1. Articles from Cell

    cell.com

  2. 1-6 of 6
    1. Interplay between traveling wave propagation and amplification at the apex of the mouse cochlea

      Interplay between traveling wave propagation and amplification at the apex of the mouse cochlea

      Sounds entering the mammalian ear produce waves that travel from the base to the apex of the cochlea. An electro-mechanical active process amplifies traveling wave motions and enables sound processing over a broad range of frequencies and intensities. The cochlear amplifier requires combining the global traveling wave with the local cellular processes that change along the length of the cochlea given the gradual changes in hair cell and supporting cell anatomy and physiology. Thus, we measured basilar membrane (BM) traveling waves in vivo along the apical turn of the mouse cochlea using volumetric optical coherence tomography and vibrometry (VOCTV). We ...

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      Mentions: UCLA
    2. In vivo dynamic 3D imaging of oocytes and embryos in the mouse oviduct

      In vivo dynamic 3D imaging of oocytes and embryos in the mouse oviduct

      Developmental biologists have always relied on imaging to shed light on dynamic cellular events. However, processes such as mammalian fertilization and embryogenesis are generally inaccessible for direct imaging. In consequence, how the oviduct (fallopian tube) facilitates the transport of gametes and preimplantation embryos continues to be unanswered. Here we present a combination of intravital window and optical coherence tomography for dynamic, volumetric, in vivo imaging of oocytes and embryos as they are transported through the mouse oviduct. We observed location-dependent circling, oscillating, and long-distance bi-directional movements of oocytes and embryos that suggest regulatory mechanisms driving transport and question established views ...

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    3. Time course of collateral vessel formation after retinal vein occlusion visualized by OCTA and elucidation of factors in their formation

      Time course of collateral vessel formation after retinal vein occlusion visualized by OCTA and elucidation of factors in their formation

      Background: It is clinically recognized that collateral vessels can form after retinal vein occlusion (RVO) in some cases and these vessels can lead to spontaneous recovery of the pathological condition. In recent years, optical coherence tomography angiography (OCTA) has become a decisive clinical instrument. Unlike previous angiography tests, OCTA enables the non-invasive visualization of fundus vasculature without the need for administration of a contrast agent. However, it remains to be determined if OCTA depicts the 'true' histological status as several studies have reported artifacts in OCTA imaging. Methods: We generated a laser-induced mouse RVO model, and evaluated the subsequent formation ...

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    4. Manipulation of the Endocochlear Potential Reveals Two Distinct Types of Cochlear Nonlinearity

      Manipulation of the Endocochlear Potential Reveals Two Distinct Types of Cochlear Nonlinearity

      The mammalian hearing organ, the cochlea, contains an active amplifier to boost the vibrational response to low level sounds. Hallmarks of this active process are sharp location-dependent frequency tuning and compressive nonlinearity over a wide stimulus range. The amplifier relies on outer hair cell (OHC) generated forces driven in part by the endocochlear potential (EP), the ̴ +80 mV potential maintained in scala media, generated by the stria vascularis. We transiently eliminated the EP in vivo by an intravenous injection of furosemide and measured the vibrations of different layers in the cochlea’s organ of Corti using optical coherence tomography. Distortion ...

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    5. Optical Coherence Tomography Angiography: A Window into Central Nervous System Neurodegeneration

      Optical Coherence Tomography Angiography: A Window into Central Nervous System Neurodegeneration

      Optical coherence tomography angiography (OCT-A) allows noninvasive visualization of intraocular tissues with high resolution. Recently, an innovative use of this technology in studying neurodegenerative diseases has emerged with the neurosensory retina as a unique window into deeper brain tissues. Here, we discuss its role in identifying biomarkers of neurodegenerative diseases.

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    6. Magnetic and Contrast Properties of Labeled Platelets for Magnetomotive Optical Coherence Tomography

      Magnetic and Contrast Properties of Labeled Platelets for Magnetomotive Optical Coherence Tomography
      This article introduces a new functional imaging paradigm that uses optical coherence tomography (OCT) to detect rehydrated, lyophilized platelets (RL platelets) that are in the preclinical trial stage and contain superparamagnetic iron oxides (SPIOs) approved by the U.S. Food and Drug Administration. Platelets are highly functional blood cells that detect and adhere to sites of vascular endothelial damage by forming primary hemostatic plugs. By applying magnetic gradient forces, induced nanoscale displacements (magnetomotion) of the SPIO-RL platelets are detected as optical phase shifts in OCT. In this article, we characterize the iron content and magnetic properties of SPIO-RL platelets, construct ...
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    1-6 of 6
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