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    1. Effect of plaque composition, morphology, and burden on DESolve novolimus-eluting bioresorbable vascular scaffold expansion and eccentricity — An optical coherence tomography analysis

      Effect of plaque composition, morphology, and burden on DESolve novolimus-eluting bioresorbable vascular scaffold expansion and eccentricity — An optical coherence tomography analysis

      Objective This study of patients treated with novolimus-eluting bioresorbable scaffold (BRS) investigated the impact of plaque burden on the acute mechanical performance of the BRS and the short-term outcome. Methods A total of 15 patients were enrolled. The following parameters were derived from optical coherence tomography (OCT) during the final pullback: mean and minimum area, residual area stenosis, incomplete strut apposition, tissue prolapse, scaffold expansion index (SEI), scaffold eccentricity index (SEC), symmetry index, strut fracture, and edge dissection. Fibrous plaque (FP) and calcific plaque (CP) characteristics were measured at each 200 μm longitudinal cross-section. The patients were divided into two ...

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    2. Spectral domain optical coherence tomography using an optical wavefront splitting interferometer

      Spectral domain optical coherence tomography using an optical wavefront splitting interferometer

      Coherence-domain ranging in optical coherence tomography (OCT) is usually performed using a Michelson interferometer. In this study, a spectrometer based OCT system with a wavefront splitting interferometer is investigated. Instead of using a transmission beam splitting mirror or fiber optic coupler, a silver coated mirror is used to split a portion of the OCT source light into the reference arm of the interferometer. Reference and backscattered sample light of the OCT system interfere non-collinearly in the wavefront splitting interferometer. The OCT system is polarization insensitive, and beam splitting ratio between sample and reference arms is adjustable through controlling the insertion ...

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      Mentions: Yimin Wang
    3. Imaging infant retinal vasculature with optical coherence tomography angiography

      Imaging infant retinal vasculature with optical coherence tomography angiography

      Study of infant retinal vascular development has been limited to histopathological reports. We report herein depth-resolved visualization of full-term infant parafoveal microvasculature and their similarity to that of young children using a portable optical coherence tomography angiography system.

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    4. Quantifying the effects of hydration on corneal stiffness with noncontact optical coherence elastography

      Quantifying the effects of hydration on corneal stiffness with noncontact optical coherence elastography

      Purpose To quantify the effects of the hydration state on the Young's modulus of the cornea . Setting Biomedical Optics Laboratory, University of Houston, Houston, Texas, USA. Design Experimental study. Methods Noncontact, dynamic optical coherence elastography (OCE) measurements were taken of in situ rabbit corneas in the whole eye–globe configuration (n = 10) and at an artificially controlled intraocular pressure of 15 mm Hg. Baseline OCE measurements were taken by topically hydrating the corneas with saline for 1 hour. The corneas were then dehydrated topically with a 20% dextran solution for another hour, and the OCE measurements were repeated. A ...

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    5. All-optical dual photoacoustic and optical coherence tomography intravascular probe

      All-optical dual photoacoustic and optical coherence tomography intravascular probe

      Intravascular imaging in percutaneous coronary interventions can be an invaluable tool in the treatment of coronary artery disease. It is of significant interest to provide molecular imaging contrast that is complementary to structural contrast provided by optical coherence tomography (OCT) and intravascular ultrasound imaging (IVUS). In this study, we developed a dual-modality intravascular imaging probe comprising a commercial OCT catheter and a high sensitivity fiber optic ultrasound sensor, to provide both photoacoustic (PA) and OCT imaging. With PA imaging, the lateral resolution varied from 18 µm to 40 µm; the axial resolution was consistently in the vicinity of 45 µm ...

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    6. OCT Angiography in Young Children with a History of Retinopathy of Prematurity

      OCT Angiography in Young Children with a History of Retinopathy of Prematurity

      Purpose To describe the size and appearance of the foveal avascular zone (FAZ) in the superficial and deep plexus in young children with treated or spontaneously regressed retinopathy of prematurity (ROP), in comparison with age-matched controls and young adults, as seen with OCT angiography (OCTA), and to compare these parameters with foveal classic OCT images and visual function . Design Prospective, cross-sectional study . Participants Twenty-five children with treated or spontaneously regressed ROP (mean 5.0±0.8 years) compared with 15 healthy term-born age-matched children and 20 healthy adults. Methods OCTA was performed using a DRI OCT Triton (Swept Source OCT ...

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    7. Neoatherosclerosis in Patients With Coronary Stent Thrombosis: Findings From Optical Coherence Tomography Imaging (A Report of the PRESTIGE Consortium)

      Neoatherosclerosis in Patients With Coronary Stent Thrombosis: Findings From Optical Coherence Tomography Imaging (A Report of the PRESTIGE Consortium)

      Objectives The purpose of this study was to assess neoatherosclerosis in a registry of prospectively enrolled patients presenting with stent thrombosis using optical coherence tomography . Background In-stent neoatherosclerosis was recently identified as a novel disease manifestation of atherosclerosis after coronary stent implantation. Methods Angiography and intravascular optical coherence tomography were used to investigate etiologic factors of neoatherosclerosis in patients presenting with stent thrombosis >1 year after implantation (very late stent thrombosis [VLST]). Clinical data were collected according to a standardized protocol. Optical coherence tomographic acquisitions were analyzed in a core laboratory. Cox regression analysis was performed to identify factors associated ...

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    8. Angiography Alone Versus Angiography Plus Optical Coherence Tomography to Guide Percutaneous Coronary Intervention: Outcomes From the Pan-London PCI Cohort

      Angiography Alone Versus Angiography Plus Optical Coherence Tomography to Guide Percutaneous Coronary Intervention: Outcomes From the Pan-London PCI Cohort

      Objectives This study aimed to determine the effect on long-term survival of using optical coherence tomography (OCT) during percutaneous coronary intervention (PCI). Background Angiographic guidance for PCI has substantial limitations. The superior spatial resolution of OCT could translate into meaningful clinical benefits, although limited data exist to date about their effect on clinical endpoints . Methods This was a cohort study based on the Pan-London (United Kingdom) PCI registry, which includes 123,764 patients who underwent PCI in National Health Service hospitals in London between 2005 and 2015. Patients undergoing primary PCI or pressure wire use were excluded leaving 87,166 ...

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    9. Will Optical Coherence Tomography Become the Standard Imaging Tool for Percutaneous Coronary Intervention Guidance?

      Will Optical Coherence Tomography Become the Standard Imaging Tool for Percutaneous Coronary Intervention Guidance?

      Editorial Comment: In the last 3 decades, intravascular ultrasound (IVUS) and, more recently, optical coherence tomography (OCT) have been increasingly used to guide percutaneous coronary intervention (PCI). Although there are randomized trials, registries, and meta-analyses suggesting better outcomes using IVUS to guide PCI (1–3), data on the clinical impact of OCT are still missing. In the United Kingdom, consecutive data of all PCI procedures must be prospectively entered in the registry organized by the British Cardiovascular Interventional Society, endorsed by the United Kingdom Department of Health, with tracking of events based on the complete and unquestionable national statistics. One ...

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      Mentions: Carlo Di Mario
    10. Bacterial inactivation and in situ monitoring of biofilm development on graphene oxide membrane using optical coherence tomography

      Bacterial inactivation and in situ monitoring of biofilm development on graphene oxide membrane using optical coherence tomography

      In an attempt to advance GO-based environmental applications, herein we probed the anti-biofouling properties and mechanisms of graphene oxide (GO) surface coating. A flexible and mechanically stable GO membrane was fabricated using vacuum filtration technique and its ability to inactivate bacterial growth and subsequent biofilm formation was investigated. Our preliminary results authenticate that the GO membrane, owing to its unique physicochemical surface properties, exhibits superior antibacterial activity against planktonic cell proliferation. An optical coherence tomography (OCT)-based nondestructive in situ monitoring of bacterial biofilm evolution and behavior revealed that the GO surface initially inhibited biofilm growth for 24 h under ...

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    11. Favorable early vessel healing after everolimus-eluting stent implantation: 3-, 6-, and 12-month follow-up of optical coherence tomography

      Favorable early vessel healing after everolimus-eluting stent implantation: 3-, 6-, and 12-month follow-up of optical coherence tomography

      Background Although a prospective randomized control study revealed that 3-month dual anti-platelet therapy (DAPT) is safe and does not compromise the efficacy of everolimus-eluting stent (EES) in selected patients, detailed vessel healing at early phase after EES implantation has yet to be investigated in Japanese patients. Methods and results A total of 27 lesions in 19 patients treated with EES were serially evaluated by using optical coherence tomography (OCT) at 3, 6, and 12 months after stent implantation. In addition to standard quantitative OCT parameters, the percentage of stents with peri-strut low-intensity area (PLIA, a region around stent struts homogenously ...

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    12. Innovative invasive management without stent implantation guided by optical coherence tomography in acute coronary syndrome

      Innovative invasive management without stent implantation guided by optical coherence tomography in acute coronary syndrome

      Background A two-step strategy of invasive management without stenting, guided by optical coherence tomography (OCT), in selected patients with acute coronary syndrome (ACS), might avoid systematic stent implantation and allow medical therapy alone. Aims To assess the feasibility and safety of such a procedure, and to define coronary imaging characteristics in a specific population. Methods This single-centre proof-of-concept study included all patients with ACS who benefited from a two-step revascularization procedure with optimal reperfusion during primary percutaneous coronary intervention followed by delayed angiography and OCT. OCT imaging determined medical therapy treatment alone without stenting in case of absence of vulnerable ...

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      Mentions: Francesco Prati
    13. Retinal racemose hemangioma with retinal artery macroaneurysm: Optical coherence tomography angiography (OCTA) findings

      Retinal racemose hemangioma with retinal artery macroaneurysm: Optical coherence tomography angiography (OCTA) findings

      Purpose To describe a rare case of retinal racemose hemangioma (RRH) with retinal artery macroaneurysm (RAM) and its optical coherence tomography angiography (OCT-A) finding before and after treatment. Observations Congenital arteriovenous (AV) communications or RRH is a rare developmental anomaly associated with various ocular conditions. RRH alone is usually asymptomatic, and vision loss occurs when associated with other ocular complications like retinal vein occlusion, hemmorage, macular edema and macroaneurysm. In this communication we describe a case of a 44-year-old female having RRH who presented with active, leaking RAM with subretinal hemmorage. OCT-A through the lesion demonstrated an active aneurysm which ...

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    14. Intraoperative optical coherence tomography-assisted retrocorneal fibrous membrane biopsy and excision

      Intraoperative optical coherence tomography-assisted retrocorneal fibrous membrane biopsy and excision

      Purpose We report a case of retrocorneal fibrous membrane (RCFM) formation following penetrating keratoplasty (PK) and intraoperative optical coherence tomography (OCT)-guided excision of this membrane. Observations A 68-year-old woman with primary open angle glaucoma and corneal decompensation of the right eye secondary to tube shunt presented for 3-month follow-up of PK. On examination of the right eye, the patient was noted to have a glassy pupillary membrane with traction on the iris. Anterior segment OCT confirmed a membrane connecting the iris to host cornea. The patient underwent biopsy and excision of the membrane assisted by intraoperative OCT. Pathological examination ...

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    15. The effect of bevacizumab before vitrectomy for diabetic tractional retinal detachment demonstrated on optical coherence tomography angiography

      The effect of bevacizumab before vitrectomy for diabetic tractional retinal detachment demonstrated on optical coherence tomography angiography

      Purpose To demonstrate the effect of intravitreal bevacizumab (IVB) on the size and vascularity of the fibro-vascular complex with the optical coherence tomography angiography (OCTA) before pars plana vitrectomy (PPV). Methods Observational case series of three eyes with active diabetic fibro-vascular complex and tractional retinal detachment (TRD) who underwent IVB (1.25 mg/0.05 ml) two days before proceeding to PPV. OCTA was carried out prior to IVB, two days after IVB and six weeks after PPV. Results OCTA showed a reduction in the size and calibre of the diabetic fibro-vascular complex two days after IVB in all the ...

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    16. Aging-associated changes in cerebral vasculature and blood flow as determined by quantitative optical coherence tomography angiography

      Aging-associated changes in cerebral vasculature and blood flow as determined by quantitative optical coherence tomography angiography

      Capillary velocity increases by 21% and velocity heterogeneity increases by 19% with older age. Abstract Normal aging is associated with significant alterations in brain’s vascular structure and function, which can lead to compromised cerebral circulation and increased risk of neurodegeneration. The in vivo examination of cerebral blood flow (CBF), including capillary beds, in aging brains with sufficient spatial detail remains challenging with current imaging modalities. In the present study, we use three-dimensional (3-D) quantitative optical coherence tomography angiography (OCTA) to examine characteristic differences of the cerebral vasculatures and hemodynamics at the somatosensory cortex (S1) between old (16-month-old) and young ...

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    17. OCT for early quality evaluation of tooth–composite bond in clinical trials

      OCT for early quality evaluation of tooth–composite bond in clinical trials

      Objectives To evaluate early quality of composite restorations with a universal adhesive in different application modes clinically and with optical coherence tomography (OCT). Methods 22 patients with four non-carious cervical lesions each received composite restorations (Filtek Supreme TM XTE, 3 M). The universal adhesive Scotchbond Universal TM (SBU, 3 M) was applied with three etching protocols: self-etch (SE), selective-enamel-etch (SEE) and etch-and-rinse (ER). The etch-and-rinse adhesive OptiBond TM FL (OFL, Kerr) served as a control. Restorations were imaged by OCT (Thorlabs) directly after application (t 0 ). After 14 days (t 1 ) and 6 month (t 2 ) OCT imaging (interfacial adhesive ...

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    18. Evaluation of fouling in nanofiltration for desalination using a resistance-in-series model and optical coherence tomography

      Evaluation of fouling in nanofiltration for desalination using a resistance-in-series model and optical coherence tomography

      Resistance-in-series models have been applied to investigate fouling behavior. However, it is difficult to model the influence of morphology on fouling behavior because resistance is indirectly calculated from the water flux and transmembrane pressure. In this study, optical coherence tomography (OCT) was applied to evaluate the resistance of the fouling layer based on fouling morphology. Sodium alginate, humic acid, and bovine serum albumin (BSA) with high salts concentrations (conductivity: 23 mS/cm) were used as model foulants. At the same total fouling resistance, BSA showed the highest cake layer thickness (BSA (114.5 μm) > humic acid (53.5 μm) > sodium ...

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    19. Angioscopic differences of coronary intima between diffuse and focal coronary vasospasm: Comparison of optical coherence tomography findings

      Angioscopic differences of coronary intima between diffuse and focal coronary vasospasm: Comparison of optical coherence tomography findings

      Background Coronary artery vasospasm (CS) can be identified as either a diffuse type or focal type; however, the difference in endothelial characteristics between these spasm types remains unclear. The features of coronary intima associated with diffuse spasm and focal spasm using coronary angioscopy (CAS) were evaluated and the optical coherence tomography (OCT) findings were compared. Methods CAS and/or OCT observational analysis was performed in 55 patients (mean age: 61.4 years, 31 men) who had acetylcholine-provoked CS (diffuse CS, 31 patients; focal CS, 24 patients). The yellowness of the intima, presence of thrombus in CAS, and intimal characteristics based ...

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    20. Which is more sensitive in multiple sclerosis: Optical coherence tomography or visual evoked potentials?

      Which is more sensitive in multiple sclerosis: Optical coherence tomography or visual evoked potentials?

      Objectives Visual involvement is a frequent feature of multiple sclerosis (MS). Visual disturbances involve up to 80% of patients and optic neuritis (ON) occurs in about 50%. Our aim was to assess the sensitivity of optic coherence tomography (OCT) and visual evoked potentials (VEPs) to visual pathway abnormalities in MS. Methods A total of 19 MS subjects, 9 with optic neuritis (ON) at least 3 months before (bilateral in 6), underwent assessment of optical coherence tomography (OCT) and VEPs. Results There were 19 patients with MS, so a total of 38 eyes. The sex ratio was 0.73 F/M ...

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    21. Postprandial Hyperchylomicronemia and Thin-Cap Fibroatheroma in Non-culprit Lesions: a Multivessel Optical Coherence Tomography Study

      Postprandial Hyperchylomicronemia and Thin-Cap Fibroatheroma in Non-culprit Lesions: a Multivessel Optical Coherence Tomography Study

      Objective: Although postprandial hypertriglyceridemia potentially plays a role as a risk factor for coronary artery disease (CAD), details of its significance remain unknown. This study aimed to investigate the correlation between the postprandial lipid profiles rigorously estimated with the meal tolerance test and the presence of lipid-rich plaque, such as thin-cap fibroatheroma (TCFA), in the non-culprit lesion. Methods: Thirty patients with stable CAD who underwent a multivessel study using optical coherence tomography during catheter intervention for the culprit lesion were enrolled. Patients were divided into two groups: those with or without TCFA (fibrous cap thickness ≤65 μm) in the non-culprit ...

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    1-24 of 848 1 2 3 4 ... 34 35 36 »
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