Articles from BJO Online

1. Evaluation of optical coherence tomography findings in age-related macular degeneration: a reproducibility study of two independent reading centres

   Explore Article BJO Online (Aug 30 2010) Ophthalmology

   Background/aims To determine the reproducibility among readers of two independent certified centres, the Vienna Reading Center (VRC) and the University of Wisconsin-Madison Reading Center (UW-FPRC) for optical coherence tomography (OCT) images in age-related macular degeneration (AMD). Methods Fast macular thickness scans and 6 mm cross hair scans were obtained from 100 eyes with all subtypes of AMD using Stratus OCT. Consensus readings were performed by two certified OCT readers of each reading center using their grading protocol. Common variables of both grading protocols, such as presence of cystoid spaces, subretinal fluid, vitreomacular traction and retinal pigment epithelial detachment, were compared ... (Read Full Article)
   

   Comment on Article Mentions:   University of Wisconsin   Medical University of Vienna   Zeiss Stratus OCT

2. Comparing the ganglion cell complex and retinal nerve fibre layer measurements by Fourier domain OCT to detect glaucoma in high myopia

   Explore Article BJO Online (Aug 30 2010) Ophthalmology

   Aim To compare the diagnostic ability to detect glaucomatous changes between peripapillary retinal nerve fibre layer (RNFL) thickness and the macular ganglion cell complex (GCC) in highly myopic patients using Fourier domain optical coherence tomography. Methods Participants, consecutively enrolled from January 2009 to June 2009, were imaged with RTVue-100 (NHM4 and MM7 scan). The sensitivity and specificity of a colour code less than 5% (red or yellow) for glaucoma diagnosis were calculated. Area under the receiver operator characteristic (AUROC) curves were generated to assess the ability of each parameter to detect glaucomatous changes. Results 73 normal controls and 77 glaucoma ... (Read Full Article)
   

   Comment on Article Mentions:   University of Ulsan   Optovue RTVue-100   Yonsei University

3. Imaging of blebs after phacotrabeculectomy with Ologen collagen matrix implants

   Explore Article BJO Online (Aug 7 2010) Ophthalmology

   Objective To analyse blebs of phacotrabeculectomies performed with Ologen collagen implants (ProTop & MediKing, Taipei, Taiwan) and to compare these with blebs of mitomycin C (MMC)–augmented phacotrabeculectomies. Methods 33 participants underwent phacotrabeculectomy with Ologen implants, and 33 controls underwent phacotrabeculectomy with MMC. Blebs were analysed for height and area using anterior segment optical coherence tomography (ASOCT) at 30, 60 and 90 days after surgery and were also graded clinically with the Moorfields bleb grading system (MBGS) 60 days after surgery. Results With ASOCT, there was no difference in mean bleb height at 30 and 60 days, but at 90 days, ... (Read Full Article)
   

   Comment on Article Mentions:   National University of Singapore   Singapore Eye Research Institute   Arun K. Narayanaswamy

4. Retinal optical coherence tomography: past, present and future perspectives

   Explore Article BJO Online (Jul 30 2010) Ophthalmology

   Optical coherence tomography (OCT) has undergone substantial changes since its first use in the 1990s. Although the first generation of OCT systems heralded a new era in the non-invasive diagnostic options in ophthalmology, they did not reveal much detail. Later devices offered more information and helped in the diagnosis and treatment of a variety of pathological conditions, primarily of the retina. With today's spectral-domain type models ophthalmologists are offered a comprehensive tool with the opportunity for early diagnosis and precise monitoring of patients with retinal and glaucomatous pathologies. However, as experience with these new devices grows and demands by clinicians ... (Read Full Article)
   

   Comment on Article Mentions:   Medical University of Vienna   Christoph K. Hitzenberger   Ursula Schmidt-Erfurth

5. Comparative study of retinal nerve fibre layer measurement by RTVue OCT and GDx VCC

   Explore Article BJO Online (Jul 28 2010) Ophthalmology

   Aim To evaluate the diagnostic performances and correlations of retinal nerve fibre layer (RNFL) thickness measured by RTVue OCT and GDx variable corneal compensation (VCC). Methods The total and regional RNFL thickness were measured by RTVue OCT and GDx VCC in 62 normal eyes and 72 glaucomatous eyes of Chinese subjects. The RNFL thickness profiles of normal and glaucomatous eyes by RTVue OCT are plotted. Correlations of RNFL thickness measured by RTVue OCT and GDx VCC were assessed using the Pearson correlation. The discriminating abilities of the two techniques for detection of glaucoma were compared by the area under the ... (Read Full Article)
   

   Comment on Article Mentions:   Optovue RTVue-100   Capital Medical University

6. Comparisons of anterior segment biometry between Chinese and Caucasians using anterior segment optical coherence tomography

   Explore Article BJO Online (Jul 7 2010) Ophthalmology

   Purpose To compare anterior segment parameters between eyes of Chinese and Caucasians using anterior segment optical coherence tomography and to evaluate the association between these parameters and anterior chamber angle width between the two ethnic groups. Methods 60 Chinese and 60 Caucasians, 30 with open angles and 30 with narrow angles (defined as Shaffer grade ≤2 in ≥3 quadrants during dark room gonioscopy) in each group, were consecutively enrolled. One eye of each subject was randomly selected for imaging in a completely darkened room. Measurements, including anterior chamber depth (ACD), scleral spur-to-scleral spur distance (anterior chamber width (ACW)), anterior chamber ... (Read Full Article)
   

   Comment on Article Mentions:   New York Eye and Ear Infirmary   The Chinese University of Hong Kong   Chris K. S. Leung

7. Optical coherence tomographical findings in a case of varix of the vortex vein ampulla

   Explore Article BJO Online (Jul 3 2010) Ophthalmology

   A patient was referred to our hospital by the local optometrist with a diagnosis of a subretinal haemorrhage in the right eye after a recent skiing crash. The patient reported repeat falls but no direct trauma to the eye. Our patient was asymptomatic and had no ophthalmic or medical history of note. On examination, Snellen visual acuity was 6/6 bilaterally. The intraocular pressures were satisfactory in both eyes, and the left fundus was normal. Right fundus examination showed a mildly elevated subretinal lesion in the superonasal peripheral retina (figure 1A). This lesion disappeared with digital pressure on the globe during ... (Read Full Article)
   

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8. Nidek MP-1 microperimetry and Fourier domain optical coherence tomography (FD-OCT) in X linked retinoschisis

   Explore Article BJO Online (Jul 1 2010) Ophthalmology

   X linked retinoschisis (XLRS) is a frequent cause of macular dystrophy in males with an estimated prevalence of between 1 in 15 000 and 1 in 30 000. The diagnosis is based on the presence of central and peripheral schisis within the inner retina and supported by electroretinography, which shows a characteristic electronegative response to a bright flash in the dark-adapted state.1 Fundus related perimetry or microperimetry is a useful tool for assessing macular function and mapping central visual fields, scotomas and fixation behaviour.2 The MP-1 microperimeter (Nidek technologies, Padua, Italy) utilises an LCD microperimeter and allows a direct correlation ... (Read Full Article)
   

   Comment on Article Mentions:   Nidek   University of Manchester

9. Correlation between fluorescein angiography and spectral-domain optical coherence tomography in the diagnosis of cystoid macular edema

   Explore Article BJO Online (Jun 28 2010) Ophthalmology

   Aims To compare the ability to detect cystoid macular edema (CME) and its late complications between spectral-domain optical coherence tomography (SD-OCT) and fluorescein angiography (FA). Methods Retrospective, observational, case series. 85 Eyes who had FA and SD-OCT performed on the same day at first visit and/or at follow-up visits were included. FA and SD-OCT images were evaluated for the evidences associated with CME and other structural changes of macula. FA and SD-OCT images were then superimposed to determine the relationships of diagnostic features between the two images. Main outcome measure was the correlation between FA and SD-OCT findings of macula ... (Read Full Article)
   

   Comment on Article Mentions:   New York Eye and Ear Infirmary   Richard B. Rosen

10. The effect of myopia on retinal nerve fibre layer measurement: a comparative study of spectral-domain optical coherence tomography and scanning laser polarimetry

    Explore Article BJO Online (Jun 27 2010) Ophthalmology

    Background/aim To evaluate the effect of myopia on retinal nerve fibre layer (RNFL) thickness measurement by using spectral domain optical coherence tomography (Cirrus HD OCT) and scanning laser polarimetry with enhanced corneal compensator (GDx ECC). Methods One hundred and forty-nine eyes of 149 myopic subjects were recruited and subdivided into three groups according to their refractive errors: high myopia group (spherical equivalent (SE)≤–6 D); moderate group (–3 D≥SE>–6 D); low group (–0.5 D≥SE>–3 D). RNFL thickness was measured by Cirrus High Definition (HD) OCT and GDx ECC. Associations between RNFL thickness and axial length/SE were evaluated by using Pearson correlation ... (Read Full Article)
    

    Comment on Article Mentions:   The Chinese University of Hong Kong   Zeiss Cirrus HD-OCT   Carl Zeiss Meditec

11. Retinal nerve fibre layer evaluation in ocular hypertensive eyes using optical coherence tomography and scanning laser polarimetry in the diagnosis of early glaucomatous defects

    Explore Article BJO Online (Jun 24 2010) Ophthalmology

    Aims To evaluate and compare the accuracy of scanning laser polarimetry with variable corneal compensation (GDx-VCC) and optical coherence tomography (OCT) for detecting glaucomatous damage observed in retinal nerve fibre layer (RNFL) monochromatic photographs from ocular hypertensive (OHT) individuals with normal visual fields. Methods A total of 181 eyes from 181 patients with intraocular pressure >22 mm Hg were enrolled in a cross-sectional, hospital clinic-based study. All patients underwent full ophthalmological examination, standard automated perimetry, red-free digital RNFL photographs, and RNFL imaging with Stratus OCT and GDx-VCC. Subjects were divided into two groups according to observations from RNFL photographs: 128 ... (Read Full Article)
    

    Comment on Article Mentions:   Zeiss Stratus OCT   Carl Zeiss Meditec

12. High-resolution spectral domain optical coherence tomography features in adult onset foveomacular vitelliform dystrophy

    Explore Article BJO Online (Jun 24 2010) Ophthalmology

    Purpose To describe the different morphological features in adult onset foveomacular vittelliform dystrophy (AOFVD) using high-resolution spectral domain optical coherence tomography (OCT). Design Prospective observational case series. Methods Complete ophthalmologic examination, including spectral domain OCT, was performed in 49 consecutive AOFVD patients (60 eyes). Results In 28/60 eyes, spectral domain OCT showed hyper-reflective clumps within the outer plexiform and outer nuclear layers. In 9/60 eyes, the photoreceptor inner segment/outer segment (IS/OS) interface appeared highly reflective like a shell all around the vitelliform material, and appeared irregular and discontinued in 27/60 eyes. The Verhoeff membrane was clearly visible at the border ... (Read Full Article)
    

    Comment on Article Mentions:   Centre Hospitalier Intercommunal de Créteil   Gisèle Soubrane   Eric H. Souied

13. Central retinal thickness measured with HD-OCT shows a weak correlation with visual acuity in eyes with CSME

    Explore Article BJO Online (Jun 7 2010) Ophthalmology

    Aims To investigate the correlation between increased retinal thickness (RT) measured with spectral domain high-definition optical coherence tomography (OCT) (Cirrus HD-OCT (Carl Zeiss Meditec, Dublin, California, USA)) and best-corrected visual acuity (BCVA) in eyes with clinically significant macular oedema (CSME) and type 2 diabetes. Methods Seventy eyes with CSME were included in this observational study. Sixty-two eyes were considered for analysis and were classified as having/not having retinal thickening in the central fovea (central 500-µm-diameter circle) by Cirrus HD-OCT. RT measurements were computed and correlated with BCVA. For comparison purposes, the Stratus OCT (Carl Zeiss Meditec, Dublin, California, USA) central ... (Read Full Article)
    

    Comment on Article Mentions:   Zeiss Stratus OCT   Carl Zeiss Meditec   Zeiss Cirrus HD-OCT

14. Imaging of periocular basal cell carcinoma using en face optical coherence tomography: a pilot study

    Explore Article BJO Online (Jun 1 2010) Oncology , Ophthalmology

    Aim To use en face optical coherence tomographic (OCT) imaging to identify features of tumour tissue and their correlation with histopathologic findings and to assess the effect of different wavelengths and resolutions of OCT in identifying tumour boundaries and features. Methods Excision specimens of consecutive biopsy-proven periocular basal cell carcinomas (BCCs) (n=8) were assessed by OCT, performing in vitro cross-section and en face scans of the tissues. Images were collected from three different machines: systems 1 and 2 had a wavelength of 1300 nm, and system 3 had a wavelength of 840 nm. System 2 used high numerical aperture interface ... (Read Full Article)
    

    Comment on Article Mentions:   University of Kent   Adrian G. Podoleanu

15. The utility of anterior segment optical coherence tomography in monitoring intraocular epithelial cysts in children: A mini case series

    Explore Article BJO Online (May 29 2010) Ophthalmology

    We present the use of anterior segment optical coherence tomography (OCT) in monitoring intraocular epithelial cysts in children. Both patients had traumatic corneal laceration and subsequently developed epithelial downgrowth cysts. Case 1 A 6-year-old boy presented 2 days after being struck with a wooden brick. On presentation, there was a full-thickness corneal laceration and two clock hours of the iris prolapsed through the limbal wound. He underwent primary repair of the wound and iris excision and was (Read Full Article)
    

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16. Comparison of retinal nerve fibre layer thickness measurements calculated by the optic nerve head map (NHM4) and RNFL3.45 modes of spectral-domain optical coherence tomography (RTVue-100)

    Explore Article BJO Online (May 27 2010) Ophthalmology

    Aim To evaluate and compare retinal nerve fibre layer (RNFL) thickness measured by direct scanning (RNFL3.45 mode) and re-sampling from datasets (NHM4 mode) of RTVue-100 optical coherence tomography (OCT). Methods Thirty-six healthy subjects and 76 subjects with glaucoma were imaged with Stratus OCT (fast RNFL mode, RNFL3) and RTVue-100 OCT (NHM4 (RNFL1) and RNFL3.45 (RNFL2) modes). Measurement reproducibility was assessed in NHM4 and RNFL3.45 modes of RTVue-100 OCT (intraclass correlation coefficient (ICC)). Agreement between different RNFL measurements was analysed by Bland–Altman plot. The areas under the receiver operating characteristic (ROC) curves (AUCs) for discrimination between healthy and glaucoma were compared ... (Read Full Article)
    

    Comment on Article Mentions:   University of Ulsan   Zeiss Stratus OCT   Optovue RTVue-100

17. Evaluation of optic nerve head configurations of superior segmental optic hypoplasia by spectral-domain optical coherence tomography

    Explore Article BJO Online (May 27 2010) Ophthalmology

    Aims To characterise the optic nerve head (ONH) configurations of superior segmental optic hypoplasia (SSOH) using a spectral-domain optical coherence tomography (SD-OCT). Methods Horizontal cross-sectional images of the ONH were obtained by a SD-OCT in 20 eyes of 14 patients with clinically typical SSOH and 20 age- and refraction-matched normal eyes. Results Extension of retinal pigment epithelium (RPE) over the disc margin was observed in 20 eyes (100%) with SSOH and eight (40%) control eyes (p<0.001). The maximum length of the overhanging RPE measured at the nasal disc margin was significantly longer in eyes with SSOH than in controls (295.9±112.6 ... (Read Full Article)
    

    Comment on Article Mentions:   Makoto Araie   Atsuo Tomidokoro   University of Tokyo

18. Retinal thickness of myopic eyes determined by spectralis optical coherence tomography

    Explore Article BJO Online (May 21 2010) Ophthalmology

    Aims To determine the relationship between the macular thickness and volume determined by spectral domain optical coherence tomography (SD-OCT) and the refractive error (RE) and axial length (AL). Methods 48 eyes of 24 healthy Japanese subjects were examined. The REs (spherical equivalent) were measured with the Tonoref RKT-7000 autorefractometer (Nidek Inc, Aichi, Japan), and the ALs were determined by the IOL-Master (Carl Zeiss Meditec Inc, Dublin, California, USA). The thicknesses and volumes of the central, inner, and outer macular areas were measured by Spectralis SD-OCT (Heidelberg Engineering, Heidelberg, Germany). The correlations between the macular thickness and volume and the RE ... (Read Full Article)
    

    Comment on Article Mentions:   Heidelberg Spectralis   Heidelberg Engineering

19. Fluorescein angiography and optical coherence tomography concordance for choroidal neovascularisation in multifocal choroidtis

    Explore Article BJO Online (May 14 2010) Ophthalmology

    Purpose To compare the utility of fluorescein angiography (FA) and optical coherence tomography (OCT) as diagnostic adjuncts in evaluating symptomatic patients with choroidal neovascularisation (CNV) due to multifocal choroiditis (MFC). Methods Patients with CNV due to MFC were retrospectively evaluated in a consecutive fashion. Fundus photography, FA, OCT and biomicroscopy were used to establish the diagnosis. Primary outcome measures included CNV classification (type 1 or occult and type 2 or classic) location and the associated FA and OCT findings. Results Twenty eyes from 17 patients were included in the study. In 19 eyes (95%) the FA revealed CNV type 2; ... (Read Full Article)
    

    Comment on Article Mentions:   University of Athens   LuEsther T. Mertz Retinal Research Center   City University of New York

20. Fourier domain optical coherence tomographic and auto-fluorescence findings in indeterminate choroidal melanocytic lesions

    Explore Article BJO Online (Apr 12 2010) Ophthalmology

    Aim To compare detection rates of drusen and subretinal fluid by Fourier domain optical coherence tomography (FD OCT) and orange pigment by fundus autofluorescence (FAF) with ophthalmoscopy in indeterminate choroidal melanocytic lesions. Methods In a consecutive case series of 38 patients with indeterminate choroidal melanocytic lesion that would have been categorised as a small tumour according to the size-based nomenclature used in the Collaborative Ocular Melanoma Study, each eye was submitted to ophthalmoscopic examination, FD OCT and FAF. The presence of drusen, subretinal fluid and orange pigment was recorded for each lesion by a single observer at the time of ... (Read Full Article)
    

    Comment on Article Mentions:   Universidade Federal de São Paulo   University of São Paulo   Cleveland Clinic

21. Imaging of the lens capsule with an ultrahigh-resolution spectral optical coherence tomography prototype based on a femtosecond laser

    Explore Article BJO Online (Mar 9 2010) Ophthalmology

    Aim To demonstrate the applicability of ultrahigh-speed, ultrahigh-resolution spectral optical coherence tomography (SOCT) to cross-sectional imaging of the capsular bag in vivo. Methods The ultrahigh-speed and ultrahigh-resolution SOCT prototype was designed and constructed at Nicolaus Copernicus University (Torun, Poland). To obtain an ultrahigh speed up to 100 000 lines/s a new spectrometer with fast CMOS line-scan camera was built. A femtosecond laser with a central wavelength of 780 nm and =160 nm enabled imaging with an axial resolution of 2.3 µm and lateral resolution of 10 µm in tissue. Lens capsules of two healthy eyes were examined with the aid ... (Read Full Article)
    

    Comment on Article Mentions:   Nicolaus Copernicus University   Maciej Wojtkowski   Andrzej A. Kowalczyk

22. Diagnostic capability of macular parameters of Stratus OCT 3 in detection of early glaucoma

    Explore Article BJO Online (Feb 5 2010) Ophthalmology

    Aim To report the diagnostic capability of Stratus OCT macular parameters in early glaucoma. Material and methods In a cross-sectional observational study, two groups of subjects (early glaucoma and normals) who satisfied the inclusion and exclusion criteria were recruited. The diagnosis of early glaucoma was based on a glaucomatous appearance of the optic disc correlating with visual-field defects (fulfilling at least two of three Anderson and Patella criteria, with a mean deviation better than or equal to −6 dB. All patients underwent a complete ophthalmic evaluation including visual-field examination (24−2/30−2 SITA standard programme) and imaging with Stratus OCT 3. The ... (Read Full Article)
    

    Comment on Article Mentions:   Carl Zeiss Meditec   Zeiss Stratus OCT

23. Evaluation of the Lenstar LS 900 non-contact biometer

    Explore Article BJO Online (Dec 21 2009) Ophthalmology

    Background/aims: Evaluation of the reproducibility of the Lenstar LS 900 non-contact biometer, and a comparison with the Visante anterior-segment optical coherence tomography (AS-OCT) and the IOLMaster. Methods: Central corneal thickness (CCT), anterior chamber depth (ACD), lens thickness (LT), keratometry (K) values, corneal diameter (CD) and axial length (AL) were obtained in 38 healthy volunteers (76 eyes) to determine the reproducibility of the Lenstar. CCT, ACD, CD, K values and AL measurements measured with the Lenstar were compared with the AS-OCT and IOLMaster. Intraocular lens (IOL) power calculations were done to study the significance of the difference between AL measurements. Results: ... (Read Full Article)
    

    Comment on Article Mentions:   Zeiss Visante OCT   Academic Hospital Maastricht   Carl Zeiss Meditec

24. Peripapillary retinal nerve fibre layer thickness profile in subjects with myopia measured using the Stratus optical coherence tomography

    Explore Article BJO Online (Dec 21 2009) Ophthalmology

    Background/aims: To evaluate the relationship between the axial length and refractive error and peripapillary retinal nerve fibre layer (RNFL) thickness profiles measured using Stratus optical coherence tomography (OCT) in subjects with myopia. Methods: Forty-eight eyes of 48 myopic subjects were recruited and divided into three groups according to their spherical equivalent (SE): low myopia (–3.0 D(Read Full Article)
    

    Comment on Article Mentions:   Zeiss Stratus OCT   Seoul National University   Carl Zeiss Meditec

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