1. Articles mentioning both University of Alabama and Johns Hopkins University

    1-12 of 12
    1. Combination Therapy with Cystic Fibrosis Transmembrane Conductance Regulator Modulators Augment the Airway Functional Microanatomy

      Combination Therapy with Cystic Fibrosis Transmembrane Conductance Regulator Modulators Augment the Airway Functional Microanatomy
      Recently approved therapies that modulate CFTR function have shown significant clinical benefit, but recent investigations regarding their molecular mechanism when used in combination have not been consistent with clinical results. We employed Micro-Optical Coherence Tomography (OCT) as a novel means to assess the mechanism of action of CFTR modulators, focusing on the effects on mucociliary clearance. Primary human airway monolayers from patients with a G551D mutation responded to ivacaftor treatment ...
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    2. A Functional Anatomic Defect of the Cystic Fibrosis Airway

      A Functional Anatomic Defect of the Cystic Fibrosis Airway
      Rationale: The mechanisms underlying cystic fibrosis (CF) lung disease pathogenesis are unknown. Objective: To establish mechanisms linking anion transport with the functional microanatomy, we evaluated normal and CF piglet trachea, as well as adult swine trachea in the presence of selective anion inhibitors. Methods: We investigated airway functional microanatomy using micro-optical coherence tomography, a new imaging modality that concurrently quantifies multiple functional parameters of airway epithelium in a co-localized fashion ...
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    3. Longitudinal study of vision and retinal nerve fiber layer thickness in multiple sclerosis

      Longitudinal study of vision and retinal nerve fiber layer thickness in multiple sclerosis
      Objective Cross-sectional studies of optical coherence tomography (OCT) show that retinal nerve fiber layer (RNFL) thickness is reduced in multiple sclerosis (MS) and correlates with visual function. We determined how longitudinal changes in RNFL thickness relate to visual loss. We also examined patterns of RNFL thinning over time in MS eyes with and without a prior history of acute optic neuritis (ON). Methods Patients underwent OCT measurement of RNFL thickness ...
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    4. Macular Volume Determined by Optical Coherence Tomography as a Measure of Neuronal Loss in Multiple Sclerosis

      Macular Volume Determined by Optical Coherence Tomography as a Measure of Neuronal Loss in Multiple Sclerosis
      ...wn University Medical Center, Washington, District of Columbia (Dr Osborne); and Department of Biostatistics, University of Alabama, Birmingham (Dr Cutter). CiteULike    Connotea    Del.icio.us    Digg    Reddit    Techn...
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    5. Optical coherence tomography: a window into the mechanisms of multiple sclerosis

      Optical coherence tomography: a window into the mechanisms of multiple sclerosis
      The pathophysiology of multiple sclerosis (MS) is characterized by demyelination, which culminates in a reduction in axonal transmission. Axonal and neuronal degeneration seem to be concomitant features of MS and are probably the pathological processes responsible for permanent disability in this disease. The retina is unique within the CNS in that it contains axons and glia but no myelin, and it is, therefore, an ideal structure within which to visualize ...
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    6. Reproducibility of Optical Coherence Tomography in Multiple Sclerosis

      Background  Optical coherence tomography (OCT) is a promising new method of quantifying axon thickness in the retinal nerve fiber layer (RNFL) that has been used predominantly by ophthalmologists to monitor glaucoma. Optical coherence tomography is being considered as a potential outcome measure in multiple sclerosis (MS) clinical trials, but no data exist on the reproducibility of this technique in MS centers.Objective  To determine the reproducibility of OCT measurement of ...
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    7. Retinal Imaging by Laser Polarimetry and Optical Coherence Tomography Evidence of Axonal Degeneration in Multiple Sclerosis

      Background Optical coherence tomography (OCT) and scanning laser polarimetry with variable corneal compensation (GDx) are similar yet provide information on different aspects of retinal nerve fiber layer (RNFL) structure (thickness values similar to histology for OCT vs birefringence of microtubules for GDx). Objectives To compare the ability of OCT and GDx to distinguish eyes of patients with multiple sclerosis (MS) from eyes of disease-free controls and thus identify RNFL abnormalities ...
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    8. 1-12 of 12
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  2. Organizations in the News

    1. (9 articles) University of Pennsylvania
    2. (9 articles) UT Southwestern Medical Center
    3. (2 articles) Harvard University
    4. (2 articles) Massachusetts General Hospital
    5. (1 articles) Emory University
    6. (1 articles) State University of New York at Buffalo
    7. (1 articles) Nanyang Technological University
    8. (1 articles) Georgetown University
    9. (1 articles) Michigan State University
    10. (1 articles) Massachusetts Institute of Technology
  3. People in the News

    1. (9 articles) Peter A. Calabresi
    2. (9 articles) Laura J. Balcer
    3. (9 articles) Elliot M. Frohman
    4. (9 articles) Gary R. Cutter
    5. (5 articles) Amy Conger
    6. (2 articles) Guillermo J. Tearney
    7. (2 articles) Linbo Liu
    8. (1 articles) Clyde Markowitz
    9. (1 articles) James G. Fujimoto