1. Articles mentioning both Felix I. Feldchtein and Natalia D. Gladkova

    1-14 of 14
    1. Optical coherence angiography for pre-treatment assessment and treatment monitoring following photodynamic therapy: a basal cell carcinoma patient study

      Optical coherence angiography for pre-treatment assessment and treatment monitoring following photodynamic therapy: a basal cell carcinoma patient study
      Microvascular networks of human basal cell carcinomas (BCC) and surrounding skin were assessed with optical coherence angiography (OCA) in conjunction with photodynamic therapy (PDT). OCA images were collected and analyzed in 31 lesions pre-treatment, and immediately/24hours/312 months post-treatment. Pre-treatment OCA enabled differentiation between prevalent subtypes of BCC (nodular and superficial) and nodular-with-necrotic-core BCC subtypes with a diagnostic accuracy of 78%; this can facilitate more accurate biopsy reducing sampling ...
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    2. In-vivo longitudinal imaging of microvascular changes in irradiated oral mucosa of radiotherapy cancer patients using optical coherence tomography

      In-vivo longitudinal imaging of microvascular changes in irradiated oral mucosa of radiotherapy cancer patients using optical coherence tomography
      Mucositis is the limiting toxicity of radio(chemo)therapy of head and neck cancer. Diagnostics, prophylaxis and correction of this condition demand new accurate and objective approaches. Here we report on an in vivo longitudinal monitoring of the oral mucosa dynamics in 25 patients during the course of radiotherapy of oropharyngeal and nasopharyngeal cancer using multifunctional optical coherence tomography (OCT). A spectral domain OCT system with a specially-designed oral imaging ...
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    3. Pixel classification method in optical coherence tomography for tumor segmentation and its complementary usage with OCT microangiography

      Pixel classification method in optical coherence tomography for tumor segmentation and its complementary usage with OCT microangiography
      A novel machine-learning method to distinguish between tumor and normal tissue in optical coherence tomography (OCT) has been developed. Pre-clinical murine ear model implanted with mouse colon carcinoma CT-26 was used. Structural-image-based feature sets were defined for each pixel and machine learning classifiers were trained using ground truth OCT images manually segmented by comparison with histology. The accuracy of the OCT tumour segmentation method was then quantified by comparing with ...
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    4. Quantitative evaluation of atherosclerotic plaques using cross-polarization optical coherence tomography, nonlinear, and atomic force microscopy

      Quantitative evaluation of atherosclerotic plaques using cross-polarization optical coherence tomography, nonlinear, and atomic force microscopy
      A combination of approaches to the image analysis in cross-polarization optical coherence tomography (CP OCT) and high-resolution imaging by nonlinear microscopy and atomic force microscopy (AFM) at the different stages of atherosclerotic plaque development is studied. This combination allowed us to qualitatively and quantitatively assess the disorganization of collagen in the atherosclerotic arterial tissue (reduction and increase of CP backscatter), at the fiber (change of the geometric distribution of fibers ...
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    5. Characterization of atherosclerotic plaques by cross-polarization optical coherence tomography

      Characterization of atherosclerotic plaques by cross-polarization optical coherence tomography
      We combined cross-polarization optical coherence tomography (CP OCT) and non-linear microscopy based on second harmonic generation (SHG) and two-photon-excited fluorescence (2PEF) to assess collagen and elastin fibers in the development of the atherosclerotic plaque (AP). The study shows potential of CP OCT for the assessment of collagen and elastin fibers condition in atherosclerotic arteries. Specifically, the additional information afforded by CP OCT, related to birefringence and cross-scattering properties of arterial ...
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    6. Multi-modal optical imaging characterization of atherosclerotic plaques

      Multi-modal optical imaging characterization of atherosclerotic plaques
      We combined cross-polarization optical coherence tomography (CP OCT) and non-linear microscopy based on second harmonic generation (SHG) and two-photon-excited fluorescence (2PEF) to assess collagen and elastin fibers and other vascular structures in the development of atherosclerosis, including identification of vulnerable plaques, which remains an important clinical problem and imaging application. CP OCT's ability to visualize tissue birefringence and cross-scattering adds new information about the microstructure and composition of the ...
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    7. Quantitative Evaluation of the Polarization Characteristics of Coronary Arteries Atherosclerotic Plaques at Different Development Stages

      Quantitative Evaluation of the Polarization Characteristics of Coronary Arteries Atherosclerotic Plaques at Different Development Stages
      The aim of the investigation was to develop an approach to quantitative evaluation of polarization properties (birefringence and cross-scattering) basing on cross-polarization OCT images (CP OCT) in order to characterize the development stages of atherosclerotic plaques and to reveal unstable ones. Materials and Methods. We report on quantitative analysis of CP OCT images of the seven development stages of atherosclerotic plaques ex vivo . Integral depolarization factor (IDF) and effective birefringence ...
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    8. Application of optical coherence tomography in the diagnosis of mucositis in patients with head and neck cancer during a course of radio(chemo)therapy

      Objective Mucositis is the most common oral complication of non-surgical therapy (chemotherapy, radiotherapy, and radio(chemo)therapy) in patients with head and neck cancer. Growing evidence indicates that more aggressive treatment regimens improve local tumor control and the survival of patients with locally advanced head and neck cancer. However combined therapy approaches are associated with higher acute toxicity. Currently there are no in vivo methods to visualize microscopic changes of ...
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    9. Optical coherence tomography apparatus, optical fiber lateral scanner and a method for studying biological tissues in vivo

      In a method for in vivo diagnostics of a biological tissue covered with epithelium an image of the biological tissue is acquired with the aid of a beam in the visible or near IR range directed towards a biological tissue by visualizing the intensity of optical radiation backscattered by the biological tissue. The basal membrane of said biological tissue, which separates the epithelium from an underlying stroma, is identified in ...
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    10. Optical coherence tomography apparatus, optical fiber lateral scanner and a method for studying biological tissues in vivo

      The present invention relates to the analysis of the internal structures of objects using optical means. According to the invention there were designed an apparatus suited for optical coherence tomography (OCT), an optical fiber lateral scanner (15), which is a part of said apparatus and is incorporated into an optical fiber probe (8), and a method for studying biological tissue in vivo, which allows for making a diagnostics of the ...
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    11. Optical coherent tomography apparatus, fiberoptic lateral scanner and method for studying biological tissues in vivo

      The present invention relates to the analysis of the internal structures of objects using optical means. According to the invention there were designed an apparatus suited for optical coherence tomography (OCT), an optical fiber lateral scanner (15), which is a part of said apparatus and is incorporated into an optical fiber probe (8), and a method for studying biological tissue in vivo, which allows for making a diagnostics of the ...
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    12. Optical fiber interferometer with PZT scanning of interferometer arm optical length

      The invention is related to technical physics, in particular to devices for investigating the internal structure of objects and can be used in medicine for diagnostics of human organs and systems, in particular for optical coherence tomography and in technical diagnostics, for example technological process control. The invention relates to the creation of an optical-fiber interferometer, which, being used in a device for optical coherence tomography, allows one to investigate ...
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    13. Optical fiber interferometer and piezoelectric modulator

      The invention is related to technical physics, in particular to devices for investigating the internal structure of objects and can be used in medicine for diagnostics of human organs and systems, in particular for optical coherence tomography and in technical diagnostics, for example technological process control. The invention relates to the creation of an optical-fiber interferometer, which, being used in a device for optical coherence tomography, allows one to investigate ...
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    14. 1-14 of 14
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  2. Organizations in the News

    1. (10 articles) Institute of Applied Physics
    2. (9 articles) Nizhny Novgorod State Medical Academy
    3. (5 articles) University of Toronto
    4. (2 articles) Ontario Cancer Institute
    5. (1 articles) Moscow State University
  3. People in the News

    1. (11 articles) Grigory V. Gelikonov
    2. (8 articles) Valentin M. Gelikonov
    3. (8 articles) Elena B. Kiseleva
    4. (5 articles) Alexander M. Sergeev
    5. (5 articles) I. Alex Vitkin
    6. (3 articles) Elena V. Zagaynova
    7. (2 articles) Mikhail Y. Kirillin
    8. (2 articles) Maria M. Karabut
  4. OCT Companies in the News

    1. (6 articles) Imalux