Purpose: To study the efficacy of swept source optical coherence tomography angiography (SSOCTA) to longitudinally follow up patients with extrafoveal polyps post laser photocoagulation and anti VEGF injection. Methods: Observational case series. Four patients diagnosed as polypoidal choroidal vasculopathy (PCV) with extrafoveal polyps on multimodal imaging were followed up serially on SSOCT, en face and cross-sectional SSOCTA at a month and then 3 monthly for a year. Indocyanine green angiography (ICGA) was repeated at 4 months and one year. Patients: 4 patient case series. Results: Anatomical regression of extrafoveal polyps was documented on a combination of en face and cross-sectional ...

Purpose: To describe the optical coherence tomography features of vitamin A deficiency. Methods: Case series includes three male patients aged 50-66 years with vitamin A deficiency and visual symptoms ranging from 2-8 months. Examination included optical coherence tomography (OCT), fundus autofluorescence imaging (FAF), full-field electroretinography (ERG) and laboratory work-up. Results: Patient 1 had inoperable pancreatic neuroendocrine tumour and presented with worsening nyctalopia. The ERG showed absent rod function two months after the onset of symptoms, followed by a decrease of cone function eight months after the onset. OCT showed poorly distinguishable outer segments of the photoreceptors (OS) with the disappearance ...

Purpose: The aim of this study was to evaluate choroidal and retinal microvasculature with optical coherence tomography angiography (OCTA) after panretinal photocoagulation (PRP) for diabetic retinopathy in a primarily Hispanic and Asian population . Design: Retrospective study. Methods: Eyes were examined by OCTA in the macula (3 × 3 mm) just before PRP treatment and 1 to 3 months afterwards. Choroidal thickness (CT) and central retinal thickness (CRT) were measured. Choroidal flow signal voids (CFSV) and choriocapillaris flow signal voids (CCFSV) were acquired. Retinal microvasculature parameters, including superficial and deep vessel density, superficial and deeper perfusion density, foveal avascular zone area, perimeter ...

Purpose: To study the effect of the suspended scattering particles in motion (SSPiM) on optical coherence tomography angiography (OCTA) vessel density metrics in eyes with diabetic macular edema (DME) Methods: Thirty-four eyes with DME from 27 patients (16 males and 11 females, 61.4 ± 9.6 years) with DME were included in this retrospective cohort study. Among these eyes, 19 (55.9%) showed the SSPiM artifact on OCTA. All participants received 3-mm and 6-mm optical coherence tomography angiography (OCTA) imaging. Perfusion density and skeletonized vessel density were calculated for the superficial capillary plexus (SCP) and the deep capillary plexus (DCP ...

Purpose: To detect keratoconus using optical coherence tomography (OCT) corneal map parameters and patterns. Setting: Casey Eye Institute, Oregon Health & Science University, Portland, Oregon, USA DESIGN:: Cross-sectional observational study. Methods: A spectral-domain OCT was used to acquire corneal and epithelial thickness maps in normal, manifest keratoconic, subclinical keratoconic, and forme fruste keratoconic (FFK) eyes. A two-step decision tree was designed. An eye will be classified as keratoconus if both decision tree conditions are met: First, at least one of the four quantitative corneal thickness (minimum, minimum-maximum, superonasal-inferotemporal) and epithelial thickness (standard deviation) map parameters exceed cutoff values. Second, presence of ...

Purpose: To report 2 cases of herpes simplex virus (HSV) stromal keratitis with epithelial ulceration that were managed using optical coherence tomography-generated pachymetric and corneal epithelial thickness maps. Methods: Two patients with a history of HSV keratitis with nonhealing epithelial defects were referred to the Athens Vision Eye Institute. Anterior segment optical coherence tomography-generated pachymetric and corneal epithelial thickness maps showed subclinical stromal edema and irregular epithelium, thus indicating diagnoses of HSV stromal keratitis with epithelial ulceration. The patients were administered topical preservative-free dexamethasone and oral antiviral therapy. Steroid tapering was guided by pachymetric and corneal epithelial thickness maps at ...

Purpose: To demonstrate the clinical and research value of a simplified technique enabling alignment of functional microperimetry data with retinal structure imaged by eye-tracked optical coherence tomography (OCT) in eyes with macular disease. Methods: Normal and diseased eyes underwent sequential Spectralis OCT macular raster scans and Macular Integrity Assessment (MAIA) microperimetry using both standard central 10° analysis and custom scan patterns. The microperimetry data were imported into Spectralis research software which was automatically registered to the scanning laser ophthalmoscopy near-infrared reflectance image obtained during OCT acquisition. The OCT B-scans were directly correlated to the microperimetry data so that retina sensitivity ...

Purpose: To evaluate correlations between the burden of anti-vascular endothelial growth factor (VEGF) treatment and microperfusion status in superficial and deep capillary plexus (SCP and DCP) using wide-field optical coherence tomography angiography (OCT-A). Methods: A total 19 eyes with branch retinal vein occlusion (BRVO) were included in this retrospective study. Area of foveal avascular zone (FAZ), capillary non-perfusion area (NPA), vascular density, and perfusion gap were compared between SCP and DCP. Internal areas of 3, 6, 12 mm in diameter around the fovea were analyzed separately. Results: Mean number of injections per months was 0.20 ± 0.12. Number of ...

Background: To determine retinal vessel density in patients with myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD). Methods: Twenty-five patients with MOGAD and 20 healthy participants were enrolled. Patients with MOGAD were divided into myelin oligodendrocyte glycoprotein antibody (MOG-Ab)-positive eyes with a history of optic neuritis (ON; MOG-Ab-ON+ group) or without a history of ON (MOG-Ab-ON- group). Visual function, retinal vessel densities, and thickness were measured. Results: The retinal nerve fiber layer, parafoveal ganglion cell and inner plexiform layers, and vessel densities in the peripapillary and parafoveal areas were significantly decreased in the MOG-Ab-ON+ eyes compared with healthy eyes and MOG-Ab-ON- ...

Background: To report a linear risk score obtained using clock-hour optical coherence tomography (OCT) data from papilledema and pseudopapilledema nerves that differentiates between the 2 diagnoses with high sensitivity and specificity. Methods: Patients presenting to a single neuro-ophthalmologist with papilledema or pseudopapilledema were included for a retrospective review. The absolute consecutive difference in OCT retinal nerve fiber layer (RNFL) thickness between adjacent clock hours and the mean magnitude of thickness for clock hours 1–12 were compared between the 2 groups using mixed-effect models adjusting for age and clock hour with a random intercept for subjects and eyes (nested within ...

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Background: Optic disc drusen (ODD) are a dynamic phenomenon, and their appearance, size, and relative location may change. The purpose of this study is to evaluate and quantify the longitudinal changes of buried ODD with enhanced depth imaging (EDI) optical coherence tomography (OCT) over time. Methods: ODD were analyzed with Spectralis OCT (Heidelberg Engineering, Heidelberg, Germany) and EDI technology. The peripapillary retinal nerve fiber layer (RNFL) thickness was also measured. The size and depth of ODD were compared between the baseline and study visit (at least 2 years of follow-up), and the changes were correlated with mean RNFL thickness. The ...

Background: The purpose of this study is to quantitatively compare the peripapillary vessel density (PPVD), measured with optical coherence tomography angiography (OCT-A), between acute nonarteritic anterior ischemic optic neuropathy (NAION) and other causes of disc swelling ("others"). Methods: In this prospective comparative case series, patients with unilateral disc swelling due to acute NAION (n = 7) and "others" (n = 7) underwent OCT-A scanning of the optic nerve head with a swept-source OCT (Triton DRI-OCT), in addition to functional assessment. OCT-A images were analyzed using an automated customized MATLAB program. Comparison was made between total and 6 sectoral PPVD (radial peripapillary capillary ...

Background/Aims: To investigate the correlation between optical coherence tomography angiography (OCTA) characteristics and visual outcomes in patients with acute and chronic nonarteritic anterior ischemic optic neuropathy (NAION). Methods: We retrospectively reviewed clinical data and OCTA images of 26 eyes of 26 patients who had been diagnosed with unilateral NAION. OCTA images were acquired from 17 eyes at the acute stage and from 21 eyes at the chronic stage of NAION. We analyzed the peripapillary vessel density (VD) and macular VD in various layers of the retina and choroid for all images. Possible correlations between the OCTA parameters and visual ...

A 79-year-old woman presented with an acute coronary syndrome...

Purpose: To investigate repeatability and agreement of total corneal and sublayer pachymetry with 2 different algorithms of fourier-domain optical coherence tomography (OCT) in myopic and post-photorefractive keratectectomy (PRK) eyes. Setting: Farabi Eye Hospital, Tehran University Of Medical Sciences, Tehran, Iran. Design: Prospective observational study. Methods: Total corneal, epithelial, and stromal thicknesses of 95 myopic, and 117 post-PRK individuals was measured using RTVue-XR OCT with Pachymetry + Cpwr (6 mm algorithm) and PachymetryWide (9 mm algorithm) scan patterns. The repeatability of 25 zones of 9 mm map and 17 zones of 6 mm map, and the agreement between measurements of these 2 ...

PURPOSE: To precisely quantify retinal nonperfusion areas (NPAs) in branch retinal vein occlusion (BRVO) using widefield optical coherence tomography angiography (OCTA), and examine their association with neovascular complications. METHODS: We enrolled 26 patients with treatment-naïve BRVO and prospectively examined them for 12 months. After three monthly ranibizumab injections to treat macular edema, each patient underwent ultra-wide field (UWF) fluorescein angiography (FA) and OCTA. UWF FA was additionally performed at Month 12. For UWF FA, the retinal NPA was measured using the equipment’s built-in software. For OCTA, we used panoramic image montaged from 5 single 12×12 mm 2 ...

Purpose: To compare widefield optical coherence tomography-angiography (OCTA) to ultra-widefield fluorescein angiography (UWFA) in the assessment of nonperfusion in retinal vein occlusion (RVO). Methods: Cross-sectional study of 43 eyes of 43 RVO patients examined using both widefield OCTA (Plexelite, Carl Zeiss Meditec) with a panoramic montage of five 12x12mm images and UWFA (Optos®, 200°). Qualitative analysis was performed according to nonperfusion areas (cutoff: 3 disc areas) on widefield OCTA. The quantitative analysis assessed the vascular density (VD) on the widefield OCTA and ischemic index (ISI) on UWFA. Results: ISI on UWFA and VD in the superficial and deep plexus correlated ...

Purpose: To describe the optical coherence tomography angiography findings in nonocular Behçet disease . Methods: The superficial capillary plexus (SCP) and deep capillary plexus (DCP) and outer retinal and choroidal flow were evaluated using optical coherence tomography angiography . Perimetry was performed to correlate any microvascular and functional changes. Results: Capillary nonperfusion areas were found in the superficial capillary plexus in 16/20 eyes (80%) and in the DCP in 17/20 eyes (85%). Perifoveal capillary arcade disruption and vessel rarefaction were present in both plexuses in all cases. Capillary telangiectasia was present in the superficial capillary plexus in five eyes ...

Purpose: To examine the relationship between macular microvasculature parameters and functional changes in persons with diabetic retinopathy (DR). Methods: Cross-sectional study of 76 eyes with varying levels of DR. Optical coherence tomography angiography (OCTA) quantified superficial and deep perifoveal vessel densities and foveal avascular zone areas. Retinal sensitivity was measured using microperimetry . Optical coherence tomography angiography parameters and retinal sensitivity were correlated. Results: Deep perifoveal vessel density decreased with increasing severity of DR (adjusted mean 51.93 vs. 49.89 vs. 47.96, P -trend = 0.005). Superficial and deep foveal avascular zone area increased with increasing DR severity (adjusted ...

Purpose: To investigate the influence of age , gender and underlying disease on the optical coherence tomography (OCT) features of choroidal neovascularization (CNV) secondary to Inflammation ( iCNV ), myopia (mCNV) and age -related macular degeneration (AMD-CNV). Methods: Demographic and clinical data of eyes with treatment naïve iCNV , mCNV and type 2 AMD-CNV were collected. OCT images were reviewed to determine the presence of pitchfork sign (PFS), pigment epithelial detachment (PED), subretinal fluid (SRF), intraretinal cysts (IRC), subretinal hyper reflective material (SHRM), atrophy and outer retinal disruption (ORD) graded 1 to 4. The influence of demographics and underlying etiology on OCT signs ...

Purpose: To report the effectiveness and clinical outcomes of corneal electrolysis for Reis-Bücklers corneal dystrophies (RBCDs) and provide in vivo histological analysis using anterior segment optical coherence tomography (AS-OCT). Methods: A total of 7 patients with RBCD (2 male patients, 5 female patients; mean age, 50.0 years) from 3 pedigrees were enrolled in this prospective study. All patients underwent corneal electrolysis for decreased visual acuity or blurred vision. Changes in visual acuity, refraction, and corneal thickness were evaluated 1 month after electrolysis and statistically analyzed. Changes observed in AS-OCT images before and after electrolysis were qualitatively and quantitatively ...

Purpose: To develop a deep learning (DL) model to detect morphologic patterns of diabetic macular edema (DME) based on optical coherence tomography (OCT) images. Methods: In the training set, 12,365 OCT images were extracted from a public dataset and an ophthalmic center. A total of 656 OCT images were extracted from another ophthalmic center for external validation. The presence or absence of three OCT patterns of DME, including diffused retinal thickening (DRT), cystoid macular edema (CME), and serous retinal detachment (SRD) were labeled with 1 or 0, respectively. A DL model was trained to detect three OCT patterns of ...

The importance of monocyte/lymphocyte ratio (MLR) has been indicated in the initiation and progression of coronary artery disease. However, few previous researches demonstrated the relationship between MLR and plaque vulnerability . We aimed to investigate coronary non-culprit plaque vulnerability in patients with acute coronary syndrome (ACS) by optical coherence tomography (OCT). A total of 72 ACS patients who underwent coronary angiography and OCT test in Beijing Anzhen Hospital were included in this retrospective study. The plaque vulnerability and plaque morphology were assessed by OCT. The non-culprit plaque in high MLR group exhibited more vulnerable features, characterizing as thinner thickness of ...