1. Articles mentioning both Michael Pircher and Ursula Schmidt-Erfurth

    1-24 of 37 1 2 »
    1. Atlas of Human Retinal Pigment Epithelium Organelles Significant for Clinical Imaging

      Atlas of Human Retinal Pigment Epithelium Organelles Significant for Clinical Imaging
      Purpose : To quantify organelles impacting imaging in the cell body and intact apical processes of human retinal pigment epithelium (RPE), including melanosomes, lipofuscinmelanolipofuscin (LM), mitochondria, and nuclei. Methods : A normal perifovea of a 21-year-old white male was preserved after rapid organ recovery. An aligned image stack was generated using serial block-face scanning electron microscopy and was annotated by expert readers (TrakEM, ImageJ). Acquired measures included cell body and nuclear volume ...
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    2. Dynamic Changes of Retinal Microaneurysms in Diabetes Imaged With In Vivo Adaptive Optics Optical Coherence Tomography

      Dynamic Changes of Retinal Microaneurysms in Diabetes Imaged With In Vivo Adaptive Optics Optical Coherence Tomography
      Purpose : To prospectively monitor microaneurysms (MAs) in three dimensions using adaptive optics optical coherence tomography (AOOCT). Methods : Patients with diabetes mellitus and parafoveal MAs were included in this longitudinal study. At baseline, MAs were identified in standard fluorescein angiography (FA) and subsequently imaged with an AOOCT prototype, incorporated into an AO fundus camera (RTX1, Imagine Eyes) device. Imaging was repeated every 3 months in each patient to explore the potential ...
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    3. Compact akinetic swept source optical coherence tomography angiography at 1060 nm supporting a wide field of view and adaptive optics imaging modes of the posterior eye

      Compact akinetic swept source optical coherence tomography angiography at 1060 nm supporting a wide field of view and adaptive optics imaging modes of the posterior eye
      Imaging of the human retina with high resolution is an essential step towards improved diagnosis and treatment control. In this paper, we introduce a compact, clinically user-friendly instrument based on swept source optical coherence tomography (SS-OCT). A key feature of the system is the realization of two different operation modes. The first operation mode is similar to conventional OCT imaging and provides large field of view (FoV) images (up to ...
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    4. THREE-DIMENSIONAL ANALYSIS OF RETINAL MICROANEURYSMS WITH ADAPTIVE OPTICS OPTICAL COHERENCE TOMOGRAPHY

      THREE-DIMENSIONAL ANALYSIS OF RETINAL MICROANEURYSMS WITH ADAPTIVE OPTICS OPTICAL COHERENCE TOMOGRAPHY
      Purpose: To characterize retinal microaneurysms (MAs) in patients with diabetes using adaptive optics optical coherence tomography (AOOCT) and compare details found in AOOCT with those found in commercially available retinal imaging techniques. Methods: Patients with diabetes and MA in the macular area were included in this pilot study. The area of interest, identified in standard fluorescein angiography, was imaged using an AO fundus camera and AOOCT. Microaneurysms were characterized in ...
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    5. IMAGING OF VITELLIFORM MACULAR LESIONS USING POLARIZATION-SENSITIVE OPTICAL COHERENCE TOMOGRAPHY

      IMAGING OF VITELLIFORM MACULAR LESIONS USING POLARIZATION-SENSITIVE OPTICAL COHERENCE TOMOGRAPHY
      Purpose: To examine the involvement of the retinal pigment epithelium (RPE) in the presence of vitelliform macular lesions (VML) in Best vitelliform macular dystrophy (BVMD), autosomal recessive bestrophinopathy, and adult-onset vitelliform macular degeneration using polarization-sensitive optical coherence tomography (PS-OCT). Methods: A total of 35 eyes of 18 patients were imaged using a PS-OCT system and blue light fundus autofluorescence imaging. Pathogenic mutations in the BEST1 gene, 3 of which were ...
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    6. Visualization of micro-capillaries using optical coherence tomography angiography with and without adaptive optics

      Visualization of micro-capillaries using optical coherence tomography angiography with and without adaptive optics
      The purpose of this work is to investigate the benefits of adaptive optics (AO) technology for optical coherence tomography angiography (OCTA). OCTA has shown great potential in non-invasively enhancing the contrast of vessels and small capillaries. Especially the capability of the technique to visualize capillaries with a lateral extension that is below the transverse resolution of the system opens unique opportunities in diagnosing retinal vascular diseases. However, there are some ...
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    7. Automated Identification and Quantification of Subretinal Fibrosis in Neovascular Age-Related Macular Degeneration Using Polarization-Sensitive OCT

      Automated Identification and Quantification of Subretinal Fibrosis in Neovascular Age-Related Macular Degeneration Using Polarization-Sensitive OCT
      Purpose : To identify and quantify subretinal fibrosis in eyes with advanced neovascular age-related macular degeneration (nAMD) using polarization-sensitive optical coherence tomography (PS-OCT). Methods : Eyes of patients with subretinal fibrosis secondary to nAMD were included in this case series. All patients underwent a complete ophthalmic examination to clearly identify advanced nAMD lesions with fibrosis. Examinations of PS-OCT were performed using a novel system with an integrated eye tracker. Areas of fibrosis ...
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    8. Multi-modal adaptive optics system including fundus photography and optical coherence tomography for the clinical setting

      Multi-modal adaptive optics system including fundus photography and optical coherence tomography for the clinical setting
      We present a new compact multi-modal imaging prototype that combines an adaptive optics (AO) fundus camera with AO-optical coherence tomography (OCT) in a single instrument. The prototype allows acquiring AO fundus images with a field of view of 4x4 and with a frame rate of 10fps. The exposure time of a single image is 10 ms. The short exposure time results in nearly motion artifact-free high resolution images of the ...
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    9. Retinal Pigment Epithelial Features in Central Serous Chorioretinopathy Identified by Polarization-Sensitive Optical Coherence Tomography

      Retinal Pigment Epithelial Features in Central Serous Chorioretinopathy Identified by Polarization-Sensitive Optical Coherence Tomography
      Purpose : To determine the subclinical RPE lesions detected by tissue selective polarization-sensitive optical coherence tomography (PS-OCT) in eyes with central serous chorioretinopathy (CSC) and to compare PS-OCT findings to current imaging standards. Methods : In this prospective observational case series, individuals with unilateral or bilateral active CSC were imaged using PS-OCT at baseline and after resolution of serous retinal detachment. Features seen on PS-OCT were compared with corresponding lesions as seen ...
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    10. Spectral degree of polarization uniformity for polarization-sensitive OCT

      Spectral degree of polarization uniformity for polarization-sensitive OCT
      Depolarization of light can be measured by polarization-sensitive optical coherence tomography (PS-OCT) and has been used to improve tissue discrimination as well as segmentation of pigmented structures. Most approaches to depolarization assessment for PS-OCT such as the degree of polarization uniformity (DOPU) rely on measuring the uniformity of polarization states using spatial evaluation kernels. In this article, we present a different approach which exploits the spectral dimension. We introduce the ...
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    11. Polarization-Sensitive Optical Coherence Tomography and Conventional Retinal Imaging Strategies in Assessing Foveal Integrity in Geographic Atrophy

      Polarization-Sensitive Optical Coherence Tomography and Conventional Retinal Imaging Strategies in Assessing Foveal Integrity in Geographic Atrophy
      Purpose : To compare current imaging methods with respect to their ability to detect the condition of the fovea in patients with geographic atrophy (GA). Methods : The retinas of 176 eyes with GA were imaged using two spectral-domain optical coherence tomography (SD-OCT) systems, Cirrus HD-OCT and Spectralis HRA+OCT, and fundus autofluorescence (FAF) and infrared imaging (IR) was used in the scanning laser ophthalmoscope (SLO) mode. Polarization-sensitive OCT (PS-OCT), which selectively ...
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    12. Polarisation-sensitive OCT is useful for evaluating retinal pigment epithelial lesions in patients with neovascular AMD

      Polarisation-sensitive OCT is useful for evaluating retinal pigment epithelial lesions in patients with neovascular AMD
      Background/aims To examine the reproducibility of lesion dimensions of the retinal pigment epithelium (RPE) in neovascular age-related macular degeneration (AMD) with polarisation-sensitive optical coherence tomography (PS-OCT), specifically imaging the RPE. Methods Twenty-six patients (28 eyes) with neovascular AMD were included in this study, and examined by a PS-OCT prototype. Each patient was scanned five times at a 1-day visit. The PS-OCT B-scan located closest to the macular centre presenting ...
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    13. Identification of Drusen Characteristics in Age-related Macular Degeneration by Polarization-Sensitive Optical Coherence Tomography

      Identification of Drusen Characteristics in Age-related Macular Degeneration by Polarization-Sensitive Optical Coherence Tomography
      ...h for articles by this author , Maria Platzer x Maria Platzer Search for articles by this author , Michael Pircher x Michael Pircher Search for articles by this author , Christoph K. Hitzenberger x Christoph K....
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    14. RETINAL PIGMENT EPITHELIUM FINDINGS IN PATIENTS WITH ALBINISM USING WIDE-FIELD POLARIZATION-SENSITIVE OPTICAL COHERENCE TOMOGRAPHY

      RETINAL PIGMENT EPITHELIUM FINDINGS IN PATIENTS WITH ALBINISM USING WIDE-FIELD POLARIZATION-SENSITIVE OPTICAL COHERENCE TOMOGRAPHY
      Purpose: To investigate pigmentation characteristics of the retinal pigment epithelium (RPE) in patients with albinism using wide-field polarization-sensitive optical coherence tomography compared with intensity-based spectral domain optical coherence tomography and fundus autofluorescence imaging. Methods: Five patients (10 eyes) with previously genetically diagnosed albinism and 5 healthy control subjects (10 eyes) were imaged by a wide-field polarization-sensitive optical coherence tomography system (scan angle: 40 x 40[degrees] on the retina), sensitive ...
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    15. Detection and Analysis of Hard Exudates by Polarization-Sensitive Optical Coherence Tomography in Patients with Diabetic Maculopathy

      Detection and Analysis of Hard Exudates by Polarization-Sensitive Optical Coherence Tomography in Patients with Diabetic Maculopathy
      Purpose: To image and analyze hard exudates (HE) and their precursors in patients with diabetic macular edema (DME) using polarization sensitive optical coherence tomography (PS-OCT). Methods: Twenty-two eyes of 16 patients with DME were imaged using color fundus photography (CF) and PS-OCT. In PS-OCT, HE were automatically detected based on their distinct polarization-scrambling qualities. CF images were manually graded for the presence of HE by two masked graders and correlated ...
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    16. Characterization of Stargardt disease using polarisation-sensitive optical coherence tomography and fundus autofluorescence imaging

      Characterization of Stargardt disease using polarisation-sensitive optical coherence tomography and fundus autofluorescence imaging
      Purpose: To identify disease-specific changes in Stargardt disease (STGD) based on imaging with polarisation-sensitive spectral-domain optical coherence tomography (PS-OCT) and to compare structural changes to those visible on blue light fundus autofluorescence (FAF)imaging. Methods: 28 eyes of 14 patients diagnosed with STGD were imaged using a novel high-speed, large-field PS-OCT system and FAF (Heidelberg Retina Angiograph/Spectralis, Heidelberg Engineering, Germany; excitation 488nm, emission 500nm). The ophthalmoscopic phenotype was classified ...
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    17. Imaging Retinal Pigment Epithelial Proliferation Secondary to PASCAL Photocoagulation In Vivo by Polarization-sensitive Optical Coherence Tomography

      Imaging Retinal Pigment Epithelial Proliferation Secondary to PASCAL Photocoagulation In Vivo by Polarization-sensitive Optical Coherence Tomography
      ...ns + Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria , * Ursula Schmidt-Erfurth Affiliations + Department of Ophthalmology, Medical University of Vienna, Vienna, Austr...
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    18. Measuring Retinal Nerve Fiber Layer Birefringence, Retardation, and Thickness Using Wide-Field, High-Speed Polarization Sensitive Spectral Domain OCT

      Measuring Retinal Nerve Fiber Layer Birefringence, Retardation, and Thickness Using Wide-Field, High-Speed Polarization Sensitive Spectral Domain OCT
      ...5. Hirofumi Yoshida^2, 6. Futoshi Hirose^2, 7. Stephan Holzer^3, 8. Julia Kroisamer^3, 9. Clemens Vass^3, 10. Ursula Schmidt-Erfurth^3 and 11. Christoph K. Hitzenberger^1 1. From the ^1Center for Medical Physics and Biom...
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    19. Lesion Size Detection in Geographic Atrophy by Polarization-sensitive Optical Coherence Tomography and Correlation to Conventional Imaging Techniques

      Lesion Size Detection in Geographic Atrophy by Polarization-sensitive Optical Coherence Tomography and Correlation to Conventional Imaging Techniques
      Purpose: To investigate the reproducibility of automated lesion size detection in patients with geographic atrophy (GA) using polarization-sensitive spectral domain-OCT (PS-OCT) and to compare findings with scanning laser ophthalmoscopy (SLO), fundus autofluorescence (FAF), and intensity based SD-OCT. Methods: 29 eyes of 22 patients with GA were examined by PS-OCT, selectively identifying the retinal pigment epithelium (RPE). A novel segmentation algorithm was applied, automatically detecting and quantifying areas of RPE atrophy ...
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    20. Large-field high-speed polarization sensitive spectral domain OCT and its applications in ophthalmology

      Large-field high-speed polarization sensitive spectral domain OCT and its applications in ophthalmology
      We present a novel spectral domain polarization sensitive OCT system (PS-OCT) that operates at an A-scan rate of 70 kHz and supports scan angles of up to 40° × 40°. The high-speed imaging allows the acquisition of up to 1024 × 250 A-scans per 3D scan, which, together with the large field of view, considerably increases the informative value of the images. To demonstrate the excellent performance of the new PS-OCT system ...
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    21. Polarization sensitive optical coherence tomography of melanin provides intrinsic contrast based on depolarization

      Polarization sensitive optical coherence tomography of melanin provides intrinsic contrast based on depolarization
      Polarization sensitive optical coherence tomography (PS-OCT) is a functional extension of OCT. In addition to imaging based on tissue reflectivity, PS-OCT also enables depth-resolved mapping of sample polarization properties such as phase-retardation, birefringent axis orientation, Stokes vectors, and degree of polarization uniformity (DOPU). In this study, PS-OCT was used to investigate the polarization properties of melanin. In-vitro measurements in samples with varying melanin concentrations revealed polarization scrambling, i.e. depolarization ...
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    22. Morphologic Characteristics of Idiopathic Juxtafoveal Telangiectasia Using Spectral-Domain and Polarization-Sensitive Optical Coherence Tomography

      Morphologic Characteristics of Idiopathic Juxtafoveal Telangiectasia Using Spectral-Domain and Polarization-Sensitive Optical Coherence Tomography
      Purpose: Idiopathic juxtafoveal telangiectasia (IJT) is characteristically associated with pigmentary changes. Polarization-sensitive spectral-domain optical coherence tomography (PS-SD-OCT) enables imaging of the retinal pigment epithelium (RPE) and similar melanin-containing structures based on specific polarization properties. This study examined IJT with the latest-generation SD-OCT and PS-SD-OCT, identifying pathophysiologically relevant characteristics of the retinal layers and RPE. Methods: Twenty-two eyes of 12 patients with IJT were examined by PS-SD-OCT, with special focus on ...
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    23. 1-24 of 37 1 2 »
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    1. (30 articles) Christoph K. Hitzenberger
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