1. Articles mentioning both I. Alex Vitkin and Ontario Cancer Institute

    1-24 of 31 1 2 »
    1. Statistical properties of dynamic speckles from flowing Brownian scatterers in the vicinity of the image plane in optical coherence tomography

      Statistical properties of dynamic speckles from flowing Brownian scatterers in the vicinity of the image plane in optical coherence tomography
      A closed-form analytical expression is obtained for the spatio-temporal correlation function of the scattered radiation detected in fiber-based optical coherence tomography (OCT), assuming a clean optical system arrangement in the OCT sample arm. It is shown that the transverse flow component causes purely translational speckle motion with the predicted speckle velocity 2x higher than the velocity of the flowing particles as would be observed in the image plane under incoherent ...
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    2. Microvascular contrast enhancement in optical coherence tomography using microbubbles

      Microvascular contrast enhancement in optical coherence tomography using microbubbles
      Gas microbubbles (MBs) are investigated as intravascular optical coherence tomography (OCT) contrast agents. Agar + intralipid scattering tissue phantoms with two embedded microtubes were fabricated to model vascular blood flow. One was filled with human blood, and the other with a mixture of human blood + MB. Swept-source structural and speckle variance (sv) OCT images, as well as speckle decorrelation times, were evaluated under both no-flow and varying flow conditions. Faster decorrelation ...
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    3. Optical clearing of melanoma in vivo: characterization by diffuse reflectance spectroscopy and optical coherence tomography

      Optical clearing of melanoma in vivo: characterization by diffuse reflectance spectroscopy and optical coherence tomography
      Melanoma is the most aggressive type of skin cancer, with significant risk of fatality. Due to its pigmentation, light-based imaging and treatment techniques are limited to near the tumor surface, which is inadequate, for example, to evaluate the microvascular density that is associated with prognosis. White-light diffuse reflectance spectroscopy (DRS) and near-infrared optical coherence tomography (OCT) were used to evaluate the effect of a topically applied optical clearing agent (OCA ...
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    4. Analysis of scattering statistics and governing distribution functions in optical coherence tomography

      Analysis of scattering statistics and governing distribution functions in optical coherence tomography
      The probability density function (PDF) of light scattering intensity can be used to characterize the scattering medium. We have recently shown that in optical coherence tomography (OCT), a PDF formalism can be sensitive to the number of scatterers in the probed scattering volume and can be represented by the K-distribution, a functional descriptor for non-Gaussian scattering statistics. Expanding on this initial finding, here we examine polystyrene microsphere phantoms with different ...
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    5. Characterization of atherosclerotic plaques by cross-polarization optical coherence tomography

      Characterization of atherosclerotic plaques by cross-polarization optical coherence tomography
      We combined cross-polarization optical coherence tomography (CP OCT) and non-linear microscopy based on second harmonic generation (SHG) and two-photon-excited fluorescence (2PEF) to assess collagen and elastin fibers in the development of the atherosclerotic plaque (AP). The study shows potential of CP OCT for the assessment of collagen and elastin fibers condition in atherosclerotic arteries. Specifically, the additional information afforded by CP OCT, related to birefringence and cross-scattering properties of arterial ...
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    6. Dynamic light scattering by flowing Brownian particles measured with optical coherence tomography: impact of the optical system

      Dynamic light scattering by flowing Brownian particles measured with optical coherence tomography: impact of the optical system
      The study of flowing Brownian particles finds numerous biomedical applications, ranging from blood flow analysis to diffusion research. A mathematical model for the correlation function of laser radiation scattered by flowing Brownian particles measured with fiber-based optical coherence tomography (OCT), which accounts for the effects of sample arm optics, is presented. It is shown that the parameters of an OCT optical system of any complexity can be taken into account ...
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    7. Multi-modal optical imaging characterization of atherosclerotic plaques

      Multi-modal optical imaging characterization of atherosclerotic plaques
      We combined cross-polarization optical coherence tomography (CP OCT) and non-linear microscopy based on second harmonic generation (SHG) and two-photon-excited fluorescence (2PEF) to assess collagen and elastin fibers and other vascular structures in the development of atherosclerosis, including identification of vulnerable plaques, which remains an important clinical problem and imaging application. CP OCT's ability to visualize tissue birefringence and cross-scattering adds new information about the microstructure and composition of the ...
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    8. Deformation-induced speckle-pattern evolution and feasibility of correlational speckle tracking in optical coherence elastography

      Deformation-induced speckle-pattern evolution and feasibility of correlational speckle tracking in optical coherence elastography
      Feasibility of speckle tracking in optical coherence tomography (OCT) based on digital image correlation (DIC) is discussed in the context of elastography problems. Specifics of applying DIC methods to OCT, compared to processing of photographic images in mechanical engineering applications, are emphasized and main complications are pointed out. Analytical arguments are augmented by accurate numerical simulations of OCT speckle patterns. In contrast to DIC processing for displacement and strain estimation ...
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    9. Imaging pancreatobiliary ductal system with optical coherence tomography: A review

      Imaging pancreatobiliary ductal system with optical coherence tomography: A review
      An accurate, noninvasive and cost-effective method of in situ tissue evaluation during endoscopy would be highly advantageous for the detection of dysplasia or early cancer and for identifying different disease stages. Optical coherence tomography (OCT) is a noninvasive, high-resolution (1-10 m) emerging optical imaging method with potential for identifying microscopic subsurface features in the pancreatic and biliary ductal system. Tissue microstructure of pancreaticobiliary ductal system has been successfully imaged by ...
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    10. Optical coherence tomography platform for microvascular imaging and quantification: initial experience in late oral radiation toxicity patients

      Optical coherence tomography platform for microvascular imaging and quantification: initial experience in late oral radiation toxicity patients
      An optical coherence tomography (OCT) microvascular imaging platform, consisting of Doppler (DOCT) and speckle variance (svOCT) modalities, and microvascular image quantification tools are developed. The quantification methods extract blood flow-related parameters from DOCT images and vessel morphological parameters from svOCT images. This platform is used to assess the microvascular (DOCT and svOCT) images obtained during a clinical study on late oral radiation toxicity. This specific pathology was considered a suitable ...
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    11. Feature Of The Week 4/21/13: University of Toronto Investigates Analysis of OCT Speckle to Differentiate Tissue Disease State

      Feature Of The Week 4/21/13: University of Toronto Investigates Analysis of OCT Speckle to Differentiate Tissue Disease State
      ...ellular level changes, as these are submicrometer in size. Recently researchers at the University of Toronto, University Health Network, and National Research Council Canada published some interesting results investigati...
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    12. Development of quantitative parameters to assess in-vivo optical coherence tomography images of late oral radiation toxicity patients

      Development of quantitative parameters to assess in-vivo optical coherence tomography images of late oral radiation toxicity patients
      ...tients Bahar Davoudi ; Vani Damodaran ; Kostadinka Bizheva ; Victor Yang ; Robert Dinniwell ; Wilfred Levin ; Alex Vitkin; Development of quantitative parameters to assess in-vivo optical coherence tomography images of l...
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    13. OCT monitoring of cosmetic creams in human skin in vivo

      OCT monitoring of cosmetic creams in human skin in vivo
      Optical coherence tomography (OCT) is a tool currently used for noninvasive diagnosis of human disease as well as for monitoring treatment during or after therapy. In this study, OCT was used to examine penetration and accumulation of cosmetic creams on human hand skin. The samples varied in collagen content with one formulation containing soluble collagen as its primary active ingredient. Collagen is a major connective tissue protein that is essential ...
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    14. 1-24 of 31 1 2 »
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  2. Organizations in the News

    1. (29 articles) University of Toronto
    2. (7 articles) Ryerson University
    3. (5 articles) University of Waterloo
    4. (4 articles) Nizhny Novgorod State Medical Academy
    5. (4 articles) Sunnybrook Health Sciences Centre
    6. (3 articles) Institute of Applied Physics
    7. (3 articles) National Research Council Canada
    8. (1 articles) Technical University of Denmark (DTU)
    9. (1 articles) University of Houston
    10. (1 articles) Massachusetts Institute of Technology
    11. (1 articles) University of Oulu
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  3. People in the News

    1. (8 articles) Victor X. D. Yang
    2. (5 articles) Kostadinka K. Bizheva
    3. (5 articles) Adrian Mariampillai
    4. (4 articles) Beau A. Standish
    5. (3 articles) Michael K. K. Leung
    6. (3 articles) Natalia D. Gladkova
    7. (3 articles) Grigory V. Gelikonov
    8. (3 articles) Nigel R. Munce
    9. (3 articles) Elena B. Kiseleva
    10. (3 articles) Kenneth K. C. Lee
    11. (3 articles) Andras A. Lindenmaier
    12. (2 articles) Costel Flueraru
  4. OCT Companies in the News

    1. (1 articles) Toptica Photonics
    2. (1 articles) Michelson Diagnostics