1. Articles mentioning both Stephen A. Boppart and Daniel L. Marks

    1-21 of 21
    1. Group refractive index reconstruction with broadband interferometric confocal microscopy

      Group refractive index reconstruction with broadband interferometric confocal microscopy

      A system and method for microscale measurement and imaging of the group refractive index of a sample. The method utilizes a broadband confocal high-numerical aperture microscope embedded into an interferometer and a spectrometric means, whereby spectral interferograms are analyzed to compute optical path delay of the beam traversing the sample as the sample is translated through the focus of an interrogating light beam. A determination of group refractive index may serve to disambiguate phase ambiguity in a measurement of refractive index at a specified wavelength. Spatial resolution of object characterization in three dimensions is achieved by imaging the object from ...

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    2. Partially coherent illumination for inverse scattering full-field interferometric synthetic aperture microscopy

      Methods and apparatus for three-dimensional imaging of a sample. A source is provided of a beam of light characterized by partial spatial coherence. The beam is focused onto a sample and scattered light from the sample is superposed with a reference beam derived from the source onto a focal plane detector array to provide an interference signal. A forward scattering model is derived relating measurement data to structure of an object to allow solutions of an inverse scattering problem, based upon the interference signal so that a three-dimensional structure of the same may be inferred. The partial spatial coherence of ...
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    3. Nonlinear interferometric vibrational imaging

      A method of examining a sample, which includes: exposing a reference to a first set of electromagnetic radiation, to form a second set of electromagnetic radiation scattered from the reference; exposing a sample to a third set of electromagnetic radiation to form a fourth set of electromagnetic radiation scattered from the sample; and interfering the second set of electromagnetic radiation and the fourth set of electromagnetic radiation. The first set and the third set of electromagnetic radiation are generated from a source; at least a portion of the second set of electromagnetic radiation is of a frequency different from that ...
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    4. Interferometric synthetic aperture microscopy

      Methods and apparatus for three-dimensional imaging of a sample. A source is provided of a beam of substantially collimated light characterized by a temporally dependent spectrum. The beam is focused in a plane characterized by a fixed displacement along the propagation axis of the beam, and scattered light from the sample is superposed with a reference beam derived from the substantially collimated source onto a focal plane detector array to provide an interference signal. A forward scattering model is derived relating measured data to structure of an object to allow solution of an inverse scattering problem based upon the interference ...
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    5. Validation of nonlinear interferometric vibrational imaging as a molecular OCT technique by the use of Raman microscopy

      We validate a molecular imaging technique called Nonlinear Interferometric Vibrational Imaging (NIVI) by comparing vibrational spectra with those acquired from Raman microscopy. This broadband coherent anti-Stokes Raman scattering (CARS) technique uses heterodyne detection and OCT acquisition and design principles to interfere a CARS signal generated by a sample with a local oscillator signal generated separately by a four-wave mixing process. These are mixed and demodulated by spectral interferometry. Its confocal configuration allows the acquisition of 3D images based on endogenous molecular signatures. Images from both phantom and mammary tissues have been acquired by this instrument and its spectrum is compared ...
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    6. Interferometric Synthetic Aperture Microscopy: Physics-Based Image Reconstruction from Optical Coherence Tomography Data

      Optical coherence tomography (OCT) is an optical ranging technique analogous to radar - detection of back-scattered light produces a signal that is temporally localized at times-of-flight corresponding to the location of scatterers in the object. However the interferometric collection technique used in OCT allows, in principle, the coherent collection of data, i.e. amplitude and phase information can be extracted. Interferometric synthetic aperture microscopy (ISAM) adds phase-stable data collection to OCT instrumentation and employs physics-based processing analogous to that used in synthetic aperture radar (SAR). That is, the complex nature of the coherent data is exploited to give gains in image ...
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    7. Volumetric endoscopic coherence microscopy using a coherent fiber bundle

      Methods for employing coherent bundles of optical fibers, whether single- or multi-mode, for optical coherence tomography or optical coherence microscopy. Either a substantially monochromatic source or a broadband source is spatially decohered and/or spatially filtered prior to coupling into the fiber bundle for illumination of a sample. A scatter signal from features disposed beneath the surface of the sample is interfered with a reference signal derived, at either end of the fiber bundle, from the identical source of illumination.
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    8. Volumetric Endoscopic Coherence Microscopy Using A Coherent Fiber Bundle (Wo 2008/091755)

      Volumetric Endoscopic Coherence Microscopy Using A Coherent Fiber Bundle (Wo 2008/091755)
      Methods for employing coherent bundles of optical fibers, whether single- or multi-mode, for optical coherence tomography or optical coherence microscopy. Either a substantially monochromatic source or a broadband source (200) has its spatial coherence reduced and/or is spatially filtered prior to coupling into the fiber bundle for 'illumination of a sample. A scattered signal from features disposed beneath the surface of the sample is interfered with a reference signal derived, at either end of the fiber bundle, from the identical source of illumination.
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    9. Stabilization of continuum generation from normally dispersive nonlinear optical fibers for a tunable broad bandwidth source for optical coherence tomography

      ... tunable broad bandwidth source for optical coherence tomography Haohua Tu, Daniel L. Marks, Yee Lin Koh, and Stephen A. Boppart Optics Letters, Vol. 32, Issue 14, pp. 2037-2039 Keywords (OCIS): (110.4500) Imaging system...
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    10. Optical coherence tomography: a review of clinical development from bench to bedside

      Adam M. Zysk, Freddy T. Nguyen, Amy L. Oldenburg et al. Since its introduction, optical coherence tomography (OCT) technology has advanced from the laboratory bench to the clinic and back again. Arising from the fields of low coherence interferometry and optical time- and frequency-domain reflectometry, OCT was initially demonstrated for retinal imaging ... [J. Biomed. Opt. 12, 051403 (2007)] published Wed Oct 24, 2007.
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    11. Optical contrast agents for optically modifying incident radiation

      A method of enhancing the contrast of an image of a sample, comprises forming an image of a mixture, by exposing the mixture to electromagnetic radiation. The mixture comprises the sample and microparticles. The enhancement is particularly suitable for optical coherence tomography.

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    12. Interferometric synthetic aperture microscopy

      Interferometric synthetic aperture microscopy
      State-of-the-art methods in high-resolution three-dimensional optical microscopy require that the focus be scanned through the entire region of interest. However, an analysis of the physics of the light–sample interaction reveals that the Fourier-space coverage is independent of depth. Here we show that, by solving the inverse scattering problem for interference microscopy, computed reconstruction yields volumes with a resolution in all planes that is equivalent to the resolution achieved only at the focal plane for conventional high-resolution microscopy. In short, the entire illuminated volume has spatially invariant resolution, thus eliminating the compromise between resolution and depth of field. We describe ...
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    13. 1-21 of 21
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  2. Organizations in the News

    1. (21 articles) University of Illinois at Urbana-Champaign
    2. (1 articles) National Institutes of Health
  3. People in the News

    1. (8 articles) P. Scott Carney
    2. (7 articles) Tyler S. Ralston
    3. (3 articles) Eric J. Chaney
    4. (1 articles) Steven G. Adie
    5. (1 articles) Haohua Tu
    6. (1 articles) Amy L. Oldenburg
  4. OCT Companies in the News

    1. (1 articles) Gould Fiber Optics