Macular disease in children is routinely recorded in drawings and color photographs, and less commonly through angiography performed under anesthesia.  Technhiques used to evaluate function include preferential looking, figure or letter recognition, visual evoked potentials, and electroretiograms.  

Methods, systems and computer program products are provided for acquiring an image set using optical coherence tomography (OCT). A first portion of a defined volume is scanned at a low-density sampling rate to obtain a plurality of low-density frames. A second portion of the defined volume is scanned at a high-density sampling rate, higher than the low-density sampling rate, to obtain at least one high-density frame. The low-density frames and the at least one high-density frame are combined to provide a complete mixed-density image set.