1. Articles mentioning both University of Alabama and Harvard University

    1-10 of 10

    1. Excess mucus viscosity and airway dehydration impact COPD airway clearance

      Explore European Respiratory Journal Pulmonology
      Excess mucus viscosity and airway dehydration impact COPD airway clearance
      The mechanisms by which cigarette smoking impairs airway mucus clearance are not well understood. We recently established a ferret model of cigarette smoke-induced chronic obstructive pulmonary disease (COPD) exhibiting chronic bronchitis. We investigated the effects of cigarette smoke on mucociliary transport (MCT). Adult ferrets were exposed to cigarette smoke for 6 months, with in vivo mucociliary clearance (MCC) measured by Tc-labeled DTPA (Tc-DTPA) retention. Excised tracheae were imaged with micro-optical ...
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      Mentions: Johns Hopkins University Massachusetts General Hospital University of Alabama

    2. Co-cultured microfluidic model of the airway optimized for microscopy and micro-optical coherence tomography imaging

      Explore OSA | OSA Publishing Pulmonology
      Co-cultured microfluidic model of the airway optimized for microscopy and micro-optical coherence tomography imaging
      We have developed a human bronchial epithelial (HBE) cell and endothelial cell co-cultured microfluidic model to mimic the in vivo human airway. This airway-on-a-chip was designed with a central epithelial channel and two flanking endothelial channels, with a three-dimensional monolayers of cells growing along the four walls of the channel, forming central clear lumens. These cultures mimic airways and microvasculature in vivo . The central channel cells are grown at air-liquid ...
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      Mentions: Massachusetts General Hospital University of Alabama Harvard University

    3. Intranasal micro-optical coherence tomography imaging for cystic fibrosis studies

      Explore Science Translational Medicine Pulmonology
      Intranasal micro-optical coherence tomography imaging for cystic fibrosis studies
      Cystic fibrosis (CF) is a genetic disease caused by mutations in the CF transmembrane conductance regulator (CFTR) gene. Although impairment of mucociliary clearance contributes to severe morbidity and mortality in people with CF, a clear understanding of the pathophysiology is lacking. This is, in part, due to the absence of clinical imaging techniques capable of capturing CFTR-dependent functional metrics at the cellular level. Here, we report the clinical translation of ...
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      Mentions: Massachusetts General Hospital University of Alabama Harvard University

    4. New intra-nasal imaging technique allows researchers to study airways in patients with cystic fibrosis

      Explore Massachusetts General Hospital Home Pulmonology
      New intra-nasal imaging technique allows researchers to study airways in patients with cystic fibrosis
      ...al Hospital Massachusetts General Hospital, founded in 1811, is the original and largest teaching hospital of Harvard Medical School. The MGH Research Institute conducts the largest hospital-based research program in the...
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      Mentions: Massachusetts General Hospital University of Alabama Harvard University

    6. Flexible, high-resolution micro-optical coherence tomography endobronchial probe toward in vivo imaging of cilia

      Explore OSA | OSA Publishing Pulmonology , Probes
      Flexible, high-resolution micro-optical coherence tomography endobronchial probe toward in vivo imaging of cilia
      We report the design and fabrication of a flexible, longitudinally scanning high-resolution micro-optical coherence tomography (OCT) endobronchial probe, optimized for micro-anatomical imaging in airways. The 2.4 mm diameter and flexibility of the probe allows it to be inserted into the instrument channel of a standard bronchoscope, enabling real-time video guidance of probe placement. To generate a depth-of-focus enhancing annular beam, we utilized a new fabrication method, whereby a hollow ...
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      Mentions: Massachusetts General Hospital University of Alabama Harvard University

    7. In vivo imaging of airway cilia and mucus clearance with micro-optical coherence tomography

      Explore OSA | OSA Publishing Pulmonology
      In vivo imaging of airway cilia and mucus clearance with micro-optical coherence tomography
      We have designed and fabricated a 4 mm diameter rigid endoscopic probe to obtain high resolution micro-optical coherence tomography (OCT) images from the tracheal epithelium of living swine. Our common-path fiber-optic probe used gradient-index focusing optics, a selectively coated prism reflector to implement a circular-obscuration apodization for depth-of-focus enhancement, and a common-path reference arm and an ultra-broadbrand supercontinuum laser to achieve high axial resolution. Benchtop characterization demonstrated lateral and axial ...
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      Mentions: Massachusetts General Hospital University of Alabama Harvard University

    8. Combination Therapy with Cystic Fibrosis Transmembrane Conductance Regulator Modulators Augment the Airway Functional Microanatomy

      Explore ajplung.physiology.org Pulmonology
      Combination Therapy with Cystic Fibrosis Transmembrane Conductance Regulator Modulators Augment the Airway Functional Microanatomy
      Recently approved therapies that modulate CFTR function have shown significant clinical benefit, but recent investigations regarding their molecular mechanism when used in combination have not been consistent with clinical results. We employed Micro-Optical Coherence Tomography (OCT) as a novel means to assess the mechanism of action of CFTR modulators, focusing on the effects on mucociliary clearance. Primary human airway monolayers from patients with a G551D mutation responded to ivacaftor treatment ...
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      Mentions: Johns Hopkins University Emory University Massachusetts General Hospital

    9. A Functional Anatomic Defect of the Cystic Fibrosis Airway

      Explore Home (thoracic) Pulmonology
      A Functional Anatomic Defect of the Cystic Fibrosis Airway
      Rationale: The mechanisms underlying cystic fibrosis (CF) lung disease pathogenesis are unknown. Objective: To establish mechanisms linking anion transport with the functional microanatomy, we evaluated normal and CF piglet trachea, as well as adult swine trachea in the presence of selective anion inhibitors. Methods: We investigated airway functional microanatomy using micro-optical coherence tomography, a new imaging modality that concurrently quantifies multiple functional parameters of airway epithelium in a co-localized fashion ...
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      Mentions: Johns Hopkins University Massachusetts General Hospital University of Alabama
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