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    1. OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY OF THE FOVEAL MICROVASCULATURE IN GEOGRAPHIC ATROPHY

      OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY OF THE FOVEAL MICROVASCULATURE IN GEOGRAPHIC ATROPHY

      Purpose: To examine the retinal and choroidal foveal and parafoveal vasculature in patients with bilateral geographic atrophy (GA) secondary to age-related macular degeneration using optical coherence tomography angiography (OCTA). Methods: Fourteen eyes from 7 patients with and without fovea-sparing bilateral GA at St. Erik Eye Hospital. All patients were examined by optical coherence tomography angiography, en face OCT and fundus autofluorescence (FAF). Segmented optical coherence tomography angiography flow scans were obtained from the superficial retinal vascular layer (SL) and the choriocapillaris (CC) and correlated with areas of retinal pigment epithelial (RPE) loss on fundus autofluorescence. The foveal avascular zone (FAZ ...

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    2. CHOROIDAL BLOOD FLOW VISUALIZATION IN HIGHLY MYOPIA USING A PROJECTION ARTIFACT METHOD IN OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY

      CHOROIDAL BLOOD FLOW VISUALIZATION IN HIGHLY MYOPIA USING A PROJECTION ARTIFACT METHOD IN OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY

      Purpose: To visualize choroidal blood flow in larger vessels in highly myopic eyes using a phenomenon of the projection artifact to in the sclera using optical coherence tomography angiography. Methods: The retrospective study included 92 eyes (54 patients) with greater than 8 diopters of myopia. All eyes were examined using optical coherence tomography angiography (RTVue XR Avanti; Optovue Inc, Fremont, CA). The blood flow in choroidal vessels was evaluated by attempting to directly segment the choroid and also by placing the segmentation layer behind the choroid, within the sclera. Subfoveal choroidal thickness was also measured at the same time. The ...

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    3. CLINICALLY INVISIBLE RETINAL HEMANGIOBLASTOMAS DETECTED BY SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY AND FLUORESCEIN ANGIOGRAPHY IN TWINS

      CLINICALLY INVISIBLE RETINAL HEMANGIOBLASTOMAS DETECTED BY SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY AND FLUORESCEIN ANGIOGRAPHY IN TWINS

      Purpose: To report subclinical retinal hemangioblastoma detected by enhanced depth imaging optical coherence tomography and fluorescein angiography in at-risk twins. Methods: Case report. Results: A set of twins, age 7 years, (Twin A and Twin B) with known family history of von Hippel-Lindau disease (gene test positive) and no systemic manifestations were evaluated. Visual acuity was 20/20 in both eyes of both twins. Anterior segment examination and intraocular pressures were unremarkable in both eyes. Twin A showed no clinically visible tumor in the right eye, and a clinically evident 4-mm hemangioblastoma in the superior retina of the left eye ...

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    4. MACULAR HOLE FORMATION IDENTIFIED WITH INTRAOPERATIVE OCT DURING VITRECTOMY FOR VITREOMACULAR TRACTION SYNDROME

      MACULAR HOLE FORMATION IDENTIFIED WITH INTRAOPERATIVE OCT DURING VITRECTOMY FOR VITREOMACULAR TRACTION SYNDROME

      Purpose: To report the identification of macular hole formation using intraoperative optical coherence tomography (OCT) during vitrectomy for vitreomacular traction syndrome. Methods: A 58-year-old woman with vitreomacular traction syndrome underwent the vitrectomy using the 25-gauge system with scanning the macular area using the integrated and intraoperative OCT (Rescan 700, Zeiss). When posterior vitreous detachment at the fovea was performed using a vitreous cutter, the hyperreflective tissue thought to be the rupture of the internal limiting membrane and the full-thickness macular hole were identified on the horizontal and vertical scans simultaneously in intraoperative OCT. Results: The procedure was completed after internal ...

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      Mentions: Hideki Koizumi
    5. EARLY CRT MONITORING USING TIME-DOMAIN OPTICAL COHERENCE TOMOGRAPHY DOES NOT ADD TO VISUAL ACUITY FOR PREDICTING VISUAL LOSS IN PATIENTS WITH CENTRAL RETINAL VEIN OCCLUSION TREATED WITH INTRAVITREAL RANIBIZUMAB: A Secondary Analysis of Trial Data

      EARLY CRT MONITORING USING TIME-DOMAIN OPTICAL COHERENCE TOMOGRAPHY DOES NOT ADD TO VISUAL ACUITY FOR PREDICTING VISUAL LOSS IN PATIENTS WITH CENTRAL RETINAL VEIN OCCLUSION TREATED WITH INTRAVITREAL RANIBIZUMAB: A Secondary Analysis of Trial Data

      Purpose: Our primary purpose was to assess the clinical (predictive) validity of central retinal thickness (CRT) and best corrected visual acuity (BCVA) at 1 week and 1 month after starting treatment with ranibizumab for central retinal vein occlusion. The authors also assessed detectability of response to treatment. Methods: The authors used data from 325 participants in the CRUISE study, which included measurement of time-domain CRT and BCVA at baseline, 1 week, 1 month, and 6 months postrandomization. Analysis of covariance models were fitted to assess clinical validity, and distributions of change were constructed to assess detectability of response. Results: There ...

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      Mentions: Paul Mitchell
    6. Optical Assessment of Soft Contact Lens Edge-Thickness

      Optical Assessment of Soft Contact Lens Edge-Thickness

      Purpose: To assess the edge shape of soft contact lenses using Gabor-Domain Optical Coherence Microscopy (GD-OCM) with a 2-μm imaging resolution in three dimensions and to generate edge-thickness profiles at different distances from the edge tip of soft contact lenses. Methods: A high-speed custom-designed GD-OCM system was used to produce 3D images of the edge of an experimental soft contact lens (Bausch + Lomb, Rochester, NY) in four different configurations: in air, submerged into water, submerged into saline with contrast agent, and placed onto the cornea of a porcine eyeball. An algorithm to compute the edge-thickness was developed and applied ...

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    7. Familial Incomplete Punctal Canalization: Clinical and Fourier Domain Optical Coherence Tomography Features

      Familial Incomplete Punctal Canalization: Clinical and Fourier Domain Optical Coherence Tomography Features

      Incomplete punctal canalization is a form of punctal dysgenesis with membranous noncanalization and can be confused with punctal agenesis. The clinical and diagnostic features are known; however, familial incomplete punctal canalization has not been reported earlier. A family with 3 affected members is presented in this series with similar incomplete punctal canalization and nasolacrimal duct obstructions. After membranotomy and endoscopic dacryocystorhinostomy with bicanalicular intubation, all of them are free of epiphora at last visit.

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    8. EN FACE OPTICAL COHERENCE TOMOGRAPHY (OCT) AND OCT ANGIOGRAPHY FINDINGS IN RETINAL ASTROCYTIC HAMARTOMAS

      EN FACE OPTICAL COHERENCE TOMOGRAPHY (OCT) AND OCT ANGIOGRAPHY FINDINGS IN RETINAL ASTROCYTIC HAMARTOMAS

      Purpose: To report spectral-domain optical coherence tomography, en face optical coherence tomography (OCT), and optical coherence tomography angiography findings in retinal astrocytic hamartomas. Methods: Four cases of retinal astrocytic hamartomas, with small white or yellowish typical retinal mass, were imaged with fundus photography, intravenous fluorescein angiography, fundus autofluorescence, spectral-domain OCT, en face OCT, and OCT angiography. Results: The tumor was solitary in all cases and involved the posterior pole. It was idiopathic in three cases and was related to tuberous sclerosis complex in one case. The OCT findings included intralesional lucencies in two cases with no exudation. The tumor was ...

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    9. Another Form of Focal Choroidal Excavation Based on Multimodality Imaging

      Another Form of Focal Choroidal Excavation Based on Multimodality Imaging

      Purpose: To describe a peculiar choroidal entity using multimodality imaging and to further understand the relationship between focal choroidal excavation and central serous chorioretinopathy. Case Report: A peculiar entity was detected in both eyes of a 20-year-old male patient who was followed for more than 4 years; one perifoveal focal choroidal excavation and two extrafoveal focal choroidal excavations were noted in each eye. The bilateral perifoveal focal choroidal excavations exhibited progressive development with repeated interconversion between the nonconforming and conforming types. Dilated choroid blood vessels were detected by en face spectral-domain optical coherence tomography (SD-OCT). Although the ellipsoid zone and ...

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    10. ALTERED PARAFOVEAL MICROVASCULATURE IN TREATMENT-NAIVE CHOROIDAL MELANOMA EYES DETECTED BY OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY

      ALTERED PARAFOVEAL MICROVASCULATURE IN TREATMENT-NAIVE CHOROIDAL MELANOMA EYES DETECTED BY OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY

      Purpose: To determine whether parafoveal microvascular changes have occurred in choroidal melanoma eyes before radiotherapy. Methods: A retrospective cohort study included 30 consecutive patients with unilateral choroidal melanoma. The microvascular structure was analyzed by optical coherence tomography angiography. Fellow eyes served as control for affected eyes. Results: Optical coherence tomography angiography demonstrated no difference in superficial foveal avascular zone (P = 0.316), but showed significant enlargement in deep foveal avascular zone (P < 0.0001) in affected eyes as compared with fellow eyes. It also showed significant decrease in superficial (P = 0.004) and deep (P = 0.0003) capillary vascular density ...

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    11. News from the Alzheimer's Association International Conference: A View from the Retina May Help in Diagnosing Alzheimer's Disease

      News from the Alzheimer's Association International Conference: A View from the Retina May Help in Diagnosing Alzheimer's Disease

      People with the thinnest retinas scored poorly on a series of tests — memory, pair matching, numeric and verbal reasoning, and reaction time, according to a large study on retinal thinning and cognitive functioning. The team of scientists from the University College London Institute of Ophthalmology assessed the thickness of the retinal nerve fiber layer (RNFL) in 33,068 people — and conducted a series of cognitive tests, making it one of the largest studies of its type to date. The findings from the study were presented here in July in a session on biomarkers at the Alzheimer's Association International Conference ...

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    12. SUPERFICIAL FOVEAL AVASCULAR ZONE DETERMINED BY OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY BEFORE AND AFTER MACULAR HOLE SURGERY

      SUPERFICIAL FOVEAL AVASCULAR ZONE DETERMINED BY OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY BEFORE AND AFTER MACULAR HOLE SURGERY

      Purpose: To determine the size of the superficial foveal avascular zone (FAZ) by optical coherence tomography angiography before and after surgery for an idiopathic macular hole. Methods: A retrospective, observational case series, in which 16 eyes of 16 patients with an idiopathic macular hole were studied. Pars plana vitrectomy was performed with internal limiting membrane peeling. The foveal retinal vasculature was examined by optical coherence tomography angiography, and the area of the superficial FAZ was determined before, and at 1 and 3 months after the surgery. The area of the macular hole was also measured in the en face optical ...

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    13. Scheimpflug and Optical Coherence Tomography Analysis of Posterior Keratoconus

      Scheimpflug and Optical Coherence Tomography Analysis of Posterior Keratoconus

      Purpose: To report a case series of 7 eyes of 6 patients with posterior keratoconus, evaluating corneal Scheimpflug tomographic changes and anterior-segment optical coherence tomography (OCT). Methods: In our descriptive study, 6 patients were diagnosed with posterior keratoconus: 5 unilateral (7-, 33-, and 42-year-old males and 64- and 60-year-old female) and 1 bilateral (45-year-old female). Patients were diagnosed with slit-lamp examination, which revealed corneal opacity with an underlying posterior corneal depression. Additional analysis with anterior-segment OCT and Scheimpflug tomography evaluation was performed. Results: Localized paracentral posterior keratoconus was diagnosed in 7 eyes. Scheimpflug images demonstrated posterior corneal depression. Clinical findings ...

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    14. Nonglaucomatous Cupping: Fundus Photography and Spectral Domain Optical Coherence Tomography Imaging Features

      Nonglaucomatous Cupping: Fundus Photography and Spectral Domain Optical Coherence Tomography Imaging Features

      Nonglaucomatous cupping is commonly encountered in neuro-ophthalmic practice. However, the progression of clinical and imaging findings over time has not been well described. We present serial fundus photographs and spectral domain optical coherence tomography from a pediatric patient with neuromyelitis optic spectrum disorder, which demonstrated progression of both cupping and optic atrophy in the setting of normal intraocular pressure.

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      Mentions: Duke University
    15. Measurement of Corneal Endothelial Surface Area Using Anterior Segment Optical Coherence Tomography in Normal Subjects

      Measurement of Corneal Endothelial Surface Area Using Anterior Segment Optical Coherence Tomography in Normal Subjects

      Purpose: To calculate the number of corneal endothelial cells (CEC) on the posterior surface of the normal human cornea by measuring specific surface areas through anterior segment optical coherence tomography. The effects of age, sex, and variations between the right and left eyes were also investigated. Methods: This study involved 60 eyes of 30 normal subjects with no history of corneal disease. Subjects were divided into the following groups according to age: group A (20-39 years old), group B (40-59 years old), and group C (60-79 years old). Set areas of the corneal posterior surface were imaged and analyzed using ...

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    16. DIFFERENTIAL MACULAR FEATURES ON OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY IN EYES WITH CHOROIDAL NEVUS AND MELANOMA

      DIFFERENTIAL MACULAR FEATURES ON OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY IN EYES WITH CHOROIDAL NEVUS AND MELANOMA

      Purpose: To evaluate optical coherence tomography angiography (OCTA) characteristics of macular vascular details in eyes with choroidal nevus and melanoma, compared with unaffected contralateral eye. Methods: Retrospective comparative analysis comprising 70 patients with choroidal nevus and 36 patients with choroidal melanoma examined with optical coherence tomography angiography. Measurements included central macular thickness (CMT), superficial (sFAZ) and deep (dFAZ) foveal avascular zone (FAZ) area, and superficial (sCVD) and deep (dCVD) capillary vascular density (CVD). Results: In patients with nevus, CMT (affected vs. unaffected eye) was similar (267 vs. 265 [mu]m, P = 0.67), whereas in patients with melanoma, CMT demonstrated ...

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    17. CLINICAL SPECTRUM OF MACULAR-FOVEAL CAPILLARIES EVALUATED WITH OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY

      CLINICAL SPECTRUM OF MACULAR-FOVEAL CAPILLARIES EVALUATED WITH OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY

      Purpose: To describe macular-foveal capillaries (MFC) by means of optical coherence tomography angiography and to identify the clinical spectrum of this angiographic feature. Methods: Patients with MFC presenting at the Medical Retina & Imaging Unit of the Department of Ophthalmology, University Vita-Salute San Raffaele in Milan were recruited. Patients underwent a complete ophthalmologic examination that included slit-lamp examination, fundus examination, measurement of best-corrected visual acuity, fundus autofluorescence, and spectral-domain optical coherence tomography (Spectralis HRA + OCT; Heidelberg Engineering, Heidelberg, Germany). Fluorescein angiography was performed in selected cases. Optical coherence tomography angiography was performed through Zeiss prototype (AngioPlex, CIRRUS HD-OCT models 5000; Carl ...

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    18. PERIPAPILLARY ARTERIAL RING OF ZINN-HALLER IN HIGHLY MYOPIC EYES AS DETECTED BY OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY

      PERIPAPILLARY ARTERIAL RING OF ZINN-HALLER IN HIGHLY MYOPIC EYES AS DETECTED BY OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY

      Purpose: To visualize the arterial circle of Zinn-Haller (ZHAC) in highly myopic patients by using OCT-A. Methods: Two hundred and fifty-three eyes of 146 consecutive patients with axial length >=26.5 mm who underwent OCT-A centered onto the optic disk were studied. Results: Arterial circle of Zinn-Haller was detectable on OCT-A images within the area of the parapapillary myopic conus in 26 (10%) of 253 eyes. The ZHAC was annular in 18 (69%) eyes, triangular in (15%) 4 eyes, and irregular (15%) in 4 eyes. The visibility of the ZHAC on OCT-A images was similar to the visibility on indocyanine ...

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    19. Evaluation of Early Graft Detachment After Descemet Membrane Endothelial Keratoplasty Using New Swept-Source Optical Coherence Tomography

      Evaluation of Early Graft Detachment After Descemet Membrane Endothelial Keratoplasty Using New Swept-Source Optical Coherence Tomography

      Purpose: To evaluate the ability of Swept-source optical coherence tomography (SS-OCT) in detecting early endothelial graft detachment after Descemet membrane endothelial keratoplasty (DMEK) and to determine the possible causes of graft detachment using 2 different protocols for anterior segment (AS) imaging. Methods: Eight eyes from 8 consecutive DMEK surgeries were evaluated. High-resolution images were captured with SS-OCT using 2 different radial protocols for AS imaging (16- and 6-mm radial protocols). Central and peripheral corneal changes were evaluated. Results: All eyes developed early graft detachment detectable with the SS-OCT. The 16-mm radial protocol scanned the cornea detecting early graft detachment in ...

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    20. OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY ASSESSMENT OF VASCULAR EFFECTS OCCURRING AFTER AFLIBERCEPT INTRAVITREAL INJECTIONS IN TREATMENT-NAIVE PATIENTS WITH WET AMD

      OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY ASSESSMENT OF VASCULAR EFFECTS OCCURRING AFTER AFLIBERCEPT INTRAVITREAL INJECTIONS IN TREATMENT-NAIVE PATIENTS WITH WET AMD

      Purpose: To investigate vessel changes occurring after aflibercept injections in treatment-naive exudative age-related macular degeneration patients. Methods: Fifteen eyes of 15 patients affected by wet age-related macular degeneration were enrolled in the study. All the patients had a diagnosis of Type 1 choroidal neovascularization and were treated with 3 monthly aflibercept intravitreal injections (IVI). Subjects were evaluated by means of optical coherence tomography angiography at baseline, the day after the first injection and one month after both the first and the second IVI. At last, all the patients were followed up to 2 months after the third IVI. Results: Foveal ...

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    21. SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY-BASED MICROSTRUCTURAL ANALYSIS OF RETINAL ARCHITECTURE POST INTERNAL LIMITING MEMBRANE PEELING FOR SURGERY OF IDIOPATHIC MACULAR HOLE REPAIR

      SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY-BASED MICROSTRUCTURAL ANALYSIS OF RETINAL ARCHITECTURE POST INTERNAL LIMITING MEMBRANE PEELING FOR SURGERY OF IDIOPATHIC MACULAR HOLE REPAIR

      Purpose: Spectral domain optical coherence tomography-based analysis of retinal architecture after internal limiting membrane peeling for macular hole surgery. Methods: Prospective, interventional study. Fifty eyes underwent the surgical procedure with minimum internal limiting membrane peel of 3 mm diameter. Automatic segmentation software was used to assess individual layers preoperatively and postoperatively, 1.5 millimeters medial and lateral to fovea at 3 months postoperative visit. Main outcome measures were final central macular thickness and variation in individual retinal layer thickness. Results: Mean central macular thickness postoperatively was 201 microns. Retinal thickening was observed, 1.5 mm medial to fovea (P < 0 ...

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    22. MACULAR MICROSTRUCTURAL FEATURES IN CHILDREN WITH TILTED DISK SYNDROME EVALUATED BY SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY

      MACULAR MICROSTRUCTURAL FEATURES IN CHILDREN WITH TILTED DISK SYNDROME EVALUATED BY SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY

      Purpose: To assess macular microstructure in eyes with tilted disk syndrome (TDS) and determine the relationship between TDS foveal morphology and visual function. Methods: Twenty-six TDS eyes from 19 children (aged 5~15 years) with a spherical equivalent refraction (SER) of -3.1 +/- 1.3 diopter (D) and 28 control eyes from 14 children (aged 7~12 years) with a SER of -3.0 +/- 0.7 D were recruited. Horizontal and vertical optical coherence tomography scans through the fovea produced images that were segmented into eight intraretinal layers. Thicknesses of the total retina and each layer were measured at the ...

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    1-24 of 899 1 2 3 4 ... 36 37 38 »
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