1. Articles mentioning both Sunnybrook Health Sciences Centre and University of Toronto

    1-24 of 48 1 2 »
    1. Endovascular optical coherence tomography imaging in cerebrovascular disease

      Endovascular optical coherence tomography imaging in cerebrovascular disease
      Endovascular optical coherence tomography (OCT) is the highest resolution imaging modality currently available with spatial resolution of 10 m. Although originally developed for interventional cardiology, the ability to visualize the luminal environment and anatomy, along with the stent-vessel interaction could be of great utility for various cerebrovascular diseases, and the adoption of endovascular OCT imaging in the evolving field of interventional neuroradiology seems instinctive. The purpose of this study is ...
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    2. 30/80 MHz Bidirectional Dual-Frequency IVUS Feasibility Evaluated In Vivo and for Stent Imaging

      30/80 MHz Bidirectional Dual-Frequency IVUS Feasibility Evaluated In Vivo and for Stent Imaging
      Although intravascular ultrasound (IVUS) is an important tool in guiding complex coronary interventions, the resolution of existing commercial IVUS devices is considerably poorer than that of optical coherence tomography. Dual-frequency IVUS (DF IVUS), incorporating a second, higher frequency transducer, has been proposed as a possible method of overcoming this limitation. Although preliminary studies have shown that DF IVUS can produce complementary images, including large-scale morphology and high detail of superficial ...
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    3. Real-time en-face Gabor optical coherence tomographic angiography on human skin using CUDA GPU

      Real-time en-face Gabor optical coherence tomographic angiography on human skin using CUDA GPU
      We recently proposed an optical coherence tomographic angiography (OCTA) algorithm, Gabor optical coherence tomographic angiography (GOCTA), which can extract microvascular signals from a spectral domain directly with lower computational complexity compared to other algorithms. In this manuscript, we combine a programmable swept source, an OCT complex signal detecting unit, and graphics process units (GPU) to achieve a real-time en-face GOCTA system for human skin microvascular imaging. The programmable swept source ...
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    4. Gabor optical coherence tomographic angiography (GOCTA) (Part II): theoretical basis of sensitivity improvement and optimization for processing speed

      Gabor optical coherence tomographic angiography (GOCTA) (Part II): theoretical basis of sensitivity improvement and optimization for processing speed
      We previously proposed a Gabor optical coherence tomography angiography (GOCTA) algorithm for spectral domain optical coherence tomography (SDOCT) to extract microvascular signals from spectral fringes directly, with speed improvement of 4 to 20 times over existing methods. In this manuscript, we explored the theoretical basis of GOCTA with comparison of experimental data using solid and liquid displacement sample targets, demonstrating that the majority of the GOCTA sensitivity advantage over speckle ...
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    5. Optical coherence tomography–guided flow diversion for aneurysmal treatment

      Optical coherence tomography–guided flow diversion for aneurysmal treatment
      A 28-year-old man presenting with right third nerve palsy was diagnosed with a giant unruptured aneurysm supplied by the right posterior communicating and cerebral arteries (figure 1, A and B). The aneurysm was treated with flow-diverting stent-assisted coiling. Two months later, he presented with new-onset left-sided weakness, and MRI showed increased edema in the thalamus (figure 1C) and increased aneurysm size and no filling. There was no evidence of stent ...
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    6. Optical coherence tomography imaging after endovascular thrombectomy for basilar artery occlusion: report of 3 cases

      Optical coherence tomography imaging after endovascular thrombectomy for basilar artery occlusion: report of 3 cases
      Studies evaluating individuals for endothelial injury after endovascular thrombectomy (EVT) have been done by means of retrieved human thrombus, MR vessel-wall imaging, and animal histopathological studies. These techniques have limitations, because MR imaging has insufficient spatial resolution to directly visualize endothelium, and histopathological examinations are performed ex vivo and are unable to provide real-time patterns of injury. The purpose of the current study was to obtain in vivo intraluminal imaging ...
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    7. Optical Coherence Tomography as an Adjunct During Carotid Artery Stenting for Carotid Atherosclerotic Disease

      Optical Coherence Tomography as an Adjunct During Carotid Artery Stenting for Carotid Atherosclerotic Disease
      Purpose Carotid artery stenting (CAS) has been proven to decrease the risk of stroke in symptomatic patients with moderate/high-grade carotid stenosis; however, there is an increased periprocedural risk of stroke with CAS compared to carotid endarterectomy. The goal of this article is to report the utilization of endovascular optical coherence tomography (OCT) during CAS to aid in the identification of stent malapposition, plaque prolapse, and adjacent residual thrombus that ...
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    8. 2D MEMS-based high-speed beam-shifting technique for speckle noise reduction and flow rate measurement in optical coherence tomography

      2D MEMS-based high-speed beam-shifting technique for speckle noise reduction and flow rate measurement in optical coherence tomography
      In this manuscript, a two-dimensional (2D) micro-electro-mechanical system (MEMS)-based, high-speed beam-shifting spectral domain optical coherence tomography (MHB-SDOCT) is proposed for speckle noise reduction and absolute flow rate measurement. By combining a zigzag scanning protocol, the frame rates of 45.2 Hz for speckle reduction and 25.6 Hz for flow rate measurement are achieved for in-vivo tissue imaging. Phantom experimental results have shown that by setting the incident beam ...
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    9. Beam-shifting technique for speckle reduction and flow rate measurement in optical coherence tomography

      Beam-shifting technique for speckle reduction and flow rate measurement in optical coherence tomography
      In this Letter, we propose a beam-shifting optical coherence tomography scheme for speckle reduction and blood flow rate calculation, where variations of the speckle pattern and Doppler angle were generated by parallel shifting of the sample beam incident on the objective lens. The resultant optical coherent tomography images could then be averaged for speckle noise reduction and simultaneously analyzed for flow rate measurement. The performance of the proposed technique was ...
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    10. Buffer-averaging super-continuum source based spectral domain optical coherence tomography for high speed imaging

      Buffer-averaging super-continuum source based spectral domain optical coherence tomography for high speed imaging
      In super-continuum (SC) source based spectral domain optical coherence tomography (SC-SDOCT), the stability of the power spectral density (PSD) has a significant impact on OCT system sensitivity and image signal to noise ratio (SNR). High speed imaging decreases the camera's exposure time, thus each A-scan contained fewer laser pulse excited SC wideband emissions, resulting in a decrease of SNR. In this manuscript, we present a buffer-averaging SC-SDOCT (BASC-SDOCT) to ...
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    11. Ultrasound and Infrared-Based Imaging Modalities for Diagnosis and Management of Cutaneous Diseases

      Ultrasound and Infrared-Based Imaging Modalities for Diagnosis and Management of Cutaneous Diseases
      Non-invasive bedside imaging tools are becoming more prevalent for assessing cutaneous lesions. Ultrasound used at specific frequencies allows us to assess margins of lesions to minimize the extent of the biopsy that is performed and improve cosmetic outcomes. Vascularity, seen on Doppler ultrasound and contrast-enhanced ultrasound, and stiffness, assessed on tissue elastography, can help differentiate between benign and malignant lesions for clinicians to be more judicious in deciding whether to ...
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    12. High speed, wide velocity dynamic range Doppler optical coherence tomography (Part V): Optimal utilization of multi-beam scanning for Doppler and speckle variance microvascular imaging

      High speed, wide velocity dynamic range Doppler optical coherence tomography (Part V): Optimal utilization of multi-beam scanning for Doppler and speckle variance microvascular imaging
      In this paper, a multi-beam scanning technique is proposed to optimize the microvascular images of human skin obtained with Doppler effect based methods and speckle variance processing. Flow phantom experiments were performed to investigate the suitability for combining multi-beam data to achieve enhanced microvascular imaging. To our surprise, the highly variable spot sizes (ranging from 13 to 77 m) encountered in high numerical aperture multi-beam OCT system imaging the same ...
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    13. Hybrid intravascular imaging: recent advances, technical considerations, and current applications in the study of plaque pathophysiology

      Hybrid intravascular imaging: recent advances, technical considerations, and current applications in the study of plaque pathophysiology
      Cumulative evidence from histology-based studies demonstrate that the currently available intravascular imaging techniques have fundamental limitations that do not allow complete and detailed evaluation of plaque morphology and pathobiology, limiting the ability to accurately identify high-risk plaques. To overcome these drawbacks, new efforts are developing for data fusion methodologies and the design of hybrid, dual-probe catheters to enable accurate assessment of plaque characteristics, and reliable identification of high-risk lesions. Today ...
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    14. Optical coherence tomography spectral analysis for detecting apoptosis in vitro and in vivo

      Optical coherence tomography spectral analysis for detecting apoptosis in vitro and in vivo
      Apoptosis is a form of programmed cell death characterized by a series of predictable morphological changes at the subcellular level, which modify the light-scattering properties of cells. We present a spectroscopic optical coherence tomography (OCT) technique to detect changes in subcellular morphology related to apoptosis in vitro and in vivo . OCT data were acquired from acute myeloid leukemia (AML) cells treated with cisplatin over a 48-h period. The backscatter spectrum ...
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    15. OCT-guided management in a patient with anterior STEMI

      OCT-guided management in a patient with anterior STEMI
      A 64-year-old man presented with an anterior ST elevation myocardial infarction. He had experienced sudden onset chest pain at the end of a hockey game. His medical history was unremarkable. His blood pressure was 150/65 mm Hg and he had a heart rate of 70 bpm. Cardiovascular examination revealed normal heart sounds and no murmurs or added sounds. Coronary angiography revealed haziness in the proximal left anterior descending artery ...
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    16. Feature Of The Week 01/18/15: An Integrated Optical Coherence Tomography-Gas Nozzle System for Surgical Laser Ablation Applications

      Comment "Dear Ms. Kumar. Thank you for your comment. Please note all three articles you mentioned above are already on OCT ..." - Eric Swanson
      Feature Of The Week 01/18/15: An Integrated Optical Coherence Tomography-Gas Nozzle System for Surgical Laser Ablation Applications
      Gas assisted laser machining of materials is a common practice in the manufacturing industry. Advantages in using gas assistance include reducing the likelihood of flare-ups in flammable materials and clearing away ablated material in the cutting path. Current surgical procedures and research do not take advantage of this and in the case for resecting osseous tissue, gas assisted ablation can help minimize charring and clear away debris from the surgical ...
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    17. Development of an integrated optical coherence tomography-gas nozzle system for surgical laser ablation applications: preliminary findings of in situ spinal cord deformation due to gas flow effects

      Development of an integrated optical coherence tomography-gas nozzle system for surgical laser ablation applications: preliminary findings of in situ spinal cord deformation due to gas flow effects
      ...ntre, 2075 Bayview Ave., Toronto, Ontario, M4N 3M5, Canada ^4Division of Neurosurgery, Faculty of Medicine, University of Toronto, 27 King’s College Circle, Toronto, Ontario, M5S 1A1, Canada ^5Division of Neurosurger...
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    18. Evaluation of flow velocities after carotid artery stenting through split spectrum Doppler optical coherence tomography and computational fluid dynamics modeling

      Evaluation of flow velocities after carotid artery stenting through split spectrum Doppler optical coherence tomography and computational fluid dynamics modeling
      ...s Centre, 2075 Bayview Avenue Toronto, ON, M4N 3M5, Canada ^4Division of Neurosurgery, Faculty of Medicine, University of Toronto, 1 King’s College Circle, Toronto, ON, M5S 1A8, Canada ^*Corresponding author: yangv@e...
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    19. Histogram flow mapping with optical coherence tomography for in vivo skin angiography of hereditary hemorrhagic telangiectasia

      Histogram flow mapping with optical coherence tomography for in vivo skin angiography of hereditary hemorrhagic telangiectasia
      ...chael’s Hospital, Dermatopathology, Department of Laboratory Medicine, Toronto M5B 1W8, Canada Peter Kertes University of Toronto, John and Liz Tory Eye Centre, Sunnybrook Health Sciences Centre, Department of Ophthalm...
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    20. High speed, wide velocity dynamic range Doppler optical coherence tomography (Part IV): split spectrum processing in rotary catheter probes

      High speed, wide velocity dynamic range Doppler optical coherence tomography (Part IV): split spectrum processing in rotary catheter probes
      ...ry, Sunnybrook Health Sciences Centre, Toronto, ON, Canada ^4Division of Neurosurgery, Faculty of Medicine, University of Toronto, ON, Canada ^*Corresponding author: yangv@ee.ryerson.ca Optics Express, Vol. 22, Iss...
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    21. Detecting apoptosis in vivo and ex vivo using spectroscopic OCT and dynamic light scattering

      Detecting apoptosis in vivo and ex vivo using spectroscopic OCT and dynamic light scattering
      We present an in vivo implementation of a multi-parametric technique for detecting apoptosis using optical coherence tomography in a mouse tumor model. Solid tumors were grown from acute myeloid leukemia cells in the hind leg of SCID mice and treated with a single dose of cisplatin and dexamethasone to induce apoptosis. Both spectral features and speckle decorrelation times indicated good consistency between control mice and reasonable agreement with in vitro ...
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    22. 1-24 of 48 1 2 »
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