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    1. Ophthalmological assessment of OCT and electrophysiological changes in migraine patients

      Ophthalmological assessment of OCT and electrophysiological changes in migraine patients

      Background: A cross-sectional study to investigate the morphological and functional changes of the visual pathway, taking place in patients with migraine. Methods: Fifteen patients (14 female, 1 male) diagnosed with migraine with aura (MA group) and 23 patients (21 female, 2 male) diagnosed with migraine without aura (MO group) were compared to 20 healthy volunteers (18 Female, 2 male). All the participants underwent optical coherence tomography (OCT) scan, electroretinogram (ERG), visual evoked potentials (VEP), and multifocal electroretinogram (mf-ERG) recording. Results: Assessing ERG recordings, no significant differences in mean N1-P1 amplitudes were measured among the groups. The mean VEP N80-P100 amplitudes ...

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    2. Optical Coherence Tomographic Elastography Reveals Mesoscale Shear Strain Inhomogeneities in the Annulus Fibrosus

      Optical Coherence Tomographic Elastography Reveals Mesoscale Shear Strain Inhomogeneities in the Annulus Fibrosus

      Study Design. Basic science study using in vitro tissue testing and imaging to characterize local strains in annulus fibrosus (AF) tissue. Objective. To characterize mesoscale strain inhomogeneities between lamellar and inter-/translamellar (ITL) matrix compartments during tissue shear loading. Summary of Background Data. The intervertebral disc (IVD) is characterized by significant heterogeneities in tissue structure and plays a critical role in load distribution and force transmission in the spine. In particular, the AF possesses a lamellar architecture interdigitated by a complex network of extracellular matrix components that form a distinct ITL compartment. Currently, there is not a firm understanding of ...

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    3. ANALYSIS OF THREE-DIMENSIONAL CHOROIDAL VOLUME WITH ENHANCED DEPTH IMAGING FINDINGS IN PATIENTS WITH BIRDSHOT RETINOCHOROIDOPATHY

      ANALYSIS OF THREE-DIMENSIONAL CHOROIDAL VOLUME WITH ENHANCED DEPTH IMAGING FINDINGS IN PATIENTS WITH BIRDSHOT RETINOCHOROIDOPATHY

      Purpose: To describe changes in three-dimensional choroidal volume and thickness with full raster scans of enhanced depth imaging optical coherence tomography in patients with birdshot retinochoroidopathy. Methods: This prospective case series collected spectral domain optical coherence tomography images with the enhanced depth imaging technique from eight eyes of eight patients with birdshot retinochoroidopathy including four active patients (four eyes) and four quiet patients (four eyes). Fifty scans of each patient were manually segmented before automated built-in calibration software was used. Results: Of all active patients, there were no statistically significant differences in the total choroidal volume and mean central choroidal ...

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    4. Correlation and Agreement Between Cirrus HD-OCT “rnfl Thickness Map” and Scan Circle Retinal Nerve Fiber Layer Thickness Measurements

      Correlation and Agreement Between Cirrus HD-OCT “rnfl Thickness Map” and Scan Circle Retinal Nerve Fiber Layer Thickness Measurements

      Purpose: To evaluate the correlation and agreement between optical coherence tomography (Cirrus HD-OCT) retinal nerve fiber layer (RNFL) thickness map and scan circle RNFL thickness measurements. Methods: ImageJ and custom Perl scripts were used to derive RNFL thickness measurements from RNFL thickness maps of optic disc scans of healthy and glaucomatous eyes. Average, quadrant, and clock-hour RNFL thickness of the map, and RNFL thickness of the areas inside/outside the scan circle were obtained. Correlation and agreement between RNFL thickness map and scan circle RNFL thickness measurements were evaluated using R 2 and Bland-Altman plots, respectively. Results: A total of ...

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    5. RETINAL VASCULAR PLEXUSES' CHANGES IN DRY AGE-RELATED MACULAR DEGENERATION, EVALUATED BY MEANS OF OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY

      RETINAL VASCULAR PLEXUSES' CHANGES IN DRY AGE-RELATED MACULAR DEGENERATION, EVALUATED BY MEANS OF OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY

      Purpose: To investigate alteration in superficial and deep retinal vascular densities and choroidal thickness, in patients affected by early and intermediate age-related macular degeneration (AMD). Methods: All patients had undergone optical coherence tomography angiography (OCTA). All eyes were grouped into two stages: "early AMD" and "intermediate AMD." Outcome measures were superficial vessel density, deep vessel density, and choroidal thickness. A control group of healthy subjects was selected for the statistical comparisons. Results: A total of 37 eyes of 37 dry AMD patients were enrolled for the study. Fourteen of 37 eyes were classified as having early AMD, the remaining 23 ...

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    6. Evaluation of Time to Donor Lenticule Apposition Using Intraoperative Optical Coherence Tomography in Descemet Stripping Automated Endothelial Keratoplasty

      Evaluation of Time to Donor Lenticule Apposition Using Intraoperative Optical Coherence Tomography in Descemet Stripping Automated Endothelial Keratoplasty

      Purpose: To evaluate the time to donor lenticule apposition in cases of Descemet stripping automated endothelial keratoplasty (DSAEK) using microscope-integrated intraoperative optical coherence tomography (iOCT). Methods: Thirty eyes of 27 patients planned to undergo Descemet stripping automated endothelial keratoplasty were enrolled in this prospective study. In group I (n = 10), continuous intracameral positive pressure was maintained for 8 minutes. In group II (n = 10) and group III (n = 10), external corneal massage was initiated simultaneously with positive intracameral air pressure. The external corneal massage was continued till complete resolution of interface fluid; the positive intracameral pressure was maintained for 8 ...

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    7. Optical Coherence Tomography Imaging of the Palisades of Vogt to Assist Clinical Evaluation and Surgical Planning in a Case of Limbal Stem-Cell Deficiency

      Optical Coherence Tomography Imaging of the Palisades of Vogt to Assist Clinical Evaluation and Surgical Planning in a Case of Limbal Stem-Cell Deficiency

      PURPOSE: To describe the use of volumetric optical coherence tomography (OCT) imaging to assist evaluation of a patient referred for autologous limbal stem-cell transplant. METHODS: This is a case report of a 50-year-old patient presenting with unilateral limbal stem-cell deficiency who was referred for autologous limbal stem-cell transplant. The presence of Salzmann nodules in the donor eye raised questions about the efficacy of transplantation, prompting examination of both eyes using volumetric OCT imaging to determine whether there were palisades of Vogt (POV) present. Image volumes were acquired in all clock hours and were compared against those of an age-matched normal ...

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    8. New Invasive Assessment Measures of Coronary Artery Disease Severity

      New Invasive Assessment Measures of Coronary Artery Disease Severity

      Ischemic heart disease is the leading cause of mortality worldwide. The assessment and treatment of patients with ischemic heart disease have advanced greatly over the last decade. Particular attention has been given recently to the recognition of lesions that cause ischemia, or that are prone to plaque rupture. New invasive measures of coronary artery disease have been developed, including fractional flow reserve, intravascular ultrasound, optical coherence tomography, and most recently, near infrared spectroscopy. These technologies have helped to guide the assessment of hemodynamically significant lesions and has shown particular promise in guiding percutaneous coronary interventions. However, mortality and the rate ...

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    9. Crowdsourcing: an overview and applications to ophthalmology

      Crowdsourcing: an overview and applications to ophthalmology

      Purpose of review: Crowdsourcing involves the use of the collective intelligence of online communities to produce solutions and outcomes for defined objectives. The use of crowdsourcing is growing in many scientific areas. Crowdsourcing in ophthalmology has been used in basic science and clinical research; however, it also shows promise as a method with wide-ranging applications. This review presents current findings on the use of crowdsourcing in ophthalmology and potential applications in the future. Recent findings: Crowdsourcing has been used to distinguish normal retinal images from images with diabetic retinopathy; the collective intelligence of the crowd was able to correctly classify ...

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    10. High-Resolution Optical Coherence Tomography Findings of Lisch Epithelial Corneal Dystrophy

      High-Resolution Optical Coherence Tomography Findings of Lisch Epithelial Corneal Dystrophy

      Purpose: To describe a case of Lisch epithelial corneal dystrophy (LECD) and present its unique characteristics on high-resolution optical coherence tomography (HR-OCT). Methods: A 78-year-old man with whorled corneal epithelial opacities in the right eye was referred for the evaluation of ocular surface squamous neoplasia. Clinical evaluation, photographs, and HR-OCT images of the cornea involved were obtained and scrapings of the affected cornea were sent for histopathologic analysis. Results: Clinically, the patient presented with an opalescent whirling epithelium in a linear pattern encroaching on the visual axis. HR-OCT showed normal thickness epithelial hyperreflectivity of involved cornea without stromal involvement, along ...

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    11. Color Reflectivity Discretization Analysis of OCT Images in the Detection of Glaucomatous Nerve Fiber Layer Defects

      Color Reflectivity Discretization Analysis of OCT Images in the Detection of Glaucomatous Nerve Fiber Layer Defects

      Purpose: To compare the ability of Cirrus retinal nerve fiber layer (RNFL) thickness and the Color Reflectivity Discretization Analysis (CORDA), a novel optical coherence tomography (OCT) analysis method, to differentiate between normal subjects, glaucoma suspects, and glaucoma patients. Patients and Methods: Analysis of peripapillary OCT images using Cirrus SD-OCT (optic nerve head cube 200x200 protocol) and postacquisition CORDA analysis of peripapillary RNFL B-scan images was performed. In total, 291 eyes of 148 subjects (94 normal eyes, 100 primary open-angle glaucoma suspect eyes, and 97 eyes with primary open-angle glaucoma) were included. Area under the receiver operating characteristic curve was estimated ...

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    12. Intraoperative Optical Coherence Tomography Enables Noncontact Imaging During Canaloplasty

      Intraoperative Optical Coherence Tomography Enables Noncontact Imaging During Canaloplasty

      Purpose: Here we describe intraoperative optical coherence tomography (iOCT) as a novel noncontact imaging tool for intraoperative monitoring and procedure evaluation during canaloplasty, as a nonpenetrating surgical technique to treat primary open angle glaucoma. Materials and Methods: Retrospective case report of a patient (63 y, female), who underwent traditional canaloplasty, using a commercially available 840 nm OCT device, mounted to an operating microscope (Rescan 700). Main outcome measures were the intraoperative visibility of chamber angle structures and the ability to conduct surveillance of the surgical procedure through the prepared Descemet window, especially correct suture positioning and visible changes of the ...

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    13. Reproducibility and Daytime-Dependent Changes of Corneal Epithelial Thickness and Whole Corneal Thickness Measured With Fourier Domain Optical Coherence Tomography

      Reproducibility and Daytime-Dependent Changes of Corneal Epithelial Thickness and Whole Corneal Thickness Measured With Fourier Domain Optical Coherence Tomography

      Purpose: To evaluate the reproducibility of Fourier domain anterior segment optical coherence tomography (RTVue) based on repeated measurements of corneal thickness (CT) and epithelial thickness (ET) and to test daytime-dependent changes of these parameters. Methods: Twenty-three eyes from 23 healthy volunteers were included in this prospective study. Three clinical observers performed 3 consecutive measurements each of CT and ET in 3 sessions using RTVue, resulting in 9 measurements per session. Session 1 was performed at 9 AM +/- 1 hour, session 2 at 4 PM +/- 1 hour on the same day, and session 3 at 9 AM +/- 1 hour 2 days ...

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    14. DIAGNOSIS OF TYPE 3 NEOVASCULARIZATION BASED ON OPTICAL COHERENCE TOMOGRAPHY IMAGES

      DIAGNOSIS OF TYPE 3 NEOVASCULARIZATION BASED ON OPTICAL COHERENCE TOMOGRAPHY IMAGES

      Purpose: To evaluate the concordance of an optical coherence tomography (OCT)-based diagnosis of Type 3 neovascularization and an indocyanine green angiography (ICGA)-based diagnosis in neovascular age-related macular degeneration (AMD). Methods: This observational case series includes 263 eyes from 263 patients who were diagnosed with treatment-naive neovascular AMD. Patients exhibiting at least three of the following OCT features were diagnosed with Type 3 neovascularization: subfoveal choroidal thickness <200 [mu]m, presence of intraretinal fluid accumulation, absence of subretinal fluid, gently-sloping dome-shaped retinal pigment epithelial detachment or trapezoid-shaped retinal pigment epithelial detachment without an obvious peak, and intraretinal mass lesion ...

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    15. New developments in anterior segment optical coherence tomography for glaucoma

      New developments in anterior segment optical coherence tomography for glaucoma

      Purpose of review: The aim of the present review was to summarize the new developments in anterior segment optical coherence tomography (AS-OCT) for glaucoma. Recent findings: Recent years have demonstrated significant advances in the measurement of glaucoma through the use of AS-OCT. Furthermore, a more widespread use of AS-OCT in the clinical study of various glaucomas warrants review, which includes angel assessment, trabecular meshwork and Schlemm's canal assessment, and assessment of the filtering bleb and tube. Summary: AS-OCT was recently developed and has become a crucial tool in glaucoma clinical practice. AS-OCT is a noncontact imaging device that provides ...

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    16. IMAGING WITH MULTIMODAL ADAPTIVE-OPTICS OPTICAL COHERENCE TOMOGRAPHY IN MULTIPLE EVANESCENT WHITE DOT SYNDROME: THE STRUCTURE AND FUNCTIONAL RELATIONSHIP

      IMAGING WITH MULTIMODAL ADAPTIVE-OPTICS OPTICAL COHERENCE TOMOGRAPHY IN MULTIPLE EVANESCENT WHITE DOT SYNDROME: THE STRUCTURE AND FUNCTIONAL RELATIONSHIP

      Purpose: To elucidate the location of pathological changes in multiple evanescent white dot syndrome (MEWDS) with the use of multimodal adaptive optics (AO) imaging . Methods: A 5-year observational case study of a 24-year-old female with recurrent MEWDS. Full examination included history, Snellen chart visual acuity, pupil assessment, intraocular pressures, slit lamp evaluation, dilated fundoscopic exam, imaging with Fourier-domain optical coherence tomography (FD-OCT), blue-light fundus autofluorescence (FAF), fundus photography, fluorescein angiography, and adaptive-optics optical coherence tomography . Results: Three distinct acute episodes of MEWDS occurred during the period of follow-up. Fourier-domain optical coherence tomography and adaptive-optics imaging showed disturbance in the photoreceptor ...

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    17. Prevalence Of Reticular Pseudodrusen In AGE-RELATED Macular Degeneration Using Multimodal Imaging

      Prevalence Of Reticular Pseudodrusen In AGE-RELATED Macular Degeneration Using Multimodal Imaging

      Purpose: To determine the rate of reticular pseudodrusen (RPD) in age-related macular degeneration using multimodal imaging, including color fundus photography, the blue channel image of fundus photography, infrared reflectance, fundus autofluorescence, multicolor imaging, and spectral domain optical coherence tomography, as well as to compare the sensitivities and specificities of these modalities for detecting RPD. Methods: This prospective study included 243 eyes from 125 consecutive patients with age-related macular degeneration. They underwent fundus examination including color fundus photography, blue channel, infrared reflectance, fundus autofluorescence, multicolor imaging, and spectral domain optical coherence tomography in both eyes. To be considered as having RPD ...

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    18. Expanded Clinical Spectrum Of Multiple Evanescent White Dot Syndrome With Multimodal Imaging

      Expanded Clinical Spectrum Of Multiple Evanescent White Dot Syndrome With Multimodal Imaging

      Purpose: To evaluate and characterize multiple evanescent white dot syndrome abnormalities with modern multimodal imaging modalities. Methods: This retrospective cohort study evaluated fundus photography, fluorescein angiography, indocyanine green angiography, optical coherence tomography, enhanced depth imaging optical coherence tomography, short-wavelength autofluorescence, and near-infrared autofluorescence.

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    19. HIGH-RESOLUTION Multimodal Imaging After Idiopathic Epiretinal Membrane Surgery

      HIGH-RESOLUTION Multimodal Imaging After Idiopathic Epiretinal Membrane Surgery

      Purpose: To investigate the changes of the vitreomacular interface during a 1-year follow-up after idiopathic epiretinal membrane (iERM) surgery. Methods: Six patients affected by fovea-attached iERM were recruited in this pilot study. Pars plana vitrectomy associated with epiretinal membrane peeling was performed uneventfully in all cases. In four cases, the inner limiting membrane was removed using Brilliant blue G. En face high-resolution adaptive optics and cross-sectional spectral domain optical coherence tomography retinal imaging were performed before and at 1, 3, 6, and 12 months after surgery. The microstructures of vitreomacular interface in high-resolution adaptive optics images were correlated to the ...

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    1-24 of 818 1 2 3 4 ... 32 33 34 »
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