1. Articles mentioning both Chang Gung University and Meng-Tsan Tsai

    1-24 of 44 1 2 »
    1. Ultrahigh-resolution optical coherence tomography/angiography with an economic and compact supercontinuum laser

      Ultrahigh-resolution optical coherence tomography/angiography with an economic and compact supercontinuum laser
      In this study, a Q-switch pumped supercontinuum laser (QS-SCL) is used as a light source for in vivo imaging via ultrahigh-resolution optical coherence tomography and angiography (UHR-OCT/OCTA). For this purpose, an OCT system based on a spectral-domain detection scheme is constructed, and a spectrometer with a spectral range of 635875 nm is designed. The effective full-width at half maximum of spectrum covers 150 nm, and the corresponding axial and ...
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    2. Non-Invasive Quantification of the Growth of Cancer Cell Colonies by a Portable Optical Coherence Tomography

      Non-Invasive Quantification of the Growth of Cancer Cell Colonies by a Portable Optical Coherence Tomography
      Investigation of tumor development is essential in cancer research. In the laboratory, living cell culture is a standard bio-technology for studying cellular response under tested conditions to predict in vivo cellular response. In particular, the colony formation assay has become a standard experiment for characterizing the tumor development in vitro. However, quantification of the growth of cell colonies under a microscope is difficult because they are suspended in a three-dimensional ...
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    3. In vivo detection of UV-induced acute skin effects using optical coherence tomography

      In vivo detection of UV-induced acute skin effects using optical coherence tomography
      Ultraviolet (UV) rays have been identified as a carcinogen with long-term irradiation and are an important risk factor for skin cancer. Here, we report the use of optical coherence tomography/optical coherence tomography angiography (OCT/OCTA) to study acute UV-induced effects on skin in vivo . To understand the relationship between the acute effects and irradiated UV power density, three groups were irradiated with different power densities in our experiments. Furthermore ...
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    4. Extending the depth of focus of fiber-optic optical coherence tomography using a chromatic dual-focus design

      Extending the depth of focus of fiber-optic optical coherence tomography using a chromatic dual-focus design
      We report a dual-focus fiber-optic probe designed to extend depth of focus (DOF) in high-resolution endoscopic optical coherence tomography. We exploited the broad spectral bandwidth of a supercontinuum source and, in the fiber probe, the foci of the 7501000 nm and 11001450 nm inputs were axially chromatically shifted. The interference signals from the two spectral bands were measured with a Si camera-based spectrometer and an InGaAs camera-based spectrometer, respectively. We ...
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    5. Assessment of temporary cerebral effects induced by focused ultrasound with optical coherence tomography angiography

      Assessment of temporary cerebral effects induced by focused ultrasound with optical coherence tomography angiography
      Focused ultrasound (FUS) in combination with microbubbles temporally and locally increases the permeability of the blood-brain barrier (BBB) for facilitating drug delivery. However, the temporary effects of FUS on the brain microstructure and microcirculation need to be addressed. We used label-free optical coherence tomography (OCT) and OCT angiography (OCTA) to investigate the morphological and microcirculation changes in mouse brains due to FUS exposure at different power levels. Additionally, the recovery ...
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    6. Noninvasive structural and microvascular anatomy of oral mucosae using handheld optical coherence tomography

      Noninvasive structural and microvascular anatomy of oral mucosae using handheld optical coherence tomography
      In this study, we demonstrated the feasibility of using a handheld optical coherence tomography (OCT) for in vivo visualizations of the microstructural and microvascular features of various oral mucosal types. To scan arbitrary locations of the oral mucosa, a scanning probe was developed, composed of a probe body fabricated by a 3D printer, miniaturized two-axis galvanometer, relay lenses, and reflective prism. With a 3D printing technique, the probe weight and ...
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    7. Using Optical Coherence Tomography to Identify of Oral Mucosae with 3D-Printing Probe

      Using Optical Coherence Tomography to Identify of Oral Mucosae with 3D-Printing Probe
      Biomedical materials have different optical properties (e.g. absorption) for different wavelengths. Therefore, probing biomedical materials with multiple wavelengths not only can get in-depth understanding of the detected biomedical materials but also can differentiate the detected biomedical materials. To achieve this purpose, in this conference paper, we present our initial results of building up a portable multiple-wavelength biomedical sensing system. At this initial phase, we assembled this kind of system ...
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    8. Contrast-enhanced optical coherence microangiography with acoustic-actuated microbubbles

      Contrast-enhanced optical coherence microangiography with acoustic-actuated microbubbles
      In this study, we propose to use gas-filled microbubbles (MBs) simultaneously actuated by the acoustic wave to enhance the imaging contrast of optical coherence tomography (OCT)-based angiography. In the phantom experiments, MBs can result in stronger backscattered intensity, enabling to enhance the contrast of OCT intensity image. Moreover, simultaneous application of low-intensity acoustic wave enables to temporally induce local vibration of particles and MBs in the vessels, resulting in ...
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    9. Noninvasive imaging of oral mucosae with optical coherence tomography

      Noninvasive imaging of oral mucosae with optical coherence tomography
      In this study, a swept-source optical coherence tomography (OCT) system is developed for in vivo visualization of structural and vascular morphology oral mucosa. For simplification of optical probe fabrication, probe weight, and system setup, the body of the scanning probe is fabricated by a 3D printer to fix the optical components and the mechanical scanning device, and a partially reflective slide is attached at the output end of probe to ...
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    10. Study on laser-assisted drug delivery with optical coherence tomography

      Study on laser-assisted drug delivery with optical coherence tomography
      The nail provides a functional protection to the fingertips and surrounding tissue from external injuries. Nail plate divided into three layers including dorsal, intermediate, and ventral layers. The dorsal layer consists of compact, hard keratins, limiting topical drug delivery through the nail. In this study, we investigate the application of fractional CO 2 laser that produces arrays of microthermal ablation zones (MAZs) to facilitate drug delivery in the nails. Moreover ...
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    11. Acoustic-actuated optical coherence angiography

      Acoustic-actuated optical coherence angiography
      Optical coherence tomography (OCT) angiography requires high sensitivity and image penetration for detailed microvascular monitoring. Unfortunately, no effective contrast-medium-enhanced scheme is currently available for imaging improvement. We here propose the simultaneous use of gas-filled microbubbles (MBs) and acoustic actuation to enhance the imaging contrast of OCT angiography. OCT-synchronized acoustic actuation was applied in the presence of MBs, and different moving object tracking angiographic algorithms were tested in in vitro tubing ...
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    12. Evaluation of Laser-Assisted Trans-Nail Drug Delivery with Optical Coherence Tomography

      Evaluation of Laser-Assisted Trans-Nail Drug Delivery with Optical Coherence Tomography
      The nail provides a functional protection to the fingertips and surrounding tissue from external injuries. The nail plate consists of three layers including dorsal, intermediate, and ventral layers. The dorsal layer consists of compact, hard keratins, limiting topical drug delivery through the nail. In this study, we investigate the application of fractional CO 2 laser that produces arrays of microthermal ablation zones (MAZs) to facilitate drug delivery in the nails ...
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    13. Optical coherence tomography-guided laser microsurgery for blood coagulation with continuous-wave laser diode

      Optical coherence tomography-guided laser microsurgery for blood coagulation with continuous-wave laser diode
      Blood coagulation is the clotting and subsequent dissolution of the clot following repair to the damaged tissue. However, inducing blood coagulation is difficult for some patients with homeostasis dysfunction or during surgery. In this study, we proposed a method to develop an integrated system that combines optical coherence tomography (OCT) and laser microsurgery for blood coagulation. Also, an algorithm for positioning of the treatment location from OCT images was developed ...
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    14. Optical inspection of solar cells using phase-sensitive optical coherence tomography

      Optical inspection of solar cells using phase-sensitive optical coherence tomography
      The inspection and measurement of solar cells has become an important technique in evaluating the efficiency and quality of solar cell devices. Currently, surface defect detection of solar cells can be achieved by several approaches such as machine vision, photoluminescence, and electroluminescence imaging techniques. Nevertheless, it is still difficult to inspect the inner structures of solar cells. In response to this need, scanning electron microscopy (SEM) and transmission electron microscopy ...
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    15. Fabrication of a novel dissolving polymer microneedle patch for transdermal drug delivery

      Fabrication of a novel dissolving polymer microneedle patch for transdermal drug delivery
      Polymer microneedles (MNs) have gained increasing attention as a minimally invasive method for efficiently delivering drugs and vaccines in a patient-friendly manner. Herein, an easy and mild process with O2 plasma treatment was used to fabricate polyvinylpyrrolidone (PVP)/polyvinyl alcohol (PVA) MN patches, and efficient, sustained transdermal delivery was achieved. The diffusion rate of the entrained molecules could be controlled by adjusting the ratio of PVP/PVA. Optical coherence tomography ...
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    16. Investigation of temporal vascular effects induced by focused ultrasound treatment with speckle-variance optical coherence tomography

      Investigation of temporal vascular effects induced by focused ultrasound treatment with speckle-variance optical coherence tomography
      Focused ultrasound (FUS) can be used to locally and temporally enhance vascular permeability, improving the efficiency of drug delivery from the blood vessels into the surrounding tissue. However, it is difficult to evaluate in real time the effect induced by FUS and to noninvasively observe the permeability enhancement. In this study, speckle-variance optical coherence tomography (SVOCT) was implemented for the investigation of temporal effects on vessels induced by FUS treatment ...
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    17. Region segmentation in 3-D optical coherence tomography images

      Region segmentation in 3-D optical coherence tomography images
      This paper describes a novel region segmentation method created to enhance spatial relationships in 3-D optical coherence tomography (OCT) images. To reduce the noise and distortion problems in low-resolution OCT images, previous work used the mean value and an enhanced-fuzzy-c-mean algorithm to cluster pixels in 2-D OCT images and find the edge between different clustered regions. To utilize more spatial relationships and to reduce computation time, the proposed method uses ...
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    18. Feature Of The Week 11/17/13: Monitoring of wound healing process of human skin after fractional laser treatments with optical coherence tomography

      Feature Of The Week 11/17/13: Monitoring of wound healing process of human skin after fractional laser treatments with optical coherence tomography
      ... after fractional laser treatments. For more information see recent Article . Courtesy of Meng-Tsan Tsai from Chang Gung University . Fractional photothermolysis induced by non-ablative fractional lasers (NAFLs) or ablat...
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    19. 1-24 of 44 1 2 »
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  2. Organizations in the News

    1. (21 articles) National Taiwan University
    2. (3 articles) Zhejiang University
    3. (3 articles) National Yang-Ming University
    4. (1 articles) Tsinghua University
    5. (1 articles) Nanyang Technological University
  3. People in the News

    1. (18 articles) Cheng-Kuang Lee
    2. (14 articles) Feng-Yu Chang
    3. (12 articles) Chih-Chung Yang
    4. (10 articles) Ya-Ju Lee
    5. (5 articles) Hsiang-Chieh Lee
    6. (1 articles) Linbo Liu