1. Articles mentioning both Sunnybrook Health Sciences Centre and Ryerson University

    1-24 of 36 1 2 »
    1. Time interval optimized optical coherence tomographic angiography for bulk motion suppression on human skin

      Time interval optimized optical coherence tomographic angiography for bulk motion suppression on human skin
      Bulk motions occurred during in vivo scanning could modulate the backscattered light signals with the same mechanism of moving scatterers (such as red blood cells), so bulk motion suppression plays a key role for optical coherence tomographic angiography (OCTA) applications. One classic method to overcome this issue is to compensate the bulk motions with image registration algorithms before calculating vascular signals, which is however computationally intensive and makes real-time screening ...
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    2. Quantification metrics for telangiectasia using optical coherence tomography

      Quantification metrics for telangiectasia using optical coherence tomography
      Hereditary hemorrhagic telangiectasia (HHT) is an autosomal dominant disorder that causes vascular malformations throughout the body. The most prevalent and accessible of these lesions are found throughout the skin and mucosa, and often rupture causing bleeding and anemia. A recent increase in potential HHT treatments have created a demand for quantitative metrics that can objectively measure the efficacy of new and developing treatments. We employ optical coherence tomography (OCT)-a ...
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    3. Gabor optical coherence tomographic angiography (GOCTA) (Part II): theoretical basis of sensitivity improvement and optimization for processing speed

      Gabor optical coherence tomographic angiography (GOCTA) (Part II): theoretical basis of sensitivity improvement and optimization for processing speed
      We previously proposed a Gabor optical coherence tomography angiography (GOCTA) algorithm for spectral domain optical coherence tomography (SDOCT) to extract microvascular signals from spectral fringes directly, with speed improvement of 4 to 20 times over existing methods. In this manuscript, we explored the theoretical basis of GOCTA with comparison of experimental data using solid and liquid displacement sample targets, demonstrating that the majority of the GOCTA sensitivity advantage over speckle ...
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    4. Optical coherence tomography–guided flow diversion for aneurysmal treatment

      Optical coherence tomography–guided flow diversion for aneurysmal treatment
      A 28-year-old man presenting with right third nerve palsy was diagnosed with a giant unruptured aneurysm supplied by the right posterior communicating and cerebral arteries (figure 1, A and B). The aneurysm was treated with flow-diverting stent-assisted coiling. Two months later, he presented with new-onset left-sided weakness, and MRI showed increased edema in the thalamus (figure 1C) and increased aneurysm size and no filling. There was no evidence of stent ...
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    5. Optical coherence tomography for dynamic axial correction of an optical end-effector for robot-guided surgical laser ablation

      Optical coherence tomography for dynamic axial correction of an optical end-effector for robot-guided surgical laser ablation
      Robot-guided laser ablation for surgical applications potentially offers many advantages compared to by-hand mechanical tissue cutting. However, given that tissue can be rough and/or uneven, ablation quality can be compromised if the beam waist deviates significantly from the target tissue surface. Therefore, we present a method that uses optical coherence tomography (OCT) for dynamic refocusing of robot-guided surgical laser ablation. A 7-DOF robotic manipulator with an OCT-equipped optical payload ...
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    6. 2D MEMS-based high-speed beam-shifting technique for speckle noise reduction and flow rate measurement in optical coherence tomography

      2D MEMS-based high-speed beam-shifting technique for speckle noise reduction and flow rate measurement in optical coherence tomography
      In this manuscript, a two-dimensional (2D) micro-electro-mechanical system (MEMS)-based, high-speed beam-shifting spectral domain optical coherence tomography (MHB-SDOCT) is proposed for speckle noise reduction and absolute flow rate measurement. By combining a zigzag scanning protocol, the frame rates of 45.2 Hz for speckle reduction and 25.6 Hz for flow rate measurement are achieved for in-vivo tissue imaging. Phantom experimental results have shown that by setting the incident beam ...
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    7. Beam-shifting technique for speckle reduction and flow rate measurement in optical coherence tomography

      Beam-shifting technique for speckle reduction and flow rate measurement in optical coherence tomography
      In this Letter, we propose a beam-shifting optical coherence tomography scheme for speckle reduction and blood flow rate calculation, where variations of the speckle pattern and Doppler angle were generated by parallel shifting of the sample beam incident on the objective lens. The resultant optical coherent tomography images could then be averaged for speckle noise reduction and simultaneously analyzed for flow rate measurement. The performance of the proposed technique was ...
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    8. Buffer-averaging super-continuum source based spectral domain optical coherence tomography for high speed imaging

      Buffer-averaging super-continuum source based spectral domain optical coherence tomography for high speed imaging
      In super-continuum (SC) source based spectral domain optical coherence tomography (SC-SDOCT), the stability of the power spectral density (PSD) has a significant impact on OCT system sensitivity and image signal to noise ratio (SNR). High speed imaging decreases the camera's exposure time, thus each A-scan contained fewer laser pulse excited SC wideband emissions, resulting in a decrease of SNR. In this manuscript, we present a buffer-averaging SC-SDOCT (BASC-SDOCT) to ...
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    9. High speed, wide velocity dynamic range Doppler optical coherence tomography (Part V): Optimal utilization of multi-beam scanning for Doppler and speckle variance microvascular imaging

      High speed, wide velocity dynamic range Doppler optical coherence tomography (Part V): Optimal utilization of multi-beam scanning for Doppler and speckle variance microvascular imaging
      In this paper, a multi-beam scanning technique is proposed to optimize the microvascular images of human skin obtained with Doppler effect based methods and speckle variance processing. Flow phantom experiments were performed to investigate the suitability for combining multi-beam data to achieve enhanced microvascular imaging. To our surprise, the highly variable spot sizes (ranging from 13 to 77 m) encountered in high numerical aperture multi-beam OCT system imaging the same ...
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    10. Intraoperative optical coherence tomography of the cerebral cortex using a 7 degree-of freedom robotic arm

      Intraoperative optical coherence tomography of the cerebral cortex using a 7 degree-of freedom robotic arm
      Optical Coherence Tomography (OCT) provides a high-resolution imaging technique with limited depth penetration. The current use of OCT is limited to relatively small areas of tissue for anatomical structure diagnosis or minimally invasive guided surgery. In this study, we propose to image a large area of the surface of the cerebral cortex. This experiment aims to evaluate the potential difficulties encountered when applying OCT imaging to large and irregular surface ...
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    11. Optical coherence tomography spectral analysis for detecting apoptosis in vitro and in vivo

      Optical coherence tomography spectral analysis for detecting apoptosis in vitro and in vivo
      Apoptosis is a form of programmed cell death characterized by a series of predictable morphological changes at the subcellular level, which modify the light-scattering properties of cells. We present a spectroscopic optical coherence tomography (OCT) technique to detect changes in subcellular morphology related to apoptosis in vitro and in vivo . OCT data were acquired from acute myeloid leukemia (AML) cells treated with cisplatin over a 48-h period. The backscatter spectrum ...
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    12. Feature Of The Week 01/18/15: An Integrated Optical Coherence Tomography-Gas Nozzle System for Surgical Laser Ablation Applications

      Comment "Dear Ms. Kumar. Thank you for your comment. Please note all three articles you mentioned above are already on OCT ..." - Eric Swanson
      Feature Of The Week 01/18/15: An Integrated Optical Coherence Tomography-Gas Nozzle System for Surgical Laser Ablation Applications
      ... site of gas delivery. For more information see recent Article . Courtesy of Ronnie Wong and Victor Yang from Ryerson University . Gas assisted laser machining of materials is a common practice in the manufacturing indus...
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    13. Development of an integrated optical coherence tomography-gas nozzle system for surgical laser ablation applications: preliminary findings of in situ spinal cord deformation due to gas flow effects

      Development of an integrated optical coherence tomography-gas nozzle system for surgical laser ablation applications: preliminary findings of in situ spinal cord deformation due to gas flow effects
      ... Ryerson University, Toronto, Ontario, M5B 2K3, Canada ^2Department of Electrical and Computer Engineering, Ryerson University, Toronto, Ontario, M5B 2K3, Canada ^3Department of Surgical Neuromonitoring, Sunnybrook H...
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    14. Evaluation of flow velocities after carotid artery stenting through split spectrum Doppler optical coherence tomography and computational fluid dynamics modeling

      Evaluation of flow velocities after carotid artery stenting through split spectrum Doppler optical coherence tomography and computational fluid dynamics modeling
      ...Sunnybrook Research Institute, 2075 Bayview Avenue,Toronto, ON, M4N 3M5, Canada ^3Division of Neurosurgery, Sunnybrook Health Sciences Centre, 2075 Bayview Avenue Toronto, ON, M4N 3M5, Canada ^4Division of Neurosurge...
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    15. Histogram flow mapping with optical coherence tomography for in vivo skin angiography of hereditary hemorrhagic telangiectasia

      Histogram flow mapping with optical coherence tomography for in vivo skin angiography of hereditary hemorrhagic telangiectasia
      ...Victor X. D. Yang Ryerson University, Biophotonics and Bioengineering Laboratory, Toronto M5B 2K3, Canada Ryerson University, Department of Electrical and Computer Engineering, Toronto M5B 2K3, Canada Sunnybrook He...
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    16. High speed, wide velocity dynamic range Doppler optical coherence tomography (Part IV): split spectrum processing in rotary catheter probes

      High speed, wide velocity dynamic range Doppler optical coherence tomography (Part IV): split spectrum processing in rotary catheter probes
      ...er Imaging Unit, British Columbia Cancer Research Centre, Vancouver, BC, Canada ^3Division of Neurosurgery, Sunnybrook Health Sciences Centre, Toronto, ON, Canada ^4Division of Neurosurgery, Faculty of Medicine, Univ...
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    17. Detecting apoptosis in vivo and ex vivo using spectroscopic OCT and dynamic light scattering

      Detecting apoptosis in vivo and ex vivo using spectroscopic OCT and dynamic light scattering
      We present an in vivo implementation of a multi-parametric technique for detecting apoptosis using optical coherence tomography in a mouse tumor model. Solid tumors were grown from acute myeloid leukemia cells in the hind leg of SCID mice and treated with a single dose of cisplatin and dexamethasone to induce apoptosis. Both spectral features and speckle decorrelation times indicated good consistency between control mice and reasonable agreement with in vitro ...
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    18. Digital image correlation–based optical coherence elastography

      Digital image correlation–based optical coherence elastography
      Optical coherence elastography (OCE) provides deformation or material properties, mapping of soft tissue. We aim to develop a robust speckle tracking OCE technique with improved resolution and accuracy. A digital image correlation (DIC)-based OCE technique was developed by combining an advanced DIC algorithm with optical coherence tomography (OCT). System calibration and measurement error evaluation demonstrated that this DIC-based OCE technique had a resolution of 0.6 m displacement and ...
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    19. Review of speckle and phase variance optical coherence tomography to visualize microvascular networks

      Review of speckle and phase variance optical coherence tomography to visualize microvascular networks
      High-resolution mapping of microvasculature has been applied to diverse body systems, including the retinal and choroidal vasculature, cardiac vasculature, the central nervous system, and various tumor models. Many imaging techniques have been developed to address specific research questions, and each has its own merits and drawbacks. Understanding, optimization, and proper implementation of these imaging techniques can significantly improve the data obtained along the spectrum of unique research projects to obtain ...
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    20. Intraoperative handheld optical coherence tomography forward-viewing probe: physical performance and preliminary animal imaging

      Intraoperative handheld optical coherence tomography forward-viewing probe: physical performance and preliminary animal imaging
      A prototype intraoperative hand-held optical coherence tomography (OCT) imaging probe was developed to provide micron resolution cross-sectional images of subsurface tissue during open surgery. This new ergonomic probe was designed based on electrostatically driven optical fibers, and packaged into a catheter probe in the form factor of clinically accepted Bayonet shaped neurosurgical probes. Optical properties of the probe were measured to have a ~20 μm spot size, 5 mm working ...
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    21. 1-24 of 36 1 2 »
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  2. Organizations in the News

    1. (31 articles) University of Toronto
    2. (5 articles) Nanjing University of Science and Technology
    3. (3 articles) University of Hong Kong
    4. (3 articles) Ontario Cancer Institute
    5. (2 articles) Institute of Applied Physics
    6. (2 articles) Harvard University
    7. (2 articles) Massachusetts General Hospital
    8. (1 articles) UCSF
    9. (1 articles) University of British Columbia
    10. (1 articles) Johns Hopkins University
    11. (1 articles) Nizhny Novgorod State Medical Academy
    12. (1 articles) Yale University
  3. OCT Companies in the News

    1. (3 articles) Conavi Medical Inc.