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    1. Nuclear Morphology Measurements with Angle-Resolved Low Coherence Interferometry for Application to Cell Biology and Early Cancer Detection

      Nuclear Morphology Measurements with Angle-Resolved Low Coherence Interferometry for Application to Cell Biology and Early Cancer Detection

      The study of intact, living cells using non-invasive optical spectroscopic methods offers the opportunity to assess cellular structure and organization in a way that is not possible with commonly used cell biology imaging techniques. We have developed a novel spectroscopic technique for diagnosing disease at the cellular level based on using low-coherence interferometry (LCI) to detect the angular distribution of scattered light. Angle-resolved LCI (a/LCI) combines the ability of LCI to isolate scattering from sub-surface tissue layers with the ability of light scattering spectroscopy to obtain structural information on sub-wavelength scales. In application to examining cellular structure, a/LCI ...

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    2. Multi-Scale, Multi-Modal Image Integration for Image-Guided Clinical Interventions in the Head and Neck Anatomy

      Multi-Scale, Multi-Modal Image Integration for Image-Guided Clinical Interventions in the Head and Neck Anatomy

      The aim of this paper is to enable model guided multi-scale and multi-modal image integration for the head and neck anatomy. The image modality used for this purpose includes multi-pose Magnetic Resonance Imaging (MRI), Mega Voltage CT, and hand-held Optical Coherence Tomography. A biomechanical model that incorporates subject-specific young's modulus and shear modulus properties is developed from multi-pose MRI, positioned in the treatment setup using Mega Voltage CT (MVCT), and actuated using multiple kinect surface cameras to mimic patient postures during Optical Coherence Microscopy (OCM) imaging. Two different 3D tracking mechanisms were employed for aligning the patient surface and ...

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    3. Visualization of Three-Dimensional Ultra-High Resolution OCT in Virtual Reality

      Visualization of Three-Dimensional Ultra-High Resolution OCT in Virtual Reality

      Three-dimensional reconstruction of optical coherence tomography (OCT) images is a modern technique that helps interpret the images and understand the underlying disease. However, the 3D reconstruction displayed on commercial devices is of limited quality: images are shown on 2D screens and it is difficult or impossible to adjust the view point and capture the data set from a meaningful perspective. We did a preliminary study to evaluate the applicability of a novel, 3D TV-based virtual reality system with interactive volume rendering software to clinical diagnostics and present a workflow, which can incorporate virtual reality technology at various levels of immersion ...

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      Mentions: UCSD
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