Articles mentioning both Tufts University and Jay S. Duker -Optical Coherence Tomography News

Articles mentioning both Tufts University and Jay S. Duker

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1. Retinal hemangioblastoma vascular detail elucidated on swept source optical coherence tomography angiography
  
  Explore ScienceDirect Dec 26 2020 Ophthalmology
  
  Purpose To report the distinct vascular pattern of a treatment-nave retinal hemangioblastoma imaged on swept source optical coherence tomography angiography (SS-OCTA). Observations A 33-year-old female with a history of Von Hippel-Lindau disease presented for follow-up of bilateral retinal hemangioblastomas. Ultra-widefield fundus photography of the left eye revealed a small, juxtapapillary lesion. SS-OCTA imaging centered at the lesion identified two distinct vascular foci. Centrally, the lesion was composed of a dense ...
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  Mentions: Jay S. Duker Tufts University
2. Swept Source Optical Coherence Tomography Angiography in Small Choroidal Melanomas and Choroidal Nevi
  
  Explore LWW Online Dec 16 2020 Ophthalmology
  
  Purpose: To evaluate the use of swept source optical coherence tomography angiography (SS-OCTA) to detect distinct vascular features in small choroidal melanomas and choroidal nevi. Methods: Patients with a choroidal nevus or a treatment-nave choroidal melanoma were imaged with color fundus photography, ultrasound and SS-OCTA (12x12mm). High-risk features including overlying fluid, orange pigment, shaggy photoreceptors, acoustic hollowness, depth 2mm, and basal diameter 5mm were assessed. OCTA vascular markers included: choroidal ...
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  Mentions: Jay S. Duker Tufts University Nadia K. Waheed
3. Efficient and high accuracy 3-D OCT angiography motion correction in pathology
  
  Explore OSA | OSA Publishing Dec 12 2020 Ophthalmology
  
  We describe a novel method for non-rigid 3-D motion correction of orthogonally raster-scanned optical coherence tomography angiography volumes. This is the first approach that aligns predominantly axial structural features such as retinal layers as well as transverse angiographic vascular features in a joint optimization. Combined with orthogonal scanning and favorization of kinematically more plausible displacements, subpixel alignment and micrometer-scale distortion correction is achieved in all 3 dimensions. As no specific ...
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  Mentions: Massachusetts Institute of Technology James G. Fujimoto Jay S. Duker
4. A practical guide to optical coherence tomography angiography interpretation
  
  Explore journalretinavitreous.biomedcentral.com Nov 17 2020 Ophthalmology
  
  Background Optical coherence tomography angiography (OCTA) can image the retinal vasculature in vivo, without the need for contrast dye. This technology has been commercially available since 2014, however, much of its use has been limited to the research setting. Over time, more clinical practices have adopted OCTA imaging. While countless publications detail OCTAs use for the study of retinal microvasculature, few studies outline OCTAs clinical utility. Body This review provides ...
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  Mentions: Jay S. Duker Tufts University Nadia K. Waheed
5. Anterior-segment spectral domain optical coherence tomography in epidermolysis bullosa
  
  Explore ScienceDirect Sep 28 2020 Ophthalmology
  
  Purpose Assess epidermolysis bullosa (EB)-related corneal pathology using anterior segment optical coherence tomography (AS-OCT) and correlate imaging with clinical metrics in EB patients versus age-matched controls. Methods EB patients and controls were recruited during an EB conference (July 2018) and at Tufts Medical Center (JuneAugust 2019). Subjects completed a questionnaire, had best corrected visual acuity (BCVA) tested, and underwent AS-OCT scanning. Stromal and epithelial thickness were measured. Depth, length ...
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  Mentions: Jay S. Duker Tufts University Nadia K. Waheed
6. Repeatability of binarization thresholding methods for optical coherence tomography angiography image quantification
  
  Explore Nature Publishing Group Sep 25 2020 Ophthalmology
  
  Binarization is a critical step in analysis of retinal optical coherence tomography angiography (OCTA) images, but the repeatability of metrics produced from various binarization methods has not been fully assessed. This study set out to examine the repeatability of OCTA quantification metrics produced using different binarization thresholding methods, all of which have been applied in previous studies, across multiple devices and plexuses. Successive 33 mm foveal OCTA images of 13 ...
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  Mentions: University of Rochester Jay S. Duker Tufts University
7. Using the Pathophysiology of Dry AMD to Guide Binarization of the Choriocapillaris on OCTA: A Model
  
  Explore TVST Journal Aug 29 2020 Ophthalmology
  
  Especially since the incorporation of swept laser sources, optical coherence tomography angiography (OCTA) has enabled quantification of choriocapillaris perfusion. A critical step in this process is binarization, which makes angiographic images quantifiable in terms of perfusion metrics. It remains challenging to have confidence that choriocapillaris perfusion metrics reflect the reality of pathophysiologic flow, largely because choice of binarization method can result in significantly different perfusion metric outcomes. This commentary discusses ...
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  Mentions: University of Rochester Jay S. Duker Tufts University
8. The long-term effects of anti-vascular endothelial growth factor therapy on the optical coherence tomography angiographic appearance of neovascularization in age-related macular degeneration
  
  Explore journalretinavitreous.biomedcentral.com Aug 26 2020 Ophthalmology
  
  Background The short-term effects of anti-vascular endothelial growth factor (anti-VEGF) treatment on macular neovascularization (MNV) morphology is well described, but long-term studies on morphologic changes and correlation of such changes to the type of MNV have not been conducted. This study aims to determine if different types of MNVs in neovascular AMD (nAMD) behave differently with anti-VEGF treatment as visualized on optical coherence tomography angiography (OCTA). Methods Treatment-nave nAMD patients ...
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  Mentions: Massachusetts Institute of Technology James G. Fujimoto Yale University
9. Model-to-Data Approach for Deep Learning in Optical Coherence Tomography Intraretinal Fluid Segmentation
  
  Explore The JAMA Network Aug 8 2020 Ophthalmology
  
  ...s with active exudative age-related macular degeneration undergoing optical coherence tomography (OCT) at the New England Eye Center from August 1, 2018, to February 28, 2019. Data were primarily analyzed from March 1 to...
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  Mentions: Jay S. Duker Tufts University Nadia K. Waheed
10. Ultrahigh Resolution Spectral Domain Optical Coherence Tomography for the Assessment of Micro-Structural Changes in Central Serous Chorioretinopathy: A Pilot Study.
  
  Explore IOVS Journal Jul 27 2020 Ophthalmology
  
  Purpose : In central serous chorioretinopathy (CSCR), choroidal hyperpermeability associated with retinal pigment epithelium (RPE) impairment causes a leakage of fluid from the choroid into the subretinal space, with potential damage to the photoreceptors. We hypothesize that ultrahigh-resolution spectral domain optical coherence tomography (UHR SD-OCT) will enable more detailed assessment of structural changes in this condition. Methods : Patients in all stages of CSCR (acute, chronic and post-resolution) were imaged using an ...
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  Mentions: Massachusetts Institute of Technology James G. Fujimoto Jay S. Duker
11. Evaluating the long-term effects of anti-vascular endothelial growth factor therapy on choroidal neovascularization in age-related macular degeneration using optical coherence tomography angiography
  
  Explore IOVS Journal Jul 27 2020 Ophthalmology
  
  Purpose : Optical coherence tomography angiography (OCTA) allows for precise, non-invasive monitoring of changes to choroidal neovascularization (CNV) structure over time. The short-term effects of anti-vascular endothelial growth factor (anti-VEGF) treatment on CNV morphology is well described, but long-term studies on morphologic changes and correlation of such to the type of CNV have not been conducted. This study aims to determine if different types of CNVs in neovascular AMD (nAMD) behave ...
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  Mentions: James G. Fujimoto Andre J. Witkin Massachusetts General Hospital
12. Bringing Deep Learning Models to the Data: An Application in Recognizing Intra-Retinal Fluid on Optical Coherence Tomography (OCT) Images
  
  Explore IOVS Journal Jul 27 2020 Ophthalmology
  
  ... of Washington was trained using a model to data approach, to identify intraretinal fluid on OCT scans at the New England Eye Center (NEEC). Patients with active exudative age-related macular degeneration(AMD) imaged at ...
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  Mentions: Jay S. Duker University of Washington Tufts University
13. Analyzing Relative Flow Speeds in Diabetic Retinopathy Using Variable Interscan Time Analysis Optical Coherence Tomography Angiography
  
  Explore ScienceDirect Jun 26 2020 Ophthalmology
  
  ...ds in the microvascular changes associated with DR. Design and Participants: In this cross-sectional study at New England Eye Center, Boston, Massachusetts, thirteen patients of varying severities of DR were enrolled. Me...
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  Mentions: Massachusetts Institute of Technology James G. Fujimoto Andre J. Witkin
14. Morphological changes in intraretinal microvascular abnormalities after anti-VEGF therapy visualized on optical coherence tomography angiography
  
  Explore Eye and Vision Jun 5 2020 Ophthalmology
  
  Background To examine the baseline morphological characteristics and alterations in intraretinal microvascular abnormalities (IRMAs) in response to anti-vascular endothelial growth factor (anti-VEGF) treatment, documented by optical coherence tomography angiography (OCTA) in diabetic eyes. Methods In this retrospective study, IRMAs were evaluated with multimodal imaging (fundus photography, fluorescein angiography, OCTA) in treatment-nave diabetic eyes before and after anti-VEGF treatment for diabetic macular edema (DME) and/or proliferative diabetic retinopathy (PDR) and ...
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  Mentions: Yale University Andre J. Witkin Jay S. Duker
15. Repeatability and reproducibility of vessel density measurements on optical coherence tomography angiography in diabetic retinopathy
  
  Explore Home - Springer May 9 2020 Ophthalmology
  
  Purpose Understanding the precision of measurements on and across optical coherence tomography angiography (OCTA) devices is critical for tracking meaningful change in disease. The purpose of this study is to investigate the repeatability and reproducibility of vessel area density and vessel skeleton density measurements from various commercial OCTA devices in diabetic eyes. Methods Patients were imaged three consecutive times each on three different OCTA devices. En face OCTA images of ...
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  Mentions: Andre J. Witkin Jay S. Duker Tufts University
16. Topographic analysis of macular choriocapillaris flow deficits in diabetic retinopathy using swept–source optical coherence tomography angiography
  
  Explore journalretinavitreous.biomedcentral.com Mar 24 2020 Ophthalmology
  
  Background The purpose of this study was to investigate the association between diabetic retinopathy (DR) severity and macular choriocapillaris (CC) flow deficit percentage (FD %) in different macular regions using swept-source optical coherence tomography angiography (SS-OCTA). Methods Diabetic patients with SS-OCTA images were graded by severity and retrospectively assessed. CC FD % was calculated in four different regions of the OCTA image: inner, middle, outer, and full-field region. The generalized estimating equations ...
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  Mentions: Massachusetts Institute of Technology James G. Fujimoto Yale University
17. SPATIAL DISTRIBUTION OF CHORIOCAPILLARIS IMPAIRMENT IN EYES WITH CHOROIDAL NEOVASCULARIZATION SECONDARY TO AGE-RELATED MACULAR DEGENERATION: A Quantitative OCT Angiography Study
  
  Explore LWW Online Feb 21 2020 Ophthalmology
  
  Purpose: To develop an optical coherence tomography angiography ( OCTA )-based framework for quantitatively analyzing the spatial distribution of choriocapillaris (CC) impairment around choroidal neovascularization ( CNV ) secondary to age-related macular degeneration. Methods: In a retrospective, cross-sectional study, 400-kHz swept-source OCTA images from 7 eyes of 6 patients with CNV secondary to age-related macular degeneration were quantitatively analyzed using custom software. A lesion-centered zonal OCTA analysis techniquewhich portioned the field-of-view into zones ...
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  Mentions: Philip J. Rosenfeld Massachusetts Institute of Technology James G. Fujimoto
18. How SD-OCT is enhancing our management of DR
  
  Explore Retina Specialist Feb 8 2020 Ophthalmology
  
  Laser therapy was a major breakthrough in diabetic retinopathy treatment, with its efficacy validated by a number of clinical studies in the last three decades of the 20th century. However, it relied on fundus photography and fluorescein angiography to diagnose clinically significant macular edema. Since then, optical coherence tomography has revolutionized the clinical management of diabetic macular edema because of its widespread availability, ease of use, and ability to quantify ...
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  Mentions: Jay S. Duker Tufts University Nadia K. Waheed
19. A Framework for Multiscale Quantitation of Relationships Between Choriocapillaris Flow Impairment and Geographic Atrophy Growth
  
  Explore American Journal of Ophthalmology Dec 13 2019 Ophthalmology
  
  Purpose To develop a multiscale analysis framework for investigating the relationships between geographic atrophy (GA) growth rate and choriocapillaris (CC) blood flow impairment using optical coherence tomography (OCT) and OCT angiography (OCTA). Design Retrospective case series. Methods We developed an OCT/OCTA analysis framework that quantitatively measures GA growth rates at global and local scales, and CC impairment at global, zonal, and local scales. A geometric GA growth model was ...
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  Mentions: Massachusetts Institute of Technology James G. Fujimoto Jay S. Duker
20. Global Analysis of Macular Choriocapillaris Perfusion in Dry Age-Related Macular Degeneration using Swept-Source Optical Coherence Tomography Angiography
  
  Explore IOVS Journal Dec 8 2019 Ophthalmology
  
  Purpose : Swept-source optical coherence tomography angiography (SS-OCTA) was used to investigate if the clinical stage of dry age-related macular degeneration (AMD) was correlated with global and regional macular choriocapillaris (CC) perfusion. Methods : In this retrospective, cross-sectional study, 6 6-mm SS-OCTA images from eyes with early, intermediate, and advanced dry AMD (56 eyes, 41 patients) were analyzed using algorithms described in the literature to assess regional flow deficit percentage (FD%) and ...
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  Mentions: Massachusetts Institute of Technology James G. Fujimoto Andre J. Witkin
21. Retinal Nonperfusion Relationship to Arteries or Veins Observed on Widefield Optical Coherence Tomography Angiography in Diabetic Retinopathy
  
  Explore IOVS Journal Oct 24 2019 Ophthalmology
  
  Purpose : To evaluate whether retinal capillary nonperfusion is found predominantly adjacent to arteries or veins in eyes with diabetic retinopathy (DR). Methods : Sixty-three eyes from 44 patients with proliferative DR (PDR) or non-PDR (NPDR) were included. Images (12 12-mm) foveal-centered optical coherence tomography (OCT) angiography (OCTA) images were taken using the Zeiss Plex Elite 9000. In 37 eyes, widefield montages with five fixation points were also obtained. A semiautomatic algorithm ...
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  Mentions: Massachusetts Institute of Technology James G. Fujimoto Andre J. Witkin
22. DISTINGUISHING INTRARETINAL MICROVASCULAR ABNORMALITIES FROM RETINAL NEOVASCULARIZATION USING OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY
  
  Explore LWW Online Oct 24 2019 Ophthalmology
  
  Purpose: With the increasing prevalence of diabetes, fast, noninvasive identification of proliferative diabetic retinopathy ( PDR ) becomes essential. This study evaluated the utility of optical coherence tomography angiography ( OCTA ) to characterize intraretinal microvascular abnormalities ( IRMA ) and retinal neovascularization (NV). Methods: Patients with severe non- PDR or PDR were imaged with fluorescein angiography and widefield swept-source OCTA (Zeiss Plex Elite 9000; Carl Zeiss Meditec, Dublin, CA). Regions suspicious for IRMA or retinal ...
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  Mentions: Jay S. Duker Carl Zeiss Meditec Tufts University
23. Controlling for Artifacts in Widefield Optical Coherence Tomography Angiography Measurements of Non-Perfusion Area
  
  Explore Nature Publishing Group Jul 1 2019 Ophthalmology
  
  The recent clinical adoption of optical coherence tomography (OCT) angiography (OCTA) has enabled non-invasive, volumetric visualization of ocular vasculature at micron-scale resolutions. Initially limited to 3mm3mm and 6mm6mm fields-of-view (FOV), commercial OCTA systems now offer 12mm12mm, or larger, imaging fields. While larger FOVs promise a more complete visualization of retinal disease, they also introduce new challenges to the accurate and reliable interpretation of OCTA data. In particular, because of vignetting ...
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  Mentions: Massachusetts Institute of Technology James G. Fujimoto Andre J. Witkin
24. Impact of Binarization Thresholding and Brightness/Contrast Adjustment Methodology on Optical Coherence Tomography Angiography Image Quantification
  
  Explore American Journal of Ophthalmology Mar 15 2019 Ophthalmology
  
  Purpose Binarization is a critical technique in OCTA image analysis, but there is no consistency in the method used in published OCTA studies. This study assessed whether differences in OCTA binarization and brightness/contrast adjustments affect quantification metrics. Design Prospective cross-sectional validity study Methods This was a single-center study examining 21 eyes of 11 healthy individuals. All eyes were imaged using the Carl Zeiss PLEX Elite 9000 swept source-OCTA, and ...
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  Mentions: Jay S. Duker Tufts University Nadia K. Waheed
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