1. Articles mentioning both National University of Singapore and Tien Yin Wong

    1-21 of 21
    1. Artificial intelligence and deep learning in ophthalmology

      Artificial intelligence and deep learning in ophthalmology
      Artificial intelligence (AI) based on deep learning (DL) has sparked tremendous global interest in recent years. DL has been widely adopted in image recognition, speech recognition and natural language processing, but is only beginning to impact on healthcare. In ophthalmology, DL has been applied to fundus photographs, optical coherence tomography and visual fields, achieving robust classification performance in the detection of diabetic retinopathy and retinopathy of prematurity, the glaucoma-like disc ...
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    2. Comparison Of Optical Coherence Tomography Angiographic Changes After Anti–Vascular Endothelial Growth Factor Therapy Alone Or In Combination With Photodynamic Therapy In Polypoidal Choroidal Vasculopathy

      Comparison Of Optical Coherence Tomography Angiographic Changes After Anti–Vascular Endothelial Growth Factor Therapy Alone Or In Combination With Photodynamic Therapy In Polypoidal Choroidal Vasculopathy
      Purpose: To compare changes in optical coherence tomography angiography in eyes with polypoidal choroidal vasculopathy after treatment with antivascular endothelial growth factor monotherapy or combined with photodynamic therapy . Methods: This is a longitudinal case-controlled study. The authors performed optical coherence tomography angiography at baseline and Month 3 in patients with treatment-naive polypoidal choroidal vasculopathy undergoing monotherapy (n = 10) or combination therapy (n = 13). We analyzed flow signal within the outer ...
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    3. Spectral Domain-Optical Coherence Tomography Measurements in Alzheimer’s Disease: A Systematic Review and Meta-analysis

      Spectral Domain-Optical Coherence Tomography Measurements in Alzheimer’s Disease: A Systematic Review and Meta-analysis
      Topic Optical coherence tomography (OCT) is a non-invasive tool to measure specific retinal layers in the eye. The relationship of retinal spectral domain-OCT (SD-OCT) measurements with Alzheimers Disease (AD) and mild cognitive impairment (MCI) remains unclear. Hence, we conducted a systematic review and meta-analysis to examine the SD-OCT measurements in AD and MCI. Clinical Relevance Current methods of diagnosing early AD are expensive and invasive. Retinal measurements of SD-OCT, which ...
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    4. Clinical Use of Optical Coherence Tomography Angiography in Diabetic Retinopathy Treatment Ready for Showtime?

      Clinical Use of Optical Coherence Tomography Angiography in Diabetic Retinopathy Treatment Ready for Showtime?
      Diabetic macular edema (DME) and proliferative diabetic retinopathy (PDR) are the 2 advanced stages of diabetic retinopathy (DR) that are the main causes for visual loss in patients with diabetes. Both DME and PDR can be readily diagnosed with clinical examination and, increasingly, by the noninvasive use of optical coherence tomography. However, another, less commonly recognized cause of visual loss in patients with diabetes is diabetic macular ischemia (DMI) in ...
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    5. Identification of imaging features that determine quality and repeatability of retinal capillary plexus density measurements in OCT angiography

      Identification of imaging features that determine quality and repeatability of retinal capillary plexus density measurements in OCT angiography
      Purpose Optical coherence tomography angiography (OCT-A) potentially allows for rapid and non-invasive quantification of retinal capillary plexus density in various disease states. This study aims to identify the key features that influenced the repeatability of OCT-A measurements. Methods We obtained OCT-A images on two separate visits in 44 healthy eyes from 44 subjects, each imaged with using the Topcon DRI OCT Triton imaging system. The parafoveal vessel density within a ...
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    6. Repeatability and Reproducibility of Retinal Neuronal and Axonal Measures on Spectral-domain Optical Coherence Tomography in Patients with Cognitive Impairment

      Repeatability and Reproducibility of Retinal Neuronal and Axonal Measures on Spectral-domain Optical Coherence Tomography in Patients with Cognitive Impairment
      Background: With increasing interest in determining if measurement of retinal neuronal structure with spectral-domain optical coherence tomography (SD-OCT) is useful in accessing neurodegenerative process in cognitive decline and development of dementia, it is important to evaluate whether the SD-OCT measurements are repeatable and reproducible in patients with Alzheimers disease (AD) or mild cognitive impairment (MCI). Methods: This is a retrospective cohort study. Patients with AD or MCI with no change ...
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    7. Artificial Intelligence With Deep Learning Technology Looks Into Diabetic Retinopathy Screening

      Artificial Intelligence With Deep Learning Technology Looks Into Diabetic Retinopathy Screening
      D iabetic retinopathy is a leading cause of vision loss in the United States and globally, particularly among working-aged individuals. Diabetic retinopathy meets all the criteria for screening: first, the condition (diabetic retinopathy) is an important public health care problem; second, the epidemiology and natural history of the condition, including development from asymptomatic latent to severe disease, are adequately understood; third, the screening test (retinal photography) is simple, safe, validated ...
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    8. Posterior Eye Shape Measurement With Retinal OCT Compared to MRI

      Posterior Eye Shape Measurement With Retinal OCT Compared to MRI
      Purpose : Posterior eye shape assessment by magnetic resonance imaging (MRI) is used to study myopia. We tested the hypothesis that optical coherence tomography (OCT), as an alternative, could measure posterior eye shape similarly to MRI. Methods : Macular spectral-domain OCT and brain MRI images previously acquired as part of the Singapore Epidemiology of Eye Diseases study were analyzed. The right eye in the MRI and OCT images was automatically segmented. Optical ...
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    9. Repeatability of Perimacular Ganglion Cell Complex Analysis with Spectral-Domain Optical Coherence Tomography

      Repeatability of Perimacular Ganglion Cell Complex Analysis with Spectral-Domain Optical Coherence Tomography
      Purpose. To assess the repeatability of spectral-domain optical coherence tomography to measure macular and perimacular ganglion cell complex thicknesses and compare retinal ganglion cell parameters between algorithms. Methods. Ninety-two nonglaucomatous eyes from 92 participants underwent macular and perimacular ganglion cell complex thickness measurement using OCT-HS100 Glaucoma 3D algorithm and these measurements were repeated for 34 subjects. All subjects also had macular ganglion cellinner plexiform layer thickness measured by Cirrus HD-OCT ...
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    10. Relationship of ocular and systemic factors to the visibility of choroidal–scleral interface using spectral domain optical coherence tomography

      Relationship of ocular and systemic factors to the visibility of choroidal–scleral interface using spectral domain optical coherence tomography
      Purpose To assess the visibility of the choroidalscleral interface (CSI) from spectral domain optical coherence tomography (SD-OCT) and evaluate the ocular and systemic factors influencing the visibility of CSI in healthy eyes from population-based Malay sample. Methods Participants were consecutively recruited from the population-based Singapore Malay Eye Study-2 (SiMES-2). SD-OCT images were obtained by Spectralis OCT with enhanced depth imaging (EDI) mode. Visibility of CSI was assessed by a grading ...
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    11. Cup-to-Disc Ratio From Heidelberg Retina Tomograph 3 and High-Definition Optical Coherence Tomography Agrees Poorly With Clinical Assessment

      Cup-to-Disc Ratio From Heidelberg Retina Tomograph 3 and High-Definition Optical Coherence Tomography Agrees Poorly With Clinical Assessment
      Purpose: To investigate the agreement of vertical cup-to-disc ratio (VCDR) measured from Heidelberg Retina Tomograph 3 (HRT-3), high-definition optical coherence tomography (HD-OCT), and clinical grading. Methods: A total of 933 consecutive subjects underwent optic nerve head imaging with HRT-3 and HD-OCT during a single visit. The vertical dimensions of the disc and cup were measured by slit-lamp examination using an eyepiece graticule. Bland-Altman plots evaluated the agreement in the VCDR ...
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    12. Retinal neurodegeneration on optical coherence tomography and cerebral atrophy

      Retinal neurodegeneration on optical coherence tomography and cerebral atrophy
      Neurodegeneration in dementia is mainly evaluated by assessing cerebral atrophy, while retinal neurodegeneration can be quantified in vivo using optical coherence tomography (OCT). We examined the association of retinal nerve fibre layer (RNFL) and ganglion cell-inner plexiform layer (GCIPL) thinning with global and regional cerebral atrophy on magnetic resonance imaging (MRI). Malay participants aged 6080 years from the Epidemiology of Dementia in Singapore Study underwent comprehensive examinations, including 3-Tesla cranial ...
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    13. A Simplified Method to Measure Choroidal Thickness Using Adaptive Compensation in Enhanced Depth Imaging Optical Coherence Tomography

      A Simplified Method to Measure Choroidal Thickness Using Adaptive Compensation in Enhanced Depth Imaging Optical Coherence Tomography
      ...pore National Eye Centre, Singapore, Singapore, Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore X * Michael J. A....
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    14. Determinants of Macular Thickness using Spectral Domain Optical Coherence Tomography in Healthy Eyes: the Singapore Chinese Eye Study

      Determinants of Macular Thickness using Spectral Domain Optical Coherence Tomography in Healthy Eyes: the Singapore Chinese Eye Study
      Purpose:To determine ocular and systemic factors influencing macular thickness measured by SD-OCT in a population-based sample of healthy eyes. Methods:490 Chinese adults aged 40 to 80 years were recruited from the Singapore Chinese Eye Study. All participants underwent a comprehensive eye examination and a standardized interview. SD-OCT (Cirrus HD-OCT, software version 6.0, Carl Zeiss Meditec, Dublin, CA) measured a range of macular thickness parameters (central foveal subfield ...
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    15. Classification Algorithms Based on Anterior Segment Optical Coherence Tomography Measurements for Detection of Angle Closure

      Classification Algorithms Based on Anterior Segment Optical Coherence Tomography Measurements for Detection of Angle Closure
      ...gapore Eye Research Institute and Singapore National Eye Center, Singapore + Yong Loo Lin School of Medicine, National University of Singapore, Singapore , * Tin Aung, PhD, FRCS(Ed) Affiliations + Singapore Eye Research ...
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    16. Determinants of Ganglion Cell–Inner Plexiform Layer Thickness Measured by High-Definition Optical Coherence Tomography

      Determinants of Ganglion Cell–Inner Plexiform Layer Thickness Measured by High-Definition Optical Coherence Tomography
      ...tre, Singapore; the 2. ^2Yong Loo Lin School of Medicine, and the 3. ^3Saw Swee Hock School of Public Health, National University of Singapore, Singapore; and the 4. ^4Centre for Eye Research Australia, University of Mel...
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    17. Determinants of Ganglion Cell-Inner Plexiform Layer Thickness Measured by High-Definition Optical Coherence Tomography

      Determinants of Ganglion Cell-Inner Plexiform Layer Thickness Measured by High-Definition Optical Coherence Tomography
      ...Eye Research Institute, Singapore National Eye Centre, Singapore 2. ^2Saw Swee Hock School of Public Health, National University of Singapore, Singapore 3. ^3Singapore Eye Research Institute, Singapore National Eye Cent...
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    18. Comparison of scanning laser ophthalmoscopy and high-definition optical coherence tomography measurements of optic disc parameters

      Comparison of scanning laser ophthalmoscopy and high-definition optical coherence tomography measurements of optic disc parameters
      ...uke-NUS Graduate Medical School, Singapore 3. ^3Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 1. Correspondence to Professor Tin Aung, Singapore Eye Research In...
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    19. Determinants of Quantitative Optic Nerve Measurements using Spectral Domain Optical Coherence Tomography in a Population-based Sample of Non-glaucomatous Subjects

      Determinants of Quantitative Optic Nerve Measurements using Spectral Domain Optical Coherence Tomography in a Population-based Sample of Non-glaucomatous Subjects
      ...e Research Australia, University of Melbourne, Australia 6. ^6. Department of Epidemiology and Public Health, National University of Singapore, Singapore 7. ^7. Department of Ophthalmology and Visual Sciences, The Chines...
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    20. Association of Narrow Angles With Anterior Chamber Area and Volume Measured With Anterior-Segment Optical Coherence Tomography]

      Association of Narrow Angles With Anterior Chamber Area and Volume Measured With Anterior-Segment Optical Coherence Tomography]
      ... National Eye Center (Drs Wu, Nongpiur, Sakata, Lavanya, Wong, and Aung) and Yong Loo Lin School of Medicine, National University of Singapore (Drs Chan, Wong, and Aung), Singapore; State Key Laboratory of Ophthalmology,...
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    21. Screening for Narrow Angles in the Singapore Population: Evaluation of New Noncontact Screening Methods

      Purpose: To assess the screening effectiveness of 3 new noncontact devices, the scanning peripheral anterior chamber depth analyzer (SPAC) (Takagi, Nagano, Japan), which measures peripheral anterior chamber depth (ACD); IOLMaster (Carl Zeiss Meditec, Jena, Germany), which measures central ACD; and Visante anterior segment optical coherence tomography (AS-OCT) (Visante, Carl Zeiss Meditec, Dublin, CA), which images the angles, and to compare these instruments with gonioscopy in identifying people with narrow angles ...
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  2. Organizations in the News

    1. (19 articles) Singapore Eye Research Institute
    2. (5 articles) Johns Hopkins University
    3. (4 articles) Duke University
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    5. (3 articles) University of Melbourne
    6. (3 articles) Erasmus University
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  3. People in the News

    1. (10 articles) Tin Aung
    2. (4 articles) Mani Baskaran
    3. (3 articles) David S. Friedman
    4. (1 articles) Chris K. S. Leung
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    1. (8 articles) Carl Zeiss Meditec
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    3. (1 articles) Heidelberg Engineering