1. 1-11 of 11
    1. The penetration of renal mass biopsy in daily practice: A survey among urologists

      The penetration of renal mass biopsy in daily practice: A survey among urologists
      Introduction: The vast increase in recent publications on renal mass biopsy (RMB) suggests an increased interest in the subject. Objective: To assess the use of RMB in the current urological practice, including related factors such as indications and patterns in practice. Methods: The link to a web-based questionnaire (www.surveymonkey.com) was sent to all registered e-mail addresses (1854) of members of the Endourological Society in December 2010. The questionnaire contained 6 epidemiological questions, 10 regarding patterns of practice, one regarding the influence of literature and one on future techniques. Chi-square test (for trends) was used to assess statistical significant ...
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    2. Nerve Mapping for Prostatectomies: Novel Technologies under Development

      Nerve Mapping for Prostatectomies: Novel Technologies under Development
      Prostatic neuroanatomy is difficult to visualize intraoperatively and can be extremely variable. Damage to these nerves during prostatectomies may lead to post-operative complications such as erectile dysfunction and incontinence. This review aims to discuss the prostatic neuroanatomy, sites of potential nerve damage during a prostatectomy, and nerve mapping technologies being developed to prevent neural injury. These technologies include stimulation, dyes, and direct visualization. Nerve stimulation works by testing an area and observing a physiologic response but is limited by the long half life for an erectile response; examples include CaverMap, ProPep, and optical nerve stimulation. Few nerve dyes have been ...
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    3. Optical Coherence Tomographic Patterns in Diabetic Macula Edema Can Predict the Effects of Intravitreal Bevacizumab Injection as Primary Treatment

      Optical Coherence Tomographic Patterns in Diabetic Macula Edema Can Predict the Effects of Intravitreal Bevacizumab Injection as Primary Treatment
      Purpose: To identify optical coherence tomography (OCT) patterns in diabetic macular edema (DME) that were predictive of visual outcomes after intravitreal bevacizumab (IVB) injection. Methods: This was a retrospective study. We examined 31 eyes (24 patients) with clinically significant macular edema that received IVB injections along with macular OCT data. The eyes were categorized into 4 groups by using OCT features: diffuse retinal thickening (DRT), cystoid macular edema (CME), serous retinal detachment (SRD), and vitreomacular interface abnormalities (VMIAs). Changes in retinal thickness, retinal volume, and visual acuity (VA) after IVB injection were compared on the basis of OCT patterns. Results ...
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    4. Evaluation of Zotarolimus-Eluting Metal Stent in Animal Ureters

      Evaluation of Zotarolimus-Eluting Metal Stent in Animal Ureters
      Background and Purpose: Drug-eluting stents proved to minimize neointimal hyperplasia in coronary vessels. Hyperplastic reaction is the most common unwelcome event related to the use of metal mesh stents in the ureter. We evaluated the effect of zotarolimus-eluting stent (ZES) Endeavor Resolute in the porcine and rabbit ureter. Materials and Methods: A ZES and a bare metal stent (BMS) were inserted in each ureter of 10 pigs and 6 rabbits. The insertion was performed by the retrograde approach. CT was used for the evaluation of porcine ureters while intraoperative intravenous urography (IVU) was used for rabbit ureters. The follow-up included ...
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    5. Advanced Diagnostics in Renal Mass Using Optical Coherence Tomography: A Preliminary Report

      Advanced Diagnostics in Renal Mass Using Optical Coherence Tomography: A Preliminary Report
      Objective: To avoid unnecessary surgical treatment of small renal masses (≤4cm), a more accurate diagnostic method would be desirable since radiological differentiation between malignant and benign is difficult and nondiagnostic biopsies account from 9% to 37%. Optical coherence tomography (OCT) measures backscattered light versus depth, with an attenuation coefficient (μt) that may vary among different histological types. We hypothesize that quantitative measurements of μt using OCT can differentiate between normal renal parenchyma and renal cell carcinoma (RCC). Materials and Methods: Both normal and tumor renal tissues (RCC) were harvested after partial or radical nephrectomy. Analysis of μt was based on ...
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    6. Macroporous Hydrogel Scaffolds and Their Characterization By Optical Coherence Tomography

      Macroporous Hydrogel Scaffolds and Their Characterization By Optical Coherence Tomography
      A simple porogen-leaching method to fabricate macroporous cyclic acetal hydrogel cell scaffolds is presented. Optical coherence tomography (OCT) was applied for nondestructive imaging and quantitative characterization of the scaffold structures. High-resolution OCT reveals the microstructures of the engineered tissue scaffolds in three dimensions. It also enables subsequent image processing to investigate quantitatively several key morphological design parameters for macroporous scaffolds, including the volume porosity, pore interconnectivity, and pore size. Two image-processing algorithms were adapted: three-dimensional labeling was applied to assess the interconnectivity, and erosion was applied to assess the pore size. Scaffolds with different design parameters were imaged, characterized, and ...
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    7. Noninvasive and High-resolution Optical Monitoring of Healing of Diabetic Dermal Excisional Wounds Implanted with Biodegradable in situ Gelable Hydrogels

      Closure of diabetic dermal chronic wounds remains a clinical challenge. Implant-assisted healing is emerging as a potential class of therapy for dermal wound closure; this advancement has not been paralleled by the development in complementary diagnostic techniques to objectively monitor the wound healing process in conjunction with assessing/monitoring of implant efficacy. Biopsies provide the most objective morphological assessments of wound healing; however, they not only perpetuate the wound presence but also increase the risk of infection. A non-invasive and high-resolution imaging technique is highly desirable to provide objective longitudinal diagnosis of implant-assisted wound healing. We investigated the feasibility of ...
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    8. Processing porcine cornea for biomedical applications

      In order to investigate the propriety of decellularized porcine corneas as a source of lamellar corneal xenografts, we treated porcine corneas with (i) freezing, (ii) three freezing-thawing, (iii) hypertonic saline, (iv) hyperosmolar glycerol, (v) trypsin/sodium dodecyl sulfate/Dispase, and (vi) DNase/RNase. After processing, we examined the cells and collagen structures of the decellularized corneas using hematoxylin-eosin staining, TUNEL assay, and transmission electron microscopy. Cell viability was also assessed via organ culture. In addition, the outcomes of porcine anterior lamellar corneal xenografting were evaluated in rabbits. Graft integration and corneal thickness were assessed using anterior optical coherence tomography, and ...
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    9. Optical Coherence Tomography (OCT): Ready for the Diagnosis of a Nephrogenic Adenoma of the Urinary Bladder?

      The feasibility of Optical Coherence Tomography (OCT) as a non-invasive technique was shown in different fields. We investigated OCT's potential to detect nephrogenic adenoma (NA) within the human bladder. Clinically non-invasive methods like ultrasonography or CT have significant limitations. We applied our experience from OCT-analyses to one case of NA. OCT in vivo examination was performed using an optical fiber which was positioned cystoscopically. Characteristic structures of NA were compared in the OCT-images and the hematoxylin and eosin histological samples. Indeed, the structure and exact position of NA could be defined in relation to surrounding layers. However, a definite ...
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    10. Assessment of Dermal Wound Repair after Collagen Implantation with Optical Coherence Tomography

      We present an animal study to examine the utility and potential limitations of optical coherence tomography (OCT) for noninvasive evaluation of biomaterial scaffold–assisted wound healing. The transverse and axial resolutions of the OCT system at the wavelength of 1.3 μm were 12 and 10 μm, respectively. A murine full-thickness transcutaneous wound model was employed, in which a 10 mm full-thickness wound was created on the back of each male Balb/cJ mouse and a porous collagen scaffold was implanted in the wound bed followed by coverage with a TegadermTM film. Sequential cross-sectional OCT scans were performed at different ...
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    1-11 of 11
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