1. Articles mentioning both Srinivas R. Sadda and UCLA

    1-24 of 79 1 2 3 4 »
    1. Impact of slab selection on quantification of choriocapillaris flow deficits by optical coherence tomography angiography

      Impact of slab selection on quantification of choriocapillaris flow deficits by optical coherence tomography angiography
      Purpose To assess the impact of slab selection on quantitative measurements of choriocapillaris (CC) flow deficits (FDs) using optical coherence tomography angiography (OCTA). Design Cross-sectional study Methods Using a swept-source OCTA device, en face slabs to isolate the CC were first generated using the manufacturers default setting: a 20 m-thick slab starting 29 m posterior to the centerline of the automatically segmented retinal pigment epithelium (RPE) band. The inner and ...
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    2. Volumetric Analysis of Vascularized Serous Pigment Epithelial Detachment Progression in Neovascular Age-Related Macular Degeneration Using Optical Coherence Tomography Angiography

      Volumetric Analysis of Vascularized Serous Pigment Epithelial Detachment Progression in Neovascular Age-Related Macular Degeneration Using Optical Coherence Tomography Angiography
      Purpose : To analyze the evolution of type 1 neovascularization associated with vascularized serous pigment epithelial detachment (vsPED) using three-dimensional, volumetric, en face optical coherence tomography angiography (OCTA). Methods : This was a retrospective case series from four tertiary medical centers. OCTA images were analyzed at baseline and at the 3-, 6-, 12-, 18-, and 24-month follow-up visit when available. Visual acuity, number of injections, PED maximal height and PED area and ...
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    3. Retinal Vascular Changes During Pregnancy Detected With Optical Coherence Tomography Angiograph

      Retinal Vascular Changes During Pregnancy Detected With Optical Coherence Tomography Angiograph
      Purpose : To evaluate retinal vascular status during pregnancy by using optical coherence tomography angiography (OCTA). Methods : Women in their third trimester of pregnancy and nonpregnant age-matched women were recruited for this prospective, case-control study. Subjects were imaged with OCTA. Main outcome measures were foveal avascular zone parameters, perfusion density (PD) percentage in the superficial retinal capillary plexus (SCP), PD percentage in the deep retinal capillary plexus (DCP), SCP vessel length ...
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    4. Optical coherence tomography risk factors for development of late age related macular degeneration in the fellow eyes of patients enrolled in the HARBOR Study

      Optical coherence tomography risk factors for development of late age related macular degeneration in the fellow eyes of patients enrolled in the HARBOR Study
      Purpose To evaluate the relationship between optical coherence tomography (OCT) features and the progression to late age related macular degeneration (AMD) in the fellow eyes of patients enrolled in the 24-month HARBOR study (NCT00891735) for neovascular AMD. Design post hoc analysis of a phase 3 multicenter, prospective, randomized, double-masked, active treatment-controlled clinical trial. Participants Evaluable subjects (N=501) with macular neovascularization (MNV) secondary to neovascular AMD and early or intermediate ...
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    5. Macular Microvascular Networks In Healthy Pediatric Subjects

      Macular Microvascular Networks In Healthy Pediatric Subjects
      Purpose: To report optical coherence tomography angiography ( OCTA ) values in healthy pediatric eyes and to identify factors that may modify these values. Methods: In this prospective observational cross-sectional study, macular OCTA images were acquired from healthy pediatric patients. Main outcome measures were 1) foveal avascular zone (FAZ) area at the level of the superficial retinal capillary plexus (SCP); 2) SCP and deep retinal capillary plexus (DCP) perfusion density (based on ...
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    6. Pearls and Pitfalls of Optical Coherence Tomography Angiography Imaging: A Review

      Pearls and Pitfalls of Optical Coherence Tomography Angiography Imaging: A Review
      Optical coherence tomography angiography (OCTA) has significantly expanded our knowledge of the ocular vasculature. Furthermore, this imaging modality has been widely adopted to investigate different ocular and systemic diseases. In this review, a discussion of the fundamental principles of OCTA is followed by the application of this imaging modality to study the retinal and choroidal vessels. A proper comprehension of this imaging modality is essential for the interpretation of OCTA ...
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    7. Identification and Characterization of Imaging Technique Errors and Artifacts using Anterior Segment Optical Coherence Tomography for Irido-Corneal Angle Evaluations in Glaucom

      Identification and Characterization of Imaging Technique Errors and Artifacts using Anterior Segment Optical Coherence Tomography for Irido-Corneal Angle Evaluations in Glaucom
      Purpose Anterior segment optical coherence tomography (ASOCT) platforms provide non-invasive and quantifiable evaluations of anterior chamber angle (ACA) anatomy. Even though these ACA measurements have been validated with high repeatability and reproducibility, we are the first study to describe in detail the technique errors and artifacts that may occur during imaging of the ACA. The purpose of this study was to define the different types and quantify the frequency of ...
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    8. Impact of segmentation density on spectral domain optical coherence tomography assessment in Stargardt disease

      Impact of segmentation density on spectral domain optical coherence tomography assessment in Stargardt disease
      Purpose Automated spectral domain optical coherence tomography (SD-OCT) segmentation algorithms currently do not perform well in segmenting individual intraretinal layers in eyes with Stargardt disease (STGD). We compared selective B-scan segmentation strategies for generating mean retinal layer thickness and preserved area data from SD-OCT scans in patients with STGD1. Methods Forty-five eyes from 40 Stargardt patients were randomly selected from the ongoing Natural History of the Progression of Atrophy Secondary ...
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    9. Summary of 6th International Meeting on OCT Angiography & Advances in OCT in Rome December 2018: A Tremendous Success

      Summary of 6th International Meeting on OCT Angiography & Advances in OCT in Rome December 2018: A Tremendous Success
      On December 14 and 15 2018, over 1400 ophthalmologists participated in Rome at tha most important meeting on OCT and OCT Angiography. the 6th international meeting on OCT Angiography, advances in OCT . The organizer, Dr Lumbroso has, since he started to organize these meetings, a well-defined objective: informing ophthalmologist in any country on the new clinical possibilities of Ocular imaging. The policy is to invite the best speakers in the ...
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    10. Evaluation of Corneal Epithelial Thickness Imaged by High Definition Optical Coherence Tomography in Healthy Eyes

      Evaluation of Corneal Epithelial Thickness Imaged by High Definition Optical Coherence Tomography in Healthy Eyes
      Purpose: To evaluate corneal epithelial thickness (CET) and corneal thickness (CT) in healthy eyes using spectral domain optical coherence tomography. Methods: Thirty-six healthy eyes were imaged using the Cirrus high-definition (HD)-optical coherence tomography device. The average CET and CT were assessed using Cirrus Review Software within predefined concentric corneal ring-shaped zones. Specific regions of CET (superior, inferior, temporal, nasal, superonasal, inferotemporal, superotemporal, and inferonasal) were also assessed. The difference ...
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    11. VISUAL FUNCTION AND OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY FEATURES IN CHILDREN BORN PRETERM

      VISUAL FUNCTION AND OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY FEATURES IN CHILDREN BORN PRETERM
      Purpose: Preterm children have an increased risk of impaired vision from retinopathy, strabismus, and high refractive error. The aim of this study was to investigate the relationship between foveal parameters generated by optical coherence tomography angiography and visual function in preterm children. Methods: Eighty eyes (32 eyes of former preterm infants and 48 age-matched full-term control eyes) were analyzed. Subjects underwent complete eye examinations including best-corrected visual acuity and retinal ...
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    12. Choriocapillaris impairment around the atrophic lesions in patients with geographic atrophy: a swept-source optical coherence tomography angiography study

      Choriocapillaris impairment around the atrophic lesions in patients with geographic atrophy: a swept-source optical coherence tomography angiography study
      ... volume 66 mm scans were acquired in patients with GA presenting between June and December 2017 at the Doheny-UCLA Eye Centers. The area of GA was delineated on the en face structural OCT fundus images. For each eye, the...
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    13. Systems, methods, and devices for optical coherence tomography multiple enface angiography averaging

      Systems, methods, and devices for optical coherence tomography multiple enface angiography averaging
      The disclosure herein provides methods, systems, and devices for improving optical coherence tomography machine outputs through multiple enface optical coherence tomography angiography averaging techniques. The embodiments disclosed herein can be utilized in ophthalmology for employing optical coherence tomography (OCT) for in vivo visualization of blood vessels and the flow of blood in an eye of a patient, which is also known generally as optical coherence tomography angiography (OCTA). The embodiments ...
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    14. Systems, methods, and devices for optical coherence tomography multiple enface angiography averaging

      Systems, methods, and devices for optical coherence tomography multiple enface angiography averaging
      Abstract The disclosure herein provides methods, systems, and devices for improving optical coherence tomography machine outputs through multiple enface optical coherence tomography angiography averaging techniques. The embodiments disclosed herein can be utilized in ophthalmology for employing optical coherence tomography (OCT) for in vivo visualization of blood vessels and the flow of blood in an eye of a patient, which is also known generally as optical coherence tomography angiography (OCTA). The ...
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    15. Error Correction and Quantitative Subanalysis of Optical Coherence Tomography Data Using Computer-Assisted Grading

      Error Correction and Quantitative Subanalysis of Optical Coherence Tomography Data Using Computer-Assisted Grading
      purpose. To demonstrate feature subanalysis and error correction of optical coherence tomography (OCT) data by using computer-assisted grading. methods. The raw exported StratusOCT (Carl Zeiss Meditec, Inc., Dublin, CA) scan data from 20 eyes of 20 patients were analyzed using custom software (termed OCTOR) designed to allow the user to define manually the retinal borders on each radial line scan. Measurements calculated by the software, including thickness of the nine ...
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    16. Errors in Retinal Thickness Measurements Obtained by Optical Coherence Tomography

      Errors in Retinal Thickness Measurements Obtained by Optical Coherence Tomography
      Objective To report the frequency and severity of optical coherence tomography (OCT) retinal thickness measurement errors and to describe parameters that predict these errors. Design Observational case series. Participants Two hundred consecutive patients undergoing OCT imaging. Methods One eye (primary) from each of 200 consecutive patients undergoing Stratus OCT imaging (Carl Zeiss Meditec, Dublin, CA) with radial lines or fast macular thickness-based acquisition protocols was selected for review by 2 ...
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    17. Distinct Retinal Capillary Plexuses in Normal Eyes as Observed in Optical Coherence Tomography Angiography Axial Profile Analysis

      Distinct Retinal Capillary Plexuses in Normal Eyes as Observed in Optical Coherence Tomography Angiography Axial Profile Analysis
      Optical coherence tomography angiography (OCTA) allows the retinal microvasculature to be visualized at various retinal depths. Previous studies introduced OCTA axial profile analysis and showed regional variations in the number and location of axially distinct vascular retinal plexuses. OCTA acquisition and processing approaches, however, vary in terms of their resulting transverse and axial resolutions, and especially the latter could potentially influence the profile analysis results. Our study imaged normal eyes ...
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    18. PROGRESSION OF MACULAR ATROPHY IN EYES WITH TYPE 1 NEOVASCULARIZATION AND AGE-RELATED MACULAR DEGENERATION RECEIVING LONG-TERM INTRAVITREAL ANTI–VASCULAR ENDOTHELIAL GROWTH FACTOR THERAPY: An Optical Coherence Tomographic Angiography Analysis

      PROGRESSION OF MACULAR ATROPHY IN EYES WITH TYPE 1 NEOVASCULARIZATION AND AGE-RELATED MACULAR DEGENERATION RECEIVING LONG-TERM INTRAVITREAL ANTI–VASCULAR ENDOTHELIAL GROWTH FACTOR THERAPY: An Optical Coherence Tomographic Angiography Analysis
      Purpose: To evaluate the size and location of macular atrophy in eyes with Type-1 neovascularization (NV) and age-related macular degeneration receiving chronic intravitreal antivascular endothelial growth factor therapy. Methods: A retrospective review of a case series of 27 eyes with Type-1 NV and retinal pigment epithelial detachment (PED) having a minimum of 12 months follow-up was performed. Demographic information and visual acuity at baseline and the final follow-up were collected ...
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    19. Multiple enface image averaging for enhanced optical coherence tomography angiography imaging

      Multiple enface image averaging for enhanced optical coherence tomography angiography imaging
      Purpose To investigate the effect of multiple enface image averaging on image quality of the optical coherence tomography angiography (OCTA). Methods Twenty‐one normal volunteers were enrolled in this study. For each subject, one eye was imaged with 3 3 mm scan protocol, and another eye was imaged with the 6 6 mm scan protocol centred on the fovea using the ZEISS Angioplex spectral‐domain OCTA device. Eyes were repeatedly ...
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    20. AMISH EYE STUDY: Baseline Spectral Domain Optical Coherence Tomography Characteristics of Age-Related Macular Degeneration

      AMISH EYE STUDY: Baseline Spectral Domain Optical Coherence Tomography Characteristics of Age-Related Macular Degeneration
      Purpose: To describe spectral domain optical coherence tomography (SD-OCT) findings in an Amish cohort to assess SD-OCT markers for early age-related macular degeneration (AMD). Methods: The authors performed a family-based prospective cohort study of 1,146 elderly Amish subjects (age range 5099 years) (2,292 eyes) who had a family history of at least 1 individual with AMD. All subjects underwent complete ophthalmic examinations, SD-OCT using both Cirrus and Spectralis ...
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    21. Quantifying vascular density and morphology using different swept-source optical coherence tomography angiographic scan patterns in diabetic retinopathy

      Quantifying vascular density and morphology using different swept-source optical coherence tomography angiographic scan patterns in diabetic retinopathy
      Aims To evaluate quantitative metrics of the retinal microvasculature in eyes with diabetic retinopathy (DR) using various en face swept-source optical coherence tomography angiography (SS-OCTA) image sizes. Methods Non-segmented and segmented images were acquired using an SS-OCTA device (PLEX Elite 9000; Carl Zeiss Meditec, Dublin, California, USA). The scanning protocols included the 33 mm, 66 mm and 1212mm fields of view. Quantitative analysis of the perfusion density (PD), vessel length ...
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    22. Biomarkers Of Neovascular Activity In AGE-RELATED Macular Degeneration Using Optical Coherence Tomography Angiography

      Biomarkers Of Neovascular Activity In AGE-RELATED Macular Degeneration Using Optical Coherence Tomography Angiography
      Purpose: To study the qualitative and quantitative features of choroidal neovascular (NV) membranes in age-related macular degeneration using optical coherence tomography angiography in patients with active and quiescent NV lesions before and after treatment with antivascular endothelial growth factor. Methods: Macular optical coherence tomography angiography images were obtained using RTVue XR Avanti with AngioVue. Morphologic features and quantitative measurements of the NV lesion were analyzed using en face projection images ...
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    23. Wide-field en face swept-source optical coherence tomography angiography using extended field imaging in diabetic retinopathy

      Wide-field en face swept-source optical coherence tomography angiography using extended field imaging in diabetic retinopathy
      Aims To examine the feasibility of wide-field en face swept-source optical coherence tomography angiography (SS-OCTA) with extended field imaging (EFI) for evaluation of the retinal vasculature in diabetic retinopathy (DR). Methods This study included 37 eyes of 27 patients (age, 6510 years; male patients, 18; female patients, 9) with DR. All patients underwent comprehensive ophthalmological examination, including OCTA and fluorescein angiography (FA). The imaging methods were compared for visible field ...
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    24. Optical coherence tomography angiography findings in diabetic retinopathy

      Optical coherence tomography angiography findings in diabetic retinopathy
      Introduction : Diabetic retinopathy (DR) is a common complication of diabetes and a leading cause of blindness in working age population. Fluorescein angiography is still the gold standard in the evaluation of retinal vascular perfusion and diagnosis of macular ischemia. However, it is a costly, time-consuming procedure and it requires intravenous injection of contrast agent, exposing patients to potential side effects. Optical coherence tomography angiography (OCTA) is a novel, non-invasive imaging ...
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