1. Articles mentioning both Tokyo Medical University and University of Tsukuba

    1-24 of 29 1 2 »
    1. Evaluation of Retinal Pigment Epithelium Layer Change in Vogt-Koyanagi-Harada Disease With Multicontrast Optical Coherence Tomography

      Evaluation of Retinal Pigment Epithelium Layer Change in Vogt-Koyanagi-Harada Disease With Multicontrast Optical Coherence Tomography
      Purpose : Clinical evaluation of retinal pigment epithelium (RPE) change is important for the therapeutic management of chronic Vogt-Koyanagi-Harada (VKH) disease. We evaluated long-term change in the RPE layer in VKH disease, using near-infrared (NIR; 817 nm) images and autofluorescence images at 488 nm (short-wavelength [SW]-AF) and 785 nm (NIR-AF), and compared those images with images from multicontrast optical coherence tomography (MC-OCT). MC-OCT is capable of simultaneous measurement of OCT ...
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    2. Clinical prototype of pigment and flow imaging optical coherence tomography for posterior eye investigation

      Clinical prototype of pigment and flow imaging optical coherence tomography for posterior eye investigation
      Measurements of the randomness of polarization (RP) obtained using polarization-sensitive optical coherence tomography (PS-OCT) are applied in several applications, and RP is attractive for posterior eye imaging. The addition of RP without retardation requires a minimal extension to standard OCT; therefore, we developed a prototype OCT system with a simplified scheme for RP measurement. A compact polarization-diversity receiver module is the only required hardware extension to a standard OCT system ...
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    3. Pixel-wise segmentation of severely pathologic retinal pigment epithelium and choroidal stroma using multi-contrast Jones matrix optical coherence tomography

      Pixel-wise segmentation of severely pathologic retinal pigment epithelium and choroidal stroma using multi-contrast Jones matrix optical coherence tomography
      Tissue segmentation of retinal optical coherence tomography (OCT) is widely used in ophthalmic diagnosis. However, its performance in severe pathologic cases is still insufficient. We propose a pixel-wise segmentation method that uses the multi-contrast measurement capability of Jones matrix OCT (JM-OCT). This method is applicable to both normal and pathologic retinal pigment epithelium (RPE) and choroidal stroma. In this method, features, which are sensitive to specific tissues of interest, are ...
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    4. High contrast and polarization-artifact-free optical coherence tomography by maximum a-posteriori estimation

      High contrast and polarization-artifact-free optical coherence tomography by maximum a-posteriori estimation
      We propose a maximum a-posteriori (MAP) intensity estimator to improve the image contrast of polarization diversity (PD)-OCT imaging to achieve high contrast polarization-artifact-free images. The MAP estimator compensates for the inevitable reduction of signal-to-noise ratio (SNR) in PD-OCT caused by the splitting of power into two polarization detection channels. It also has low noise-offset in low intensity regions such as the vitreous. This method is applied to posterior eye ...
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    5. Evaluation of intraretinal migration of retinal pigment epithelial cells with Jones matrix optical coherence tomography

      Evaluation of intraretinal migration of retinal pigment epithelial cells with Jones matrix optical coherence tomography
      We evaluated intraretinal RPE migration in AMD using multimodal imaging including polarimetric images. Depolarized light images were computed using a PS-SLO. M-DOPU was calculated using multifunctional Jones-matrix OCT. RPE migration was detected in 59 of 155 eyes. Focal similarities could be confirmed among en-face projection images of minimum M-DOPU, depolarized light images, and NIR-AF images.
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    6. Noise-immune complex correlation for vasculature imaging based on standard and Jones-matrix optical coherence tomography

      Noise-immune complex correlation for vasculature imaging based on standard and Jones-matrix optical coherence tomography
      A new optical coherence angiography (OCA) method, called correlation mapping OCA (cmOCA), is presented by using the SNR-corrected complex correlation. An SNR-correction theory for the complex correlation calculation is presented. The method also integrates a motion-artifact-removal method for the sample motion induced decorrelation artifact. The theory is further extended to compute more reliable correlation by using multi- channel OCT systems, such as Jones-matrix OCT. The high contrast vasculature imaging of ...
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    7. Quantitative polarization and flow evaluation of choroid and sclera by multifunctional Jones matrix optical coherence tomography

      Quantitative polarization and flow evaluation of choroid and sclera by multifunctional Jones matrix optical coherence tomography
      Quantitative evaluation of optical properties of choroid and sclera are performed by multifunctional optical coherence tomography. Five normal eyes, five glaucoma eyes and one choroidal atrophy eye are examined. The refractive error was found to be correlated with choroidal birefringence, polarization uniformity, and flow in addition to scleral birefringence among normal eyes. The significant differences were observed between the normal and the glaucoma eyes, as for choroidal polarization uniformity, flow ...
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    8. Birefringence imaging of posterior eye by multi-functional Jones matrix optical coherence tomography

      Birefringence imaging of posterior eye by multi-functional Jones matrix optical coherence tomography
      A clinical grade prototype of posterior multifunctional Jones matrix optical coherence tomography (JM-OCT) is presented. This JM-OCT visualized depth-localized birefringence in addition to conventional cumulative phase retardation imaging through local Jones matrix analysis. In addition, it simultaneously provides a sensitivity enhanced scattering OCT, a quantitative polarization uniformity contrast, and OCT-based angiography. The probe beam is at 1- m wavelength band. The measurement speed and the depth-resolution were 100,000 A-lines ...
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    9. Noninvasive vascular imaging of ruptured retinal arterial macroaneurysms by Doppler optical coherence tomography

      Noninvasive vascular imaging of ruptured retinal arterial macroaneurysms by Doppler optical coherence tomography
      Background To describe Doppler optical coherence tomography (OCT) imaging of ruptured retinal arterial macroaneurysms (RAMs). Methods Four eyes of four patients with ruptured RAMs were prospectively studied. Vascular imaging was obtained using swept-source Doppler OCT, and compared with indocyanine green angiography images. Results En face projection of Doppler OCT images clearly showed RAMs at the corresponding locations of lesions in the indocyanine green angiography images. In Doppler OCT images, RAMs ...
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    10. Noninvasive Vascular Imaging of Polypoidal Choroidal Vasculopathy by Doppler Optical Coherence Tomography

      Noninvasive Vascular Imaging of Polypoidal Choroidal Vasculopathy by Doppler Optical Coherence Tomography
      Purpose. To noninvasively investigate the vascular architecture of polypoidal lesions in polypoidal choroidal vasculopathy (PCV) using Doppler optical coherence tomography (OCT), and to evaluate the clinical usefulness of Doppler OCT for the assessment of therapeutic effects in PCV. Methods. Fifteen eyes of 15 patients with treatment-nave PCV were prospectively studied. Vascular imaging was obtained using 1060-nm swept-source Doppler OCT, and compared with indocyanine green angiography (ICGA) images. The therapeutic effect ...
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    11. Simultaneous Investigation of Vascular and Retinal Pigment Epithelial Pathologies of Exudative Macular Diseases by Multi-Functional Optical Coherence Tomography

      Simultaneous Investigation of Vascular and Retinal Pigment Epithelial Pathologies of Exudative Macular Diseases by Multi-Functional Optical Coherence Tomography
      ...University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8573, Japan 5. ^5Computational Optics Group, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba, Ibaraki, 305-8571, Japan 1. ↵* Computational Optics Grou...
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    12. Scleral birefringence as measured by polarization-sensitive optical coherence tomography and ocular biometric parameters of human eyes in vivo

      Scleral birefringence as measured by polarization-sensitive optical coherence tomography and ocular biometric parameters of human eyes in vivo
      ...^1Computational Optics Group, University of Tsukuba, Tsukuba, Ibaraki, Japan ^2Department of Ophthalmology, Tokyo Medical University Ibaraki Medical Center, Ami, Ibaraki, Japan ^3Department of Ophthalmology, Faculty ...
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    13. Non-invasive assessment of corneal crosslinking changes using polarization sensitive optical coherence tomography

      Non-invasive assessment of corneal crosslinking changes using polarization sensitive optical coherence tomography
      Collagen crosslinking (CXL) has shown promising results in the prevention of the progression of keratoconus and corneal ectasia. However, techniques for in vivo and in situ assessment of the treatment are limited. In this study, ex vivo porcine eyes were treated with a chemical CXL agent (glutaraldehyde), during which polarization sensitive optical coherence tomography (PS-OCT) recordings were acquired simultaneously to assess the sensitivity of the technique to assess changes in ...
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    14. Optical Rheology of Porcine Sclera by Birefringence Imaging

      Optical Rheology of Porcine Sclera by Birefringence Imaging
      Purpose To investigate a relationship between birefringence and elasticity of porcine sclera ex vivo using polarization-sensitive optical coherence tomography (PS-OCT). Methods Elastic parameters and birefringence of 19 porcine eyes were measured. Four pieces of scleral strips which were parallel to the limbus, with a width of 4 mm, were dissected from the optic nerve head to the temporal side of each porcine eye. Birefringence of the sclera was measured with ...
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    15. Office based multi-functional anterior eye segment optical coherence tomography

      Office based multi-functional anterior eye segment optical coherence tomography
      An office based Doppler and polarization sensitive swept-source optical coherence tomography (Doppler-PS-SS-OCT) was developed for diagnosis and evaluation of abnormalities of anterior eye segment in clinic. A healthy eye was measured in vivo by the Doppler PS-OCT. The results showed that the Doppler PS-OCT may have potential to identify blood vessels and discriminate fibrous tissues in abnormalities, such as scarring in bleb, and scleral inflammation.
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    16. Choroidal thickness measurement in healthy Japanese subjects by three-dimensional high-penetration optical coherence tomography

      Choroidal thickness measurement in healthy Japanese subjects by three-dimensional high-penetration optical coherence tomography
      Background We performed retinal and choroidal thickness mapping by three-dimensional high-penetration optical coherence tomography (OCT) and evaluated the choroidal thickness distribution throughout the macula in healthy eyes. Methods Forty-three eyes of 43 healthy Japanese volunteers were evaluated by 1060-nm swept-source OCT. The eyes were scanned with a three-dimensional raster scanning protocol, and the mean retinal and choroidal thicknesses of the posterior sectors were obtained. The sectors were defined by the ...
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    17. Fast retinal layer identification for optical coherence tomography images

      Fast retinal layer identification for optical coherence tomography images
      Fast method for identifying the internal limiting membrane (ILM) and retinal pigment epithelium (RPE) from optical coherence tomography images is demonstrated. To avoid unnecessary increment of calculation time, a strong downsampling of the original data set is performed to reduce a number of processed pixels. In ILM segmentation, the obtained data cube is filtered with two different kinds of parameters and two estimates for the position of ILM is determined ...
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    18. Comprehensive in vivo micro-vascular imaging of the human eye by dual-beam-scan Doppler optical coherence angiography

      Comprehensive in vivo micro-vascular imaging of the human eye by dual-beam-scan Doppler optical coherence angiography
      Comprehensive angiography provides insight into the diagnosis of vascular-related diseases. However, complex microvascular networks of unstable in vivo organs such as the eye require micron-scale resolution in three dimensions and a high sampling rate to access a wide area as maintaining the high resolution. Here, we introduce dual-beam-scan Doppler optical coherence angiography (OCA) as a label-free comprehensive ophthalmic angiography that satisfies theses requirements. In addition to high resolution and high ...
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    19. 1-24 of 29 1 2 »
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    1. (4 articles) University of Oulu
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    1. (27 articles) Yoshiaki Yasuno
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