Articles from Scitation

1. In vivo photoacoustic tomography and its clinical application.

   Explore Article Scitation (Oct 11 2009)

   High-resolution volumetric optical imaging modalities, such as confocal microscopy, two-photon microscopy, and optical coherence tomography, have become increasingly important in biomedicine. However, due to strong light scattering, the penetration depths of these imaging modalities are limited to the optical transport mean free path (1 mm) in biological tissues. Photoacoustic imaging, an emerging hybrid modality that can provide strong endogenous and exogenous optical absorption contrasts with high ultrasonic spatial resolution, has overcome the fundamental depth limitation while maintaining high spatial resolution. The image resolution, as well as the maximum imaging depth, is scalable with ultrasonic frequency within the reach of diffuse ... (Read Full Article)
   

   Comment on Article Mentions:   Lihong V. Wang   Washington University in St. Louis

2. Live imaging of rat embryos with Doppler swept-source optical coherence tomography

   Explore Article Scitation (Oct 1 2009) Developmental Biology , Doppler

   The rat has long been considered an excellent system to study mammalian embryonic cardiovascular physiology, but has lacked the extensive genetic tools available in the mouse to be able to create single gene mutations. However, the recent establishment of rat embryonic stem cell lines facilitates the generation of new models in the rat embryo to link changes in physiology with altered gene function to define the underlying mechanisms behind congenital cardiovascular birth defects. Along with the ability to create new rat genotypes there is a strong need for tools to analyze phenotypes with high spatial and temporal resolution. Doppler OCT ... (Read Full Article)
   

   Comment on Article Mentions:   Kirill V. Larin   University of Houston

3. On the possibility of time-lapse ultrahigh-resolution optical coherence tomography for bladder cancer grading

   Explore Article Scitation (Sep 16 2009) Oncology , Urology

   has been recently demonstrated that the cellular details of bladder epithelium embedded in speckle noise can be uncovered with time-lapse ultrahigh-resolution optical coherence tomography (TL-uOCT) by proper time-lapse frame averaging that takes advantage of cellular micromotion in fresh biological tissue ex vivo. Here, spectral-domain 3-D TL-uOCT is reported to further improve the image fidelity, and new experimental evidence is presented to differentiate normal and cancerous nuclei of rodent bladder epithelia. Results of animal cancer study reveal that despite a slight overestimation (e.g., <10%) of nuclear size (DN) to histological evaluation, TL-uOCT is capable of distinguishing normal (DN7 µm) and cancerous ... (Read Full Article)
   

   Comment on Article Mentions:   Yingtian Pan   SUNY at Stony Brook

4. Enhanced mixing and spatial instability in concentrated bacterial suspensions

   Explore Article Scitation (Sep 10 2009) Other Non-Medical

   High-resolution optical coherence tomography is used to study the onset of a large-scale convective motion in free-standing thin films of adjustable thickness containing suspensions of swimming aerobic bacteria. Clear evidence is found that beyond a threshold film thickness there exists a transition from quasi-two-dimensional collective swimming to three-dimensional turbulent behavior. The latter state, qualitatively different from bioconvection in dilute bacterial suspensions, is characterized by enhanced diffusivities of oxygen and bacteria. These results emphasize the impact of self-organized bacterial locomotion on the onset of three-dimensional dynamics, and suggest key ingredients necessary to extend standard models of bioconvection to incorporate effects of ... (Read Full Article)
   

   Comment on Article Mentions:   Felix I. Feldchtein   Imalux   Igor Aranson

5. High-repetition-rate optical delay line using a micromirror array and galvanometer mirror for a terahertz system

   Explore Article Scitation (Jul 13 2009)

   We developed a high-repetition-rate optical delay line based on a micromirror array and galvanometer mirror for terahertz time-domain spectroscopy. The micromirror array is fabricated by using the x-ray lithographic technology. The measurement of terahertz time-domain waveforms with the new optical delay line is demonstrated successfully up to 25 Hz. ©2009 American Institute of Physics (Read Full Article)
   

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6. A review of some recent developments in polarization-sensitive optical imaging techniques for the study of articular cartilage

   Explore Article Scitation (May 20 2009)

   This article reviews recent developments in the optical imaging of articular cartilage using polarized-light methods, with an emphasis on tools that could be of use in tissue engineering approaches to treatment. Both second-harmonic generation microscopy and polarization-sensitive optical coherence tomography are described and their potential role in the treatment of cartilage disorders such as osteoarthritis is suggested. Key results are reviewed and future developments are discussed. ©2009 American Institute of Physics (Read Full Article)
   

   Comment on Article Mentions:   Steven J. Matcher   University of Sheffield

7. Phase-sensitive swept source optical coherence tomography for imaging and quantifying of microbubbles in clear and scattering media

   Explore Article Scitation (May 20 2009)

   phase resolved system based on swept source optical coherence tomography (SSOCT) called as phase-sensitive SSOCT to detect and quantify gas microbubbles in aqueous and tissue simulated media is developed. The structural images of gas microbubbles are obtained using conventional SSOCT, while common path SSOCT was used to perform the phase-sensitive measurements. The system shows an axial resolution of 10 µm, a phase sensitivity of 0.03 rad, an imaging depth of up to 6 mm in air, and a scanning speed of 20 kHz for a single A-line. The structural images of the bubbles show an accuracy of 10 µm, whereas ... (Read Full Article)
   

   Comment on Article Mentions:   Kirill V. Larin   University of Houston   Saratov State University

8. Spectral-domain low coherence interferometry/optical coherence tomography system for fine needle breast biopsy guidance

   Explore Article Scitation (Feb 26 2009) Oncology , Probes

   A novel technology and instrumentation for fine needle aspiration (FNA) breast biopsy guidance is presented. This technology is based on spectral-domain low coherence interferometry (SD-LCI). The method, apparatus, and preliminary in vitro/in vivo results proving the viability of the method and apparatus are presented in detail. An advanced tissue classification algorithm, preliminarily tested on breast tissue specimens and a mouse model of breast cancer is presented as well. Over 80% sensitivity and specificity in differentiating all tissue types and 93% accuracy in differentiating fatty tissue from fibrous or tumor tissue was obtained with this technology and apparatus. These results suggest ... (Read Full Article)
   

   Comment on Article Mentions:   Daniel X. Hammer   Physical Sciences Incorporated   R. Daniel Ferguson

9. Prospects of photoacoustic tomography

   Explore Article Scitation (Feb 1 2009)

   Commercially available high-resolution three-dimensional optical imaging modalities—including confocal microscopy, two-photon microscopy, and optical coherence tomography—have fundamentally impacted biomedicine. Unfortunately, such tools cannot penetrate biological tissue deeper than the optical transport mean free path (~1 mm in the skin). Photoacoustic tomography, which combines strong optical contrast and high ultrasonic resolution in a single modality, has broken through this fundamental depth limitation and achieved superdepth high-resolution optical imaging. In parallel, radio frequency-or microwave-induced thermoacoustic tomography is being actively developed to combine radio frequency or microwave contrast with ultrasonic resolution. In this Vision 20/20 article, the prospects of photoacoustic tomography are envisaged in ... (Read Full Article)
   

   Comment on Article Mentions:   Lihong V. Wang   Washington University in St. Louis

10. Nonlocal quantum macroscopic superposition in a high-thermal low-purity state

    Explore Article Scitation (Dec 16 2008)

    Quantum state exchange between light and matter is an important ingredient for future quantum information networks as well as other applications. Photons are the fastest and simplest carriers of information for transmission but in general, it is difficult to localize and store photons, so usually one prefers choosing matter as quantum memory elements. Macroscopic superposition and nonlocal quantum interactions have received considerable interest for this purpose over recent years in fields ranging from quantum computers to cryptography, in addition to providing major insights into physical laws. However, these experiments are generally performed either with equipment or under conditions that are ... (Read Full Article)
    

    Comment on Article Mentions:   Mark E. Brezinski   Harvard University   Brigham and Women’s Hospital

11. Real-time processing for Fourier domain optical coherence tomography using a field programmable gate array

    Explore Article Scitation (Nov 3 2008)

    Teoman E. Ustun, Nicusor V. Iftimia, R. Daniel Ferguson, and Daniel X. Hammer Real-time display of processed Fourier domain optical coherence tomography (FDOCT) images is important for applications that require instant feedback of image information, for example, systems developed for rapid screening or image-guided surgery. However, the computational requirements for high-spe ... [Rev. Sci. Instrum. 79, 114301 (2008)] published Mon Nov 3, 2008. (Read Full Article)
    

    Comment on Article Mentions:   Physical Sciences Incorporated   Daniel X. Hammer   R. Daniel Ferguson

12. Durable optical phantoms with complex geometries and tissue-like mechanical properties

    Explore Article Scitation (Aug 12 2008)

    In this paper, we present an approach toward the creation of coronary artery phantoms for optical coherence tomography (OCT). By mixing alumina powder in a matrix of transparent silicone, it is expected that the amplitude of the OCT signal and the soft tissue elasticity can be reproduced. The fabrication process to produce such multiple layer phantoms is presented along with optical and characterization experiments. (Read Full Article)
    

    Comment on Article Mentions:   Ecole Polytechnique de Montréal   Guy Lamouche   National Research Council Canada

13. 3×3 MZI with unbalanced differential detection for full range swept-source optical coherence tomography

    Explore Article Scitation (Aug 12 2008) Tunable Sources

    Quadrature interferometry based on 3×3 fiber couplers could be used to double the effective imaging depth in Swept- Source Optical Coherence Tomography. This is due to its ability to suppress the complex conjugate artifact naturally. We present theoretical and experimental results for a 3×3 Mach-Zehnder interferometer using a new unbalanced differential optical detection method. The new interferometer provides simultaneous access to complementary phase components of the complex interferometric signal. No calculations by trigonometric relationships are needed. We demonstrate a complex conjugate artifact suppression of 27 dB obtained in a swept-source optical coherence tomography using our unbalanced differential detection. We show ... (Read Full Article)
    

    Comment on Article Mentions:   Costel Flueraru   National Research Council Canada   Shoude Chang

14. Fiber probes used in optical coherence tomography

    Explore Article Scitation (Aug 12 2008) Endoscopy , Probes

    Quality and parameters of probing optical beams are extremely important in optical coherence tomography (OCT) systems both for image quality and light coupling efficiency considerations. For example, the shape, size, focal position, and focal range of such beams could have a great impact on the lateral resolution, penetration depth, and signal-to-noise ratio of the image. We present a design, construction and characterization of different variations of GRIN and ball fiber lenses, for ultra-small OCT probes. Those fiber probes are made of a single mode fiber and a GRIN or ball fiber lens with or without a fiber spacer between them. ... (Read Full Article)
    

    Comment on Article Mentions:   Costel Flueraru   National Research Council Canada   Sherif S. Sherif

15. Applications of Doppler optical coherence tomography based on zero-crossing detection to flow monitoring inside a stenosis phantom

    Explore Article Scitation (Aug 12 2008) Cardiology , Doppler

    Most of the time, arterial stenoses caused by atherosclerosis, hardening of the artery walls, or buildup of fatty deposits prevent the blood from flowing normally. Blood flow characteristics in the vicinity of a stenosis are therefore very important since the restriction may accelerate fatty deposits and thus quickly clog the artery. Doppler Optical Coherence Tomography (DOCT) is a biomedical technique that allows simultaneous structural imaging and flow monitoring inside biological tissues and materials with spatial resolution at least one order of magnitude better than ultrasound. This study deals with the application of a Near Infrared DOCT system for imaging and ... (Read Full Article)
    

    Comment on Article Mentions:   Ecole Polytechnique de Montréal   Romain Maciejko

16. Spatial-domain optical coherence tomography

    Explore Article Scitation (Aug 12 2008)

    Optical coherence tomography (OCT) is a non-invasive imaging technique invented in 1991 and allowing the observation of biological tissues with millimeter depth of penetration and a few micrometer resolution. In the standard time-domain OCT setup (TD-OCT), a broadband light source is used with a Michelson interferometer where one of the mirrors is replaced by the sample (which is mechanically moved transversally during data acquisition) while the other is axially vibrating. By analyzing the temporal signal at the exit of the interferometer, a high resolution tomographic cut of the sample can be obtained. A number of new OCT setups have been ... (Read Full Article)
    

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17. First experimental demonstration of a Fresnel axicon

    Explore Article Scitation (Aug 12 2008)

    Nondiffracting or Bessel beams find applications in diverse fields like optical tweezers/spanners, microscopy, super-resolution and optical coherence tomography. An axicon, energywise, is the most efficient method for generating a diffraction-free beam. Yet one of the impediments to wide use of these optical elements is the cost related to the way they are manufactured. Recently we proposed a novel optical element - Fresnel axicon (Opt. Lett. 31, 1890, 2006) - which enables to overcome this problem while providing advantages such as compactness and very low bulk absorption. Prototypes of the Fresnel axicon were manufactured. In the present work we report the ... (Read Full Article)
    

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18. Real-time optical reflectometry enabled by amplified dispersive Fourier transformation

    Explore Article Scitation (Jul 23 2008)

    Keisuke Goda, Daniel R. Solli, and Bahram Jalali The axial scan rate of optical frequency-domain reflectometry and optical coherence tomography can be increased to megahertz frequencies by dispersive Fourier transformation. However, the fundamental connection between dispersion and loss creates a trade-off between detection sensitivity and acquisi ... [Appl. Phys. Lett. 93, 031106 (2008)] published Wed Jul 23, 2008. (Read Full Article)
    

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19. Imaging Depth-Resolved Tissue Birefringence With a Single Detector

    Explore Article Scitation (Jun 26 2008)

    We report a novel frequency multiplexed optical coherence tomography (FM-OCT) system that is capable of measuring depth-resolved tissue birefringence from a single record of a single detector. The FM-OCT system utilizes polarization-maintaining-fiber based components. The orthogonal channels of the polarization-maintaining-fiber and the cross-terms are frequency multiplexed. After recording the interference signal, a set of digital band-pass filters extract the polarization information. A rapid scanning optical delay line in the reference arm compensates for dispersion and allows a real-time display of tissue birefringence. The axial resolution provided by a superluminescent diode working at 855 nm with 28 nm bandwidth is 12 ... (Read Full Article)
    

    Comment on Article Mentions:   Taner Akkin   University of Minnesota

20. Optical coherence tomography picorheology of biopolymer solutions

    Explore Article Scitation (May 2 2008) NDE/NDT , Other Non-Medical

    Ramesh C. Sharma, Aristeidis Papagiannopoulos, and Thomas A. Waigh We describe an interferometric optical fiber based dynamic light scattering technique to study the linear viscoelasticity of complex fluids. This digital correlator based method enables viscoelasticity to be probed at high frequencies (1010 Hz) over picoliter regions of an aqueous sample. We demons ... [Appl. Phys. Lett. 92, 173903 (2008)] published Fri May 2, 2008. (Read Full Article)
    

    Comment on Article Mentions:   University of Manchester

21. Human Skin as Arrays of Helical Antennas in the Millimeter and Submillimeter Wave Range

    Explore Article Scitation (Mar 27 2008) Dermatology

    Author(s): Yuri Feldman, Alexander Puzenko, Paul Ben Ishai, Andreas Caduff, and Aharon J. AgranatRecent studies of the minute morphology of the skin by optical coherence tomography showed that the sweat ducts in human skin are helically shaped tubes, filled with a conductive aqueous solution. A computer simulation study of these structures in millimeter and submillimeter wave bands show that th...[Phys. Rev. Lett. 100, 128102] Published Thu Mar 27, 2008 (Read Full Article)
    

    Comment on Article Mentions:   Andreas Caduff

22. Quantitative analysis on tongue inspection in traditional Chinese medicine using optical coherence tomography

    Explore Article Scitation (Mar 22 2008)

    Tongue inspection (TI) is an important and unique diagnostic method in traditional Chinese medicine (TCM), because significant connections between various viscerae diseases and abnormalities in the tongue have been verified. In TCM, TI is simple and non invasive, but in clinical applications, TI is subjectively based on the experience and technique of physicians. To avoid this problem, optical coherence tomography (OCT) imaging is introduced here for TI. We study OCT imaging in rats in vivo from chronic gastritis group (model) and normal group (control) and quantitatively analyze the relative parameters, such as the thickness and the moisture degree of TI. ... (Read Full Article)
    

    Comment on Article Mentions:   Oregon Health & Science University   Ruikang K. Wang

23. Mid-infrared optical coherence tomography

    Explore Article Scitation (Dec 18 2007)

    Christopher S. Colley, Jeremy C. Hebden, David T. Delpy, Alison D. Cambrey, Robert A. Brown et al. A time domain optical coherence tomography (OCT) system is described that uses mid-infrared light (68 [mu]m). To the best of our knowledge, this is the first OCT system that operates in the mid-infrared spectral region. It has been designed to characterize bioengineered tissues in terms of their st ... [Rev. Sci. Instrum. 78, 123108 (2007)] published Tue Dec 18, 2007. (Read Full Article)
    

    Comment on Article Mentions:   University of Sheffield   University College London   David T. Delpy

24. Common-path optical coherence tomography with side-viewing bare fiber probe for endoscopic optical coherence tomography

    Explore Article Scitation (Nov 14 2007) Endoscopy , Ophthalmology

    Common-path optical coherence tomography with side-viewing bare fiber probe for endoscopic optical coherence tomography Rev. Sci. Instrum. 78, 113102 (2007) (4 pages) Published Date: 6 November 2007 Utkarsh Sharma and Jin U. Kang Department of Electrical and Computer Engineering, Johns Hopkins University, 3400 N. Charles Street, Baltimore, Maryland 21218, USA All-fiber-optic^ common-path optical coherence tomography (OCT) using a side-viewing bare fiber^ probe has been demonstrated and analyzed. (Read Full Article)
    

    Comment on Article Mentions:   Johns Hopkins University   Jin U. Kang

25. Fingerprint detection using full-field swept-source optical coherence tomography

    Explore Article Scitation (Oct 30 2007) Other Non-Medical

    Fingerprint detection using full-field swept-source optical coherence tomography Appl. Phys. Lett. 91, 181106 (2007) (3 pages) Issue Date: 29 October 2007 Satish Kumar Dubey, Tulsi Anna, Chandra Shakher, and Dalip Singh Mehta Laser Applications and Holography Laboratory, Instrument Design Development Centre, Indian Institute of Technology Delhi, Hauz Khas, New Delhi 110 016, India We^ report the application of full-field swept-source optical coherence tomography for^ fingerprint detection. This (Read Full Article)
    

    Comment on Article Mentions:   Satish Kumar Dubey   Chandra Shakher   Indian Institute of Technology at Delhi

26. Optical coherence computed tomography

    Explore Article Scitation (Oct 2 2007)

    Li Li and Lihong V. Wang Optical Imaging Laboratory, Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, Missouri 63130, USA A time-resolved optical tomography, optical coherence computed tomography, is proposed to bridge the gap between diffuse optical tomography and optical coherence tomography. Both ballistic and multiple-scattered photons are measured at multiple source-detection positions by low-coherence interferometry providing a temporal resolution smalle (Read Full Article)
    

    Comment on Article Mentions:   Li Li   Lihong V. Wang   Washington University in St. Louis

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