1. Articles mentioning both Michael A. Choma and Yale University

    1-25 of 25
    1. Ex vivo visualization of human ciliated epithelium and quantitative analysis of induced flow dynamics by using optical coherence tomography

      Ex vivo visualization of human ciliated epithelium and quantitative analysis of induced flow dynamics by using optical coherence tomography
      Background and Objective Cilia-driven mucociliary clearance is an important self-defense mechanism of great clinical importance in pulmonary research. Conventional light microscopy possesses the capability to visualize individual cilia and its beating pattern but lacks the throughput to assess the global ciliary activities and flow dynamics. Optical coherence tomography (OCT), which provides depth-resolved cross-sectional images, was recently introduced to this area. Materials and Methods Fourteen de-identified human tracheobronchial tissues are directly ...
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    2. Analysis of Craniocardiac Malformations in Xenopus using Optical Coherence Tomography : Scientific Reports

      Analysis of Craniocardiac Malformations in Xenopus using Optical Coherence Tomography : Scientific Reports
      Birth defects affect 3% of children in the United States. Among the birth defects, congenital heart disease and craniofacial malformations are major causes of mortality and morbidity. Unfortunately, the genetic mechanisms underlying craniocardiac malformations remain largely uncharacterized. To address this, human genomic studies are identifying sequence variations in patients, resulting in numerous candidate genes. However, the molecular mechanisms of pathogenesis for most candidate genes are unknown. Therefore, there is a ...
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    3. Improved velocimetry in optical coherence tomography using Bayesian analysis

      Improved velocimetry in optical coherence tomography using Bayesian analysis
      OCT is a popular cross-sectional microscale imaging modality in medicine and biology. While structural imaging using OCT is a mature technology in many respects, flow and motion estimation using OCT remains an intense area of research. In particular, there is keen interest in maximizing information extraction from the complex-valued OCT signal. Here, we introduce a Bayesian framework into the data workflow in OCT-based velocimetry. We demonstrate that using prior information ...
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    4. Three-dimensional, three-vector-component velocimetry of cilia-driven fluid flow using correlation-based approaches in optical coherence tomography

      Three-dimensional, three-vector-component velocimetry of cilia-driven fluid flow using correlation-based approaches in optical coherence tomography
      Microscale quantification of cilia-driven fluid flow is an emerging area in medical physiology, including pulmonary and central nervous system physiology. Cilia-driven fluid flow is most completely described by a three-dimensional, three-component (3D3C) vector field. Here, we generate 3D3C velocimetry measurements by synthesizing higher dimensional data from lower dimensional measurements obtained using two separate optical coherence tomography (OCT)-based approaches: digital particle image velocimetry (DPIV) and dynamic light scattering (DLS)-OCT ...
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    5. Quantifying hyperoxia-mediated damage to mammalian respiratory cilia-driven fluid flow using particle tracking velocimetry optical coherence tomography

      Quantifying hyperoxia-mediated damage to mammalian respiratory cilia-driven fluid flow using particle tracking velocimetry optical coherence tomography
      Oxygen supplementation [hyperoxia, increased fraction of inspired oxygen ( FiO 2 )] is an indispensable treatment in the intensive care unit for patients in respiratory failure. Like other treatments or drugs, hyperoxia has a risk-benefit profile that guides its clinical use. While hyperoxia is known to damage respiratory epithelium, it is unknown if damage can result in impaired capacity to generate cilia-driven fluid flow. Here, we demonstrate that quantifying cilia-driven fluid flow ...
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    6. Post-doctoral Research Fellowship at Yale in Cardiovascular Molecular and Translational Imaging

      Post-doctoral Research Fellowship at Yale in Cardiovascular Molecular and Translational Imaging
      ...rant PI) or Michael Choma, MD, PhD (michael.choma@yale.edu, potential postdoc advisor) for more information. Yale University is an Affirmative Action/Equal Opportunity employer and welcomes applications from women, pers...
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    7. Low-spatial coherence electrically-pumped semiconductor laser for speckle-free full-field imaging

      Low-spatial coherence electrically-pumped semiconductor laser for speckle-free full-field imaging
      The spatial coherence of laser sources has limited their application to parallel imaging and projection due to coherent artifacts, such as speckle. In contrast, traditional incoherent light sources, such as thermal sources or light emitting diodes (LEDs), provide relatively low power per independent spatial mode. Here, we present a chip-scale, electrically-pumped semiconductor laser based on a novel design, demonstrating high power per mode with much lower spatial coherence than conventional ...
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    8. Yale University Receives NIH Grant for Development of a New Light Sources for Parallel Optical Coherence Tomography

      Yale University Receives NIH Grant for Development of a New Light Sources for Parallel Optical Coherence Tomography
      ...T system developed here will serve as a prototype upon which future translational research will be developed. Yale University Received a 2014 NIH Grant for $201,881 for Development of a New Light Sources for Parallel Opt...
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    9. Researchers at Yale Work to Improve Health of Premature Babies

      Researchers at Yale Work to Improve Health of Premature Babies
      Theres ongoing research to help babies born too soon. Yale researchers are looking into improving the health of premature babies by focusing on their under-developed lungs. What Yale researchers are doing is looking at the intricacies of how bacteria and viruses are moved in and out of the lungs in hopes of developing therapies and technology that could someday improve a premature babys chance of survival as well as quality ...
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    10. Systems And Methods For Imaging Using A Random Laser

      Systems And Methods For Imaging Using A Random Laser
      Systems and methods are provided for imaging using complex lasers. In general, a complex laser may be used as an electromagnetic source for an imaging application. The use of a lower spatial coherence configured complex laser in imaging applications may advantageously mitigate coherent artifacts in imaging such as cross-talk and speckle and improve overall image quality. Imaging applications where a complex laser may be useful include both incoherent imaging applications ...
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    11. Feature Of The Week 2/12/12: Researchers at Yale University use OCT to Characterize Microfluidic Ciliary Induced Fluid Flow

      Feature Of The Week 2/12/12: Researchers at Yale University use OCT to Characterize Microfluidic Ciliary Induced Fluid Flow
      ...or more information see resent  Article. Courtesy Michael Choma from Yale University. Recently researchers at Yale University demonstrated a very novel application of optical coherence tomography using a Thorlabs OCT sys...
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    12. Microfluidic characterization of cilia-driven fluid flow using optical coherence tomography-based particle tracking velocimetry

      Microfluidic characterization of cilia-driven fluid flow using optical coherence tomography-based particle tracking velocimetry
      ...ms : Motion estimation and optical flow Citation Stephan Jonas, Dipankan Bhattacharya, Mustafa K. Khokha, and Michael A. Choma, "Microfluidic characterization of cilia-driven fluid flow using optical coherence tomography...
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    13. Physiological homology between Drosophila melanogaster and vertebrate cardiovascular systems

      Physiological homology between Drosophila melanogaster and vertebrate cardiovascular systems
      ...odel of complex cardiovascular disease. Footnotes * ↵* Present address: Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, CT 06520-8043, USA * Received January 3, 2010. * Accepted Octob...
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  2. Organizations in the News

    1. (6 articles) National Institutes of Health
    2. (2 articles) RWTH Aachen University
    3. (1 articles) Harvard University
    4. (1 articles) Massachusetts General Hospital
    5. (1 articles) Drexel University
    6. (1 articles) Columbia University
    7. (1 articles) University of Arizona
  3. People in the News

    1. (1 articles) Brett E. Bouma
    2. (1 articles) Christine P. Fleming Hendon
    3. (1 articles) Benjamin J. Vakoc
    4. (1 articles) Melissa J. Suter
  4. OCT Companies in the News

    1. (1 articles) Thorlabs