1. Articles mentioning both Harvard University and James G. Fujimoto

    1-24 of 58 1 2 3 »
    1. Healed Culprit Plaques in Patients With Acute Coronary Syndrome

      Healed Culprit Plaques in Patients With Acute Coronary Syndrome
      ackground Healed plaques, morphologically characterized by a layered phenotype, are frequently found in subjects with sudden cardiac death. However, in vivo data are lacking. Objectives The purpose of this study was to determine the prevalence, morphological characteristics, and clinical significance of healed culprit plaques in patients with acute coronary syndromes (ACS) using optical coherence tomography (OCT). Methods A total of 376 ACS patients (252 ST-segment elevation myocardial infarction [MI] and ...
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    2. Computer-Aided Analysis of Gland-Like Subsurface Hyposcattering Structures in Barrett’s Esophagus Using Optical Coherence Tomography

      Computer-Aided Analysis of Gland-Like Subsurface Hyposcattering Structures in Barrett’s Esophagus Using Optical Coherence Tomography
      (1) Background: Barretts esophagus (BE) is a complication of chronic gastroesophageal reflux disease and is a precursor to esophageal adenocarcinoma. The clinical implication of subsurface glandular structures of Barretts esophagus is not well understood. Optical coherence tomography (OCT), also known as volumetric laser endomicroscopy (VLE), can assess subsurface glandular structures, which appear as subsurface hyposcattering structures (SHSs). The aim of this study is to develop a computer-aided algorithm and apply ...
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    3. Feature Of The Week 10/08/2018: Clinical Utility of Ultrahigh-Speed Endoscopic Optical Coherence Tomography in Gastroenterology

      Feature Of The Week 10/08/2018: Clinical Utility of Ultrahigh-Speed Endoscopic Optical Coherence Tomography in Gastroenterology
      Barretts esophagus (BE) surveillance is limited by biopsy sampling error. Optical coherence tomography (OCT) enables microscopic resolution, high speed, volumetric imaging and is commercially available as volumetric laser endomicroscopy (VLE, NinePoint Medical). Studies investigated cross-sectional OCT dysplasia features, including a diagnostic algorithm (VLE-DA), however, many VLE studies used ex vivo specimens due to challenges in registering biopsy with OCT. We previously demonstrated ultrahigh-speed endoscopic OCT 10x faster than commercial instruments ...
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    4. Cycloid scanning for wide field optical coherence tomography endomicroscopy and angiography in vivo

      Cycloid scanning for wide field optical coherence tomography endomicroscopy and angiography in vivo
      Devices that perform wide field-of-view (FOV) precision optical scanning are important for endoscopic assessment and diagnosis of luminal organ disease such as in gastroenterology. Optical scanning for in vivo endoscopic imaging has traditionally relied on one or more proximal mechanical actuators, limiting scan accuracy and imaging speed. There is a need for rapid and precise two-dimensional (2D) microscanning technologies to enable the translation of benchtop scanning microscopies to in vivo ...
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    5. Clinical Predictors for Lack of Favorable Vascular Response to Statin Therapy in Patients With Coronary Artery Disease: A Serial Optical Coherence Tomography Study

      Clinical Predictors for Lack of Favorable Vascular Response to Statin Therapy in Patients With Coronary Artery Disease: A Serial Optical Coherence Tomography Study
      Background Previous studies have demonstrated that statin therapy improves cardiac outcomes, probably by stabilizing thin‐cap fibroatheroma in patients with coronary artery disease. However, major adverse cardiac events still occur in some patients, despite statin therapy. The aim of this study is to identify clinical predictors for the lack of a favorable vascular response to statin therapy in patients with coronary artery disease. Methods and Results A total of 140 ...
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    6. Endoscopic forward-viewing optical coherence tomography and angiography with MHz swept source

      Endoscopic forward-viewing optical coherence tomography and angiography with MHz swept source
      Endoscopic optical coherence tomography (OCT) instruments are mostly side viewing and rely on at least one proximal scan, thus limiting accuracy of volumetric imaging and en face visualization. Previous forward-viewing OCT devices had limited axial scan speeds. We report a forward-viewing fiber scanning 3D-OCT probe with 900 m field of view and 5 m transverse resolution, imaging at 1 MHz axial scan rate in the human gastrointestinal tract. The probe ...
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    7. Assessment of the radiofrequency ablation dynamics of esophageal tissue with optical coherence tomography

      Assessment of the radiofrequency ablation dynamics of esophageal tissue with optical coherence tomography
      Radiofrequency ablation (RFA) is widely used for the eradication of dysplasia and the treatment of early stage esophageal carcinoma in patients with Barretts esophagus (BE). However, there are several factors, such as variation of BE epithelium (EP) thickness among individual patients and varying RFA catheter-tissue contact, which may compromise RFA efficacy. We used a high-speed optical coherence tomography (OCT) system to identify and monitor changes in the esophageal tissue architecture ...
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    8. Clinical Significance of Lipid-Rich Plaque Detected by Optical Coherence Tomography : A 4-Year Follow-Up Study

      Clinical Significance of Lipid-Rich Plaque Detected by Optical Coherence Tomography : A 4-Year Follow-Up Study
      Background Lipid-rich plaque (LRP) is thought to be a precursor to cardiac events. However, its clinical significance in coronary arteries has never been systematically investigated. Objectives This study investigated the prevalence and clinical significance of LRP in the nonculprit region of the target vessel in patients undergoing percutaneous coronary intervention (PCI). Methods The study included 1,474 patients from 20 sites across 6 countries undergoing PCI, who had optical coherence ...
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    9. Circumferential optical coherence tomography angiography imaging of the swine esophagus using a micromotor balloon catheter

      Circumferential optical coherence tomography angiography imaging of the swine esophagus using a micromotor balloon catheter
      ... (2008). [Crossref] [PubMed] D. C. Adler, C. Zhou, T. H. Tsai, H. C. Lee, L. Becker, J. M. Schmitt, Q. Huang, J. G. Fujimoto, and H. Mashimo, “Three-dimensional optical coherence tomography of Barrett’s esophagus and bur...
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    10. Carmen A. Puliafito, MD, MBA, Former Dean of Keck School of Medicine of the University of Southern California, Joins Ophthotech as Chief of Strategic Development

      Carmen A. Puliafito, MD, MBA, Former Dean of Keck School of Medicine of the University of Southern California, Joins Ophthotech as Chief of Strategic Development
      ...search Laboratory and associate professor of ophthalmology at Harvard Medical School. A cum laude graduate of Harvard College and a magna cum laude graduate of Harvard Medical School, he completed his residency and fello...
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    11. Quantitative analysis of the side-branch orifice after bifurcation stenting using en-face processing of OCT images: a comparison between Xience V and Resolute Integrity stents

      Quantitative analysis of the side-branch orifice after bifurcation stenting using en-face processing of OCT images: a comparison between Xience V and Resolute Integrity stents
      Objective: Methods for intravascular assessment of the side-branch (SB) orifice after stenting are not readily available. The aim of this study was to assess the utility of an en-face projection processing for optical coherence tomography (OCT) images for SB evaluation. Methods: Measurements of the SB orifice obtained using en-face OCT images were validated using a phantom model. Linear regression modeling was applied to estimated area measurements made on the en-face ...
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    12. Feature Of The Week 03/08/2015: Endoscopic Optical Coherence Angiography Enables Three Dimensional Visualization of Subsurface Microvasculature

      Feature Of The Week 03/08/2015: Endoscopic Optical Coherence Angiography Enables Three Dimensional Visualization of Subsurface Microvasculature
      ...phy for Gastroenterology , Biomedical Optics Express 5 (12), 4387-4404 (2014). Courtesy of Tsung-Han Tsal and James Fujimoto and from Massachusetts Institute of Technology . To share this article click Here . Endoscopic ...
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    13. Ultrahigh speed endoscopic optical coherence tomography for gastroenterology

      Ultrahigh speed endoscopic optical coherence tomography for gastroenterology
      We describe an ultrahigh speed endoscopic swept source optical coherence tomography (OCT) system for clinical gastroenterology using a vertical-cavity surface-emitting laser (VCSEL) and micromotor imaging catheter. The system had a 600 kHz axial scan rate and 8 m axial resolution in tissue. Imaging was performed with a 3.2 mm diameter imaging catheter at 400 frames per second with a 12 m spot size. Three-dimensional OCT (3D-OCT) imaging was performed ...
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    14. Endothelial Shear Stress and Coronary Plaque Characteristics in Humans: A Combined Frequency-Domain Optical Coherence Tomography and Computational Fluid Dynamics Study

      Endothelial Shear Stress and Coronary Plaque Characteristics in Humans: A Combined Frequency-Domain Optical Coherence Tomography and Computational Fluid Dynamics Study
      ... Hospital, Harvard Medical School, Boston, MA 2. ^2Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 3. ^3Thoraxcenter, Erasmus Medical Center, Rotterdam, The Netherlands 4...
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    15. Computer-Aided Image Analysis Algorithm to Enhance In Vivo Diagnosis of Plaque Erosion by Intravascular Optical Coherence Tomography

      Computer-Aided Image Analysis Algorithm to Enhance In Vivo Diagnosis of Plaque Erosion by Intravascular Optical Coherence Tomography
      ...spital, Harvard Medical School, Boston, MA 4. ^4MGH Biostatistics Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 5. ^5Cardiology Division, Massachusetts General Hospital, Harvard Medic...
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    16. State of the Industry report on Optical Coherence Tomography

      State of the Industry report on Optical Coherence Tomography
      The first commercial optical coherence tomography (OCT) imagers were introduced to ophthalmology by Advanced Ophthalmic Devices (now owned by Zeiss Meditec) in 1992. Since then, the market for OCT systems has grown at an impressive compounded annual rate of about 45%. This segment of the biophotonics marketplace has flourished because OCT enables sub-surface imaging of translucent or opaque materials, such as human tissue, in real time at micron resolution and ...
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    17. Silencing Of The Drosophila Ortholog Of SOX5 In Heart Leads To Cardiac Dysfunction As Detected By Optical Coherence Tomography

      Silencing Of The Drosophila Ortholog Of SOX5 In Heart Leads To Cardiac Dysfunction As Detected By Optical Coherence Tomography
      ...neral Hospital and Harvard Medical School, MA 5. ^5Department of Medicine, Massachusetts General Hospital and Harvard Medical School, MA 6. ^6Framingham Heart Study, The National Heart, Lung, and Blood Institute (NHLBI),...
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  2. Organizations in the News

    1. (53 articles) Massachusetts Institute of Technology
    2. (20 articles) Massachusetts General Hospital
    3. (8 articles) Tufts University
    4. (7 articles) Beth Israel Deaconess Medical Center
    5. (6 articles) Brigham and Women’s Hospital
    6. (5 articles) Massachusetts General Hospital OCT Registry
    7. (5 articles) Massachusetts Eye and Ear Infirmary
    8. (5 articles) University of Pittsburgh
    9. (4 articles) University of Southern California
    10. (3 articles) Oregon Health & Science University
    11. (3 articles) Kawasaki Medical School
    12. (2 articles) University of Pennsylvania
  3. People in the News

    1. (17 articles) Hiroshi Mashimo
    2. (17 articles) Hsiang-Chieh Lee
    3. (16 articles) Tsung-Han Tsai
    4. (14 articles) Chao Zhou
    5. (11 articles) Zhao Wang
    6. (10 articles) Osman O. Ahsen
    7. (9 articles) Ik-Kyung Jang
    8. (9 articles) Desmond C. Adler
    9. (8 articles) Benjamin M. Potsaid
    10. (8 articles) Aaron D. Aguirre
    11. (8 articles) Joseph M. Schmitt
    12. (7 articles) David Huang
  4. OCT Companies in the News

    1. (12 articles) St. Jude Medical
    2. (10 articles) Thorlabs
    3. (6 articles) Praevium Research
    4. (5 articles) Carl Zeiss Meditec
    5. (3 articles) Optovue
    6. (3 articles) NinePoint Medical
    7. (2 articles) Topcon Medical Systems
    8. (2 articles) Tomey Corporation
    9. (1 articles) Heliotis AG
    10. (1 articles) Imalux
    11. (1 articles) ISIS Optronics
    12. (1 articles) Shenzhen Moptim Imaging Technique Co.