Articles from BJO Online

1. Imaging of the lens capsule with an ultrahigh-resolution spectral optical coherence tomography prototype based on a femtosecond laser

   Explore Article BJO Online (Mar 9 2010) Ophthalmology

   Aim To demonstrate the applicability of ultrahigh-speed, ultrahigh-resolution spectral optical coherence tomography (SOCT) to cross-sectional imaging of the capsular bag in vivo. Methods The ultrahigh-speed and ultrahigh-resolution SOCT prototype was designed and constructed at Nicolaus Copernicus University (Torun, Poland). To obtain an ultrahigh speed up to 100 000 lines/s a new spectrometer with fast CMOS line-scan camera was built. A femtosecond laser with a central wavelength of 780 nm and =160 nm enabled imaging with an axial resolution of 2.3 µm and lateral resolution of 10 µm in tissue. Lens capsules of two healthy eyes were examined with the aid of the instrument using ... (Read Full Article)
   

   Comment on Article Mentions:   Nicolaus Copernicus University   Maciej Wojtkowski   Andrzej A. Kowalczyk

2. Diagnostic capability of macular parameters of Stratus OCT 3 in detection of early glaucoma

   Explore Article BJO Online (Feb 5 2010) Ophthalmology

   Aim To report the diagnostic capability of Stratus OCT macular parameters in early glaucoma. Material and methods In a cross-sectional observational study, two groups of subjects (early glaucoma and normals) who satisfied the inclusion and exclusion criteria were recruited. The diagnosis of early glaucoma was based on a glaucomatous appearance of the optic disc correlating with visual-field defects (fulfilling at least two of three Anderson and Patella criteria, with a mean deviation better than or equal to −6 dB. All patients underwent a complete ophthalmic evaluation including visual-field examination (24−2/30−2 SITA standard programme) and imaging with Stratus OCT 3. The ... (Read Full Article)
   

   Comment on Article Mentions:   Carl Zeiss Meditec   Zeiss Stratus OCT

3. Evaluation of the Lenstar LS 900 non-contact biometer

   Explore Article BJO Online (Dec 21 2009) Ophthalmology

   Background/aims: Evaluation of the reproducibility of the Lenstar LS 900 non-contact biometer, and a comparison with the Visante anterior-segment optical coherence tomography (AS-OCT) and the IOLMaster. Methods: Central corneal thickness (CCT), anterior chamber depth (ACD), lens thickness (LT), keratometry (K) values, corneal diameter (CD) and axial length (AL) were obtained in 38 healthy volunteers (76 eyes) to determine the reproducibility of the Lenstar. CCT, ACD, CD, K values and AL measurements measured with the Lenstar were compared with the AS-OCT and IOLMaster. Intraocular lens (IOL) power calculations were done to study the significance of the difference between AL measurements. Results: ... (Read Full Article)
   

   Comment on Article Mentions:   Zeiss Visante OCT   Academic Hospital Maastricht   Carl Zeiss Meditec

4. Peripapillary retinal nerve fibre layer thickness profile in subjects with myopia measured using the Stratus optical coherence tomography

   Explore Article BJO Online (Dec 21 2009) Ophthalmology

   Background/aims: To evaluate the relationship between the axial length and refractive error and peripapillary retinal nerve fibre layer (RNFL) thickness profiles measured using Stratus optical coherence tomography (OCT) in subjects with myopia. Methods: Forty-eight eyes of 48 myopic subjects were recruited and divided into three groups according to their spherical equivalent (SE): low myopia (–3.0 D<SE<0.0 D), moderate myopia (–6.0 D<SE<=–3.0 D) and high myopia (SE<=–6.0 D) groups. All individuals underwent the imaging with the Stratus OCT. The RNFL thickness profiles were compared between the groups. Results: The global average RNFL was significantly thinner in the high myopia group than ... (Read Full Article)
   

   Comment on Article Mentions:   Zeiss Stratus OCT   Seoul National University   Carl Zeiss Meditec

5. Correlation between Fluorescein Angiography and Spectral Domain Optical Coherence Tomography in the Diagnosis of Cystoid Macular Edema

   Explore Article BJO Online (Dec 4 2009) Ophthalmology

   Aims: To compare the ability to detect cystoid macular edema (CME) and its late complications between Spectral Domain Optical Coherence Tomography (SD-OCT) and Fluorescein Angiography (FA). Methods: Retrospective, observational, case series. 85 eyes who had FA and SD-OCT performed on the same day at first visit and/or at follow-up visits were included. FA and SD-OCT images were evaluated for the evidences associated with CME and other structural changes of macula. FA and SD-OCT images were then superimposed to determine the relationships of diagnostic features between the two images. Main outcome measure was the correlation between FA and SD-OCT findings of ... (Read Full Article)
   

   Comment on Article Mentions:   New York Eye and Ear Infirmary   Richard B. Rosen

6. Pattern electroretinography of larger stimulus field size and spectral-domain optical coherence tomography in patients with Stargardt disease

   Explore Article BJO Online (Nov 27 2009) Ophthalmology

   Aims: To investigate the importance of a larger stimulus field for pattern electroretinography (PERG) in evaluating macular function in Stargardt disease, and to determine the relationship between PERG and spectral-domain optical coherence tomography (SD-OCT). Methods: In this prospective cross-sectional study, PERG from standard (12°×16°) and larger (24°×32°) stimulus fields and SD-OCT were recorded in 18 patients with genetically confirmed Stargardt disease, and in 18 control subjects. Results: A PERG P50 response to the larger stimulus field was detectable in 86% of eyes, with a mean P50 amplitude of 2.3 μV, compared with 22% and 1.0 μV for the standard stimulus ... (Read Full Article)
   

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7. Presumed idiopathic outer lamellar defects of the fovea and chronic solar retinopathy: an OCT and fundus autofluorescence study

   Explore Article BJO Online (Oct 23 2009) Ophthalmology

   Aim: To examine fundus autofluorescence (FAF) findings in eyes with presumed idiopathic outer lamellar defects (OLD) at the fovea and to discuss their pathogenesis. Methods: Prospective observational case series of five eyes of four patients presenting with OLD at the fovea defined as discrete lesions of 50–100 µm in size located at the level of the outer retina on biomicroscopy and imaged on optical coherence tomography (OCT) as cylindrical, well-demarcated interruption of hyper-reflective bands corresponding to the inner/outer segments junction of photoreceptors and to the complex retinal pigment epithelium–choriocapillaris; none of the enrolled patients had any positive history for direct ... (Read Full Article)
   

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8. Macular thickness decreases with age in normal eyes: a study on the macular thickness map protocol in the Stratus OCT

   Explore Article BJO Online (Oct 23 2009) Ophthalmology

   Background/aim: Retinal and retinal nerve fibre layer (RNFL) thinning with age have been described in histological studies. In vivo techniques like optical coherence tomography (OCT) have shown thinning of optic nerve RNFL and the retina in specific areas. One would expect thinning of the total macula, but so far, no correlation with the quantitative OCT macular map tool and age has been found. Methods: Sixty-seven healthy individuals underwent three repeated scans in both eyes with the macular thickness map protocol in the Stratus OCT. That protocol divides the macula area into nine ETDRS fields. The RNFL was measured in one ... (Read Full Article)
   

   Comment on Article Mentions:   Zeiss Stratus OCT   Carl Zeiss Meditec

9. Ethnic Differences in Optic Nerve Head and Retinal Nerve Fibre Layer Thickness Parameters

   Explore Article BJO Online (Oct 12 2009) Ophthalmology

   Purpose: To examine ethnic differences in optic nerve head and retinal nerve fibre layer (RNFL) parameters between European Caucasian and East Asian children aged 6 and 12 years. Methods: Of 4118 children examined in the Sydney Childhood Eye Study (incorporating the Sydney Myopia Study) from 34 randomly selected primary and 21 secondary schools during 2003-5, 3382 (82.1%) had optical coherence tomography (OCT; Zeiss Stratus) data suitable for analysis. "Fast" optic disc and RNFL scans were used. Ethnicity was defined only when both parents were of the same ethnicity. Results: East Asian children tended to have a lower birth weight, were ... (Read Full Article)
   

   Comment on Article Mentions:   Zeiss Stratus OCT   Paul Mitchell   University of Sydney

10. Simultaneous Spectral Domain OCT and Fundus Autofluorescence Imaging of the Macula and Microperimetric Correspondence After Successful Repair of Rhegmatogenous Retinal Detachment

    Explore Article BJO Online (Oct 12 2009) Ophthalmology

    Background/Aims: To evaluate the ultrastructural changes in the macula after successful repair of rhegmatogenous retinal detachment (RRD) using simultaneous spectral domain optical coherence tomography (sdOCT) and fundus autofluorescence (FAF) imaging and to perform functional correlations with microperimetry. Methods: Simultaneous sdOCT and FAF imaging were performed using a combined sdOCT-confocal scanning laser ophthalmoscope (cSLO) system. Microperimetry was performed in a subgroup of these patients. Results: 17 patients with macular-on RRD and 20 with macular-off RRD were recruited. sdOCT images revealed disruption of the external limiting membrane, inner segment/outer segment junction, or the Verhoeff's membrane in 16 eyes (43.2%). The presence of ... (Read Full Article)
    

    Comment on Article Mentions:   The Chinese University of Hong Kong

11. Fourier Domain Optical Coherence Tomographic and Auto-Fluorescence Findings in Choroidal Melanocytic Lesions

    Explore Article BJO Online (Oct 12 2009) Oncology , Ophthalmology

    Purpose: To compare detection rates of drusen and subretinal fluid by Fourier domain optical coherence tomography (FD OCT) and orange pigment by fundus autofluorescence (FAF) with ophthalmoscopy in indeterminate choroidal melanocytic lesions. Methods: In a consecutive case series of 38 patients with indeterminate choroidal melanocytic lesion that would have been categorized as small tumor according to the size-based nomenclature used in the Collaborative Ocular Melanoma Study, each eye was submitted to ophthalmoscopic examination, FD OCT and FAF. The presence of drusen, subretinal fluid, and orange pigment was recorded for each lesion by a single observer at the time of initial ... (Read Full Article)
    

    Comment on Article Mentions:   Cleveland Clinic   Peter K. Kaiser

12. High-definition spectral domain optical coherence tomography in the evaluation of ataxia with visual impairment

    Explore Article BJO Online (Oct 12 2009) Ophthalmology

    A 36-year old man was evaluated for a 10 year history of visual decline and 5 year history of gait, limb, and speech ataxia. His neurologic exam was remarkable for a wide based ataxic gait with appendicular, axial, and speech ataxia. His eye exam revealed saccadic pursuits and reduced visual acuity. Ophthalmoscopic evaluation of the fundus was remarkable for diffuse attenuation of the arterioles and minimal foveal fine pigmentary mottling. A full-field electroretinogram revealed abnormalities that tended to be more prominent in cone mediated responses. Visual field assessment showed increased blind spot and a left pericentral scotoma. Fluorescein angiography showed ... (Read Full Article)
    

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13. Optical Coherence Tomography Features of Acute Central Serous Chorioretinopathy versus Neovascular Age-Related Macular Degeneration

    Explore Article BJO Online (Oct 12 2009) Ophthalmology

    Objective: To compare the optical coherence tomography (OCT) features of acute central serous chorioretinopathy (CSC) versus exudative age-related macular degeneration (AMD), and to determine if OCT features can distinguish between these two entities. Methods: A retrospective, observational study of 50 eyes with CSC and 50 eyes with exudative AMD. Five millimeter Stratus OCT line scans were reviewed for presence of subretinal/intraretinal fluid and retinal pigment epithelium detachment. The height of the fluid and detachments were measured using the OCT manual calipers, and the morphology of the highly reflective line was described. Results: Intraretinal fluid (IRF), pigment epithelial detachment (PED), irregularities, ... (Read Full Article)
    

    Comment on Article Mentions:   Zeiss Stratus OCT   Carl Zeiss Meditec

14. Intraocular architecture of secondary implanted anterior chamber iris-claw lenses in aphakic eyes evaluated with anterior segment optical coherence tomography

    Explore Article BJO Online (Sep 23 2009) Ophthalmology

    Aim: To evaluate the intraocular stability and safety of secondary iris-claw intraocular lenses (IOLs) in aphakic patients. Methods: Eighteen eyes of 16 patients received iris-claw IOLs to correct for aphakia. Primary outcome measurements included visual acuity (6 m Snellen charts), central endothelium cell count (ECC) and intraocular position of the IOL assessed with anterior segment optical coherence tomography (OCT). Results: Sixteen patients (mean age 66 (range 16–84) years; axial length 24.44 mm) were re-examined 22 months postoperatively (range 12–38 months). Preoperative decimal best corrected visual acuity (BCVA) was 0.51, intraocular pressure (IOP) 15.3 mmHg and central ECC 1816 per mm2. ... (Read Full Article)
    

    Comment on Article Mentions:   Baylor College of Medicine

15. Predictive factors of visual and anatomical outcome after intravitreal bevacizumab treatment of neovascular age-related macular degeneration: an optical coherence tomography study

    Explore Article BJO Online (Sep 23 2009) Ophthalmology

    Aim: To evaluate the baseline visual and optical coherence tomography (OCT) factors on outcomes after intravitreal bevacizumab treatment of subfoveal neovascular age-related macular degeneration (AMD). Methods: A retrospective analysis of 73 eyes treated with intravitreal bevacizumab for subfoveal neovascular AMD was performed. Change in best corrected Snellen visual acuity (BCVA) and central retinal thickness (CRT) on OCT were the primary outcomes. Automated and manual measurements were made for all OCT characteristics. Results: Seventy-three (100%) and 58 (79.5%) eyes were followed for 3 and 6 months, respectively. The mean BCVA improved from 20/177 to 20/160 (p = 0.03) at 3 months ... (Read Full Article)
    

    Comment on Article Mentions:   Cleveland Clinic   Peter K. Kaiser

16. Retinal Imaging Using Commercial Broadband Optical Coherence Tomography

    Explore Article BJO Online (Sep 20 2009) Ophthalmology

    Aims: To examine the practical improvement in image quality afforded by a broadband light source in a clinical setting and to define image quality metrics for future use in evaluating spectral domain optical coherence tomography (SD-OCT) images. Methods: A commercially available SD-OCT system, configured with a standard source as well as an external broadband light source was used to acquire 4mm horizontal line scans of the right eye of 10 normal subjects. Scans were averaged to reduce speckling and multiple retinal layers were analyzed in the resulting images. Results: For all layers a significant improvement in the mean local contrast ... (Read Full Article)
    

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17. Determination of Treatment Strategies for Granular Corneal Dystrophy Type 2 Using Fourier-Domain Optical Coherence Tomography

    Explore Article BJO Online (Aug 31 2009) Ophthalmology

    Purpose: To evaluate the use of Fourier-domain optical coherence tomography (FD-OCT) in the selection and planning of surgical procedures to treat GCDII (granular corneal dystrophy type 2). Methods: An RTVue-100 FD-OCT (Optovue, Inc, Fremont, CA) was used to determine the size, depth, and location of deposits in six patients with homozygous or heterozygous GCDII. Results: The RTVue-100 FD-OCT revealed the depth of the deposits quite precisely, allowing the determination of the appropriate depth of PTK and the appropriate selection of lamellar vs. penetrating keratoplasty as the procedure of choice. In each case, visually significant opacities were adequately removed or would ... (Read Full Article)
    

    Comment on Article Mentions:   Optovue   Optovue RTVue-100   Yonsei University

18. Optical coherence tomography algorithm failure to detect nerve fibre layer defects: report of two cases

    Explore Article BJO Online (Aug 23 2009) Ophthalmology

    Glaucomatous damage typically causes retinal ganglion cell and retinal nerve fibre layer (RNFL) loss that can occur diffusely and focally. Optical coherence tomography (OCT) is a non-invasive, non-contact technology that allows cross-sectional high-resolution in vivo imaging of intraretinal layers. Since structural abnormalities may precede functional abnormalities, it might be expected that an OCT RNFL abnormality would be observed when glaucomatous visual field (VF) loss is present. We report two patients who demonstrated clinically evident focal RNFL defects with corresponding VF loss that failed to be recognised as outside normal limits by OCT analysis. (Read Full Article)
    

    Comment on Article Mentions:   University of Pittsburgh   Zeiss Stratus OCT   Carl Zeiss Meditec

19. Peripapillary Retinal Nerve Fiber Layer Thickness Profile in Subjects with Myopia Measured Using the Stratus Optical Coherence Tomography

    Explore Article BJO Online (Aug 17 2009) Ophthalmology

    Background/aims: To evaluate the relationship between the axial length and refractive error and peripapillary retinal nerve fiber layer(RNFL) thickness profiles measured using the Stratus optical coherence tomography(OCT) in subjects with myopia. Methods: Forty-eight eyes of 48 myopic subjects were recruited and divided into three groups according to their spherical equivalent(SE):low (- 3.0 D < SE < 0.0 D), moderate (-6.0 D < SE ≤ -3.0 D) and high (SE ≤ -6.0 D) myopia groups. All individuals underwent the imaging with the Stratus OCT.The RNFL thickness profiles were compared between the groups. Results: The global average RNFL was significantly thinner in ... (Read Full Article)
    

    Comment on Article Mentions:   Zeiss Stratus OCT   Seoul National University   Eun Ji Lee

20. Evaluation of the Lenstar LS 900 all-in-one non contact biometry meter

    Explore Article BJO Online (Aug 17 2009) Ophthalmology

    Background/aims: Evaluation of the reproducibility of the Lenstar LS 900 non-contact biometer, and a comparison with the Visante anterior-segment Optical Coherence Tomography (AS-OCT) and the IOLMaster. Methods: Central corneal thickness (CCT), anterior chamber depth (ACD), lens thickness (LT), keratometry (K)-values, corneal diameter (CD), and axial length (AL) were obtained in 38 healthy volunteers (76 eyes) to determine the reproducibility of the Lenstar. CCT, ACD, CD, K-values, and AL measurements measured with the Lenstar were compared to the AS-OCT and IOLMaster. Intraocular lens (IOL) power calculations were done to study the significance of the difference between AL measurements. Results: Reproducibility of ... (Read Full Article)
    

    Comment on Article Mentions:   Zeiss Visante OCT   Academic Hospital Maastricht   Muriël Doors

21. A Comparison between Microperimetry and Standard Achromatic Perimetry of the Central Visual Field in Eyes with Glaucomatous Paracentral Visual Field Defects

    Explore Article BJO Online (Aug 17 2009) Ophthalmology

    Background and Aims: We correlated retinal sensitivity as determined by scanning laser ophthalmoscope microperimetry (SLO-MP) in glaucomatous eyes with paracentral visual field (VF) defects detected by standard automated perimetry (SAP). Methods: Twenty eyes with glaucomatous optic neuropathy and a SAP VF defect involving the central 16 test points (at least one point with p<1% in the 24-2 VF) were enrolled. Eyes with diseases other than glaucoma were excluded. All patients underwent SLO-MP and SAP of the central 10 degrees. Results from each eye were divided into 4 quadrants for analysis. Normal and abnormal quadrants by SAP were compared to the ... (Read Full Article)
    

    Comment on Article Mentions:   New York Eye and Ear Infirmary   Robert Ritch   Richard B. Rosen

22. Macular morphology and visual acuity after macular hole surgery with or without internal limiting membrane peeling

    Explore Article BJO Online (Aug 17 2009) Ophthalmology

    Aim: To examine postoperative macular morphology and visual outcome after 12 months in relation to internal limiting membrane (ILM) peeling versus no peeling, indocyanine green (ICG)-staining, and reoperation in eyes that achieved macular hole closure after surgery. Methods: Seventy-four eyes with closed stage 2 or 3 macular holes were recruited from a randomized clinical trial comparing (1) vitrectomy without ILM peeling, (2) vitrectomy with 0.05 % isotonic ICG-assisted ILM peeling, and (3) vitrectomy with 0.15 % trypan blue-assisted ILM peeling. Contrast-enhanced Stratus optical coherence tomography was used to assess central foveal thickness (CFT), central photoreceptor layer thickness (CPRT), central photoreceptor ... (Read Full Article)
    

    Comment on Article Mentions:   Technical University of Denmark   Zeiss Stratus OCT   University of Copenhagen

23. Spectral domain optical coherence tomography detects early stages of chloroquine retinopathy similar to multifocal electroretinography, fundus autofluorescence and near-infrared autofluorescence

    Explore Article BJO Online (Aug 17 2009) Ophthalmology

    Aims: To compare spectral domain optical coherence tomography (sdOCT) to melanin-related near-infrared fundus autofluorescence (NIA, excitation 787nm, emission >800nm), lipofuscin-related fundus autofluorescence (FAF, excitation 488nm, emission >500nm) and multifocal electroretinography (mfERG) in patients with long-term chloroquin (CQ) treatment. Methods: Eight patients with 5.5-22 years of CQ treatment underwent clinical examination, mfERG recording, FAF and NIA imaging using a confocal scanning laser ophthalmoscope (Heidelberg Retina Angiograph 2) and sdOCT imaging (Spectralis OCT Heidelberg Retina Angiograph). Results: In three patients all test results were normal after 5.5-16 years of CQ treatment. Five patients presented with variably progressed CQ retinopathy (10-22 years of ... (Read Full Article)
    

    Comment on Article Mentions:   Heidelberg Spectralis   Heidelberg Engineering

24. Retinal nerve fibre layer thickness measurement reproducibility improved with spectral domain optical coherence tomography

    Explore Article BJO Online (Jul 23 2009) Ophthalmology

    Background/aims: To investigate retinal nerve fibre layer (RNFL) thickness measurement reproducibility using conventional time-domain optical coherence tomography (TD-OCT) and spectral-domain OCT (SD-OCT), and to evaluate two methods defining the optic nerve head (ONH) centring: Centred Each Time (CET) vs Centred Once (CO), in terms of RNFL thickness measurement variability on SD-OCT. Methods: Twenty-seven eyes (14 healthy subjects) had three circumpapillary scans with TD-OCT and three raster scans (three-dimensional or 3D image data) around ONH with SD-OCT. SD-OCT images were analysed in two ways: (1) CET: ONH centre was defined on each image separately and (2) CO: ONH centre was defined ... (Read Full Article)
    

    Comment on Article Mentions:   University of Pittsburgh   Massachusetts Institute of Technology   James G. Fujimoto

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