1. Articles mentioning both University of Toronto and Institute of Applied Physics

    1-18 of 18
    1. Optical coherence angiography for pre-treatment assessment and treatment monitoring following photodynamic therapy: a basal cell carcinoma patient study

      Optical coherence angiography for pre-treatment assessment and treatment monitoring following photodynamic therapy: a basal cell carcinoma patient study
      Microvascular networks of human basal cell carcinomas (BCC) and surrounding skin were assessed with optical coherence angiography (OCA) in conjunction with photodynamic therapy (PDT). OCA images were collected and analyzed in 31 lesions pre-treatment, and immediately/24hours/312 months post-treatment. Pre-treatment OCA enabled differentiation between prevalent subtypes of BCC (nodular and superficial) and nodular-with-necrotic-core BCC subtypes with a diagnostic accuracy of 78%; this can facilitate more accurate biopsy reducing sampling ...
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    2. Analysis of low-scattering regions in optical coherence tomography

      Analysis of low-scattering regions in optical coherence tomography
      Analysis of semi-transparent low scattering biological structures in optical coherence tomography (OCT) has been actively pursued in the context of lymphatic imaging, with most approaches relying on the relative absence of signal as a means of detection. Here we present an alternate methodology based on spatial speckle statistics, utilizing the similarity of a distribution of given voxel intensities to the power distribution function of pure noise, to visualize the low-scattering ...
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    3. Optical coherence tomography‐based angiography device with real‐time angiography B‐scans visualization and hand‐held probe for everyday clinical use

      Optical coherence tomography‐based angiography device with real‐time angiography B‐scans visualization and hand‐held probe for everyday clinical use
      ...xander Moiseev, Nano‐optics and highly sensitive optical measurement department, Institute of Applied Physics Russian Academy of Sciences, Nizhny Novgorod, Russia.Email: aleksandr.moiseev@gmail.com Alexander Moiseev, Nan...
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    4. Quantitative Cross-Polarization Optical Coherence Tomography Detection of Infiltrative Tumor Margin in a Rat Glioma Model: a Pilot Study

      Quantitative Cross-Polarization Optical Coherence Tomography Detection of Infiltrative Tumor Margin in a Rat Glioma Model: a Pilot Study
      Determining boundaries of infiltrative glial tumors remains a challenging problem in neurooncology. Optical coherence tomography (OCT) with cross-polarization (CP) visualization is a promising technique as a surgical guidance tool. However, the outcome of the procedures performed under OCT guidance strongly depends on the surgeons qualification. Thus, a quantitative method for assessing resection margins with OCT is required. The aim of this study was to develop a robust quantitative approach for ...
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    5. Pixel classification method in optical coherence tomography for tumor segmentation and its complementary usage with OCT microangiography

      Pixel classification method in optical coherence tomography for tumor segmentation and its complementary usage with OCT microangiography
      A novel machine-learning method to distinguish between tumor and normal tissue in optical coherence tomography (OCT) has been developed. Pre-clinical murine ear model implanted with mouse colon carcinoma CT-26 was used. Structural-image-based feature sets were defined for each pixel and machine learning classifiers were trained using ground truth OCT images manually segmented by comparison with histology. The accuracy of the OCT tumour segmentation method was then quantified by comparing with ...
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    6. Multiparameter thermo-mechanical OCT-based characterization of laser-induced cornea reshaping

      Multiparameter thermo-mechanical OCT-based characterization of laser-induced cornea reshaping
      Phase-sensitive optical coherence tomography (OCT) is used for visualizing dynamic and cumulative strains and corneashape changes during laser-produced tissue heating. Such non-destructive (non-ablative) cornea reshaping can be used as a basis of emerging technologies of laser vision correction. In experiments with cartilaginous samples, polyacrilamide phantoms and excised rabbit eyes we demonstrate ability of the developed OCT system to simultaneously characterize transient and cumulated strain distributions, surface displacements, scattering tissue properties ...
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    7. Vessel-contrast enhancement in label-free optical coherence angiography based on phase and amplitude speckle variability

      Vessel-contrast enhancement in label-free optical coherence angiography based on phase and amplitude speckle variability
      Recently proposed in vivo label-free optical coherence angiography techniques based on phase and amplitude speckle variability often require additional signal pre- and post processing operations to enhance vessel-contrast. We observe here 1) contrast enhancement by optimizing the signal normalization/weighing before processing; 2) algorithm based on Kasai estimator for phase compensation between processed A-scans to reduce masking role of motion artifacts; and 3) image projection through the imaging depth for ...
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    8. Robust strain mapping in optical coherence elastography by combining local phase-resolved measurements and cumulative displacement tracking

      Robust strain mapping in optical coherence elastography by combining local phase-resolved measurements and cumulative displacement tracking
      We report a novel hybrid method of robust strain mapping in compressional optical coherence elastography using combined phase measurements on sub-wavelength-scale and cumulative pixel-scale displacement tracking. This hybrid nature significantly extends the range of measurable displacements and strains in comparison with conventional direct phase-resolved measurements. As a result, the proposed strain-mapping method exhibits significantly increased robustness with respect to both additive noise and decorrelation noise produced by displacements and strains ...
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    9. Characterization of atherosclerotic plaques by cross-polarization optical coherence tomography

      Characterization of atherosclerotic plaques by cross-polarization optical coherence tomography
      We combined cross-polarization optical coherence tomography (CP OCT) and non-linear microscopy based on second harmonic generation (SHG) and two-photon-excited fluorescence (2PEF) to assess collagen and elastin fibers in the development of the atherosclerotic plaque (AP). The study shows potential of CP OCT for the assessment of collagen and elastin fibers condition in atherosclerotic arteries. Specifically, the additional information afforded by CP OCT, related to birefringence and cross-scattering properties of arterial ...
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    10. Multi-modal optical imaging characterization of atherosclerotic plaques

      Multi-modal optical imaging characterization of atherosclerotic plaques
      We combined cross-polarization optical coherence tomography (CP OCT) and non-linear microscopy based on second harmonic generation (SHG) and two-photon-excited fluorescence (2PEF) to assess collagen and elastin fibers and other vascular structures in the development of atherosclerosis, including identification of vulnerable plaques, which remains an important clinical problem and imaging application. CP OCT's ability to visualize tissue birefringence and cross-scattering adds new information about the microstructure and composition of the ...
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    11. Deformation-induced speckle-pattern evolution and feasibility of correlational speckle tracking in optical coherence elastography

      Deformation-induced speckle-pattern evolution and feasibility of correlational speckle tracking in optical coherence elastography
      Feasibility of speckle tracking in optical coherence tomography (OCT) based on digital image correlation (DIC) is discussed in the context of elastography problems. Specifics of applying DIC methods to OCT, compared to processing of photographic images in mechanical engineering applications, are emphasized and main complications are pointed out. Analytical arguments are augmented by accurate numerical simulations of OCT speckle patterns. In contrast to DIC processing for displacement and strain estimation ...
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    12. The Use of Cross-Polarization OCT in Determining the Dynamics of the State of Pathological and Normal Tissues During Radiation and Photodynamic Therapy

      The Use of Cross-Polarization OCT in Determining the Dynamics of the State of Pathological and Normal Tissues During Radiation and Photodynamic Therapy
      ...ls and Methods. The CP OCT investigation was performed with an OCT-1300U (Institute of Applied Physics of the Russian Academy of Sciences, LLC Biomedtech, Russia) tomograph. The monitoring of the two types of treatment w...
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    13. The Development of the Methodology of Monitoring Experimental Tumors Using Multimodal Optical Coherence Tomography: the Choice of an Optimal Tumor Model

      The Development of the Methodology of Monitoring Experimental Tumors Using Multimodal Optical Coherence Tomography: the Choice of an Optimal Tumor Model
      ...imental high-speed spectral-domain multimodal OCT system developed at the Institute of Applied Physics of the Russian Academy of Sciences (Russia). The technical characteristics of the system are the following: speed of ...
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    14. Scan-pattern and signal processing for microvasculature visualization with complex SD-OCT: tissue-motion artifacts robustness and decorrelation time - blood vessel characteristics

      Scan-pattern and signal processing for microvasculature visualization with complex SD-OCT: tissue-motion artifacts robustness and decorrelation time - blood vessel characteristics
      We propose a modification of OCT scanning pattern and corresponding signal processing for 3D visualizing blood microcirculation from complex-signal B-scans. We describe the scanning pattern modifications that increase the methods robustness to bulk tissue motion artifacts, with speed up to several cm/s. Based on these modifications, OCT-based angiography becomes more realistic under practical measurement conditions. For these scan patterns, we apply novel signal processing to separate the blood vessels ...
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    15. Recent Trends in Multimodal Optical Coherence Tomography. II. The Correlation-Stability Approach in OCT Elastography and Methods for Visualization of Microcirculation

      Recent Trends in Multimodal Optical Coherence Tomography. II. The Correlation-Stability Approach in OCT Elastography and Methods for Visualization of Microcirculation
      ...ch in OCT Elastography and Methods for Visualization of Microcirculation Institute of Applied Physics of the Russian Academy of Sciences, Nizhny Novgorod, Russia Medical Academy of Nizhny Novgorod, Nizhny Novgorod, Rus...
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  2. Organizations in the News

    1. (14 articles) Nizhny Novgorod State Medical Academy
    2. (3 articles) Ontario Cancer Institute
    3. (2 articles) Massachusetts General Hospital
    4. (2 articles) Nicolaus Copernicus University
    5. (2 articles) University of Texas at Austin
    6. (2 articles) Duke University
    7. (2 articles) Sunnybrook Health Sciences Centre
    8. (2 articles) FDA
    9. (2 articles) National Research Council Canada
    10. (1 articles) UC Irvine
    11. (1 articles) Case Western Reserve University
    12. (1 articles) Massachusetts Institute of Technology
  3. OCT Companies in the News

    1. (2 articles) Optovue
    2. (2 articles) Thorlabs
    3. (2 articles) Avinger
    4. (2 articles) Oncoscope
    5. (2 articles) Topcon Medical Systems
    6. (2 articles) Nidek
    7. (2 articles) Diagnostic Photonics
    8. (2 articles) Terumo Corporation
    9. (2 articles) Santec
    10. (2 articles) Aquyre Biosences
    11. (2 articles) NinePoint Medical
    12. (2 articles) Michelson Diagnostics