1. Articles mentioning both Joseph A. Izatt and Sina Farsiu

    1-24 of 53 1 2 3 »
    1. Statistical Models of Signal and Noise and Fundamental Limits of Segmentation Accuracy in Retinal Optical Coherence Tomography

      Statistical Models of Signal and Noise and Fundamental Limits of Segmentation Accuracy in Retinal Optical Coherence Tomography
      Optical coherence tomography (OCT) has revolutionized diagnosis and prognosis of ophthalmic diseases by visualization and measurement of retinal layers. To speed up quantitative analysis of disease biomarkers, an increasing number of automatic segmentation algorithms have been proposed to estimate the boundary locations of retinal layers. While the performance of these algorithms has significantly improved in recent years, a critical question to ask is how far we are from a theoretical ...
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    2. Characterization of Long Working Distance Optical Coherence Tomography for Imaging of Pediatric Retinal Pathology

      Characterization of Long Working Distance Optical Coherence Tomography for Imaging of Pediatric Retinal Pathology
      Purpose : We determined the feasibility of fovea and optic nerve head imaging with a long working distance (LWD) swept source optical coherence tomography (OCT) prototype in adults, teenagers, and young children. Methods : A prototype swept source OCT system with a LWD (defined as distance from the last optical element of the imaging system to the eye) of 350 mm with custom fixation targets was developed to facilitate imaging of children ...
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    3. Retinal imaging in human autopsy eyes using a custom optical coherence tomography periscope

      Retinal imaging in human autopsy eyes using a custom optical coherence tomography periscope
      Age-related macular degeneration (AMD) is a major cause of vision loss in the elderly. To better study the pathobiology of AMD, postmortem eyes offer an excellent opportunity to correlate optical coherence tomography (OCT) imaging characteristics with histopathology. However, postmortem eyes from autopsy present challenges to standard OCT imaging including opaque anterior segment structures and standard of care autopsy processing resulting in oblique views to the macula. To overcome these challenges ...
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    4. Enhanced visualization of peripheral retinal vasculature with wavefront sensorless adaptive optics optical coherence tomography angiography in diabetic patients

      Enhanced visualization of peripheral retinal vasculature with wavefront sensorless adaptive optics optical coherence tomography angiography in diabetic patients
      Optical coherence tomography angiography (OCTA) is a promising technique for non-invasive visualization of vessel networks in the human eye. We debut a system capable of acquiring wide field-of-view ( 70 70 ) OCT angiograms without mosaicking. Additionally, we report on enhancing the visualization of peripheral microvasculature using wavefront sensorless adaptive optics (WSAO). We employed a fast WSAO algorithm that enabled wavefront correction in 2 s 2s by iterating the mirror shape at ...
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    5. Wide-field retinal optical coherence tomography with wavefront sensorless adaptive optics for enhanced imaging of targeted regions

      Wide-field retinal optical coherence tomography with wavefront sensorless adaptive optics for enhanced imaging of targeted regions
      The peripheral retina of the human eye offers a unique opportunity for assessment and monitoring of ocular diseases. We have developed a novel wide-field (70) optical coherence tomography system (WF-OCT) equipped with wavefront sensorless adaptive optics (WSAO) for enhancing the visualization of smaller (25) targeted regions in the peripheral retina. We iterated the WSAO algorithm at the speed of individual OCT B-scans (~20 ms) by using raw spectral interferograms to ...
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    6. Needle Depth and Big-Bubble Success in Deep Anterior Lamellar Keratoplasty: An Ex Vivo Microscope-Integrated OCT Study

      Needle Depth and Big-Bubble Success in Deep Anterior Lamellar Keratoplasty: An Ex Vivo Microscope-Integrated OCT Study
      Purpose: To examine big-bubble (BB) formation success rates in deep anterior lamellar keratoplasty (DALK) at various corneal depths using real-time guidance from swept-source, microscope-integrated optical coherence tomography (SS-MIOCT). Methods: The DALK procedure was performed ex vivo with 34 human donor corneoscleral buttons on pressurized artificial anterior chambers using the BB technique employed by Anwar and Teichmann. We inserted a needle under controlled ex vivo conditions to corneal depths ranging from ...
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    7. Live volumetric (4D) visualization and guidance of in vivo human ophthalmic surgery with intraoperative optical coherence tomography

      Live volumetric (4D) visualization and guidance of in vivo human ophthalmic surgery with intraoperative optical coherence tomography
      Minimally-invasive microsurgery has resulted in improved outcomes for patients. However, operating through a microscope limits depth perception and fixes the visual perspective, which result in a steep learning curve to achieve microsurgical proficiency. We introduce a surgical imaging system employing four-dimensional (live volumetric imaging through time) microscope-integrated optical coherence tomography (4D MIOCT) capable of imaging at up to 10 volumes per second to visualize human microsurgery. A custom stereoscopic heads-up ...
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    8. Length-adaptive graph search for automatic segmentation of pathological features in optical coherence tomography images

      Length-adaptive graph search for automatic segmentation of pathological features in optical coherence tomography images
      We introduce a metric in graph search and demonstrate its application for segmenting retinal optical coherence tomography (OCT) images of macular pathology. Our proposed adjusted mean arc length (AMAL) metric is an adaptation of the lowest mean arc length search technique for automated OCT segmentation. We compare this method to Dijkstras shortest path algorithm, which we utilized previously in our popular graph theory and dynamic programming segmentation technique. As an ...
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    9. Impact of Microscope-Integrated OCT on Ophthalmology Resident Performance of Anterior Segment Surgical Maneuvers in Model Eyes

      Impact of Microscope-Integrated OCT on Ophthalmology Resident Performance of Anterior Segment Surgical Maneuvers in Model Eyes
      Purpose : The integration of swept-source optical coherence tomography (SS-OCT) into the operating microscope enables real-time, tissue-level three-dimensional (3D) imaging to aid in ophthalmic microsurgery. In this prospective randomized controlled study, we evaluated the impact of SS microscope-integrated OCT (MI-OCT) on ophthalmology residents' performance of ophthalmic microsurgical maneuvers. Methods : Fourteen ophthalmology residents from a single institution were stratified by year of training and randomized to perform four anterior segment surgical maneuvers ...
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    10. Posterior Eye Shape Measurement With Retinal OCT Compared to MRI

      Posterior Eye Shape Measurement With Retinal OCT Compared to MRI
      Purpose : Posterior eye shape assessment by magnetic resonance imaging (MRI) is used to study myopia. We tested the hypothesis that optical coherence tomography (OCT), as an alternative, could measure posterior eye shape similarly to MRI. Methods : Macular spectral-domain OCT and brain MRI images previously acquired as part of the Singapore Epidemiology of Eye Diseases study were analyzed. The right eye in the MRI and OCT images was automatically segmented. Optical ...
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    11. Postdoctoral Research Fellowship in ophthalmic adaptive optics optical coherence tomography imaging at Duke University

      Postdoctoral Research Fellowship in ophthalmic adaptive optics optical coherence tomography imaging at Duke University
      ... supervised by Prof. Joseph A. Izatt ( http://bme.duke.edu/faculty/joseph-izatt ) in collaboration with Prof. Sina Farsiu ( http://people.duke.edu/~sf59/ ). Multiple previous PhD students and postdocs from this team are ...
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    12. Intrasurgical Human Retinal Imaging With Manual Instrument Tracking Using a Microscope-Integrated Spectral-Domain Optical Coherence Tomography Device

      Intrasurgical Human Retinal Imaging With Manual Instrument Tracking Using a Microscope-Integrated Spectral-Domain Optical Coherence Tomography Device
      Purpose: : To characterize the first in-human intraoperative imaging using a custom prototype spectral-domain microscope-integrated optical coherence tomography (MIOCT) device during vitreoretinal surgery with instruments in the eye. Methods: : Under institutional review board approval for a prospective intraoperative study, MIOCT images were obtained at surgical pauses with instruments held static in the vitreous cavity and then concurrently with surgical maneuvers. Postoperatively, MIOCT images obtained at surgical pauses were compared with images ...
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    13. INTRAOPERATIVE SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY IMAGING AFTER INTERNAL LIMITING MEMBRANE PEELING IN IDIOPATHIC EPIRETINAL MEMBRANE WITH CONNECTING STRANDS

      INTRAOPERATIVE SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY IMAGING AFTER INTERNAL LIMITING MEMBRANE PEELING IN IDIOPATHIC EPIRETINAL MEMBRANE WITH CONNECTING STRANDS
      Purpose: To report the intraoperative optical coherence tomography findings in idiopathic epiretinal membrane (ERM) with connecting strands and to describe the postoperative outcomes. Methods: A retrospective, case series study within a prospective observational intraoperative optical coherence tomography imaging study was performed. Epiretinal membranes with connecting strands were characterized on preoperative spectral domain optical coherence tomography images and assessed against corresponding intraoperative (after internal limiting membrane [ILM] peeling) and postoperative spectral ...
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    14. Kernel regression based segmentation of optical coherence tomography images with diabetic macular edema

      Kernel regression based segmentation of optical coherence tomography images with diabetic macular edema
      We present a fully automatic algorithm to identify fluid-filled regions and seven retinal layers on spectral domain optical coherence tomography images of eyes with diabetic macular edema (DME). To achieve this, we developed a kernel regression (KR)-based classification method to estimate fluid and retinal layer positions. We then used these classification estimates as a guide to more accurately segment the retinal layer boundaries using our previously described graph theory ...
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    15. 3-D Adaptive Sparsity Based Image Compression with Applications to Optical Coherence Tomography

      3-D Adaptive Sparsity Based Image Compression with Applications to Optical Coherence Tomography
      We present a novel general-purpose compression method for tomographic images, termed 3D adaptive sparse representation based compression (3D-ASRC). In this paper, we focus on applications of 3D-ASRC for the compression of ophthalmic 3D optical coherence tomography (OCT) images. The 3D-ASRC algorithm exploits correlations among adjacent OCT images to improve compression performance, yet is sensitive to preserving their differences. Due to the inherent denoising mechanism of the sparsity based 3D-ASRC, the ...
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    16. Fully automated detection of diabetic macular edema and dry age-related macular degeneration from optical coherence tomography images

      Fully automated detection of diabetic macular edema and dry age-related macular degeneration from optical coherence tomography images
      ...tions Pratul P. Srinivasan,^1,^2,^* Leo A. Kim,^3 Priyatham S. Mettu,^4 Scott W. Cousins,^4 Grant M. Comer,^5 Joseph A. Izatt,^1,^4 and Sina Farsiu^1,^4,^2,^6 ^1Department of Biomedical Engineering, Duke University, Du...
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    17. Segmentation and identification of layered structures in images

      Segmentation and identification of layered structures in images
      Disclosed herein are systems and method for segmentation and identification of structured features in images. According to an aspect, a method may include representing an image as a graph of nodes connected together by edges. For example, the image may be an ocular image showing layered structures or other features of the retina. The method may also include adding, to the graph, nodes adjacent to nodes along first and second ...
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    18. 1-24 of 53 1 2 3 »
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  2. Organizations in the News

    1. (53 articles) Duke University
    2. (3 articles) National Institutes of Health
    3. (1 articles) Harvard University
    4. (1 articles) University of Michigan
    5. (1 articles) Columbia University
    6. (1 articles) Erasmus University
    7. (1 articles) Massachusetts Eye and Ear Infirmary
    8. (1 articles) National University of Singapore
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    11. (1 articles) The Chinese University of Hong Kong
    12. (1 articles) Cleveland Clinic
  3. People in the News

    1. (29 articles) Cynthia A. Toth
    2. (15 articles) Stephanie J. Chiu
    3. (11 articles) Anthony N. Kuo
    4. (6 articles) Oscar Carrasco-Zevallos
    5. (4 articles) Yuankai K. Tao
    6. (4 articles) Paul V. Hahn
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    8. (3 articles) Justis P. Ehlers
    9. (2 articles) Sharon F. Freedman
    10. (1 articles) Tien Yin Wong
    11. (1 articles) Al-Hafeez Dhalla
    12. (1 articles) Mingtao Zhao
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