1. Articles mentioning both Guillermo J. Tearney and Massachusetts General Hospital

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    1. Intranasal micro-optical coherence tomography imaging for cystic fibrosis studies

      Intranasal micro-optical coherence tomography imaging for cystic fibrosis studies
      Cystic fibrosis (CF) is a genetic disease caused by mutations in the CF transmembrane conductance regulator (CFTR) gene. Although impairment of mucociliary clearance contributes to severe morbidity and mortality in people with CF, a clear understanding of the pathophysiology is lacking. This is, in part, due to the absence of clinical imaging techniques capable of capturing CFTR-dependent functional metrics at the cellular level. Here, we report the clinical translation of ...
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    2. New intra-nasal imaging technique allows researchers to study airways in patients with cystic fibrosis

      New intra-nasal imaging technique allows researchers to study airways in patients with cystic fibrosis
      ..., PhD, a pathologist and investigator for the department of Pathology and Wellman Center for Photomedicine at Massachusetts General Hospital (MGH), the Remondi Family MGH Research Institute Chair, and professor of pathol...
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    3. Imaging the Human Prostate Gland Using 1-μm-Resolution Optical Coherence Tomography

      Imaging the Human Prostate Gland Using 1-μm-Resolution Optical Coherence Tomography
      Context. The accuracy of needle biopsy for the detection of prostate cancer is limited by well-known sampling errors. Thus, there is an unmet need for a microscopic screening tool that can screen large regions of the prostate comprehensively for cancer. Previous prostate imaging by optical coherence tomography (OCT) has had insufficient resolution for imaging cellular features related to prostate cancer. We have recently developed micro-optical coherence tomography (OCT) that generates ...
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    4. Plaque burden can be assessed using intravascular optical coherence tomography and a dedicated automated processing algorithm: a comparison study with intravascular ultrasound

      Plaque burden can be assessed using intravascular optical coherence tomography and a dedicated automated processing algorithm: a comparison study with intravascular ultrasound
      Aims Plaque burden (PB) measurement using intravascular optical coherence tomography (IVOCT) is currently thought to be inferior to intravascular ultrasound (IVUS). We developed an automated IVOCT image processing algorithm to enhance the external elastic lamina (EEL) contour. Thus, we investigated the accuracies of standard IVOCT and an IVOCT enhancement algorithm for measuring PB using IVUS as the reference standard. Methods and results The EEL-enhancement algorithm combined adaptive attenuation compensation, exponentiation ...
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    5. Methods, systems, arrangements and computer-accessible medium for providing micro-optical coherence tomography procedures

      Methods, systems, arrangements and computer-accessible medium for providing micro-optical coherence tomography procedures
      Exemplary apparatus and method can be provided for obtaining data regarding a plurality of samples. For example, using at least one arrangement, it is possible to receive interferometric information that is based on radiations provided from a reference and the samples that are provided in respective chambers. Alternatively and/or in addition, based on the interferometric information, it is possible to discriminate between agents to identify a particular agent that ...
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    6. Optical coherence tomography-guided laser marking with tethered capsule endomicroscopy in unsedated patients

      Optical coherence tomography-guided laser marking with tethered capsule endomicroscopy in unsedated patients
      Tethered capsule endomicroscopy (TCE) is an emerging screening technology that comprehensively obtains microstructural OCT images of the gastrointestinal (GI) tract in unsedated patients. To advance clinical adoption of this imaging technique, it will be important to validate TCE images with co-localized histology, the current diagnostic gold standard. One method for co-localizing OCT images with histology is image-targeted laser marking, which has previously been implemented using a driveshaft-based, balloon OCT catheter ...
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    7. Postdoctoral Research Fellowships in Optical Coherence Tomography at The Tearney Lab at the Wellman Center for Photomedicine at the Massachusetts General Hospital Boston, MA USA

      Postdoctoral Research Fellowships in Optical Coherence Tomography at The Tearney Lab at the Wellman Center for Photomedicine at the Massachusetts General Hospital Boston, MA USA
      ... of optical coherence tomography (OCT) is available in the Tearney Lab at the Massachusetts General Hospital (MGH) in the Wellman Center for Photomedicine. This appointment will be made at the rank of postdoctoral fellow...
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    8. Postdoctoral Research Fellowship Opening in In Vivo Microscopy at the Wellman Center for Photomedicine at the Massachusetts General Hospital, Boston USA

      Postdoctoral Research Fellowship Opening in In Vivo Microscopy at the Wellman Center for Photomedicine at the Massachusetts General Hospital, Boston USA
      ...ship in the area of In Vivo Microscopy is available in the Tearney Lab at the Massachusetts General Hospital (MGH) in the Wellman Center for Photomedicine. This appointment will be made at the rank of postdoctoral fellow...
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    9. Pilot Study for OCT Guided In Vivo Laser Capture Microdissection for Assessing the Prognosis of Barrett's Esophagus

      Pilot Study for OCT Guided In Vivo Laser Capture Microdissection for Assessing the Prognosis of Barrett's Esophagus
      The investigators have developed a new technology, termed in-vivo laser capture microdissection (IVLCM), that addresses the limitations of endoscopic biopsy for screening for BE and provides targeted genomic profiling of aberrant tissue for more precise prediction of EAC risk. The device is a tethered capsule endomicroscope (TCE) that implements optical coherence tomography (OCT) to grab 10-mm-resolution, cross-sectional microscopic images of the entire esophagus after the capsule is swallowed. This OCT-based ...
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    10. Beth Israel Deaconess Medical Center Receives NIH Grant for Intravascular Molecular-Structural Imaging of Coronary Stent Pathobiology

      Beth Israel Deaconess Medical Center Receives NIH Grant for Intravascular Molecular-Structural Imaging of Coronary Stent Pathobiology
      ...eaders in engineering, optical imaging, vascular biology, and coronary stent design — Dr. Gary Tearney (MGH), Dr. Peter Libby (Brigham and Women's Hospital), and Dr. Elazer Edelman (Massachusetts Institute of Techn...
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    11. Measuring Barrett’s Epithelial Thickness with Volumetric Laser Endomicroscopy as a Biomarker to Guide Treatment

      Measuring Barrett’s Epithelial Thickness with Volumetric Laser Endomicroscopy as a Biomarker to Guide Treatment
      Background Radiofrequency ablation (RFA) treatment outcomes vary for unknown reasons. One hypothesis is that variations in Barretts epithelial thickness (BET) are associated with reduced RFA efficacy for thicker BET and strictures for thinner BET. Volumetric laser endomicroscopy (VLE) is an imaging modality that acquires high-resolution, depth-resolved images of BE. However, the attenuation of light by tissue and the lack of layering in Barretts tissue challenge BET measurements and the study ...
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    12. MGH Receives NIH Grant for Unique Value of Real-TIme Shear Stress to Enhance Coronary Disease Management.

      MGH Receives NIH Grant for Unique Value of Real-TIme Shear Stress to Enhance Coronary Disease Management.
      ... Unique Value of Real-TIme Shear Stress to Enhance Coronary Disease Management. The principal investigator is Guillermo Tearney. The program began in 2018 and ends in 2020. Below is a summary of the proposed work. Manag...
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    13. Imaging the Human Prostate Gland Using 1-μm-Resolution Optical Coherence Tomography

      Imaging the Human Prostate Gland Using 1-μm-Resolution Optical Coherence Tomography
      Context. The accuracy of needle biopsy for the detection of prostate cancer is limited by well-known sampling errors. Thus, there is an unmet need for a microscopic screening tool that can screen large regions of the prostate comprehensively for cancer. Previous prostate imaging by optical coherence tomography (OCT) have had insufficient resolution for imaging cellular features related to prostate cancer. We have recently developed micro-optical coherence tomography (OCT) that generates ...
      Read Full Article
    14. In Vivo and Ex Vivo Microscopy: Moving Toward the Integration of Optical Imaging Technologies Into Pathology Practice

      In Vivo and Ex Vivo Microscopy: Moving Toward the Integration of Optical Imaging Technologies Into Pathology Practice
      The traditional surgical pathology assessment requires tissue to be removed from the patient, then processed, sectioned, stained, and interpreted by a pathologist using a light microscope. Today, an array of alternate optical imaging technologies allow tissue to be viewed at high resolution, in real time, without the need for processing, fixation, freezing, or staining. Optical imaging can be done in living patients without tissue removal, termed in vivo microscopy, or ...
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    15. Postdoctoral Research Fellowships (Optical Coherence Tomography) The Tearney Lab at the Wellman Center for Photomedicine

      Postdoctoral Research Fellowships (Optical Coherence Tomography) The Tearney Lab at the Wellman Center for Photomedicine
      ... of optical coherence tomography (OCT) is available in the Tearney Lab at the Massachusetts General Hospital (MGH) in the Wellman Center for Photomedicine. This appointment will be made at the rank of postdoctoral fellow...
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    16. 1-24 of 238 1 2 3 4 5 6 7 8 9 10 »
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