1. Comparison of Glaucoma Progression Detection by Optical Coherence Tomography and Visual Field

      Comparison of Glaucoma Progression Detection by Optical Coherence Tomography and Visual Field
      Purpose To compare longitudinal glaucoma progression detection using optical coherence tomography (OCT) and visual field (VF). Design Validity assessment Method We analyzed subjects with more than 5 follow-up visits (every 6 months) in the multi-center Advanced Imaging for Glaucoma Study. Fourier-domain optical coherence tomography (OCT) was used to map the thickness of the peripapillary retinal nerve fiber layer (NFL) and ganglion cell complex (GCC). OCT-based progression detection was defined as ...
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    2. Methods and systems to measure corneal epithelial thickness and power, stromal thickness, subepithelial corneal power and topography for disease diagnosis

      Methods and systems to measure corneal epithelial thickness and power, stromal thickness, subepithelial corneal power and topography for disease diagnosis
      This invention discloses methods and systems for measuring corneal epithelial thickness and power, stromal thickness, subepitheila corneal power and topography. The systems and methods disclosed herein are non-invasive, non-contact and automated imaging methods which preferably makes use of Fourier-domain optical tomography. Also disclosed herein are scanning patterns and image analysis methods for utilizing and analyzing Fourier-domain optical coherence tomography images to obtain information about conical epithelial and stromal properties as ...
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    3. Longitudinal and Cross-Sectional Analyses of Age and Intraocular Pressure Effects on Retinal Nerve Fiber Layer and Ganglion Cell Complex Thickness

      Longitudinal and Cross-Sectional Analyses of Age and Intraocular Pressure Effects on Retinal Nerve Fiber Layer and Ganglion Cell Complex Thickness
      Purpose : To study the effect of age and intraocular pressure (IOP) on retinal nerve fiber layer (NFL) and ganglion cell complex (GCC) thickness in normal eyes. Methods : We analyzed the data from subjects enrolled in the multi-center longitudinal Advanced Imaging for Glaucoma (AIG) Study (www.AIGStudy.net). The data included yearly visits from the normal subjects group in the AIGS study. Fourier-domain optical coherence tomography (OCT) was used to map ...
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    4. Regression Analysis of Optical Coherence Tomography Disc Variables for Glaucoma Diagnosis

      Regression Analysis of Optical Coherence Tomography Disc Variables for Glaucoma Diagnosis
      Purpose: To report diagnostic accuracy of optical coherence tomography (OCT) disc variables using both time-domain (TD) and Fourier-domain (FD) OCT, and to improve the use of OCT disc variable measurements for glaucoma diagnosis through regression analyses that adjust for optic disc size and axial length-based magnification error. Design: Observational, cross-sectional. Participants: In total, 180 normal eyes of 112 participants and 180 eyes of 138 participants with perimetric glaucoma from the ...
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    5. Combining measurements from three anatomical areas for glaucoma diagnosis using Fourier-domain optical coherence tomography

      Combining measurements from three anatomical areas for glaucoma diagnosis using Fourier-domain optical coherence tomography
      ...ardens, Florida, USA 6. ^6USC Eye Institute and the Department of Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA 1. Correspondence to David Huang, Casey Eye ...
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    6. Measurement of retinal blood flow in normal Chinese American subjects by Doppler Fourier-domain optical coherence tomography

      Measurement of retinal blood flow in normal Chinese American subjects by Doppler Fourier-domain optical coherence tomography
      ..., USC, Los Angeles, CA, 90089, United States 4. ^4Doheny Eye Institute, University of Southern California Keck School of Medicine, 1450 sanpablo st, Los Angeles, CA, 90033, United States 5. ^5Oregon Health and Sc...
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    7. Advanced Imaging for Glaucoma Study: Design, Baseline Characteristics, and Inter-Site Comparison

      Advanced Imaging for Glaucoma Study: Design, Baseline Characteristics, and Inter-Site Comparison
      ...USA ^∗ , Rohit Varma x Rohit Varma Search for articles by this author Affiliations * Department of Ophthalmology, University of Southern California, Los Angeles, CA, USA , David S. Greenfield x David S....
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    8. Grader learning effect and reproducibility of Doppler Spectral‐Domain Optical Coherence Tomography derived retinal blood flow measurements

      Grader learning effect and reproducibility of Doppler Spectral‐Domain Optical Coherence Tomography derived retinal blood flow measurements
      ...& Science University, Portland, Oregon, USA 5. ^5 Department of Ophthalmology, Keck School of Medicine of the University of Southern California, Los Angeles, California, USA ^* Correspondence Professor Christopher Huds...
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    9. Pilot Study of Doppler optical coherence tomography of retinal blood flow following laser photocoagulation in poorly controlled diabetic patients

      Pilot Study of Doppler optical coherence tomography of retinal blood flow following laser photocoagulation in poorly controlled diabetic patients
      ...450 san pablo street,suite 3607, Los Angeles, California, 90033, United States 4. ^4Doheny Eye Institute, University of Southern California Keck School of Medicine, 1450 San Pablo Street, Los Angeles, CA, 90033, Unit...
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    10. Pattern analysis of retinal maps for the diagnosis of optic nerve diseases by optical coherence tomography

      Pattern analysis of retinal maps for the diagnosis of optic nerve diseases by optical coherence tomography
      Methods for analyzing retinal tomography maps to detect patterns of optic nerve diseases such as glaucoma, optic neuritis, anterior ischemic optic neuropathy are disclosed in this invention. The areas of mapping include the macula centered on the fovea, and the region centered on the optic nerve head. The retinal layers that are analyzed include the nerve fiber, ganglion cell, inner plexiform and inner nuclear layers and their combinations. The overall ...
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    11. ARVO Champalimaud Award Lecture Videos By James G. Fujimoto and David R. Williams

      ARVO Champalimaud Award Lecture Videos By James G. Fujimoto and David R. Williams
      The 2012 Antnio Champalimaud Vision Award recognized the development of two novel approaches to visualising the living human retina in health and disease: OCT and adaptive optics. The award citation for OCT states, "Optical Coherence Tomography, or OCT, was developed by merging interferometric methodologies with insights for their clinical ocular applicantion by a multidisciplinary effort of engineers, scientists, and physicians accomplished by James Fujimoto, Eric Swanson, David Huang, Carmen Puliafito ...
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    12. Quantitative OCT angiography of optic nerve head blood flow

      Quantitative OCT angiography of optic nerve head blood flow
      Optic nerve head (ONH) blood flow may be associated with glaucoma development. A reliable method to quantify ONH blood flow could provide insight into the vascular component of glaucoma pathophysiology. Using ultrahigh-speed optical coherence tomography (OCT), we developed a new 3D angiography algorithm called split-spectrum amplitude-decorrelation angiography (SSADA) for imaging ONH microcirculation. In this study, a method to quantify SSADA results was developed and used to detect ONH perfusion changes ...
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    13. OHSU Casey Eye Institute Inventor Dr. David Huang Earns International Award for Advances in Eye Imaging

      OHSU Casey Eye Institute Inventor Dr. David Huang Earns International Award for Advances in Eye Imaging
      ...ujimoto; Huang; Carmen Puliafito, M.D., M.B.A., dean and professor of ophthalmology, Keck School of Medicine, University of Southern California; Joel Schuman, M.D., Eye and Ear Foundation Professor and Chairman of Ophtha...
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    14. Methods and systems for blood flow measurement using doppler optical coherence tomography

      Methods and systems for blood flow measurement using doppler optical coherence tomography
      This invention provides methods for non-invasive, real-time measuring and/or monitoring of local blood flow in a subject. Methods of the invention generally include the steps of obtaining Doppler shift images of at least two planes intersecting blood vessels at the scanned location; determining Doppler angles using the Doppler shift images; and then using the Doppler angles thus determined together with the Doppler shift signals to arrive at a measure ...
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    15. Combining Information From 3 Anatomic Regions in the Diagnosis of Glaucoma With Time-Domain Optical Coherence Tomography

      Combining Information From 3 Anatomic Regions in the Diagnosis of Glaucoma With Time-Domain Optical Coherence Tomography
      Purpose: To improve the diagnosis of glaucoma by combining time-domain optical coherence tomography (TD-OCT) measurements of the optic disc, circumpapillary retinal nerve fiber layer (RNFL), and macular retinal thickness. Patients and Methods: Ninety-six age-matched normal and 96 perimetric glaucoma participants were included in this observational, cross-sectional study. Or-logic, support vector machine, relevance vector machine, and linear discrimination function were used to analyze the performances of combined TD-OCT diagnostic variables. Results ...
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    16. Patterns of Ganglion Cell Complex and Nerve Fiber Layer Loss in Nonarteritic Ischemic Optic Neuropathy by Fourier-Domain Optical Coherence Tomography

      Patterns of Ganglion Cell Complex and Nerve Fiber Layer Loss in Nonarteritic Ischemic Optic Neuropathy by Fourier-Domain Optical Coherence Tomography
      ...rsity, Portland, Oregon; and the 3. ^3Department of Neuro-Ophthalmology, Doheny Eye Institute of the Keck/University of Southern California School of Medicine, Los Angeles, California. 1. Corresponding author: A...
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    17. Does optic nerve head size variation affect circumpapillary retinal nerve fiber layer thickness measurement by optical coherence tomography?

      Does optic nerve head size variation affect circumpapillary retinal nerve fiber layer thickness measurement by optical coherence tomography?
      ...f Medicine, Los Angeles, California, United States 3. ^3Doheny Eye Institute and Department of Ophthalmology, University of Southern California, Keck School of Medicine, Los Angeles, CA, United States 1. ↵* Casey Eye Ins...
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    18. Study of Anterior Chamber Aqueous Tube Shunt by Fourier-Domain Optical Coherence Tomography

      Study of Anterior Chamber Aqueous Tube Shunt by Fourier-Domain Optical Coherence Tomography
      Purpose . This cross-sectional, observational study used Fourier-domain optical coherence tomography (OCT) to examine the position, patency, and the interior entrance site of anterior chamber (AC) aqueous tube shunts. Methods. The OCT, slitlamp biomicroscopy, and gonioscopy findings of 23 eyes of 18 patients with AC shunts were collected and compared. Results. OCT images demonstrated the shunt position and patency in all 23 eyes, and the details of the AC entrance in ...
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    19. Patterns of Ganglion Cell Complex and Nerve Fiber Layer Loss in Non-Arteritic Ischemic Optic Neuropathy by Fourier-Domain Optical Coherence Tomography

      Patterns of Ganglion Cell Complex and Nerve Fiber Layer Loss in Non-Arteritic Ischemic Optic Neuropathy by Fourier-Domain Optical Coherence Tomography
      Purpose: To characterize by Fourier-domain optical coherence tomography (FD-OCT) the loss of nerve fiber layer (NFL) and ganglion cell complex (GCC) in non-arteritic ischemic optic neuropathy (NAION). Methods: Patients diagnosed with NAION were enrolled and categorized into "superior field loss (SFL)," "inferior field loss (IFL)," and "bihemispheric field loss (BFL)" groups based on the Swedish interactive threshold algorithm 30-2 achromatic visual field (VF) tests. Six months after presentation, they were ...
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