1. Articles from jhltonline.org

  2. 1-6 of 6
    1. Assessment of Cardiac Allograft Vasculopathy from OCT Images: Automated Analysis is as Good as Expert-Guided Approach

      Assessment of Cardiac Allograft Vasculopathy from OCT Images: Automated Analysis is as Good as Expert-Guided Approach

      Purpose Cardiac Allograft Vasculopathy (CAV) is a frequent complication after heart transplantation (HTx). To help identify patients at risk of CAV, 3D quantitative analysis of coronary wall thickening is of major importance. Until now, substantial manual tracing effort was required. We report a fully automated approach using optical coherence tomography (OCT) imaging. Methods Lumen surface, intimal and medial layers were identified using our LOGISMOS segmentation framework. Coronary wall regions with layered appearance were automatically identified in each OCT frame using deep learning. These segmentation and classification approaches were newly combined in one fully automated system. The comparison between fully automated ...

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    2. Bioresorbable vascular scaffolds to treat coronary allograft vasculopathy: Insights from optical coherence tomography imaging

      Bioresorbable vascular scaffolds to treat coronary allograft vasculopathy: Insights from optical coherence tomography imaging

      Cardiac allograft vasculopathy (CAV) constitutes a major impediment in long-term survival after heart transplantation (HTx). Nowadays, percutaneous coronary intervention for CAV is attempted when significant, focal stenosis has developed, notwithstanding the lack of evidence for survival benefit over medical therapy. The advent of new-generation drug-eluting stents (DESs) did not reduce in-stent restenosis rates compared with first-generation DESs. 1 Therefore, there is still a need for improvements in revascularization strategies for CAV.

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    3. Optical Coherence Tomography for Characterization of Cardiac Allograft Vasculopathy in Late Survivors of Pediatric Heart Transplantation

      Optical Coherence Tomography for Characterization of Cardiac Allograft Vasculopathy in Late Survivors of Pediatric Heart Transplantation

      Background Optical coherence tomography (OCT) has been shown to reliably detect cardiac allograft vasculopathy (CAV). In recent studies performed in adult heart transplant (HTx) recipients, OCT revealed the presence of vulnerable plaques and complicated coronary artery lesions, thus challenging the current concept that CAV disease is a diffuse concentric and fibrosing vasculopathy. The aim of our study was to characterize CAV by OCT in a young population of HTx recipients. Methods We prospectively enrolled 21 young HTx recipients (mean age 27; range 22–38 years) to undergo OCT of the left anterior descending coronary artery (LAD) in addition to annual ...

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      Mentions: Francesco Prati
    4. Comparison of Optical Coherence Tomography (OCT) and Intravascular Ultrasound (IVUS) for the Early Diagnosis of Cardiac Allograft Vasculopathy in Heart Transplant Patients

      Comparison of Optical Coherence Tomography (OCT) and Intravascular Ultrasound (IVUS) for the Early Diagnosis of Cardiac Allograft Vasculopathy in Heart Transplant Patients

      Purpose Cardiac Allograft Vasculopathy (CAV) is one of the leading causes of death after cardiac transplantation. IntraVascular Ultrasound (IVUS) measures the increase in intima-media thickness (IMT) observed in CAV and is more sensitive for diagnosis of CAV than coronary angiography. Optical Coherence Tomography (OCT), a new intracoronary imaging technique, allows more precise measurement of IMT as compared to IVUS. Objective Demonstrate that OCT is better than IVUS for CAV detection in heart transplant patients. Methods and Materials Comparison of OCT and IVUS in heart transplant patients with or without angiographic CAV, performed during their systematic follow-up coronary angiography. Results Among ...

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    5. Detection of Cardiac Allograft Vasculopathy with the New Optical Coherence Tomography in Pediatric Heart Transplant Recipients – Initial Experience

      Detection of Cardiac Allograft Vasculopathy with the New Optical Coherence Tomography in Pediatric Heart Transplant Recipients – Initial Experience

      Purpose Cardiac allograft vasculopathy (CAV) is the main cause of graft failure in heart transplant (HTx) recipients. Coronary angiography remains the principal tool for CAV in most institutions. However, coronary angiography might miss CAV. Optical coherence tomography (OCT) might be used for visualisation of coronary pahtology in HTx recipients. Methods and Materials OCT is using near infrared light capturing micrometer resolution with three-dimensional imaging. OCT was used with the 5 Fr. Guiding catheter over a 0.014inch guide wire in the left and right coronary artery. OCT was used with a blood free pullback (20 mm/sec) with 100 frames ...

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    6. Optical coherence tomography for characterization of cardiac allograft vasculopathy after heart transplantation (OCTCAV study)

      Optical coherence tomography for characterization of cardiac allograft vasculopathy after heart transplantation (OCTCAV study)

      BACKGROUND Optical coherence tomography (OCT) is a novel intravascular imaging modality with excellent spatial resolution. This study explored the utility of OCT in cardiac transplantation for the detection and characterization of early changes associated with coronary allograft vasculopathy (CAV). METHODS Fifteen consecutive patients, 1 to 4 years after transplant with no angiographic evidence of CAV, underwent successful OCT imaging using the Fourier-domain OCT system (C7-XR, St. Jude Medical, St. Paul, MN) in the left anterior descending artery. Analysis included measurements of the lumen, intima, and media layers, and characterization of atherosclerotic plaques. Patients were stratified by intima-to-media (I/M) ratio ...

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    1-6 of 6
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