1. Articles mentioning both Harvey O. Coxson and Stephen Lam

    1-12 of 12
    1. Sex Differences in Airway Remodeling in a Mouse Model of Chronic Obstructive Pulmonary Disease

      Sex Differences in Airway Remodeling in a Mouse Model of Chronic Obstructive Pulmonary Disease
      Rationale: Adjusting for the amount of smoking, women have a 50% increased risk of COPD compared with men. It is not known what the anatomic basis/mechanism(s) of these sex-related differences in COPD might be. Objective: To characterize the impact of female sex hormones on chronic cigarette smoke-induced airway remodeling and emphysema in a mouse model of COPD. Methods: Airway remodeling and emphysema were determined morphometrically in male, female ...
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    2. Bronchial thermoplasty in asthma: 2-year follow-up using optical coherence tomography

      Bronchial thermoplasty in asthma: 2-year follow-up using optical coherence tomography
      Bronchial thermoplasty (BT) is a novel, nonpharmacological procedure for treatment of severe asthma. Recently, the Asthma Intervention Research 2 clinical trial demonstrated asthmatics had fewer hospitalisations following BT, which persisted 5 years after therapy [1]. However, it is well recognised that asthma is a heterogeneous disease with distinct asthma phenotypes and, not surprisingly, not all asthmatics in that trial benefited from BT [2].
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    3. Automated segmentation of porcine airway wall layers using optical coherence tomography: comparison with manual segmentation and histology

      Automated segmentation of porcine airway wall layers using optical coherence tomography: comparison with manual segmentation and histology
      ...nd histology Miranda Kirby ; Anthony M. D. Lee ; Tara Candido ; Calum MacAulay ; Pierre Lane ; Stephen Lam ; Harvey O. Coxson; Automated segmentation of porcine airway wall layers using optical coherence tomography: com...
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    4. Quantitative Assessment of the Airway Wall Using Computed Tomography and Optical Coherence Tomography

      Ever since the site and nature of airflow obstruction in chronic obstructive pulmonary disease was described by Hogg, Thurlbeck, and Macklem, investigators have been looking for methods to noninvasively measure the airway wall dimensions. Recent advances in computed tomography technology and new computer algorithms have made it possible to visualize and measure the airway wall and lumen without the need for tissue. However, while there is great hope for computed ...
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    5. New and Current Clinical Imaging Techniques To Study Chronic Obstructive Pulmonary Disease

      Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease, characterized by both small airway and parenchymal abnormalities. There is increasing evidence to suggest that these two morphologic phenotypes, while related, may have different clinical presentations, prognosis and therapeutic responses to medications. With the advent of novel imaging modalities, it is now possible to evaluate these two morphologic phenotypes in large clinical studies using non or minially invasive methods such as ...
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    6. Gender Differences in Airway Wall Measurements with Optical Coherence Tomography (OCT).

      Purpose: To examine the difference in the relationship between airway wall dimensions and lung function in male and female smokers. Methods: 35 male and 18 female subjects from the BC Lung Health Cohort, who underwent OCT imaging and spirometry, were studied. OCT images, acquired at the time of bronchoscopy, were converted to digital images at 0.5s intervals using frame capture software. Airways were measured using ImageJ (NIH) image analysis ...
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    7. Inter- and Intra-Observer Variability in Measurements of Airways Using Optical Coherence Tomography (OCT).

      Purpose: To devise a protocol for the measurement of airways using optical coherence tomography (OCT) with acceptable inter− and intra−observer variability. Methods: 59 subjects from the British Columbia Lung Health Cohort who underwent OCT imaging were studied. OCT images, acquired at the time of bronchoscopy were converted to digital images at 0.5s intervals using frame capture software. Airways were measured using ImageJ (NIH) image analysis software on 5 ...
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    8. Airway Wall Thickness Assessed Using Computed Tomography and Optical Coherence Tomography

      Airway Wall Thickness Assessed Using Computed Tomography and Optical Coherence Tomography
      Rationale: Computed tomography (CT) has been shown to reliably measure the airway wall dimensions of medium to large airways. Optical coherence tomography (OCT) is a promising new micron-scale resolution imaging technique that can image small airways 2 mm in diameter or less. Objectives: To correlate OCT measurements of airway dimensions with measurements assessed using CT scans and lung function. Methods: Forty-four current and former smokers received spirometry, CT scans, and ...
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  2. Organizations in the News

    1. (8 articles) British Columbia Cancer Agency
    2. (8 articles) University of British Columbia
    3. (1 articles) Peking University
  3. People in the News

    1. (4 articles) Pierre M. Lane
    2. (2 articles) Grace Parraga
    3. (2 articles) Wei Zhang
  4. OCT Companies in the News

    1. (4 articles) Abbot