectroscopy and optical coherence tomography device for tissue characterization
      We report a dual-modal device capable of sequential acquisition of Raman spectroscopy (RS) and optical coherence tomography (OCT) along a common optical axis. The device enhances application of both RS and OCT by precisely guiding RS acquisition with OCT images while also compensating for the lack of molecular specificity in OCT with the biochemical specificity of RS. We characterize the system performance and demonstrate the capability to identify structurally ambiguous ...
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    1. (2 articles) University of Twente