1. Articles mentioning both Cornell University and Steven G. Adie

    1-14 of 14
    1. Volumetric optical coherence microscopy with a high space-bandwidth-time product enabled by hybrid adaptive optics

      Volumetric optical coherence microscopy with a high space-bandwidth-time product enabled by hybrid adaptive optics
      Optical coherence microscopy (OCM) is a promising modality for high resolution imaging, but has limited ability to capture large-scale volumetric information about dynamic biological processes with cellular resolution. To enhance the throughput of OCM, we implemented a hybrid adaptive optics (hyAO) approach that combines computational adaptive optics with an intentionally aberrated imaging beam generated via hardware adaptive optics. Using hyAO, we demonstrate the depth-equalized illumination and collection ability of an ...
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    2. Photonic force optical coherence elastography for three-dimensional mechanical microscopy

      Photonic force optical coherence elastography for three-dimensional mechanical microscopy
      Optical tweezers are an invaluable tool for non-contact trapping and micro-manipulation, but their ability to facilitate high-throughput volumetric microrheology of biological samples for mechanobiology research is limited by the precise alignment associated with the excitation and detection of individual bead oscillations. In contrast, radiation pressure from a low-numerical aperture optical beam can apply transversely localized force over an extended depth range. Here we present photonic force optical coherence elastography (PF-OCE ...
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    3. Depth-resolved measurement of optical radiation-pressure forces with optical coherence tomography

      Depth-resolved measurement of optical radiation-pressure forces with optical coherence tomography
      A weakly focused laser beam can exert sufficient radiation pressure to manipulate microscopic particles over a large depth range. However, depth-resolved continuous measurement of radiation-pressure force profiles over an extended range about the focal plane has not been demonstrated despite decades of research on optical manipulation. Here, we present a method for continuous measurement of axial radiation-pressure forces from a weakly focused beam on polystyrene micro-beads suspended in viscous fluids ...
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    4. Photonic force optical coherence elastography for threedimensional mechanical microscopy

      Photonic force optical coherence elastography for threedimensional mechanical microscopy
      Optical tweezers are an invaluable tool for non-contact trapping and micro-manipulation, but their ability to facilitate high-throughput volumetric microrheology of biological samples for mechanobiology research is limited by the precise alignment associated with the excitation and detection of individual bead oscillations. In contrast, radiation pressure from a low numerical aperture optical beam can apply transversely localized force over an extended depth range. We propose photonic force optical coherence elastography (PF-OCE ...
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    5. Cornell University Receives NIH Grant for Development of Hybrid Adaptive Optics for Multimodal Microscopy Deep in The Mouse Brain

      Cornell University Receives NIH Grant for Development of Hybrid Adaptive Optics for Multimodal Microscopy Deep in The Mouse Brain
      ...nt of Hybrid Adaptive Optics for Multimodal Microscopy Deep in The Mouse Brain. The principal investigator is Steven Adie. The program began in 2017 and ends in 2019. Below is a summary of the proposed work.

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    6. Measurement of dynamic cell-induced 3D displacement fields in vitro for traction force optical coherence microscopy

      Measurement of dynamic cell-induced 3D displacement fields in vitro for traction force optical coherence microscopy
      Traction force microscopy (TFM) is a method used to study the forces exerted by cells as they sense and interact with their environment. Cell forces play a role in processes that take place over a wide range of spatiotemporal scales, and so it is desirable that TFM makes use of imaging modalities that can effectively capture the dynamics associated with these processes. To date, confocal microscopy has been the imaging ...
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    7. Computational adaptive optics for broadband interferometric tomography of tissues and cells

      Computational adaptive optics for broadband interferometric tomography of tissues and cells
      Adaptive optics (AO) can shape aberrated optical wavefronts to physically restore the constructive interference needed for high-resolution imaging. With access to the complex optical field, however, many functions of optical hardware can be achieved computationally, including focusing and the compensation of optical aberrations to restore the constructive interference required for diffraction-limited imaging performance. Holography, which employs interferometric detection of the complex optical field, was developed based on this connection between ...
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    8. GPU-based computational adaptive optics for volumetric optical coherence microscopy

      GPU-based computational adaptive optics for volumetric optical coherence microscopy
      Optical coherence tomography (OCT) is a non-invasive imaging technique that measures reflectance from within biological tissues. Current higher-NA optical coherence microscopy (OCM) technologies with near cellular resolution have limitations on volumetric imaging capabilities due to the trade-offs between resolution vs. depth-of-field and sensitivity to aberrations. Such trade-offs can be addressed using computational adaptive optics (CAO), which corrects aberration computationally for all depths based on the complex optical field measured by ...
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    9. 1-14 of 14
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  2. Organizations in the News

    1. (4 articles) University of Illinois at Urbana-Champaign
    2. (2 articles) National Institutes of Health
    3. (2 articles) University of Western Australia
  3. People in the News

    1. (4 articles) P. Scott Carney
    2. (4 articles) Stephen A. Boppart
    3. (3 articles) Nathan D. Shemonski
    4. (2 articles) Adeel Ahmad
    5. (2 articles) Fredrick A. South