1. 1-24 of 24
    1. Retinal astrocytic hamartoma: Spectral-domain optical coherence tomography classification and correlation with tuberous sclerosis complex

      Retinal astrocytic hamartoma: Spectral-domain optical coherence tomography classification and correlation with tuberous sclerosis complex

      Retinal astrocytic hamartoma (RAH) is the best-known ocular manifestation of tuberous sclerosis complex (TSC). We classified RAHs using spectral-domain OCT in 86 eyes and correlate each class with systemic manifestations of TSC.

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    2. Analysis of plus disease using handheld spectral-domain optical coherence tomography in nonsedated neonates

      Analysis of plus disease using handheld spectral-domain optical coherence tomography in nonsedated neonates

      Spectral Domain Optical Coherence Tomography (SDOCT) has only recently been explored in neonates with retinopathy of prematurity (ROP). Vessel architecture has not been studied. This study provides an SDOCT analysis of vascular features in plus disease in nonsedated neonates.

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    3. Detection of optic nerve disease in retinoblastoma by use of spectral domain optical coherence tomography

      Detection of optic nerve disease in retinoblastoma by use of spectral domain optical coherence tomography

      We present the case of a child affected with retinoblastoma and evolving optic nerve pathology detected by spectral domain optical coherence tomography (SD-OCT) before magnetic resonance imaging. At 6 months of age, the patient was diagnosed with bilateral retinoblastoma, which was managed with systemic chemotherapy and focal therapy. Six months after the third and final cycle of systemic chemotherapy, the right optic disk clinically appeared progressively edematous, raising concerns of tumor infiltration of the optic nerve head. Images obtained via magnetic resonance imaging could not confirm the presence of a tumor at the optic nerve head, whereas findings on SD-OCT ...

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    4. Spectral domain optical coherence tomography findings in retinal folds associated with posterior microphthalmos

      Spectral domain optical coherence tomography findings in retinal folds associated with posterior microphthalmos

      Posterior microphthalmos is a rare congenital malformation characterized by normal anterior segment dimensions with an abnormally small posterior segment resulting in high hyperopia. Reduced visual acuity in these cases is sometimes caused by the presence of papillomacular retinal folds. We report two cases of posterior microphthalmos in which the papillomacular folds could be visualized on spectral domain optical coherence tomography with sufficient detail to illustrate that only the layers of neural retina within the external limiting membrane were involved.

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    5. Measurement of retinal nerve fiber layer thickness, macular thickness, and foveal volume in amblyopic eyes using spectral-domain optical coherence tomography

      Measurement of retinal nerve fiber layer thickness, macular thickness, and foveal volume in amblyopic eyes using spectral-domain optical coherence tomography

      Although the changes in the anatomy of the visual cortex and lateral geniculate nucleus as the result of amblyopia have been well documented, retinal involvement is still controversial. Time-domain optical coherence tomography with an axial resolution of 10 μm has been used to evaluate retinal and peripapillary tissues in amblyopic eyes with contradictory results. Spectral domain optical coherence tomography has a greater resolution (5–10 μm) and can determine retinal layers more precisely. Our purpose was assess by means of spectral domain optical coherence tomography whether the retinal nerve fiber layer thickness, macular thickness, and foveal volume of the amblyopic ...

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    6. Detection of macular changes by optical coherence tomography after inferior oblique muscle surgery

      Detection of macular changes by optical coherence tomography after inferior oblique muscle surgery
      Purpose: To detect macular changes after inferior oblique muscle myectomy and anterior transposition by the use of 3-dimensional optical coherence tomography (OCT).Methods: Patients who received surgery for correction of horizontal strabismus and weakening of inferior oblique muscle overaction were included. OCT was performed shortly before surgery and again 1 day, 1 week, and 1 month postoperatively.Results: A total of 23 eyes of 16 patients were included. OCT showed no significant macular changes after inferior oblique myectomy or anterior transposition.Conclusions: We documented no harmful effects on the macula after manipulation of the inferior oblique muscle during standard weakening ...
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    7. A morpho-functional study of amblyopic eyes with the use of optical coherence tomography and microperimetry

      A morpho-functional study of amblyopic eyes with the use of optical coherence tomography and microperimetry

      Purpose: To determine whether retinal nerve fiber layer thickness (RNFLT), macular thickness, foveal volume, macular sensitivity, and fixation in patients with amblyopia differ between the amblyopic eye and the fellow eye.Methods: Optical coherence tomography (OCT) and microperimetry (MP-1) were used to evaluate patients with unilateral amblyopia. Patients were divided into 2 groups, those with strabismic amblyopia and those with refractive amblyopia. OCT maps were used to calculate foveal volume, macular thickness, and RNFLT; MP-1 was used to determine macular sensitivity and fixation.Results: A total of 30 patients were included (13 males; mean age 19.7 years [range, 10-38 ...

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    8. Chorioretinal architecture in Aicardi syndrome: An optical coherence tomography and fluorescein angiography study

      Chorioretinal architecture in Aicardi syndrome: An optical coherence tomography and fluorescein angiography study
      Aicardi syndrome is a rare congenital disorder with a classic triad of infantile spasms, chorioretinal lacunae, and agenesis of the corpus callosum. We report the use of fluorescein angiography and spectral domain optical coherence tomography to examine the posterior segment structures in an 8-month-old girl with Aicardi syndrome. Most of the observed features correlated with previously published histopathological findings, but inner nuclear layer cysts have not been previously described. To our knowledge, this is the first study of the tomographic and angiographic chorioretinal features in vivo.
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    9. Longitudinal reproducibility of optical coherence tomography measurements in children

      Longitudinal reproducibility of optical coherence tomography measurements in children
      Introduction: In healthy eyes of children, optical coherence tomography (OCT) measurements of macular and retinal nerve fiber layer (RNFL) thickness are reproducible within the same day and average RNFL has been correlated with axial length (AL). We evaluated longitudinal reproducibility of OCT measurements in children as AL changed.
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    10. Applying newer technology to your practice in pediatric ophthalmology and strabismus

      Applying newer technology to your practice in pediatric ophthalmology and strabismus
      Relevance: Imaging modalities like optical coherence tomography enable us to view and document details of ocular anatomy. These tools which are commonly used by our colleagues in cornea, glaucoma and retina, should be incorporated in the pediatric ophthalmology practice. Posterior segment OCT can be used to objectively monitor children with glaucoma, measure RNFL changes in papilledema or optic atrophy, study foveal morphology in diseases like retinoschisis. Anterior segment OCT can be used to assess anterior chamber depth, measure white-to-white distance, document the thickness of both the ciliary body and lens in children with anterior segment abnormalities. Newer technology now allow ...
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    11. Somewhere over the rainbow

      Somewhere over the rainbow
      The endoscopic management of Barrett’s esophagus associated neoplasia has traditionally been done by using endoscopic imaging with random biopsies, followed later by treatment. Endoscopic, as opposed to surgical, treatment is increasingly becoming the standard of care as evidenced by recent landmark studies on the effectiveness of radiofrequency ablation1 and photodynamic therapy.2 Proper treatment is predicated on accurate detection and precise localization of neoplasia. It has been well-known that routine endoscopic imaging with random biopsy has major limitations. More recently, methods such as high-definition, narrow-band imaging (NBI) have been shown to substantially increase the rate of detection and reduce ...
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    12. Optical coherence tomography in the evaluation of neurofibromatosis type 1 subjects with optic pathway gliomas

      Introduction: Neurofibromatosis type 1 (NF1) is the most common hereditary neurocutaneous disorder and associated with optic pathway gliomas (OPGs) in ∼15% of affected children. OPGs can be difficult to detect on clinical inspection, often requiring neuro-imaging. Optical coherence tomography (OCT) has been shown to be a useful diagnostic technology in several pediatric eye conditions including glaucoma and idiopathic intracranial hypertension. Our prospective case-series evaluates OCT findings of retinal nerve fiber layer (RNFL) loss from optic atrophy due to OPGs in pediatric NF1 subjects.
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    13. Reproducibility of OCT in children with glaucoma

      Introduction: Optical Coherence Tomography(OCT) has been proven to be a useful clinical tool in the follow-up of adult glaucoma(IOVS2008;49:4886-4892.). Its use in pediatric glaucoma is limited because reproducibility has been assessed only in normal children and on the same visit (AJO,2007;143:484–488). This study's purpose is to evaluate the reproducibility of OCT in children with stable glaucoma in a clinical setting.
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    14. Systematic transition to a portable spectral domain optical coherence tomography (SD OCT) handheld system for imaging neonates, infants, and children

      Introduction: Optical coherence tomography (OCT) imaging of the retina and optic nerve is often used in the diagnosis of older children and adults. The purpose of this study was to adapt SD OCT technology for clnical use in infants, taking into account the unique optical characteristic of the infant eye, and customizing SD OCT parameters accordingly.
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    15. Subclinical foveal hypoplasia in normal children detected by OCT

      Introduction: Foveal hypoplasia is usually associated with significant visual dysfunction and an absent foveal reflex on biomicroscopy. Optical coherence tomography(OCT) easily provides accurate images of the foveal anatomy. Among a group of normal children having OCT for the development of a normative database (Arch Ophthalmol 2009;127), we identified a few with underdeveloped foveal architecture despite normal clinical examination. This study's purpose is to characterize the prevalence and features of subclinical foveal hypoplasia in the eyes of normal children.
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    16. Does this child have glaucoma? Applying newer technologies to the diagnosis and management of pediatric glaucoma

      Does this child have glaucoma? Applying newer technologies to the diagnosis and management of pediatric glaucoma. Synopsis: Pediatric glaucoma sometimes presents with clear objective signs that make its diagnosis (though not necessarily its successful treatment!) rather straightforward. Yet at other times, abnormalities of the optic nerve or other features of the child's case raise suspicion of the glaucoma diagnosis but doubt remains. This workshop is intended to review cases of known and suspected glaucoma, with emphasis on newer technologies and thorough discussion of what the ‘experts’ really use to make (or exclude) the diagnosis of pediatric glaucoma. Technologies to ...
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    17. Spectral domain optical coherence tomography for detection of foveal morphology in patients with nystagmus

      Purpose: To evaluate the feasibility of spectral domain optical coherence tomography (SD-OCT) macular scanning as a means of studying the afferent visual system in nystagmus patients.Methods: Nystagmus patients who underwent SD-OCT, clinical evaluation, and eye movement recordings were recruited for this prospective, single-center, noncomparative study. Three SD-OCT macular three-dimensional cube scans per eye (200 × 200 × 1024 samplings in a 6 × 6 mm region) were obtained for qualitative retinal morphology analysis.Results: Nineteen patients (6-68 years; average, 19 years) were analyzed. Of these, 17 patients had infantile nystagmus syndrome, and 2 had fusion maldevelopment nystagmus; 17 patients (89%) had associated ...
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    18. Macular thickness, retinal thickness, and optic disk parameters in dominant compared with nondominant eyes

      Purpose To determine whether differences exist in morphological structures of dominant and nondominant eyes in children ages 6 or 12 years. The following structural features were assessed: axial length, refraction, corneal radius of curvature, and retinal features—measured with the use of optical coherence tomography (OCT)—including macular and retinal nerve fiber layer thickness and optic disk parameters. Methods Of 4,118 children examined from 2003 to 2005 in the Sydney Myopia Study, 3,382 (82.1%) had OCT data for analysis. Comprehensive standardized eye examinations were performed, including best-corrected visual acuity. Ocular dominance was determined using the hole-in-card test ...
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    19. Unilateral amblyopia: An optical coherence tomography study

      Purpose: To determine whether retinal nerve fiber layer thickness (RNFLT), macular thickness (MT), and foveal volume (FV) in patients with unilateral amblyopia differ between the amblyopic and the sound eye.Methods: A Humphrey-Zeiss Stratus (OCT3) with software 4.0.3.1 was used to evaluate 40 patients (17 male, 23 female; mean age, 15.2 years; range, 5–56 years) with unilateral amblyopia. Patients were divided into 2 groups: 20 strabismic and 20 anisometropic. Maps of macular thickness and RNFL thickness (3.46) created by the use of optical coherence tomography were applied to calculate FV and MT and RNFLT ...
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    1-24 of 24
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