1. Articles mentioning both National University of Singapore and Michaël J. A. Girard

    1-26 of 26
    1. Efficacy and Reproducibility of Attenuation-Compensated Optical Coherence Tomography for Assessing External Elastic Membrane Border and Plaque Composition in Native and Stented Segments ― An In Vivo and Histology-Based Study ―

      Efficacy and Reproducibility of Attenuation-Compensated Optical Coherence Tomography for Assessing External Elastic Membrane Border and Plaque Composition in Native and Stented Segments ― An In Vivo and Histology-Based Study ―
      Background: Attenuation-compensated (AC) technique was recently introduced to improve the plaque characterization of optical coherence tomography (OCT). Histological validation demonstrated promising results but the efficacy and reproducibility of this technique for assessing in-vivo tissue composition remains unclear. Methods and Results: OCT images portraying native (n=200) and stented (n=200) segments and 31 histological cross-sections were analyzed. AC-OCT appeared superior to conventional (C)-OCT in detecting the external elastic lamina ...
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    2. DeshadowGAN: A Deep Learning Approach to Remove Shadows from Optical Coherence Tomography Images

      DeshadowGAN: A Deep Learning Approach to Remove Shadows from Optical Coherence Tomography Images
      Purpose: To remove retinal shadows from optical coherence tomography (OCT) images of the optic nerve head (ONH). Methods: 2328 OCT images acquired through the center of the ONH using a Spectralis OCT machine for both eyes of 13 subjects were used to train a generative adversarial network (GAN) using a custom loss function.Image quality was assessed qualitatively (for artifacts) and quantitatively using the intralayer contrast € a measure of shadow ...
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    3. A Deep Learning Approach to Denoise Optical Coherence Tomography Images of the Optic Nerve Head

      A Deep Learning Approach to Denoise Optical Coherence Tomography Images of the Optic Nerve Head
      Optical coherence tomography (OCT) has become an established clinical routine for the in vivo imaging of the optic nerve head (ONH) tissues, that is crucial in the diagnosis and management of various ocular and neuro-ocular pathologies. However, the presence of speckle noise affects the quality of OCT images and its interpretation. Although recent frame-averaging techniques have shown to enhance OCT image quality, they require longer scanning durations, resulting in patient ...
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    4. DRUNET: a dilated-residual U-Net deep learning network to segment optic nerve head tissues in optical coherence tomography images

      DRUNET: a dilated-residual U-Net deep learning network to segment optic nerve head tissues in optical coherence tomography images
      Given that the neural and connective tissues of the optic nerve head (ONH) exhibit complex morphological changes with the development and progression of glaucoma, their simultaneous isolation from optical coherence tomography (OCT) images may be of great interest for the clinical diagnosis and management of this pathology. A deep learning algorithm (custom U-NET) was designed and trained to segment 6 ONH tissue layers by capturing both the local (tissue texture ...
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    5. DRUNET: A Dilated-Residual U-Net Deep Learning Network to Digitally Stain Optic Nerve Head Tissues in Optical Coherence Tomography Images

      DRUNET: A Dilated-Residual U-Net Deep Learning Network to Digitally Stain Optic Nerve Head Tissues in Optical Coherence Tomography Images
      Given that the neural and connective tissues of the optic nerve head (ONH) exhibit complex morphological changes with the development and progression of glaucoma, their simultaneous isolation from optical coherence tomography (OCT) images may be of great interest for the clinical diagnosis and management of this pathology. A deep learning algorithm was designed and trained to digitally stain (i.e. highlight) 6 ONH tissue layers by capturing both the local ...
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    6. Imaging of the lamina cribrosa and its role in glaucoma: a review

      Imaging of the lamina cribrosa and its role in glaucoma: a review
      The lamina cribrosa of the optic nerve head serves two contrasting roles; it must be porous to allow retinal ganglion cell axons to pass through, and yet at the same time, it must also provide adequate structural support to withstand the stresses and strains across it. Improvements in imaging such as optical coherence tomography image capture and image processing have allowed detailed in vivo studies of lamina cribrosa macro- and ...
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    7. A Deep Learning Approach to Digitally Stain Optical Coherence Tomography Images of the Optic Nerve Head

      A Deep Learning Approach to Digitally Stain Optical Coherence Tomography Images of the Optic Nerve Head
      Purpose. To develop a deep learning approach to digitally-stain optical coherence tomography (OCT) images of the optic nerve head (ONH). Methods. A horizontal B-scan was acquired through the center of the ONH using OCT (Spectralis) for 1 eye of each of 100 subjects (40 normal 60 glaucoma). All images were enhanced using adaptive compensation. A custom deep learning network was then designed and trained with the compensated images to digitally ...
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    8. Feature Of The Week 05/28/2017: In Vivo 3-Dimensional Strain Mapping Confirms Large Optic Nerve Head Deformations Following Horizontal Eye Movements

      Feature Of The Week 05/28/2017: In Vivo 3-Dimensional Strain Mapping Confirms Large Optic Nerve Head Deformations Following Horizontal Eye Movements
      ...nts and axonal loss in optic neuropathies. For more information see recent Article. Courtesy Xiaofei Wang and Michaël J. A. Girard from National University of Singapore....
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    9. A Digital Staining Algorithm for Optical Coherence Tomography Images of the Optic Nerve Head

      A Digital Staining Algorithm for Optical Coherence Tomography Images of the Optic Nerve Head
      Purpose : To digitally stain spectral-domain optical coherence tomography (OCT) images of the optic nerve head (ONH), and highlight either connective or neural tissues. Methods : OCT volumes of the ONH were acquired from one eye of 10 healthy subjects. We processed all volumes with adaptive compensation to remove shadows and enhance deep tissue visibility. For each ONH, we identified the four most dissimilar pixel-intensity histograms, each of which was assumed to ...
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    10. In Vivo 3-Dimensional Strain Mapping Confirms Large Optic Nerve Head Deformations Following Horizontal Eye Movements

      In Vivo 3-Dimensional Strain Mapping Confirms Large Optic Nerve Head Deformations Following Horizontal Eye Movements
      Purpose : To measure lamina cribrosa (LC) strains (deformations) following abduction and adduction in healthy subjects and to compare them with those resulting from a relatively high acute intraocular pressure (IOP) elevation. Methods : A total of 16 eyes from 8 healthy subjects were included. Among the 16 eyes, 11 had peripapillary atrophy (PPA). For each subject, both optic nerve heads (ONHs) were imaged using optical coherence tomography (OCT) at baseline (twice ...
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    11. Enhancement of Corneal Visibility in Optical Coherence Tomography Images with Corneal Opacification

      Enhancement of Corneal Visibility in Optical Coherence Tomography Images with Corneal Opacification
      Purpose : To establish and to rank the performance of a corneal adaptive compensation (CAC) algorithm in enhancing corneal images with scars acquired from three commercially available anterior segment optical coherence tomography (ASOCT) devices. Methods : Horizontal B-scans of the cornea were acquired from 10 patients using three ASOCT devices (Spectralis, RTVue, and Cirrus). We compared ASOCT image quality (with and without CAC) by computing the intralayer contrast (a measure of shadow ...
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    12. In Vivo 3-Dimensional Strain Mapping of the Optic Nerve Head Following Intraocular Pressure Lowering by Trabeculectomy

      In Vivo 3-Dimensional Strain Mapping of the Optic Nerve Head Following Intraocular Pressure Lowering by Trabeculectomy
      Purpose To map the 3-dimensional (3D) strain of the optic nerve head (ONH) in vivo after intraocular pressure (IOP) lowering by trabeculectomy (TE) and to establish associations between ONH strain and retinal sensitivity. Design Observational case series. Participants Nine patients with primary open-angle glaucoma (POAG) and 3 normal controls. Methods The ONHs of 9 subjects with POAG (pre-TE IOP: 25.313.9 mmHg; post-TE IOP: 11.88.6 mmHg) were ...
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    13. Automatic Feature Extraction of Optical Coherence Tomography for Lamina Cribrosa Detection

      Automatic Feature Extraction of Optical Coherence Tomography for Lamina Cribrosa Detection
      T his paper presents a framework to segment and extract key features automatically in Optical Coherence Tomography (OCT) scans. One of the main features to be detected is the Lamina Cribrosa (LC), which is an optic nerve head structure believed to play a crucial role in glaucomatous optic neuropathy. Detection of the LC aids in understanding pathogenesis and detection of glaucoma. Automatic segmentation allows a quick and objective way of ...
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    14. Enhancement of Corneal Visibility in Optical Coherence Tomography Images Using Corneal Adaptive Compensation

      Enhancement of Corneal Visibility in Optical Coherence Tomography Images Using Corneal Adaptive Compensation
      Purpose: To improve the contrast of optical coherence tomography (OCT) images of the cornea (post processing). Methods: We have recently developed standard compensation (SC) algorithms to remove light attenuation artifacts. A more recent approach, namely adaptive compensation (AC), further limited noise overamplification within deep tissue regions. AC was shown to work efficiently when all A-scan signals were fully attenuated at high depth. But in many imaging applications (e.g., OCT ...
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    15. Lamina Cribrosa Visibility using Optical Coherence Tomography: Comparison of Devices and Effects of Image Enhancement Techniques

      Lamina Cribrosa Visibility using Optical Coherence Tomography: Comparison of Devices and Effects of Image Enhancement Techniques
      ... 9. Mani Baskaran2, 10. Tin Aung8 and 11. Nicholas G. Strouthidis9,* 1. ^1Department of Bioengineering, National University of Singapore, In vivo Biomechanics Laboratory, 9 Engineering Drive 1, Block EA #03-12, Sin...
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    16. Feature of The Week 12/14/14: Penetrate Deeper Using Extended Source OCT

      Feature of The Week 12/14/14: Penetrate Deeper Using Extended Source OCT
      We have developed an extended source optical coherence tomography (SEES-OCT) technique in an attempt to improve signal strength for ophthalmic imaging. A line illumination with a visual angle of 7.9 mrad is produced by introducing a dispersive element in the infinity space of the sample arm. The maximum permissible exposure (MPE) of such an extended source is 3.1 times larger than that of a standard point source OCT ...
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    17. A Simplified Method to Measure Choroidal Thickness Using Adaptive Compensation in Enhanced Depth Imaging Optical Coherence Tomography

      A Simplified Method to Measure Choroidal Thickness Using Adaptive Compensation in Enhanced Depth Imaging Optical Coherence Tomography
      ...pore National Eye Centre, Singapore, Singapore, Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore X * Michael J. A....
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    18. In vivo optic nerve head biomechanics: performance testing of a three-dimensional tracking algorithm

      In vivo optic nerve head biomechanics: performance testing of a three-dimensional tracking algorithm
      ...3. Adrien Desjardins5, 4. Jean Martial Mari3,6 and 5. C. Ross Ethier3,7 1. ^1Department of Bioengineering, National University of Singapore, Singapore, Republic of Singapore 2. ^2Singapore Eye Research Institute, Si...
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    19. Intracoronary imaging using attenuation-compensated optical coherence tomography allows better visualisation of coronary artery diseases

      Intracoronary imaging using attenuation-compensated optical coherence tomography allows better visualisation of coronary artery diseases
      Purpose To allow an accurate diagnosis of coronary artery diseases by enhancing optical coherence tomography (OCT) images of atheromatous plaques using a novel automated attenuation compensation technique. Background One of the major drawbacks of coronary OCT imaging is the rapid attenuation of the OCT signal, limiting penetration in tissue to only few millimetres. Visualisation of deeper anatomy is however critical for accurate assessment of plaque burden in-vivo. Methods A compensation ...
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    20. Enhancement of Lamina Cribrosa Visibility in Optical Coherence Tomography Images using Adaptive Compensation

      Enhancement of Lamina Cribrosa Visibility in Optical Coherence Tomography Images using Adaptive Compensation
      ...ics Laboratory, 9 Engineering Drive 1, Block EA #03-12, Singapore, 117576 1. ↵* Department of Bioengineering, National University of Singapore, In vivo Biomechanics Laboratory, 9 Engineering Drive 1, Block EA #03-12, Sin...
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    21. Feature Of The Week 9/9/12: Imaging of Coronary Artery Plaques Using Contrast Enhanced Optical Coherence Tomography

      Feature Of The Week 9/9/12: Imaging of Coronary Artery Plaques Using Contrast Enhanced Optical Coherence Tomography
      ...tion see recent Article. Courtesy of Nicolas Foin from the Imperial College London and Michal Girard from the National University of Singapore. Optical Coherence Tomography (OCT) has recently emerged as a promising techn...
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    22. Imaging of coronary artery plaques using contrast-enhanced optical coherence tomography

      Imaging of coronary artery plaques using contrast-enhanced optical coherence tomography
      Optical coherence tomography (OCT) has recently emerged as a promising technology for intravascular guidance of interventions. With a resolution on the order of 10m, intravascular OCT surpasses intravascular ultrasounds, and allows for precise measurement of cap thickness and identification of lipid-rich thin-cap fibroatheroma. The diagnostic accuracy and assessment of atherosclerotic plaque
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    23. Shadow removal and contrast enhancement in optical coherence tomography images of the human optic nerve head

      Shadow removal and contrast enhancement in optical coherence tomography images of the human optic nerve head
      Purpose.To improve the quality of optical coherence tomography (OCT) images of the optic nerve head (ONH). Methods.Two algorithms were developed, one to compensate for light attenuation and the other to enhance contrast in OCT images. The former was borrowed from developments in ultrasound imaging and proven suitable with either time- or spectral-domain OCT. The latter was based on direct application of pixel intensity exponentiation. The performances of these ...
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    24. 1-26 of 26
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  2. Organizations in the News

    1. (15 articles) Singapore Eye Research Institute
    2. (10 articles) University College London
    3. (6 articles) Imperial College London
    4. (4 articles) Nanyang Technological University
    5. (3 articles) University of Sydney
    6. (3 articles) Royal Brompton Hospital
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    12. (1 articles) New York Eye and Ear Infirmary
  3. People in the News

    1. (11 articles) Tin Aung
    2. (4 articles) Nicolas Foin
    3. (4 articles) Xiaofei Wang
    4. (3 articles) Carlo Di Mario
    5. (3 articles) Mani Baskaran
    6. (2 articles) Linbo Liu
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    8. (1 articles) Christos V. Bourantas
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    10. (1 articles) Tien Yin Wong
    11. (1 articles) Patrick W. Serruys
    12. (1 articles) Tadamichi Akagi
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    1. (1 articles) St. Jude Medical
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