1. Articles mentioning both David D. Sampson and Brendan F. Kennedy

    1-24 of 41 1 2 »
    1. Ultrahigh-Resolution Optical Coherence Elastography Images Cellular-Scale Stiffness of Mouse Aorta

      Ultrahigh-Resolution Optical Coherence Elastography Images Cellular-Scale Stiffness of Mouse Aorta
      Cellular-scale imaging of the mechanical properties of tissue has helped to reveal the origins of disease; however, cellular-scale resolution is not readily achievable in intact tissue volumes. Here, we demonstrate volumetric imaging of Youngs modulus using ultrahigh-resolution optical coherence elastography, and apply it to characterizing the stiffness of mouse aortas. We achieve isotropic resolution of better than 15 m over a 1-mm lateral field of view through the entire depth ...
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    2. OncoRes Medical backed by MRCF to develop innovative imaging technology for breast cancer surgery

      OncoRes Medical backed by MRCF to develop innovative imaging technology for breast cancer surgery
      ...pic level. The engineers include Dr. Brendan Kennedy, Dr. Robert McLaughlin, Dr. Kelsey Kennedy and Professor David Sampson from the School of Electrical, Electronic and Computer Engineering at The University of Western ...
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    3. The emergence of optical elastography in biomedicine

      The emergence of optical elastography in biomedicine
      Optical elastography, the use of optics to characterize and map the mechanical properties of biological tissue, involves measuring the deformation of tissue in response to a load. Such measurements may be used to form an image of a mechanical property, often elastic modulus, with the resulting mechanical contrast complementary to the more familiar optical contrast. Optical elastography is experiencing new impetus in response to developments in the closely related fields ...
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    4. Depth-encoded optical coherence elastography for simultaneous volumetric imaging of two tissue faces

      Depth-encoded optical coherence elastography for simultaneous volumetric imaging of two tissue faces
      Depth-encoded optical coherence elastography (OCE) enables simultaneous acquisition of two three-dimensional (3D) elastograms from opposite sides of a sample. By the choice of suitable path-length differences in each of two interferometers, the detected carrier frequencies are separated, allowing depth-ranging from each interferometer to be performed simultaneously using a single spectrometer. We demonstrate depth-encoded OCE on a silicone phantom and a freshly excised sample of mouse liver. This technique minimizes the ...
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    5. Investigation of optical coherence micro-elastography as a method to visualize micro-architecture in human axillary lymph nodes

      Investigation of optical coherence micro-elastography as a method to visualize micro-architecture in human axillary lymph nodes
      Background Evaluation of lymph node involvement is an important factor in detecting metastasis and deciding whether to perform axillary lymph node dissection (ALND) in breast cancer surgery. As ALND is associated with potentially severe long term morbidity, the accuracy of lymph node assessment is imperative in avoiding unnecessary ALND. The mechanical properties of malignant lymph nodes are often distinct from those of normal nodes. A method to image the micro-scale ...
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    6. Wide-field optical coherence micro-elastography for intraoperative assessment of human breast cancer margins

      Wide-field optical coherence micro-elastography for intraoperative assessment of human breast cancer margins
      Incomplete excision of malignant tissue is a major issue in breast-conserving surgery, with typically 20 - 30% of cases requiring a second surgical procedure arising from postoperative detection of an involved margin. We report advances in the development of a new intraoperative tool, optical coherence micro-elastography, for the assessment of tumor margins on the micro-scale. We demonstrate an important step by conducting whole specimen imaging in intraoperative time frames with a ...
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    7. Promising New Imaging Tool Allows Surgeons to Detect Malignant Tissue During Breast-Conserving Surgery for Breast Cancer

      Promising New Imaging Tool Allows Surgeons to Detect Malignant Tissue During Breast-Conserving Surgery for Breast Cancer
      ...f undergoing surgery again and can delay other related treatments.”  Working closely with Brendan Kennedy and David Sampson, professors of electronic engineering and Christobel Saunders, a professor of surgery at the Uni...
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    8. Simplifying the assessment of human breast cancer by mapping a micro-scale heterogeneity index in optical coherence elastography

      Simplifying the assessment of human breast cancer by mapping a micro-scale heterogeneity index in optical coherence elastography
      Surgical treatment of breast cancer aims to identify and remove all malignant tissue. Intraoperative assessment of tumor margins is, however, not exact; thus, re-excision is frequently needed, or excess normal tissue is removed. Imaging methods applicable intraoperatively could help to reduce re-excision rates whilst minimizing removal of excess healthy tissue. Optical coherence elastography (OCE) has been proposed for use in breast-conserving surgery; however, intraoperative interpretation of complex OCE images may ...
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    9. Investigation of optical attenuation imaging using optical coherence tomography for monitoring of scars undergoing fractional laser treatment

      Investigation of optical attenuation imaging using optical coherence tomography for monitoring of scars undergoing fractional laser treatment
      En face 2D OCT attenuation coefficient map of a treated immature scar derived from the pre-treatment (top) and the post-treatment (bottom) scans. (Vasculature (black) is masked out.) The scale bars are 0.5 mm. We demonstrate the use of the near-infrared attenuation coefficient, measured using optical coherence tomography (OCT), in longitudinal assessment of hypertrophic burn scars undergoing fractional laser treatment. The measurement method incorporates blood vessel detection by speckle decorrelation ...
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    10. Quantifying the influence of Bessel beams on image quality in optical coherence tomography

      Quantifying the influence of Bessel beams on image quality in optical coherence tomography
      Light scattered by turbid tissue is known to degrade optical coherence tomography (OCT) image contrast progressively with depth. Bessel beams have been proposed as an alternative to Gaussian beams to image deeper into turbid tissue. However, studies of turbid tissue comparing the image quality for different beam types are lacking. We present such a study, using numerically simulated beams and experimental OCT images formed by Bessel or Gaussian beams illuminating ...
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    11. Ultrahigh-resolution optical coherence elastography

      Ultrahigh-resolution optical coherence elastography
      Visualizing stiffness within the local tissue environment at the cellular and subcellular level promises to provide insight into the genesis and progression of disease. In this Letter, we propose ultrahigh-resolution optical coherence elastography (UHROCE), and demonstrate 3D imaging of local axial strain of tissues undergoing compressive loading. We combine optical coherence microscopy (OCM) and phase-sensitive detection of local tissue displacement to produce strain elastograms with resolution (
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    12. Optical coherence tomography for longitudinal monitoring of vasculature in scars treated with laser fractionation - Gong - 2015 - Journal of Biophotonics - Wiley Online Library

      Optical coherence tomography for longitudinal monitoring of vasculature in scars treated with laser fractionation - Gong - 2015 - Journal of Biophotonics - Wiley Online Library
      En face optical coherence tomography vasculature images pre-treatment (top) and 20 weeks after the first laser treatment (bottom) of a mature burn scar. Arrows mark the same vessel pattern. This study presents the first in vivo longitudinal assessment of scar vasculature in ablative fractional laser treatment using optical coherence tomography (OCT). A method based on OCT speckle decorrelation was developed to visualize and quantify the scar vasculature over the treatment ...
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    13. Investigation of optical coherence micro-elastography as a method to visualize cancers in human breast tissue

      Investigation of optical coherence micro-elastography as a method to visualize cancers in human breast tissue
      Accurate intraoperative identification of malignant tissue is a challenge in the surgical management of breast cancer. Imaging techniques that help address this challenge could contribute to more complete and accurate tumor excision, and thereby help reduce the current high re-excision rates without resorting to the removal of excess healthy tissue. Optical coherence micro-elastography (OCME) is a three-dimensional, high-resolution imaging technique that is sensitive to micro-scale variations of the mechanical properties ...
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    14. Near video-rate optical coherence elastography by acceleration with a graphics processing unit

      Near video-rate optical coherence elastography by acceleration with a graphics processing unit
      We present a graphics processing unit (GPU)- accelerated optical coherence elastography (OCE) system capable of generating strain images (elastograms) of soft tissue at near video-rates. The system implements phase-sensitive compression OCE using a pipeline of GPU kernel functions to enable a highly parallel implementation of OCE processing using the OpenCL framework. Developed on a commercial-grade GPU and desktop computer, the system achieves a processing rate of 21 elastograms per second ...
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    15. Parametric imaging of viscoelasticity using optical coherence elastography

      Parametric imaging of viscoelasticity using optical coherence elastography
      We demonstrate imaging of soft tissue viscoelasticity using optical coherence elastography. Viscoelastic creep deformation is induced in tissue using step-like compressive loading and the resulting time-varying deformation is measured using phase-sensitive optical coherence tomography. From a series of co-located B-scans, we estimate the local strain rate as a function of time, and parameterize it using a four-parameter KelvinVoigt model of viscoelastic creep. The estimated viscoelastic strain and time constant are ...
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    16. A review of optical coherence tomography in breast cancer

      A review of optical coherence tomography in breast cancer
      Optical coherence tomography (OCT) is a medical imaging modality that opens up new opportunities for imaging in breast cancer. It provides two- and three-dimensional micro-scale images of tissue structure from bulk tissue, in vivo or freshly excised without labeling or staining, is capable of video-rate acquisition speeds, and is compatible with compact imaging probes. In this paper, the authors briefly describe OCT technology and describe in detail its capabilities for ...
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    17. Optical coherence micro-elastography: mechanical-contrast imaging of tissue microstructure

      Optical coherence micro-elastography: mechanical-contrast imaging of tissue microstructure
      We present optical coherence micro-elastography, an improved form of compression optical coherence elastography. We demonstrate the capacity of this technique to produce en face images, closely corresponding with histology, that reveal micro-scale mechanical contrast in human breast and lymph node tissues. We use phase-sensitive, three-dimensional optical coherence tomography (OCT) to probe the nanometer-to-micrometer-scale axial displacements in tissues induced by compressive loading. Optical coherence micro-elastography incorporates common-path interferometry, weighted averaging of ...
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    18. Needle optical coherence elastography for the measurement of microscale mechanical contrast deep within human breast tissues

      Needle optical coherence elastography for the measurement of microscale mechanical contrast deep within human breast tissues
      ...s, which is critical to the success of breast-conserving surgery. Kelsey M. Kennedy ; Robert A. McLaughlin ; Brendan F. Kennedy ; Alan Tien ; Bruce Latham, et al. "Needle optical coherence elastography for the measurem...
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    19. 1-24 of 41 1 2 »
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  2. Organizations in the News

    1. (41 articles) University of Western Australia
    2. (4 articles) University of Illinois at Urbana-Champaign
    3. (1 articles) Medical University of Vienna
    4. (1 articles) Harvard University
    5. (1 articles) Sir Charles Gairdner Hospital
    6. (1 articles) University of Washington
    7. (1 articles) Massachusetts Institute of Technology
    8. (1 articles) Nicolaus Copernicus University
    9. (1 articles) Massachusetts General Hospital
    10. (1 articles) National Research Council Canada
  3. People in the News

    1. (18 articles) Robert A. McLaughlin
    2. (12 articles) Andrea Curatolo
    3. (12 articles) Kelsey M. Kennedy
    4. (4 articles) Timothy R. Hillman
    5. (4 articles) Rodney W. Kirk
    6. (3 articles) Steven G. Adie
    7. (3 articles) Stephen A. Boppart
    8. (2 articles) Dirk Lorenser
    9. (2 articles) Peter R. T. Munro
    10. (2 articles) Xing Liang
    11. (2 articles) Loretta Scolaro
    12. (1 articles) Julian J. Armstrong
  4. OCT Companies in the News

    1. (2 articles) OncoRes Medical
    2. (1 articles) Compact Imaging, Inc