1. Articles mentioning both University of Washington and Lin An

    1-24 of 24
    1. Methods of reducing motion artifacts for optical coherence tomography angiography

      Methods of reducing motion artifacts for optical coherence tomography angiography
      A method for reducing motion artifacts in optical coherence tomography (OCT) angiography images is disclosed. The method is applied to the intensity or complex OCT data prior to applying the motion contrast analysis and involves determining sub-pixel level shifts between at least two B-scans repeated approximately at the same location and applying the sub-pixel level shifts to the B-scans to be able to correct for motion and accurately determine motion ...
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    2. Comparison Between Spectral-Domain and Swept-Source Optical Coherence Tomography Angiographic Imaging of Choroidal Neovascularization

      Comparison Between Spectral-Domain and Swept-Source Optical Coherence Tomography Angiographic Imaging of Choroidal Neovascularization
      Purpose : The purpose of this study was to compare imaging of choroidal neovascularization (CNV) using swept-source (SS) and spectral-domain (SD) optical coherence tomography angiography (OCTA). Methods : Optical coherence tomography angiography was performed using a 100-kHz SS-OCT instrument and a 68-kHz SD-OCTA instrument (Carl Zeiss Meditec, Inc.). Both 3 3- and 6 6-mm 2 scans were obtained on both instruments. The 3 3-mm 2 SS-OCTA scans consisted of 300 A-scans per ...
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    3. Projection Artifact Removal Improves Visualization and Quantitation of Macular Neovascularization Imaged by Optical Coherence Tomography Angiography

      Projection Artifact Removal Improves Visualization and Quantitation of Macular Neovascularization Imaged by Optical Coherence Tomography Angiography
      Purpose To visualize and quantify the size and vessel density of macular neovascularization (MNV) using optical coherence tomography angiography (OCTA) with a projection artifact removal algorithm. Design Multicenter, observational study. Participants Subjects with MNV in 1 eye. Methods Patients were imaged using either a swept-source OCTA prototype system or a spectral-domain OCTA prototype system. The optical microangiography (OMAG) algorithm was used to generate the OCTA images. Projection artifacts from the ...
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    4. Optical Coherence Tomography Angiography of Asymptomatic Neovascularization in Intermediate Age-Related Macular Degeneration

      Optical Coherence Tomography Angiography of Asymptomatic Neovascularization in Intermediate Age-Related Macular Degeneration
      Purpose To determine whether angiography with swept-source (SS) optical coherence tomography (OCT) identifies subclinical type 1 neovascularization in asymptomatic eyes with intermediate age-related macular degeneration (iAMD). Design Prospective, observational, consecutive case series. Participants Patients with asymptomatic iAMD in one eye and neovascular age-related macular degeneration (AMD) in their fellow eye. Methods The patients underwent SS OCT angiography (OCTA), fluorescein angiography (FA), and indocyanine green angiography (ICGA), and the images from ...
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    5. SWEPT SOURCE OCT ANGIOGRAPHY OF NEOVASCULAR MACULAR TELANGIECTASIA TYPE 2

      SWEPT SOURCE OCT ANGIOGRAPHY OF NEOVASCULAR MACULAR TELANGIECTASIA TYPE 2
      Background/Purpose: To image subretinal neovascularization in proliferative macular telangiectasia Type 2 (MacTel2) using swept source optical coherence tomography based microangiography (OMAG). Methods: Patients with macular telangiectasia Type 2 were enrolled in a prospective, observational study known as the MacTel Project and evaluated using a high-speed 1,050 nm swept-source OCT prototype system. The OMAG algorithm generated en face flow images from three retinal layers, and the region bounded by ...
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    6. Wide-field imaging of retinal vasculature using optical coherence tomography-based microangiography provided by motion tracking.

      Wide-field imaging of retinal vasculature using optical coherence tomography-based microangiography provided by motion tracking.
      Optical coherence tomography (OCT)-based optical microangiography (OMAG) is a high-resolution, noninvasive imaging technique capable of providing three-dimensionalin vivoblood flow visualization within microcirculatory tissue beds in the eye. Although the technique has demonstrated early clinical utility by imaging diseased eyes, its limited field of view (FOV) and the sensitivity to eye motion remain the two biggest challenges for the widespread clinical use of the technology. Here, we report the results ...
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    7. Development of Spectral Domain Optical Coherence Tomography for in vivo Functional Imaging of Biological Tissues (Thesis)

      Development of Spectral Domain Optical Coherence Tomography for in vivo Functional Imaging of Biological Tissues (Thesis)
      Optical coherence tomography is a rapidly developing optical imaging modality capable of noninvasively providing depth resolved information of biological tissue at micrometer scale. Since its first report in 1991, it has made tremendous progress leading to successful applications in a number of fields, such as ophthalmology, gastroenterology, dermatology, dentistry, dermatology, cardiology, etc. According to [1], there are more than 15, 000 OCT units that had been put into service in ...
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    8. Noninvasive imaging of pulsatile movements of the optic nerve head in normal human subjects using phase-sensitive spectral domain optical coherence tomography

      Noninvasive imaging of pulsatile movements of the optic nerve head in normal human subjects using phase-sensitive spectral domain optical coherence tomography
      ...ent of Bioengineering, University of Washington, Seattle, Washington 98195, USA 2Department of Ophthalmology, University of Washington, Seattle, Washington 98104, USA We report use of high-speed spectral domain optical c...
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    9. High-resolution 1050 nm spectral domain retinal optical coherence tomography at 120 kHz A-scan rate with 6.1 mm imaging depth

      High-resolution 1050 nm spectral domain retinal optical coherence tomography at 120 kHz A-scan rate with 6.1 mm imaging depth
      We report a newly developed high speed 1050nm spectral domain optical coherence tomography (SD-OCT) system for imaging posterior segment of human eye. The system is capable of an axial resolution at ~10 m in air, an imaging depth of 6.1 mm in air, a system sensitivity fall-off at ~6 dB/3mm and an imaging speed of 120,000 A-scans per second. We experimentally demonstrate the systems capability to perform ...
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    10. Extended imaging depth to 12 mm for 1050-nm spectral domain optical coherence tomography for imaging the whole anterior segment of the human eye at 120-kHz A-scan rate

      Extended imaging depth to 12 mm for 1050-nm spectral domain optical coherence tomography for imaging the whole anterior segment of the human eye at 120-kHz A-scan rate
      We demonstrate a 1050-nm spectral domain optical coherence tomography (OCT) system with a 12mm imaging depth in air, a 120kHz A-scan rate and a 10m axial resolution for anterior-segment imaging of human eye, in which a new prototype InGaAs linescan camera with 2048 active-pixel photodiodes is employed to record OCT spectral interferograms in parallel. Combined with the full-range complex technique, we show that the system delivers comparable imaging performance to ...
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    11. Optical microangiography provides correlation between microstructure and microvasculature of optic nerve head in human subjects

      Optical microangiography provides correlation between microstructure and microvasculature of optic nerve head in human subjects
      It is demonstrated that optical microangiography (OMAG) is capable of imaging the detailed microstructure and microvasculature of the in vivo human optic nerve head (ONH), including the prelaminar tissue, the lamina cribrosa, the scleral rim and the vessels in the region of the circle of Zin-Haller. For demonstration, an ultrahigh sensitive OMAG system operating in the 850 nm wavelength region and a 500 kHz A-scan rate resulting in a spatial ...
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    12. Quantifying Optical Microangiography Images Obtained from a Spectral Domain Optical Coherence Tomography System

      Quantifying Optical Microangiography Images Obtained from a Spectral Domain Optical Coherence Tomography System
      The blood vessel morphology is known to correlate with several diseases, such as cancer, and is important for describing several tissue physiological processes, like angiogenesis. Therefore, a quantitative method for characterizing the angiography obtained from medical images would have several clinical applications. Optical microangiography (OMAG) is a method for obtaining three-dimensional images of blood vessels within a volume of tissue. In this study we propose to quantify OMAG images obtained ...
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    13. Automated segmentation of intramacular layers in Fourier domain optical coherence tomography structural images from normal subjects

      Automated segmentation of intramacular layers in Fourier domain optical coherence tomography structural images from normal subjects
      Segmentation of optical coherence tomography (OCT) cross-sectional structural images is important for assisting ophthalmologists in clinical decision making in terms of both diagnosis and treatment. We present an automatic approach for segmenting intramacular layers in Fourier domain optical coherence tomography (FD-OCT) images using a searching strategy based on locally weighted gradient extrema, coupled with an error-removing technique based on statistical error estimation. A two-step denoising preprocess in different directions is ...
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    14. Using ultrahigh sensitive optical microangiography to achieve comprehensive depth resolved microvasculature mapping for human retina

      Using ultrahigh sensitive optical microangiography to achieve comprehensive depth resolved microvasculature mapping for human retina
      ...ses with significant vascular involvement, such as diabetic retinopathy and age-related macular degeneration. Lin An, Tueng T. Shen and Ruikang K. Wang, "Using ultrahigh sensitive optical microangiography to achieve comp...
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    15. Multifunctional imaging of human retina and choroid with 1050-nm spectral domain optical coherence tomography at 92-kHz line scan rate

      Multifunctional imaging of human retina and choroid with 1050-nm spectral domain optical coherence tomography at 92-kHz line scan rate
      ... the volumetric imaging of microstructure and microvasculature within retina and choroid. Ruikang K. Wang and Lin An, "Multifunctional imaging of human retina and choroid with 1050-nm spectral domain optical coherence to...
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  2. Organizations in the News

    1. (6 articles) University of Miami
    2. (2 articles) Oregon Health & Science University
    3. (1 articles) Universidade Federal de São Paulo
    4. (1 articles) George Washington University
    5. (1 articles) FDA
  3. People in the News

    1. (23 articles) Ruikang K. Wang
    2. (6 articles) Mary K. Durbin
    3. (6 articles) Philip J. Rosenfeld
    4. (5 articles) Utkarsh Sharma
    5. (5 articles) Giovanni Gregori
    6. (4 articles) Zhongwei Zhi
    7. (4 articles) Peng Li
    8. (3 articles) Roberto Reif
    9. (3 articles) Tueng T. Shen
    10. (2 articles) Douglas S. Malchow
    11. (2 articles) Yali Jia
    12. (1 articles) Johannes F. de Boer
  4. OCT Companies in the News

    1. (8 articles) Carl Zeiss Meditec
    2. (2 articles) UTC Aerospace Systems