1. Articles mentioning both Erasmus University and Harvard University

    1-25 of 25
    1. Optical coherence tomography in coronary atherosclerosis assessment and intervention

      Optical coherence tomography in coronary atherosclerosis assessment and intervention
      Since optical coherence tomography (OCT) was first performed in humans two decades ago, this imaging modality has been widely adopted in research on coronary atherosclerosis and adopted clinically for the optimization of percutaneous coronary intervention. In the past 10 years, substantial advances have been made in the understanding of in vivo vascular biology using OCT. Identification by OCT of culprit plaque pathology could potentially lead to a major shift in ...
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    2. Intravascular Polarimetry: Clinical Translation and Future Applications of Catheter-Based Polarization Sensitive Optical Frequency Domain Imaging

      Intravascular Polarimetry: Clinical Translation and Future Applications of Catheter-Based Polarization Sensitive Optical Frequency Domain Imaging
      Optical coherence tomography (OCT) and optical frequency domain imaging (OFDI) visualize the coronary artery wall and plaque morphology in great detail. The advent of these high-resolution intracoronary imaging modalities has propelled our understanding of coronary atherosclerosis and provided enhanced guidance for percutaneous coronary intervention. Yet, the lack of contrast between distinct tissue types and plaque compositions impedes further elucidation of the complex mechanisms that contribute to acute coronary syndrome (ACS ...
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    3. Intravascular Polarimetry in Patients With Coronary Artery Disease

      Intravascular Polarimetry in Patients With Coronary Artery Disease
      Objectives The aims of this first-in-human pilot study of intravascular polarimetry were to investigate polarization properties of coronary plaques in patients and to examine the relationship of these features with established structural characteristics available to conventional optical frequency domain imaging (OFDI) and with clinical presentation. Background Polarization-sensitive OFDI measures birefringence and depolarization of tissue together with conventional cross-sectional optical frequency domain images of subsurface microstructure. Methods Thirty patients undergoing polarization-sensitive ...
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    4. Measuring Barrett’s Epithelial Thickness with Volumetric Laser Endomicroscopy as a Biomarker to Guide Treatment

      Measuring Barrett’s Epithelial Thickness with Volumetric Laser Endomicroscopy as a Biomarker to Guide Treatment
      Background Radiofrequency ablation (RFA) treatment outcomes vary for unknown reasons. One hypothesis is that variations in Barretts epithelial thickness (BET) are associated with reduced RFA efficacy for thicker BET and strictures for thinner BET. Volumetric laser endomicroscopy (VLE) is an imaging modality that acquires high-resolution, depth-resolved images of BE. However, the attenuation of light by tissue and the lack of layering in Barretts tissue challenge BET measurements and the study ...
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    5. Intravascular imaging for characterization of coronary atherosclerosis

      Intravascular imaging for characterization of coronary atherosclerosis
      This short review surveys recent developments in coronary intravascular imaging technologies. We present an outline of the applications of intravascular imaging for guidance of percutaneous coronary interventions and imaging of atherosclerosis, along with emerging clinical evidence for use. Imaging of tissue composition is important for understanding the relation between the presence of a lesion and clinical sequelae. We describe the recent innovations to enable imaging of unstable atherosclerotic plaques, focusing ...
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    6. Is quantitative coronary angiography reliable in assessing the late lumen loss of the everolimus eluting bioresorbable polylactide scaffold in comparison with the cobalt chromium metallic stent?

      Is quantitative coronary angiography reliable in assessing the late lumen loss of the everolimus eluting bioresorbable polylactide scaffold in comparison with the cobalt chromium metallic stent?
      Aims: Immediately after stent/scaffold implantation, quantitative coronary angiography (QCA) with respect to optical coherence tomography (OCT) more severely underestimates the lumen diameter (LD) in Absorb than in XIENCE. This OCT-QCA discrepancy has not been evaluated at long-term follow-up. The present study aimed to assess the accuracy of QCA with reference to OCT in Absorb as compared to XIENCE.
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    7. EuroIntervention Automated characterisation of lipid core plaques in vivo by quantitative optical coherence tomography tissue type imaging

      EuroIntervention Automated characterisation of lipid core plaques in vivo by quantitative optical coherence tomography tissue type imaging
      Aims: Qualitative criteria for plaque tissue characterisation by OCT are well established, but quantitative methods lack systematic validation in vivo . High optical attenuation coefficient t has been associated with unstable plaque features, such as lipid core. The purpose of this study was to validate optical coherence tomography (OCT) attenuation imaging for tissue characterisation in vivo , specifically to detect lipid core in coronary atherosclerotic plaques, and to evaluate quantitatively the ability ...
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    8. Hybrid intravascular imaging: recent advances, technical considerations, and current applications in the study of plaque pathophysiology

      Hybrid intravascular imaging: recent advances, technical considerations, and current applications in the study of plaque pathophysiology
      Cumulative evidence from histology-based studies demonstrate that the currently available intravascular imaging techniques have fundamental limitations that do not allow complete and detailed evaluation of plaque morphology and pathobiology, limiting the ability to accurately identify high-risk plaques. To overcome these drawbacks, new efforts are developing for data fusion methodologies and the design of hybrid, dual-probe catheters to enable accurate assessment of plaque characteristics, and reliable identification of high-risk lesions. Today ...
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    9. Biomechanical stress in coronary atherosclerosis: emerging insights from computational modelling

      Biomechanical stress in coronary atherosclerosis: emerging insights from computational modelling
      Coronary plaque rupture is the most common cause of vessel thrombosis and acute coronary syndrome. The accurate early detection of plaques prone to rupture may allow prospective, preventative treatment; however, current diagnostic methods remain inadequate to detect these lesions. Established imaging features indicating vulnerability do not confer adequate specificity for symptomatic rupture. Similarly, even though experimental and computational studies have underscored the importance of endothelial shear stress in progressive atherosclerosis ...
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    10. Endothelial Shear Stress and Coronary Plaque Characteristics in Humans: A Combined Frequency-Domain Optical Coherence Tomography and Computational Fluid Dynamics Study

      Endothelial Shear Stress and Coronary Plaque Characteristics in Humans: A Combined Frequency-Domain Optical Coherence Tomography and Computational Fluid Dynamics Study
      ... Hospital, Harvard Medical School, Boston, MA 2. ^2Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 3. ^3Thoraxcenter, Erasmus Medical Center, Rotterdam, The Netherlands 4...
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    11. Feature Of The Week 3/2/14: Erasmus MC Investigates Fusion of OCT and Coronary Angiography for Accurate Assessment of the Local Blood Flow Patterns

      Feature Of The Week 3/2/14: Erasmus MC Investigates Fusion of OCT and Coronary Angiography for Accurate Assessment of the Local Blood Flow Patterns
      ...S on neointimal proliferation. For more information see recent Article . Courtesy Christos Bourantas from the Erasmus Medical Center . Intravascular ultrasound (IVUS)-based reconstructions have been traditionally used to...
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    12. Effect of the Endothelial Shear Stress Patterns on Neointimal Proliferation Following Drug-Eluting Bioresorbable Vascular Scaffold Implantation : An Optical Coherence Tomography Study

      Effect of the Endothelial Shear Stress Patterns on Neointimal Proliferation Following Drug-Eluting Bioresorbable Vascular Scaffold Implantation : An Optical Coherence Tomography Study
      Objectives The goal of this study was to investigate the effect of endothelial shear stress (ESS) on neointimal formation following an Absorb bioresorbable vascular scaffold (BVS) (Abbott Vascular, Santa Clara, California) implantation. Background Cumulative evidence, derived from intravascular ultrasoundbased studies, has demonstrated a strong association between local ESS patterns and neointimal formation in bare-metal stents, whereas in drug-eluting stents, there are contradictory data about the effect of ESS on the ...
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    13. Fusion of optical coherence tomographic and angiographic data for more accurate evaluation of the endothelial shear stress patterns and neointimal distribution after bioresorbable scaffold implantation: comparison with intravascular ultrasound-derived rec

      Fusion of optical coherence tomographic and angiographic data for more accurate evaluation of the endothelial shear stress patterns and neointimal distribution after bioresorbable scaffold implantation: comparison with intravascular ultrasound-derived rec
      ...with intravascular ultrasound-derived reconstructions Department of Interventional Cardiology, Thoraxcenter, Erasmus University Medical Centre, ‘s-Gravendijkwal 230, 3015 CE, Rotterdam, The Netherlands Cardiovascular D...
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    14. In vivo assessment of the three-dimensional haemodynamic micro-environment following drug-eluting bioresorbable vascular scaffold implantation in a human coronary artery: fusion of frequency domain optical coherence tomography and angiography

      In vivo assessment of the three-dimensional haemodynamic micro-environment following drug-eluting bioresorbable vascular scaffold implantation in a human coronary artery: fusion of frequency domain optical coherence tomography and angiography
      The biplane angiographic data, acquired after implantation of an everolimus-eluting bioresorbable vascular scaffold (Absorb BVS; Abbott Vascular, Santa Clara, CA, USA) in the right coronary artery of a 46-year-old patient, were separately fused with frequency domain optical coherence tomography (FD-OCT) and intravascular ultrasound (IVUS) data to reconstruct the three-dimensional (3-D) anatomy. The local shear stress (SS) distribution in the FD-OCT- and IVUS-based models was assessed using computational fluid dynamics. The ...
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    15. Frequency domain multiplexing for speckle reduction in optical coherence tomography

      Frequency domain multiplexing for speckle reduction in optical coherence tomography
      Quantitative analysis of optical coherence tomography data can be strongly hampered by speckle. Here, we introduce a new method to reduce speckle, which leverages from Fourier-domain configurations and operates on individual axial scans. By subdividing the digitized spectrum into a number of distinct narrower windows, each with a different center frequency, several independent speckle patterns result. These can be averaged to yield a lower-resolution image with strongly reduced speckle. The ...
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    16. Expert review document part 2: methodology, terminology and clinical applications of optical coherence tomography for the assessment of interventional procedures

      Expert review document part 2: methodology, terminology and clinical applications of optical coherence tomography for the assessment of interventional procedures
      Introduction This document is complementary to an Expert Review Document on Optical Coherence Tomography (OCT) for the study of coronary arteries and atherosclerosis.1 The goal of this companion manuscript is to provide a practical guide framework for the appropriate use and reporting of the novel frequency domain (FD) OCT imaging to guide interventional procedures, with a particular interest on the comparison with intravascular ultrasound (IVUS).1–4 Technique for ...
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    17. Interstudy reproducibility of the second generation, Fourier domain optical coherence tomography in patients with coronary artery disease and comparison with intravascular ultrasound: a study applying automated contour detection

      Interstudy reproducibility of the second generation, Fourier domain optical coherence tomography in patients with coronary artery disease and comparison with intravascular ultrasound: a study applying automated contour detection
      Recently, Fourier domain OCT (FD-OCT) has been introduced for clinical use. This approach allows in vivo, high resolution (15 micron) imaging with very fast data acquisition, however, it requires brief flushing of the lumen during imaging. The reproducibility of such fast data acquisition under intracoronary flush application is poorly understood. To assess the inter-study variability of FD-OCT and to compare lumen morphometry to the established invasive imaging method, IVUS. 18 ...
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    18. Wavelength multiplexing for FD-OCT speckle averaging

      Wavelength multiplexing for FD-OCT speckle averaging
      Quantitative analysis of OCT data can be strongly hampered by speckle. We propose a new method to reduce speckle, operating on a single Fourier-domain optical coherence tomography (FD-OCT) A-line. The full acquired spectrum is used for image generation, exhibiting fully developed speckle. By subdividing the same acquired spectrum in a number of distinct narrower windows, each with a different center frequency, several independent speckles can be generated. These can be ...
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    19. Witnessed Coronary Plaque Rupture During Cardiac Catheterization

      Witnessed Coronary Plaque Rupture During Cardiac Catheterization
      Acute myocardial infarction is primarily caused by atherosclerotic plaque rupture within coronary arteries accompanied by intraluminal thrombus formation, sudden vessel occlusion, and impaired oxygen supply to the myocardium. However, study of plaque rupture has been previously limited to histological analysis of autopsy specimens and animal experiments. Using a high-resolution imaging technique, called intracoronary optical frequency domain imaging (OFDI), we have directly observed the microstructural detail of human coronary plaque rupture ...
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    20. Atherosclerotic tissue characterization in vivo by optical coherence tomography attenuation imaging

      ...January 2010 ABSTRACT REFERENCES (53) Gijs van Soest, Thadé Goderie, and Evelyn Regar Erasmus Medical Center, Thorax Center, PO Box 2040, Rotterdam 3000CA, The Netherlands Senada Koljenović and Geert L. J. H. van Leender...
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    21. Expert review document on methodology, terminology, and clinical applications of optical coherence tomography: physical principles, methodology of image acquisition, and clinical application for assessment of coronary arteries and atherosclerosis

      ...iew Document 1 Interventional Cardiology, San Giovanni Hospital, Via dell'Amba Aradam, 8, 00184 Rome, Italy 2 Thoraxcenter, University Hospital Rotterdam, Rotterdam, the Netherlands 3 Washington Hospital Center, Washingt...
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    22. 59 Optical Coherence Tomography Papers Presentations at Transcatheter Cardiovascular Therapeutics Conference (TCT 2009)

      59 Optical Coherence Tomography Papers Presentations at Transcatheter Cardiovascular Therapeutics Conference (TCT 2009)
      Optical Coherence Tomography (OCT) continues to make substantial progress in cardiovascular applications as evidence by the impressive number of OCT papers presented at this years Transcatheter Cardiovascular Therapeutics Conference (TCT 2009). The table below contains a list of the presenters and titles. Additional information on these talks can be found in the Symposia CD when it is released. See the Cardiology category above for additional information on OCT in cardiology.
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  2. Organizations in the News

    1. (20 articles) Massachusetts General Hospital
    2. (6 articles) University of Ioannina
    3. (5 articles) Brigham and Women’s Hospital
    4. (5 articles) Massachusetts Institute of Technology
    5. (4 articles) Kyoto University Graduate School of Medicine
    6. (4 articles) Wakayama Medical University
    7. (3 articles) Cardiovascular Research Foundation
    8. (3 articles) University of Melbourne
    9. (3 articles) University of Athens
    10. (3 articles) Ospedali Riuniti di Bergamo
    11. (3 articles) Leiden University
    12. (2 articles) Columbia University
  3. OCT Companies in the News

    1. (3 articles) Abbott
    2. (2 articles) Terumo Corporation
    3. (1 articles) Boston Scientific