1. Measurement of biofilm growth and local hydrodynamics using optical coherence tomography

      Measurement of biofilm growth and local hydrodynamics using optical coherence tomography
      We report on localized and simultaneous measurement of biofilm growth and local hydrodynamics in a microfluidic channel using optical coherence tomography. We measure independently with high spatio-temporal resolution the longitudinal flow velocity component parallel to the imaging beam and the transverse flow velocity component perpendicular to the imaging beam. Based on the measured velocities we calculate the shear-rates in the flow channel. We show the relation between the measured biofilm ...
      Read Full Article
    2. Localized measurement of longitudinal and transverse flow velocities in colloidal suspensions using optical coherence tomography

      Localized measurement of longitudinal and transverse flow velocities in colloidal suspensions using optical coherence tomography
      We report on localized measurement of the longitudinal and transverse flow velocities in a colloidal suspension using optical coherence tomography. We present a model for the path-length resolved autocorrelation function including diffusion and flow, which we experimentally verify. For flow that is not perpendicular to the incident beam, the longitudinal velocity gradient over the coherence gate causes additional decorrelation, which is described by our model. We demonstrate simultaneous imaging of ...
      Read Full Article
    3. Integrated-optics-based optical coherence tomography (Thesis)

      Integrated-optics-based optical coherence tomography (Thesis)
      Optical coherence tomography (OCT) is a high resolution, imaging technique that has developed over the last 20 years from a complicated laboratory setup into a ready-to-use commercially available device. Instead of using electronic time gating as being used by ultrasound (US) imaging, in OCT, the optical analogue of US imaging, determines the time of flight using low coherence interferometry. To date, OCT has many clinical applications and is widely used ...
      Read Full Article
    4. Common detector for combined raman spectroscopy-optical coherence tomography

      Common detector for combined raman spectroscopy-optical coherence tomography
      An apparatus includes first and second light sources for respectively generating broadband and monochromatic lights, a beamsplitter optically coupled to the first light source for splitting the broadband light into a reference light and a sample light, a reference arm optically coupled to the beamsplitter for receiving the reference light and returning the received reference light into the beamsplitter, a sample arm optically coupled to the beamsplitter and the second ...
      Read Full Article
    5. Feature Of The Week 1/27/13: An Exciting and Promising Area for OCT System Research and Commercial Opportunities

      Feature Of The Week 1/27/13: An Exciting and Promising Area for OCT System Research and Commercial Opportunities
      ...-based OCT imaging. For more information see recent Article . Courtesy Jeroen Kalkman and Duc Nguyen from the Academic Medical Center at the University of Amsterdam . One of the most promising areas for OCT system resear...
      Read Full Article
    6. Integrated-optics-based swept-source optical coherence tomography

      Integrated-optics-based swept-source optical coherence tomography
      We designed, fabricated, and characterized an integrated-optics-based swept-source optical coherence tomography (SS-OCT) system in TriPleX technology. An external 1300 nm swept source is coupled to the chip, which contains waveguide structures for interferometric depth ranging and balanced detection. The complete OCT chip has a footprint of 0.4 cm 1.8 cm . Light from the chip is focused onto the s.ample using an aspheric lens; the lateral resolution is ...
      Read Full Article
    7. Multiple scattering effects in Doppler optical coherence tomography of flowing blood

      Multiple scattering effects in Doppler optical coherence tomography of flowing blood
      We investigate the effect of multiple scattering on the optical coherence tomography (OCT) signal and the Doppler OCT signal of flowing blood. Doppler OCT measurements at 1300 nm are performed on flowing diluted porcine blood with hematocrit ranging between 0% and 15%. Measured blood hematocrit and mean red blood cell volume are used to calculate, using the discrete dipole approximation model, the (single) scattering coefficient and scattering anisotropy of blood ...
      Read Full Article
    8. Development of functional near-infrared optical coherence tomography (Thesis)

      Development of functional near-infrared optical coherence tomography (Thesis)
      Medical imaging is a discipline where the fields of mathematics, physics, biology, and medicine are combined in the acquisition, computation and interpretation of threedimensional images of (human) tissue. A variety of imaging modalities that provide information about morphological structure and function of biological tissues has been developed. These modalities are based on electromagnetic waves (magnetic resonance imaging, X-ray computed tomography, confocal microscopy), sound (ultrasonography), or nuclear tracers (positron emission tomography ...
      Read Full Article
    9. Toward Spectral-domain Optical Coherence Tomography on a Chip

      Toward Spectral-domain Optical Coherence Tomography on a Chip
      We present experimental results of a spectraldomain optical coherence tomography system based on an integrated optical spectrometer. A 195-channel arrayedwaveguide- grating (AWG) spectrometer with 0.4-nm channel spacing centered at 1300 nm and a 125-channel AWG with 0.16-nm channel spacing centered at 800 nm have been fabricated in silicon oxynitride waveguide technology. Interferometric distance measurements have been performed by launching light from a broadband source into a free-space Michelson ...
      Read Full Article
    10. Feature Of The Week 5/29/11: Researchers at University of Twente and University of Amsterdam Investigate Miniaturization of SD-OCT Systems using Integrated Optics

      Feature Of The Week 5/29/11: Researchers at University of Twente and University of Amsterdam Investigate Miniaturization of SD-OCT Systems using Integrated Optics
      ...aging of a multi-layered scattering phantom is demonstrated.For more information see recent Article. Courtesy Jeroen Kalkman and Duc Nguyen. Optical coherence tomography (OCT) is an interferometric imaging technique whic...
      Read Full Article
    11. Heartbeat-induced axial motion artifacts in optical coherence tomography measurements of the retina

      Heartbeat-induced axial motion artifacts in optical coherence tomography measurements of the retina
      ...xial motion artifacts in optical coherence tomography measurements of the retina 1. Roy de Kinkelder^1,^3, 2. Jeroen Kalkman^1, 3. Dirk J. Faber^1,^2, 4. Olaf Schraa^4, 5. Pauline H.B. Kok^2, 6. Frank D. Verbraak^1,^2 an...
      Read Full Article
    12. Determination of the scattering anisotropy with optical coherence tomography

      Determination of the scattering anisotropy with optical coherence tomography
      In this work we demonstrate measurements with optical coherence tomography (OCT) of the scattering phase function in the backward direction and the scattering anisotropy parameter g. Measurements of the OCT attenuation coefficient and the backscattering amplitude are performed on calibrated polystyrene microspheres with a time-domain OCT system. From these measurements the phase function in the backward direction is determined. The measurements are described by the single scattering model and match ...
      Read Full Article
    13. Integrated system for combined Raman spectroscopy–spectral domain optical coherence tomography

      Integrated system for combined Raman spectroscopy–spectral domain optical coherence tomography
      Raman spectroscopy (RS) and optical coherence tomography (OCT) are powerful tools for optical analysis of tissues with mutually complementary strengths and limitations. OCT excels at visualizing tissue microstructure but lacks molecular specificity, while RS can relay tissue biochemical composition but typically cannot relate microstructure. Previous implementations of combined RS-OCT have utilized a common sample arm while maintaining independent RS and OCT detection arms. We present the design and application of ...
      Read Full Article
    14. Path-Length-Resolved Diffusive Particle Dynamics in Spectral-Domain Optical Coherence Tomography

      Path-Length-Resolved Diffusive Particle Dynamics in Spectral-Domain Optical Coherence Tomography
      We describe a new method to measure the decorrelation rate of the optical coherence tomography (OCT) magnitude simultaneously in space and time.We measure the decorrelation rate of the OCT magnitude in a Fourier-domain OCT system for a large range of translational diffusion coefficients by varying the sphere diameter. The described method uses the sensitivity advantage of Fourier-domain OCT over time-domain OCT to increase the particle diffusion imaging speed by ...
      Read Full Article
    15. SiON Integrated Optics Elliptic Couplers for Fizeau-Based Optical Coherence Tomography

      SiON Integrated Optics Elliptic Couplers for Fizeau-Based Optical Coherence Tomography
      Integrated optics potentially can offer significant cost reductions and new applications to Optical Coherence Tomography (OCT). We design, fabricate, and characterize Silicon oxynitride (SiON) elliptic couplers, which can be used to focus light from a chip into the off-chip environment. Fizeau-based OCT measurements are performed with elliptic couplers and a moveable mirror. The optical fields at the output of the elliptic coupler are simulated and measured. Good agreement is observed ...
      Read Full Article
    16. Structural and biochemical characterization of the rat retina with combined Raman spectroscopy-optical coherence tomography (RS-SDOCT)

      Structural and biochemical characterization of the rat retina with combined Raman spectroscopy-optical coherence tomography (RS-SDOCT)
      ...s: Fabrice Manns, Per G. Söderberg, Arthur Ho ABSTRACT REFERENCES (16) Chetan A. Patil Vanderbilt Univ. (USA) Jeroen Kalkman and Dirk Faber Amsterdam Medical Ctr. (Netherlands) John S. Penn Vanderbilt Univ. Medical Ctr. ...
      Read Full Article
    17. Multiple and dependent scattering effects in Doppler optical coherence tomography

      Multiple and dependent scattering effects in Doppler optical coherence tomography
      Doppler optical coherence tomography (OCT) is a technique to image tissue morphology and to measure flow in turbid media. In its most basic form, it is based on single (Mie) scattering. However, for highly scattering and dense media multiple and concentration dependent scattering can occur. For Intralipid solutions with varying scattering strength, the effect of multiple and dependent scattering on the OCT signal attenuation and Doppler flow is investigated. We ...
      Read Full Article
    18. 1-19 of 19
  1. Categories

    1. Applications:

      Art, Cardiology, Dentistry, Dermatology, Developmental Biology, Gastroenterology, Gynecology, Microscopy, NDE/NDT, Neurology, Oncology, Ophthalmology, Other Non-Medical, Otolaryngology, Pulmonology, Urology
    2. Business News:

      Acquisition, Clinical Trials, Funding, Other Business News, Partnership, Patents
    3. Technology:

      Broadband Sources, Probes, Tunable Sources
    4. Miscellaneous:

      Jobs & Studentships, Student Theses, Textbooks
  2. Organizations in the News

    1. (9 articles) University of Twente
    2. (3 articles) Vanderbilt University
    3. (2 articles) University of Oulu
    4. (1 articles) Delft University of Technology
    5. (1 articles) VU University Amsterdam
  3. People in the News

    1. (18 articles) Ton G. van Leeuwen
    2. (7 articles) Van Duc Nguyen
    3. (6 articles) Dirk J. Faber
    4. (4 articles) Kerstin Wörhoff
    5. (3 articles) Markus Pollnau
    6. (3 articles) B. Imran Akca
    7. (3 articles) René M. de Ridder
    8. (3 articles) Anita Mahadevan-Jansen
    9. (2 articles) Chetan A. Patil
    10. (2 articles) Alexander V. Bykov
    11. (1 articles) Roy de Kinkelder
    12. (1 articles) Frank D. Verbraak
  4. OCT Companies in the News

    1. (1 articles) Topcon Medical Systems