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    1. Optical Coherence Tomography Angiography to Assess Vascular Remodeling of the Choriocapillaris After Low-Fluence Photodynamic Therapy for Chronic Central Serous Chorioretinopathy

      Optical Coherence Tomography Angiography to Assess Vascular Remodeling of the Choriocapillaris After Low-Fluence Photodynamic Therapy for Chronic Central Serous Chorioretinopathy

      Background To evaluate the efficacy of optical coherence tomography angiography (OCTA) in identifying changes in the choriocapillaris layer after low-fluence verteporfin photodynamic therapy (vPDT) in patients affected by chronic central serous chorioretinopathy (CSCR). Methods Low-fluence vPDT was performed on 28 eyes of 27 patients with CSCR. All patients underwent the following tests at baseline and 6 months after treatment: best corrected visual acuity (BCVA), fluorescein angiography, indocyanine green angiography, enhanced depth imaging OCT and OCTA. Results Subretinal fluid was completely absorbed in 18 of the 28 affected eyes (64.3%) after low-fluence vPDT (“responders”), and incompletely absorbed in 10 eyes ...

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    2. Pars plana vitrectomy with intraoperative optical coherence tomography for sub-internal limiting membrane fibrosis excision in a child with Terson syndrome: Surgical and pathological correlation

      Pars plana vitrectomy with intraoperative optical coherence tomography for sub-internal limiting membrane fibrosis excision in a child with Terson syndrome: Surgical and pathological correlation

      Purpose To report the intraoperative optical coherence tomography (OCT)-guided surgery of a consolidated sub-internal limiting membrane (ILM) hemorrhage that developed into a sub-ILM fibrotic membrane in a child with a history of Terson syndrome. Observations A one year-old boy with a history of Terson syndrome due to a motor vehicle accident presented three months after trauma with a white feather-shaped membrane in the left macula. Preoperative OCT showed a preretinal hyperreflective tissue at the foveal center. The patient underwent pars plana vitrectomy. After separation of the posterior hyaloid, intraoperative OCT did not show any change in structural components. After ...

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    3. In Vivo Mapping of the Choriocapillaris in Healthy Eyes: a Widefield Swept Source Optical Coherence Tomography Angiography Study

      In Vivo Mapping of the Choriocapillaris in Healthy Eyes: a Widefield Swept Source Optical Coherence Tomography Angiography Study

      Purpose To report variation of choriocapillaris (CC) flow in peripapillary, macular and near/mid periphery regions in healthy subjects using widefield swept source optical coherence tomography angiography (SS-OCTA). Design Prospective, cross-sectional study. Subjects Fifty healthy subjects. Methods Healthy young subjects were imaged with the SS-OCTA system (PLEX Elite 9000, Carl Zeiss Meditec Inc., Dublin, CA, USA). OCTA scans were taken in primary and extremes of gaze and a montage was automatically created. The en face CC images were then exported to imageJ and a semi-automated algorithm was used for subsequent quantitative analysis. Main outcome measures Quantitative analysis of the CC ...

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    4. Time course of swept-source optical coherence tomography angiography findings after photodynamic therapy and aflibercept in eyes with age-related macular degeneration

      Time course of swept-source optical coherence tomography angiography findings after photodynamic therapy and aflibercept in eyes with age-related macular degeneration

      Purpose To report swept-source optical coherence tomography angiography (SS-OCTA) findings after full-fluence photodynamic therapy (PDT) and aflibercept intravitreal injection (IVA) for age-related macular degeneration (AMD). Methods Five eyes of five patients with AMD treated with PDT and IVA were include into the study. We retrospectively reviewed the data obtained from the five patients using SS-OCTA before and after treatment. Three eyes had type 1 choroidal neovascularization (CNV) and two eyes had polypoidal choroidal vasculopathy. Results Before treatment, the CNV signals detected in all cases, decreased in three eyes and were not detected completely in two eyes at 1 months after ...

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      Mentions: Osaka University
    5. DNA Damage and Repair in Patients with Coronary Artery Disease: Correlation with Plaque Morphology Using Optical Coherence Tomography (DECODE Study)

      DNA Damage and Repair in Patients with Coronary Artery Disease: Correlation with Plaque Morphology Using Optical Coherence Tomography (DECODE Study)

      Objective The aim of this study was to examine DNA ligase activity and expression of DNA damage response pathway (DDR) genes in patients with stable angina (SA) and non-ST elevation myocardial infarction (NSTEMI) and determine whether they correlate with plaque morphology. Background Patients with coronary artery disease (CAD) have evidence of deoxyribonucleic acid (DNA) damage in peripheral blood mononuclear cells (PBMCs). It is unclear whether this represents excess damage or defective DNA repair activity. Methods DNA ligase activity and the expression of 22 DDR genes were measured in PBMCs of patients (both SA ( n = 47) and NSTEMI ( n = 42)) and ...

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    6. Ocular albinism with mutation in GPR143: Findings in wide-field autofluorescence and optical coherence tomography

      Ocular albinism with mutation in GPR143: Findings in wide-field autofluorescence and optical coherence tomography

      A 12 year-old boy who consulted due to nystagmus and low vision from birth. His mother also consulted for low vision of the right eye since she was a child, which worsened recently. The physical examination revealed no alterations in skin and hair pigmentation. In the examination of the anterior segment of the child, areas of slight circumferential hypopigmentation were observed in the iris in both eyes. The fundus examination revealed a choroidal fundus due to the absence of melanin in the retinal pigment epithelium. In the autofluorescence, an absence of physiological macular hypo-autofluorescence was observed and, in optical coherence ...

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    7. Classification and treatment follow-up of a juxtapapillary retinal hemangioblastoma with optical coherence tomography angiography

      Classification and treatment follow-up of a juxtapapillary retinal hemangioblastoma with optical coherence tomography angiography

      Purpose Only an endophytic growth pattern in juxtapapillary retinal hemangioblastoma (JRH) is an indication for surgical treatment, but classification of growth types is difficult using conventional imaging techniques. This case report describes the use of optical coherence tomography angiography (OCT-A) features for classification and treatment follow-up in a case with JRH. Observations The JRH of this patient was easily detected with two different OCT-A methods in both en-face and cross-sectional B-scan images, and was classified as a sessile growth type. This growth type excluded the treatment option of vitreoretinal surgery with excision of the lesion or ligation of the feeder ...

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    8. OCT-Detected Optic Nerve Head Neural Canal Direction, Obliqueness and Minimum Cross-Sectional Area in Healthy Eyes

      OCT-Detected Optic Nerve Head Neural Canal Direction, Obliqueness and Minimum Cross-Sectional Area in Healthy Eyes

      Purpose To assess anterior scleral canal opening (ASCO) offset relative to Bruch’s membrane opening (BMO) (ASCO/BMO offset) so as to determine neural canal direction, obliqueness, and minimum cross-sectional area (NCMCA) in 362 healthy eyes. Design Cross-sectional study Methods After OCT optic nerve head (ONH) and retinal nerve fiber layer thickness (RNFLT) imaging, BMO and ASCO were manually segmented and planes, centroids, size and shape were calculated. Neural canal direction was defined by projecting the neural canal axis vector (connecting BMO and ASCO centroids) onto the BMO plane. Neural canal obliqueness was defined by the angle between the neural ...

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    9. First Report of Edge Vascular Response at 12 Months of Magmaris, A Second-Generation Drug-Eluting Resorbable Magnesium Scaffold, Assessed by Grayscale Intravascular Ultrasound, Virtual Histology, and Optical Coherence Tomography. A Biosolve-II Trial Sub-S

      First Report of Edge Vascular Response at 12 Months of Magmaris, A Second-Generation Drug-Eluting Resorbable Magnesium Scaffold, Assessed by Grayscale Intravascular Ultrasound, Virtual Histology, and Optical Coherence Tomography. A Biosolve-II Trial Sub-S

      Introduction and objective The edge vascular response (EVR) remains unknown in second generation drug-eluting Resorbable Magnesium Scaffold (RMS), such as Magmaris. The aim of the study was to evaluate tissue modifications in the RMS edges over time, assessed by different invasive imaging modalities. Methods The patients treated with the device were assessed by optical coherence tomography (OCT), grayscale intravascular ultrasound (IVUS), and virtual histology IVUS at baseline and 12 months. The EVR study performed a segment- and frame-level analysis of the 5 mm segments proximal and distal of the actual RMS. Results The segment-level grayscale IVUS (n = 10), virtual histology ...

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    10. Impact of Swept Source optical coherence tomography in patients with photoreceptor dystrophies

      Impact of Swept Source optical coherence tomography in patients with photoreceptor dystrophies

      The use of optical coherence tomography to diagnose conditions that predominantly affect the photoreceptor layer is postulated as a technique that allows to evaluate the relationship between retinal changes and loss of visual acuity. Two clinical cases are presented on patients with a bilateral decrease of their visual acuity and alteration in chromatic perception. Optical coherence tomography revealed subfoveal focal hypo-reflective defects on the hyper-reflective band (known as the ellipsoid zone).

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    11. Speckle reduction based on fractional-order filtering and boosted singular value shrinkage for optical coherence tomography image

      Speckle reduction based on fractional-order filtering and boosted singular value shrinkage for optical coherence tomography image

      Optical coherence tomography (OCT) is a micrometer-resolution optical imaging technology that has been widely used in many fields, such as medicine and materials science. However, OCT images inevitably suffer from speckle noise which obscures the structural information of image. To remove speckle noise, a boosted singular value shrinkage algorithm based on fractional-order filtering is proposed in this paper. An OCT image is first divided into many overlapping image blocks and each block is filtered using a fractional mask, and then an absolute distance is used as a similarity criterion for block matching to form a low rank group matrix. Furthermore ...

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    12. Optical coherence tomography tissue coverage and characterization with grey-scale signal intensity analysis after bifurcation stenting with new generation bioabsorbable polymer drug-eluting stent

      Optical coherence tomography tissue coverage and characterization with grey-scale signal intensity analysis after bifurcation stenting with new generation bioabsorbable polymer drug-eluting stent

      Purpose Bifurcation stenting is thought to be associated with delayed healing and a subsequent risk of stent failure. The aim of this study was to further evaluate healing of thin-strut bioabsorbable polymer everolimus-eluting stents (EES) post bifurcation stenting by optical coherence tomography (OCT) including grey-scale signal intensity (GSI) analysis. Methods Patients receiving bifurcation stenting with a planned two-stent approach using EES with OCT follow-up at 3–6 months post-stenting were included in this study. Morphometric analysis of contiguous cross-sections was performed at 1 mm longitudinal intervals within the stented segment. GSI analysis of neointimal regions of interest (ROI) overlying stent ...

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    13. Good neointimal coverage of a crushed stent segment protruding into the main vessel by follow-up optical coherence tomography in a patient with a diagonal branch lesion

      Good neointimal coverage of a crushed stent segment protruding into the main vessel by follow-up optical coherence tomography in a patient with a diagonal branch lesion

      There is currently no consensus regarding the optimum treatment strategy for an isolated side branch lesion . The usefulness of a side branch stenting technique with a balloon crushing the segment protruding into the main vessel has been reported; however, there remain concerns about malapposition of crushed stent struts and a consequent risk of stent thrombosis . We herein report a case with a diagonal branch lesion that was successfully treated with this technique. Follow-up optical coherence tomography clearly revealed that the protruding stent struts in the main vessel were crushed and covered almost completely. Our findings may support the feasibility of ...

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    14. Quantitative assessment of skin swelling using optical coherence tomography

      Quantitative assessment of skin swelling using optical coherence tomography

      Background Preclinical and clinical studies suggest that optical coherence tomography (OCT) is a useful tool to visualize inflammatory conditions. Objective The objective of this study was to evaluate the usefulness of combining OCT and various image processing techniques for quantitative assessment of histamine-induced tissue swelling. Methods Both time-domain and frequency-domain OCT were used on a mouse ear model. The ear thickness and volume before and after histamine challenge were determined from pixel locations in 2D scans and voxel number counting in 3D scans. Swelling kinetics was analyzed on 3D contour mapping. Microvessel network was visualized using speckle decorrelation analysis. Results ...

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    15. Optical coherence tomography angiography in optic nerve sheath meningioma

      Optical coherence tomography angiography in optic nerve sheath meningioma

      This study describes Spectral Domain-Optical Coherence Tomography (SD-OCT) and Optical Coherence Tomography Angiography (OCTA) features of Optic Nerve Sheath Meningioma (ONSM). A 22-year-old woman, diagnosed with meningiom encircling the right optic nerve inside the intraorbital segment optic canal at the magnetic resonance imaging, showed a normal fundus examination. Instead, SD-OCT and OCTA revealed alterations in the neurostructure and microvascular network of the optic nerve. Despite fundoscopy and fluorescein angiography, SD-OCT and OCTA represent valid, non-invasive and reliable methods to evaluate neurostructural and vascular irregularities in this benign tumor of the optic nerve.

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    16. Filigree vascular pattern in Combined Hamartoma of Retina and Retinal Pigment Epithelium on Optical Coherence Tomography Angiography

      Filigree vascular pattern in Combined Hamartoma of Retina and Retinal Pigment Epithelium on Optical Coherence Tomography Angiography

      Objective To evaluate the vascular structure within combined hamartoma of retina and retinal pigment epithelium (CHRRPE) lesions using optical coherence tomography angiography (OCT-A). Design: Multicentre retrospective observational analysis Subjects: 20 eyes of patients diagnosed with CHRRPE Methods Retrospective analysis of color fundus photographs, optical coherence tomography (OCT) and OCT-A of 20 eyes with CHRRPE. Morphological characteristics of CHRRPE and the OCT features were correlated with the density of the filigree vascular pattern and with the published histopathology of CHRRPE. Main Outcome Measure Density of flow signals - “filigree” vascular pattern seen on OCT-A in the deep capillary plexus (DCP), graded as ...

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    17. Retinal layers in Parkinson's disease: A meta-analysis of spectral-domain optical coherence tomography studies

      Retinal layers in Parkinson's disease: A meta-analysis of spectral-domain optical coherence tomography studies

      Background Patients with Parkinson's disease experience visual symptoms , partially originating from retinal changes. Since 2011, multiple case-control studies using spectral-domain OCT, which allows for studying individual retinal layers, have been published. The aim of this study was to substantiate the occurrence, extent, and location of retinal degeneration in Parkinson's by meta-analysis . Methods Spectral-domain OCT case-control data were collected by performing a search in PubMed and Embase with terms: “optical coherence tomography” and “parkinson”, up to November 5th, 2018. Studies with fewer than 10 patients or controls were excluded. We performed a random effects meta-analysis. Heterogeneity was evaluated with ...

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    18. Influence of ezetimibe on plaque morphology in patients with ST Elevation Myocardial Infarction assessed by Optical Coherence Tomography: An OCTIVUS sub-study

      Influence of ezetimibe on plaque morphology in patients with ST Elevation Myocardial Infarction assessed by Optical Coherence Tomography: An OCTIVUS sub-study

      Aims The aim of the trial was to examine the influence of ezetimibe on plaque morphology in patients with ST-segment Elevation Myocardial Infarction (STEMI) with respect to fibrous cap thickness (FCT) and arcs of lipid plaque, calcific plaque, and macrophages using Optical Coherence Tomography (OCT). Methods and results In 87 statin naïve patients with STEMI treated with primary percutaneous intervention, a non-culprit study plaque in a non-infarct related coronary artery was assessed with OCT at baseline and after 12 months. Patients were treated with atorvastatin 80 mg and randomized (1:1) to ezetimibe 10 mg (n = 43) or placebo ...

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    19. Optical coherence tomography-guided balloon pulmonary angioplasty of a web lesion

      Optical coherence tomography-guided balloon pulmonary angioplasty of a web lesion

      We present the case of a 73-year-old woman with a history of pulmonary embolism referred to our department due to suspected pulmonary hypertension . She was in WHO II functional class and the transthoracic echocardiogram showed pulmonary artery systolic pressure of 58 mmHg, with no right ventricular dilatation or dysfunction. Ventilation/perfusion scan after 3 months of oral anticoagulation confirmed the perfusion defects and right heart catheterization confirmed precapillary pulmonary hypertension (mean pulmonary artery pressure 36 mmHg, pulmonary vascular resistance 5.19 Wood units), so a diagnosis of chronic thromboembolic pulmonary hypertension was established. The patient refused pulmonary thromboendarterectomy and vasodilator ...

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    20. Collateral Vessels in Branch Retinal Vein Occlusion: Anatomic and Functional Analyses by Optical Coherence Tomography Angiography

      Collateral Vessels in Branch Retinal Vein Occlusion: Anatomic and Functional Analyses by Optical Coherence Tomography Angiography

      Purpose To anatomically and functionally analyze collateral vessels (CVs) associated with branch retinal vein occlusion (BRVO) using optical coherence tomography angiography (OCTA). Design Retrospective review Participants Twenty-nine consecutive cases with BRVO. Methods The distribution of the CVs 12 months after the onset of BRVO was studied using spectral-domain OCTA. En-face 3×3-mm OCTA images were acquired from nine locations centered on the fovea and used to create a montage image of an 8.1 × 8.1-mm square. The CVs were identified in three separate areas: the radial peripapillary capillary (RPC), superficial capillary plexus (SCP), and deep capillary plexus (DCP) layers ...

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    21. Spectral interferogram prediction in high resolution dual- and multiple-band Fourier domain optical coherence tomography

      Spectral interferogram prediction in high resolution dual- and multiple-band Fourier domain optical coherence tomography

      Using dual-band in Fourier domain optical coherence tomography (FD-OCT) aims at improving resolution. Previous work showed that direct application of Fourier transform to the spectral interferogram with gap between the two bands leads in many cases to resolution poorer than using a single band. In this work we propose an algorithm to fill in the gap in the spectral interferogram based on the linear prediction technique. The results showed that in dual-band FD-OCT we can get resolution equivalent to a continuous band whose width is the sum of the widths of the two bands and plus the width of the ...

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    22. Retinal single-layer analysis with optical coherence tomography (OCT) in schizophrenia spectrum disorder

      Retinal single-layer analysis with optical coherence tomography (OCT) in schizophrenia spectrum disorder

      Background Volume reductions in brain structures of patients with schizophrenia spectrum disorder (SSD) have repeatedly been found in voxel-based morphometry MRI studies. Hence, an underlying neurodegenerative etiological component of SSD is currently being discussed. In recent years, the imaging method of optical coherence tomography (OCT) has shown its potential in evaluating structural changes in the retina in patients with confirmed neurodegenerative disorders, providing a window into the brain. Methods Twenty-six patients with schizophrenia or schizoaffective disorder and 23 age- and sex-matched healthy controls were examined with the Heidelberg Spectralis OCT system to derive a single-layer analysis of both retinas. The ...

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