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    1. Optical coherence tomography as a method for quantitative skin evaluation in systemic sclerosis

      Optical coherence tomography as a method for quantitative skin evaluation in systemic sclerosis

      Improved, non-invasive techniques for the diagnosis, classification and monitoring of patients with systemic sclerosis (SSc) are needed. One potential technique for quantifying the extent of cutaneous sclerosis in these patients is optical coherence tomography (OCT). 1 , 2 Recently, Abignano et al 3 suggested the use of OCT as a feasible and reliable technique to evaluate skin fibrosis in SSc. Based on that initial work, the aim of this study was to evaluate OCT images and compare the findings with the modified Rodnan skin score (mRSS) in patients with SSc. Thirty-three Brazilian patients with SSc (28 women; mean age 46.1 ...

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    2. Virtual skin biopsy by optical coherence tomography: the first quantitative imaging biomarker for scleroderma

      Virtual skin biopsy by optical coherence tomography: the first quantitative imaging biomarker for scleroderma

      Background Skin involvement is of major prognostic value in systemic sclerosis (SSc) and often the primary outcome in clinical trials. Nevertheless, an objective, validated biomarker of skin fibrosis is lacking. Optical coherence tomography (OCT) is an imaging technology providing high-contrast images with 4 μm resolution, comparable with microscopy (‘virtual biopsy’). The present study evaluated OCT to detect and quantify skin fibrosis in SSc. Methods We performed 458 OCT scans of hands and forearms on 21 SSc patients and 22 healthy controls. We compared the findings with histology from three skin biopsies and by correlation with clinical assessment of the skin ...

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