1. Confocal Laser Endomicroscopy and Optical Coherence Tomography for the Diagnosis of Prostate Cancer: A Needle-Based, In Vivo Feasibility Study Protocol (IDEAL Phase 2A)

      Confocal Laser Endomicroscopy and Optical Coherence Tomography for the Diagnosis of Prostate Cancer: A Needle-Based, In Vivo Feasibility Study Protocol (IDEAL Phase 2A)
      Background: Focal therapy for prostate cancer has been proposed as an alternative treatment to whole-gland therapies in selected men to diminish side effects in localized prostate cancer. As nowadays imaging cannot offer complete prostate cancer disease characterization, multicore systematic biopsies are recommended (transrectal or transperineal). Optical imaging techniques such as confocal laser endomicroscopy and optical coherence tomography allow in vivo, high-resolution imaging. Moreover, they can provide real-time visualization and analysis ...
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    2. Ex-vivo study in nephroureterectomy specimens defining the role of 3-D upper urinary tract visualization using optical coherence tomography and endoluminal ultrasound

      Ex-vivo study in nephroureterectomy specimens defining the role of 3-D upper urinary tract visualization using optical coherence tomography and endoluminal ultrasound
      Minimal invasive endoscopic treatment for upper urinary tract urothelial carcinoma (UUT-UC) is advocated in patients with low-risk disease and limited tumor volume. Diagnostic ureterorenoscopy combined with biopsy is the diagnostic standard. This study aims to evaluate two alternative diagnostic techniques for UUT-UC: optical coherence tomography (OCT) and endoluminal ultrasound (ELUS). Following nephroureterectomy, OCT, ELUS, and computed tomography (CT) were performed of the complete nephroureterectomy specimen. Visualization software (AMIRA) was used ...
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    3. Optical Coherence Tomography as a Tool for in Vivo Staging and Grading of Upper Urinary Tract Urothelial Carcinoma: A Study for Diagnostic Accuracy

      Optical Coherence Tomography as a Tool for in Vivo Staging and Grading of Upper Urinary Tract Urothelial Carcinoma: A Study for Diagnostic Accuracy
      Purposes Biopsies and cytology are cornerstones in the diagnosis of upper urinary tract urothelial carcinoma (UTUC). However, a high rate of non-diagnostic biopsies, tumor upgrading and -staging after nephroureterectomy is observed. In this prospective in vivo study we aimed to evaluate the diagnostic accuracy of OCT for grading and staging of UTUC Material Methods Twenty-six patients underwent diagnostic URS including biopsies and OCT imaging, followed by nephroureterectomy or segmental ureter ...
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    4. Prostate cancer diagnosis by optical coherence tomography: First results from a needle based optical platform for tissue sampling

      Prostate cancer diagnosis by optical coherence tomography: First results from a needle based optical platform for tissue sampling
      The diagnostic accuracy of Optical Coherence Tomography (OCT) based optical attenuation coefficient analysis is assessed for the detection of prostate cancer. Needle-based OCT-measurements were performed on the prostate specimens. Attenuation coefficients were determined by an earlier described in-house developed software package. The mean attenuation coefficients (benign OCT data; malignant OCT data; p-value Mann-Whitney U test) were: (3.56 mm 1 ; 3.85 mm 1 ; p 0.0001) for all patients ...
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    5. Beyond Endoscopy-Ultrasound, Optical Coherence Tomography and Confocal Laser Endomicroscopy (Book Chapter)

      Beyond Endoscopy-Ultrasound, Optical Coherence Tomography and Confocal Laser Endomicroscopy (Book Chapter)
      One of the main challenges in endoscopic diagnosis and treatment of upper urinary tract urothelial carcinoma is the complicated anatomy and the small size of the upper urinary tract, resulting in high demands on the armamentarium and expertise of the urologist. Difficulties to reach the complete collecting system could result in an incomplete visual inspection.
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    6. Optical Coherence Tomography in Bladder Cancer (Book Chapter)

      Optical Coherence Tomography in Bladder Cancer (Book Chapter)
      The current diagnostic standard for grading and staging of non-muscle-invasive bladder cancer (NMIBC) is based on the histopathology obtained during transurethral resection of the bladder tumour (TURBT) or biopsies. Although considered reference standard, this technique has some limitations: First, no real-time intraoperative histological information is obtained on stage and grade. Real-time intraoperative histological information could be helpful when NMIBC is treated by electric coagulation or laser ablation. The urologist has ...
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    7. Video Interview on Optical coherence tomography as a tool for in vivo staging and grading of upper urinary tract urothelial cell carcinoma: Comparison with biopsies and histopathology of the resected specimen

      Video Interview on Optical coherence tomography as a tool for in vivo staging and grading of upper urinary tract urothelial cell carcinoma: Comparison with biopsies and histopathology of the resected specimen
      Introduction and Objectives: Optical Coherence Tomography (OCT) has potential to provide real-time information on UUT-UC grade and stage. In this study we compare a) biopsy and b) OCT with gold standard histopathology of the resected specimen (HRS) for grading and staging of low- and high-grade UUT-UC. Methods: 16 patients with UUT-UC underwent diagnostic URS, including OCT and biopsy of places with visible tumour. The 2.7 Fr OCT probe was ...
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    8. Optical diagnostics for Upper Urinary Tract Urothelial cancer: technology, thresholds and clinical applications

      Optical diagnostics for Upper Urinary Tract Urothelial cancer: technology, thresholds and clinical applications
      Purpose: Developments in optical diagnostics have potential for less invasive diagnose of upper urinary tract urothelial carcinoma (UUT-UC). This systematic review provides an overview of technology, applications and limitations of recently developed optical diagnostics in the upper urinary tract and outlines their potential for future clinical applications. In addition, current evidence was evaluated. Literature search: A PubMed literature search was performed and papers on Narrow Band Imaging (NBI), Photodynamic Diagnosis ...
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    9. Feature Of The Week 11/10/13: Volumetric In-Vivo Visualization of Upper Urinary Tract Tumors Using Optical Coherence Tomography: A Pilot Study

      Feature Of The Week 11/10/13: Volumetric In-Vivo Visualization of Upper Urinary Tract Tumors Using Optical Coherence Tomography: A Pilot Study
      ...oups around the world that are making excellent progress in this area.  One example recently published by the Academic Medical Center at the University of Amsterdam investigated the use of OCT in the upper urinary tract ...
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    10. Volumetric In-Vivo Visualization of Upper Urinary Tract Tumors Using Optical Coherence Tomography: A Pilot Study

      Volumetric In-Vivo Visualization of Upper Urinary Tract Tumors Using Optical Coherence Tomography: A Pilot Study
      Purpose Knowledge on tumor stage and grade is paramount for treatment decision in Upper Urinary Tract Urothelial Carcinoma (UUT-UC), but cannot be accurately assessed by current techniques. Optical Coherence Tomography (OCT) is a technique, which can hypothetically provide the urologist with real-time intra-operative information on tumor grade and stage. In this pilot study the first results of OCT in grading and staging of UUT-UC are presented. Material Methods Eight consecutive ...
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    11. Emerging optical techniques in advanced cystoscopy for bladder cancer diagnosis: A review of the current literature

      Emerging optical techniques in advanced cystoscopy for bladder cancer diagnosis: A review of the current literature
      Background and objective : The current standard for the diagnosis and followup of bladder cancer remains white light cystoscopy, despite its well-known limitations. The aim of this paper is to review the current literature on three optical diagnostics that have been developed to improve the performance of white light cystoscopy: photodynamic diagnosis, narrow-band imaging and optical coherence tomography. Materials and Methods : A PubMed search was performed for all articles on bladder ...
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    12. Feature Of The Week 2/6/11: Investigation into using Optical Coherence Tomography for Grading Urothelial Carcinoma - Recent Work from Academic Medical Center Amsterdam and University of Twente

      Feature Of The Week 2/6/11: Investigation into using Optical Coherence Tomography for Grading Urothelial Carcinoma - Recent Work from Academic Medical Center Amsterdam and University of Twente
      Feature Of The Week 2/6/11: Achieving the goal of a real-time in-situ high-resolution optical biopsy using OCT would be a tremendous boost to medicine and mankind. However is it quite a complex and difficult challenge that has not been fully realized to date. Many people believe this challenge will be realized in the not too distant future as understanding, approaches, and technology is improved due to progress at ...
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    13. Quantitative measurement of attenuation coefficients of bladder biopsies using optical coherence tomography for grading urothelial carcinoma of the bladder

      Quantitative measurement of attenuation coefficients of bladder biopsies using optical coherence tomography for grading urothelial carcinoma of the bladder
      ...Center, Department of Biomedical Engineering and Physics, P. O. Box 22660, 1100 DD Amsterdam, The Netherlands Theo M. de Reijke Academic Medical Center, Department of Urology, P. O. Box 22660, 1100 DD Amsterdam, The Neth...
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    14. How to improve the effectiveness of transurethral resection in nonmuscle invasive bladder cancer?

      Purpose of review: The high rate of early recurrences in nonmuscle invasive bladder cancer is considered to be strongly related to the effectiveness of transurethral resection (TUR). The aim of this article is to review methods, currently available or in development, that aim at improving TUR, with an emphasis on studies over the past year. Recent findings: It has been shown that re-TUR diminishes staging error and improves local tumour ...
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    15. A New Generation of Optical Diagnostics for Bladder Cancer: Technology, Diagnostic Accuracy, and Future Applications

      Abstract: Context: New developments in optical diagnostics have a potential for less invasive and improved detection of bladder cancer.Objective: To provide an overview of the technology and diagnostic yield of recently developed optical diagnostics for bladder cancer and to outline their potential future applications.Evidence acquisition: A PubMed literature search was performed, and papers on Raman spectroscopy (RS), optical coherence tomography (OCT), photodynamic diagnosis (PDD) and narrow-band imaging (NBI ...
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