1. Articles mentioning both Pearse A. Keane and Adnan Tufail

    1-22 of 22
    1. Clinically applicable deep learning for diagnosis and referral in retinal disease

      Clinically applicable deep learning for diagnosis and referral in retinal disease
      The volume and complexity of diagnostic imaging is increasing at a pace faster than the availability of human expertise to interpret it. Artificial intelligence has shown great promise in classifying two-dimensional photographs of some common diseases and typically relies on databases of millions of annotated images. Until now, the challenge of reaching the performance of expert clinicians in a real-world clinical pathway with three-dimensional diagnostic scans has remained unsolved. Here ...
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    2. COMPARING FUNDUS FLUORESCEIN ANGIOGRAPHY AND SWEPT-SOURCE OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY IN THE EVALUATION OF DIABETIC MACULAR PERFUSION

      COMPARING FUNDUS FLUORESCEIN ANGIOGRAPHY AND SWEPT-SOURCE OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY IN THE EVALUATION OF DIABETIC MACULAR PERFUSION
      Purpose: To compare fundus fluorescein angiography (FFA) and swept-source optical coherence tomography angiography (SS-OCTA) in the evaluation of macular perfusion in diabetic patients. Methods: Forty-one eyes (21 diabetic patients) seen at Moorfields Eye Hospital (London) over a 1-month interval underwent color fundus photography, FFA, and SS-OCTA imaging of the capillary superficial plexus using 2 different protocols: 3 3 mm and 4.5 4.5 mm. Quantitative assessment (foveal avascular zone ...
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    3. Optical coherence tomography angiography of foveal hypoplasia

      Optical coherence tomography angiography of foveal hypoplasia
      Aims To discuss foveal development in the context of detailed retinal vasculature imaging in foveal hypoplasia using optical coherence tomography angiography. Methods In this case series, the optical coherence tomography angiography results of four patients with idiopathic foveal hypoplasia and two patients with foveal hypoplasia secondary to oculocutaneous albinism are presented. Results Cases with intact visual acuity demonstrated lower grades of foveal hypoplasia on optical coherence tomography, while those with ...
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    4. Optical coherence tomography angiography of foveal hypoplasia

      Optical coherence tomography angiography of foveal hypoplasia
      Aims To discuss foveal development in the context of detailed retinal vasculature imaging in foveal hypoplasia using optical coherence tomography angiography. Methods In this case series, the optical coherence tomography angiography results of four patients with idiopathic foveal hypoplasia and two patients with foveal hypoplasia secondary to oculocutaneous albinism are presented. Results Cases with intact visual acuity demonstrated lower grades of foveal hypoplasia on optical coherence tomography, while those with ...
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    5. Use of Mechanical Turk as a MapReduce Framework for Macular OCT Segmentation

      Use of Mechanical Turk as a MapReduce Framework for Macular OCT Segmentation
      Purpose . To evaluate the feasibility of using Mechanical Turk as a massively parallel platform to perform manual segmentations of macular spectral domain optical coherence tomography (SD-OCT) images using a MapReduce framework. Methods. A macular SD-OCT volume of 61 slice images was map-distributed to Amazon Mechanical Turk. Each Human Intelligence Task was set to 0.01 and required the user to draw five lines to outline the sublayers of the retinal ...
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    6. The Evaluation of Diabetic Macular Ischemia Using Optical Coherence Tomography Angiography

      The Evaluation of Diabetic Macular Ischemia Using Optical Coherence Tomography Angiography
      Purpose : The purpose of this study was to compare optical coherence tomography (OCT) angiography to standard fluorescein angiography (FA) in the grading of diabetic macular ischemia. Methods : In our study, OCT angiography and traditional FA images were acquired from 24 diabetic patients. The level of diabetic macular ischemia in the superficial capillary plexus was graded with standard Early Treatment Diabetic Retinopathy Study (ETDRS) protocols and a comparison between conventional FA ...
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    7. Optical coherence tomography angiography and indocyanine green angiography for corneal vascularisation

      Optical coherence tomography angiography and indocyanine green angiography for corneal vascularisation
      Background/Aim To describe an optical coherence tomography angiography (OCTA) system adapted for anterior segment imaging, compared with indocyanine green angiography (ICGA) in eyes with corneal vascularisation. Methods Retrospective study of subjects with corneal vascularisation secondary to microbial keratitis who had OCTA scans performed using a commercially available split-spectrum amplitude-decorrelation algorithm angiography system (AngioVue; Optovue Inc., Fremont, California, USA) and ICGA images (Spectralis; Heidelberg Engineering, Heidelberg, Germany). The agreement between ...
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    8. Systematic Evaluation of Optical Coherence Tomography Angiography in Retinal Vein Occlusion

      Systematic Evaluation of Optical Coherence Tomography Angiography in Retinal Vein Occlusion
      Purpose To evaluate the clinical utility of optical coherence tomography angiography (OCTA) in patients with retinal vein occlusion (RVO), and to systematically compare OCTA images with changes seen on color fundus photography and fluorescein angiography (FA). Design Reliability analysis. Methods 81 eyes of 76 patients with a history of RVO (branch, central or hemi-central), both acute and chronic, underwent OCTA (AngioVue, Optovue, Inc. Fremont, CA, USA) and color fundus photography ...
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    9. Evaluation of objective vitritis grading method using optical coherence tomography: influence of phakic status and previous vitrectomy - American Journal of Ophthalmology

      Evaluation of objective vitritis grading method using optical coherence tomography: influence of phakic status and previous vitrectomy - American Journal of Ophthalmology
      Purpose To evaluate a proposed method for objective measurement of vitreous inflammation using an spectral domain optical coherence tomography (SD-OCT) device in a large cohort of uveitis eyes, including pseudophakic eyes and vitrectomized eyes. Design Retrospective, observational, cohort study. Methods One-hundred five uveitis eyes (105 patients) with different vitreous haze score grades according to standardized protocols and corresponding SD-OCT images (Cirrus HD-OCT, Carl Zeiss Meditec) were included. Clinical data recorded ...
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    10. En face optical coherence tomography angiography for corneal neovascularisation

      En face optical coherence tomography angiography for corneal neovascularisation
      Background/aim Recently, there has been an increasing clinical need for objective evaluation of corneal neovascularisation, a condition which cause significant ocular morbidity. We describe the use of a rapid, non-invasive en face optical coherence tomography angiography (OCTA) system for the assessment of corneal neovascularisation. Methods Consecutive patients with abnormal corneal neovascularisation were scanned using a commercially available AngioVue OCTA system (Optovue, Fremont, California, USA) with the split-spectrum amplitude decorrelation ...
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    11. Optical Coherence Tomography Angiography for Anterior Segment Vasculature Imaging

      Optical Coherence Tomography Angiography for Anterior Segment Vasculature Imaging
      Purpose To evaluate the application of an optical coherence tomography angiography (OCTA) system adapted for the assessment of anterior segment vasculature. Design Cross-sectional, observational study. Participants Consecutive subjects with normal eyes on slit-lamp clinical examination and patients with abnormal corneal neovascularization. Methods All scans were performed using a commercially available AngioVue OCTA system (Optovue, Inc., Fremont, CA) using an anterior segment lens adapter and the split-spectrum amplitude decorrelation angiography algorithm ...
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    12. Quantitative Analysis of Diabetic Macular Ischemia using Optical Coherence Tomography

      Quantitative Analysis of Diabetic Macular Ischemia using Optical Coherence Tomography
      Purpose: To describe the optical coherence tomography (OCT) features of diabetic macular ischemia (DMI), and correlate these findings with visual acuity (VA). Methods: Clinical and imaging data were collected from 100 patients with type 2 diabetes. Qualitative grading of DMI severity was determined according to criteria defined by the Early Treatment Diabetic Retinopathy Study. Quantitative analysis of foveal avascular zone (FAZ), and OCT images were performed using custom software. Results ...
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    13. Optical Coherence Tomography in Pediatric Ophthalmology: Current Roles and Future Directions

      Optical Coherence Tomography in Pediatric Ophthalmology: Current Roles and Future Directions
      The application of existing optical coherence tomography (OCT) technology to the pediatric population is limited in both the design specification of the device and its hardware. However, the potential of OCT in the pediatric population has not been fully realized. The authors review the literature, highlighting the currently available spectral-domain OCT technology and summarizing the reported normal pediatric OCT parameters for retinal nerve fiber layer and macular thickness. They also ...
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    14. Evaluation of retinal pigment epithelium-Bruch's membrane complex thickness in dry age-related macular degeneration using optical coherence tomography

      Evaluation of retinal pigment epithelium-Bruch's membrane complex thickness in dry age-related macular degeneration using optical coherence tomography
      Aim To compare retinal pigment epitheliumBruch's membrane (RPEBM) complex thickness in patients with early and intermediate dry age-related macular degeneration (AMD) and age-matched controls using spectral domain optical coherence tomography (SD-OCT). Methods In this retrospective, cross-sectional study, 25 patients with dry AMD and 25 controls were recruited. SD-OCT scans were manually segmented by two independent investigators. Thickness values were calculated for the nine Early Treatment Diabetic Retinopathy Study (ETDRS ...
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    15. Choroidal assessment in idiopathic panuveitis using optical coherence tomography

      Choroidal assessment in idiopathic panuveitis using optical coherence tomography
      Background Idiopathic panuveitis is a diagnosis of exclusion that lacks distinguishing features on fluorescein and indocyanine green angiography. Choroidal hypoperfusion or ischaemia has been implicated in panuveitis of different aetiologies. In this study, we use enhanced depth imaging optical coherence tomography (OCT) to examine the choroid and its vasculature in patients with this disease. Methods In this retrospective, cross-sectional study, OCT-derived measurements of retinal and choroidal thickness were obtained after ...
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    16. Repeatability and Reproducibility of Choroidal Vessel Layer Measurements in Diabetic Retinopathy using Enhanced Depth Optical Coherence Tomography

      Repeatability and Reproducibility of Choroidal Vessel Layer Measurements in Diabetic Retinopathy using Enhanced Depth Optical Coherence Tomography
      Purpose: To describe novel segmentation protocols for choroidal layers - Sattler's medium and Haller's large vessel layers, using enhanced depth imaging optical coherence tomography (EDI-OCT), and to examine the repeatability and reproducibility of these measurements in eyes with diabetic retinopathy. Methods: Fifty-one patients with Type 2 diabetes mellitus were imaged using custom EDI scanning protocols. Detailed segmentation was performed to quantify the retina, choroid, Haller's large, and Sattler ...
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    17. Assessment of Differential Pharmacodynamic Effects using Optical Coherence Tomography in Neovascular Age-Related Macular Degeneration

      Assessment of Differential Pharmacodynamic Effects using Optical Coherence Tomography in Neovascular Age-Related Macular Degeneration
      Purpose: To assess the differential pharmacodynamic effects of bevacizumab (Avastin), pegaptanib (Macugen), and verteporfin photodynamic therapy (PDT), using novel OCT parameters, in a recently completed phase III/IV clinical trial. Methods: Data from 122 patients participating in the Avastin (Bevacizumab) for Choroidal neovascularization (ABC) trial, were evaluated. Stratus OCT images were analyzed using custom software - changes in volume of the neurosensory retina, subretinal fluid (SRF), pigment epithelium detachment (PED), and ...
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    18. 1-22 of 22
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  2. Organizations in the News

    1. (22 articles) University College London
    2. (4 articles) University of Southern California
    3. (1 articles) Singapore Eye Research Institute
    4. (1 articles) Harvard University
    5. (1 articles) National Institutes of Health
    6. (1 articles) University of Washington
    7. (1 articles) National Eye Institute
    8. (1 articles) UCLA
    9. (1 articles) Massachusetts Eye and Ear Infirmary
    10. (1 articles) University of Cologne
  3. People in the News

    1. (6 articles) Praveen J. Patel
    2. (6 articles) Srinivas R. Sadda
    3. (2 articles) Florian M. Heussen
    4. (2 articles) Robert B. Nussenblatt
    5. (1 articles) Sandra Liakopoulos
    6. (1 articles) Alexander C. Walsh
    7. (1 articles) Yanling Ouyang
  4. OCT Companies in the News

    1. (4 articles) Optovue
    2. (1 articles) Carl Zeiss Meditec