1. Articles from iovs.org

  2. 241-264 of 575 « 1 2 ... 8 9 10 11 12 13 14 ... 22 23 24 »
    1. Patterns of Ganglion Cell Complex and Nerve Fiber Layer Loss in Non-Arteritic Ischemic Optic Neuropathy by Fourier-Domain Optical Coherence Tomography

      Patterns of Ganglion Cell Complex and Nerve Fiber Layer Loss in Non-Arteritic Ischemic Optic Neuropathy by Fourier-Domain Optical Coherence Tomography

      Purpose: To characterize by Fourier-domain optical coherence tomography (FD-OCT) the loss of nerve fiber layer (NFL) and ganglion cell complex (GCC) in non-arteritic ischemic optic neuropathy (NAION). Methods: Patients diagnosed with NAION were enrolled and categorized into "superior field loss (SFL)," "inferior field loss (IFL)," and "bihemispheric field loss (BFL)" groups based on the Swedish interactive threshold algorithm 30-2 achromatic visual field (VF) tests. Six months after presentation, they were scanned by FD-OCT to map peripapillary NFL and macular GCC thicknesses. Age-matched normals were selected from participants in the Advanced Imaging for Glaucoma Study (www.AIGStudy.net). Deviation maps were ...

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    2. En face enhanced depth imaging optical coherence tomography of fibrovascular pigment epithelium detachment

      En face enhanced depth imaging optical coherence tomography of fibrovascular pigment epithelium detachment

      Purpose:To analyze the internal structure of fibrovascular pigment epithelial detachment (FV-PED) due to age-related macular degeneration (AMD) using en face enhanced depth imaging (EDI) spectral-domain optical coherence tomography (SD-OCT). Methods:We enrolled 38 consecutive patients presenting to our hospitals with FV-PED due to AMD. Retinal images were automatically obtained with the Spectralis SD-HRA+OCT; the typical inverted 97 sections at 30µm intervals, each comprised of 9 averaged B-scans, were acquired in less than 60 seconds. The resultant images of en face cross-sections of the choroid (C-scans) were compared with indocyanine green angiography (ICGA) images, currently the only technique available ...

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    3. Spectral-Domain Optical Coherence Tomography as a Noninvasive Method to Assess Damaged and Regenerating Adult Zebrafish Retinas

      Spectral-Domain Optical Coherence Tomography as a Noninvasive Method to Assess Damaged and Regenerating Adult Zebrafish Retinas

      Purpose. These experiments assessed the ability of spectral-domain optical coherence tomography (SD-OCT) to accurately represent the structural organization of the adult zebrafish retina and reveal the dynamic morphologic changes during either light-induced damage and regeneration of photoreceptors or ouabain-induced inner retinal damage. Methods. Retinas of control dark-adapted adult albino zebrafish were compared with retinas subjected to 24 hours of constant intense light and recovered for up to 8 weeks or ouabain-damaged retinas that recovered for up to 3 weeks. Images were captured and the measurements of retinal morphology were made by SD-OCT, and then compared with those obtained by histology ...

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      Mentions: Bioptigen
    4. Corneal Topographic Analysis by 3-Dimensional Anterior Segment Optical Coherence Tomography after Endothelial Keratoplasty

      Corneal Topographic Analysis by 3-Dimensional Anterior Segment Optical Coherence Tomography after Endothelial Keratoplasty

      Purpose: To investigate the characteristics of the corneal topography with three-dimensional (3-D) anterior segment optical coherence tomography (AS-OCT) following Descemet stripping automated endothelial keratoplasty (DSAEK). Methods: Thirty-four eyes of 33 patients following DSAEK were studied. In addition to conventional topographic maps, the elevation map of the intrastromal interface and pachymetric maps of the host and graft were obtained by corneal topographic analysis using 3-D AS-OCT. The coefficient of variation of the corneal power (CV-Pa, CV-Pp) and root mean squares of the corneal elevation (RMS-Ea, RMS-Ep) of the anterior and posterior corneal surfaces were determined. Based on the combination of the ...

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      Mentions: Osaka University
    5. The Effects of Peripapillary Atrophy on the Diagnostic Ability of Stratus and Cirrus OCT in the Analysis of Optic Nerve Head Parameters and the Disc Size

      The Effects of Peripapillary Atrophy on the Diagnostic Ability of Stratus and Cirrus OCT in the Analysis of Optic Nerve Head Parameters and the Disc Size

      Purpose: We compared the diagnostic ability of Stratus and Cirrus optical coherence tomography (OCT) in optic nerve head (ONH) analysis, and examined the effects of optic disc size and peripapillary atrophy (PPA) on their diagnostic capacity. Methods: Stratus and Cirrus OCT were performed in 28 control and 78 glaucomatous eyes. ONH parameters and diagnostic capacity calculated from the area under the receiver operating characteristics curve (AUC) were compared between the two modalities. Glaucomatous eyes were classified by optic disc size and the presence/absence of PPA, and their AUCs were compared. Results: Rim area (AUC, 0.936) and rim volume ...

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    6. Biometric evaluation of anterior chamber changes after physiologic pupil dilation using Pentacam and anterior segment optical coherence tomography

      Biometric evaluation of anterior chamber changes after physiologic pupil dilation using Pentacam and anterior segment optical coherence tomography

      Purpose: To evaluate changes in anterior chamber (AC) morphology and iris volume induced by physiological mydriasis in fellow eyes of acute angle-closure patients and age-, sex-, and central AC depth-matched primary angle-closure suspects (PACS). Methods: Twenty-one fellow eyes of acute angle-closure patients and 40 eyes of 40 age-, sex-, and central AC depth-matched PACS were imaged using a Pentacam and anterior segment optical coherence tomography (AS-OCT) under light conditions, and after 5 min of darkness using AS-OCT. Iris volume was estimated using AS-OCT and a customized image-processing software. Results: Central AC depth, corneal curvature, axial length, and lens thickness did ...

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    7. Monitoring Morphological Changes in the Retina of Rhodopsin-/- Mice with Spectral Domain Optical Coherence Tomography

      Monitoring Morphological Changes in the Retina of Rhodopsin-/- Mice with Spectral Domain Optical Coherence Tomography

      Purpose: The rhodopsin-/- C57Bl/6 (rho-/-) mouse is a very important model for understanding retinal degenerative diseases. We used spectral domain optical coherence tomography (SD-OCT) to monitor the dynamic morphological changes in retina of rho-/- mice. Methods: Rho-/- mice and wild type C57Bl/6 (B6) mice at the age of 3, 6, 9 and 12 weeks were investigated using SD-OCT to obtain cross-sectional images of retina. The outer nuclear layer thickness was measured. Histological sections were used to compare with the OCT data. Electroretinograms (ERG) were performed to evaluate the physiological change for establishing the relationship between retinal morphology and ...

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    8. Automated Quantification of Volumetric Optic Disc Swelling in Papilledema Using Spectral-Domain Optical Coherence Tomography

      Automated Quantification of Volumetric Optic Disc Swelling in Papilledema Using Spectral-Domain Optical Coherence Tomography

      Purpose: To develop an automated method for the quantification of volumetric optic disc swelling in papilledema subjects using spectral-domain optical coherence tomography (SD-OCT) and to determine the extent that such volumetric measurements correlate with Frisén scale grades (from fundus photographs) and 2-D peripapillary retinal-nerve-fiber-layer (RNFL) and total-retinal (TR) thickness measurements from SD-OCT. Methods: A custom image-analysis algorithm was developed to obtain peripapillary circular RNFL thickness, TR thickness, and TR volume measurements from SD-OCT volumes of subjects with papilledema. In addition, peripapillary RNFL thickness measures from the commercially available Zeiss SD-OCT machine were obtained. Expert Frisén scale grades were independently obtained ...

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    9. Spatial correlation between hyperpigmentary changes on color fundus photography and hyperreflective foci on SDOCT in intermediate AMD

      Spatial correlation between hyperpigmentary changes on color fundus photography and hyperreflective foci on SDOCT in intermediate AMD

      Purpose: Macular hyperpigmentation is associated with progression from intermediate to advanced age-related macular degeneration (AMD). The purpose of this study was to accurately correlate hyperpigmentary changes with spectral domain optical coherence tomography (SDOCT) hyperreflective foci in eyes with non-advanced AMD. Methods: A prospective cross-sectional analysis of 314 eyes (314 subjects) with intermediate AMD was performed in the multicenter AREDS2 Ancillary SDOCT Study to correlate hyperpigmentary changes on color fundus photographs (CFP) with abnormal morphology on SDOCT. Spatial coregistration was performed with an automated algorithm in 2 non-overlapping subsets of 20 study eyes with double-masked CFP and SDOCT grading by certified ...

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    10. Quantification of retinal neural loss in patients with neuromyelitis optica and multiple sclerosis with or without optic neuritis using optical coherence tomography

      Quantification of retinal neural loss in patients with neuromyelitis optica and multiple sclerosis with or without optic neuritis using optical coherence tomography

      Objective: To compare retinal nerve fiber layer (RNFL) and macular thickness measurements in patients with multiple sclerosis (MS) and neuromyelitis optica (NMO) with or without history of optic neuritis and in controls using Fourier-domain (FD) optical coherence tomography (OCT). Methods: Patients with MS (n=60), NMO (n=33), longitudinal extensive transverse myelitis (LETM) (n=28) and healthy controls (n=41) were submitted to ophthalmic examination, including automated perimetry, and to FD-OCT RNFL and macular thickness measurements. Five groups of eyes were compared: MS with or without previous optic neuritis, NMO, LETM and controls. Correlation between OCT and visual field (VF ...

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    11. Morphologic Analysis in Pathologic Myopia Using High-Penetration Optical Coherence Tomography

      Morphologic Analysis in Pathologic Myopia Using High-Penetration Optical Coherence Tomography

      PURPOSE. To retrospectively evaluate the morphologic choroidal and scleral characteristics in eyes with pathologic myopia using high-penetration optical coherence tomography (HP-OCT). METHODS. The subfoveal choroidal and scleral thicknesses were measured using the prototype HP-OCT with a 1,060-nm light source. We also measured the scleral thickness 3 mm superior, inferior, nasal, and temporal to the fovea on the horizontal and vertical OCT sections. The axial length (AL) in all eyes was measured using optical biometry. RESULTS. Fifty-eight eyes of 35 patients (7 men, 28 women; mean age, 65.5 years) with an AL exceeding 26.5-mm were examined. The mean ...

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    12. Measurement of Optic Disc Size and Rim Area with Spectral-Domain OCT and Scanning Laser Ophthalmoscopy

      Measurement of Optic Disc Size and Rim Area with Spectral-Domain OCT and Scanning Laser Ophthalmoscopy

      Purpose: To compare optic disc and neuroretinal rim area measurements from spectral-domain optical coherence tomography (SD-OCT) to those from confocal scanning laser ophthalmoscopy. Methods: Seventy-one eyes from 43 normal subjects or suspected/definite glaucoma patients were prospectively enrolled. All subjects had biometry with the IOLMaster and disc/retinal nerve fiber layer (RNFL) imaging with Cirrus SD-OCT (Optic Disc Cube 200x200) and Heidelberg Retina Tomograph (HRT). Keratometry-corrected (K-corrected) HRT measurements and uncorrected Cirrus disc and rim areas and disc measurements corrected for eye magnification with Bennett's formula (AL-corrected) along with 30-degree sectoral rim areas, vertical cup-to-disc ratio (VCDR), and cup ...

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    13. Detection of Localized Retinal Nerve Fiber Layer Defects with Posterior Pole Asymmetry Analysis of Spectral-domain Optical Coherence Tomography

      Detection of Localized Retinal Nerve Fiber Layer Defects with Posterior Pole Asymmetry Analysis of Spectral-domain Optical Coherence Tomography

      Purpose:To investigate the diagnostic ability of posterior pole asymmetry analysis (PPAA) with spectral domain optical coherence tomography (Spectralis SD-OCT, Heidelberg Engineering, Heidelberg, Germany) for detecting localized retinal nerve fiber layer (RNFL) defects. Methods:Eighty-four open-angle glaucoma subjects (84 eyes) with localized, wedge-shape RNFL defects by red-free RNFL photography and 122 eyes of normal subjects were enrolled. The subjects were examined by SD-OCT to obtain circumpapillary RNFL (cpRNFL) thickness as well as PPAA. The PPAA provides a corresponding cell to cell comparison between hemispheres within the central 20° and presents the difference using gray scale. Area under the receiver operating ...

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    14. Reproducibility of Macular, Retinal Nerve Fiber Layer and Optic Nerve Head Measurements by Optical Coherence Tomography in Rhesus Monkeys

      Reproducibility of Macular, Retinal Nerve Fiber Layer and Optic Nerve Head Measurements by Optical Coherence Tomography in Rhesus Monkeys

      Purpose. To evaluate repeatability and reproducibility of measurements of the retinal nerve fiber layer thickness (RNFLT), optic nerve head (ONH) and macular inner retinal layer (MIRL) by spectral-domain optical coherence tomography (OCT) (RTVue) in normal Rhesus monkeys. Method. The experimental study included 15 adult rhesus macaque monkeys. RNFLT, ONH parameters (area of disc, cup and rim; volume of cup and rim; cup/disc ratios) and MIRL thickness were imaged at three separate examinations within one month. Each eye was imaged three times at the first examination, and once at each of the two following examinations. We determined the intra-session and ...

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    15. Thickness, phase retardation, birefringence, and reflectance of the retinal nerve fiber layer in normal and glaucomatous non-human primates

      Thickness, phase retardation, birefringence, and reflectance of the retinal nerve fiber layer in normal and glaucomatous non-human primates

      Purpose. Identify candidate markers for early glaucoma diagnosis. Measure time variation of retinal nerve fiber layer (RNFL) thickness, phase retardation, birefringence, and reflectance using polarization sensitive optical coherence tomography (PS-OCT) in three non-human primates with induced glaucoma in one eye. Characterize time variation of RNFL thickness, phase retardation, birefringence, and reflectance with elevated intraocular pressure (IOP). Methods. One eye of each of three non-human primates was laser treated to increase IOP. Each primate was followed for a 30 week period. PS-OCT measurements were recorded at weekly intervals. Reflectance index (RI) is introduced to characterize RNFL reflectance. Associations between elevated IOP ...

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    16. Detection of Glaucoma Progression by Assessment of Segmented Macular Thickness Data Obtained Using Spectral Domain Optical Coherence Tomography

      Detection of Glaucoma Progression by Assessment of Segmented Macular Thickness Data Obtained Using Spectral Domain Optical Coherence Tomography

      Purpose: To evaluate the clinical utility of segmented macular layer thickness measurement in terms of both glaucoma diagnosis and the ability to detect progression, and to compare such outcomes with those by circumpapillary retinal nerve fiber layer (cRNFLT) and total macular thickness (TMT) measurements. Methods: One-hundred-and-forty-one glaucomatous and 61 healthy eyes were included. All glaucomatous eyes were subjected to at least four spectral domain optical coherence tomography (SD-OCT) examinations (mean follow-up; 2.13 years). Segmented macular layers were the macular NFL, GCA (ganglion cell and inner plexiform layer), and outer retinal layer (ORL; from outer plexiform layer to retinal pigment ...

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    17. Long-Term Characterization of Retinal Degeneration in rd1 and rd10 Mice Using Spectral Domain Optical Coherence Tomography

      Long-Term Characterization of Retinal Degeneration in rd1 and rd10 Mice Using Spectral Domain Optical Coherence Tomography

      Purpose. To characterize the in vivo changes over time in the retinal structure of wild-type mice alongside two lines of mice deficient in the ß-subunit of phosphodiesterase (rd1 and rd10 mice) using Spectral Domain Optical Coherence Tomography (SD-OCT). Methods. SD-OCT images were obtained using the Bioptigen Spectral Domain Ophthalmic Imaging System (SDOIS). Wild-type C57BL/6J, rd1 and rd10 mice ranging in age from P14 to P206 were sedated with 1% isoflurane. Horizontal and vertical linear scans through the optic nerve and annular scans around the optic nerve were obtained. Results. SD-OCT imaging of wild-type mice demonstrated visibility of the inner ...

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    18. In Vivo Human Choroidal Vascular Pattern Visualization Using High-Speed Swept-Source Optical Coherence Tomography at 1060 nm

      In Vivo Human Choroidal Vascular Pattern Visualization Using High-Speed Swept-Source Optical Coherence Tomography at 1060 nm

      Purpose. To investigate the retinal and choroidal vascular pattern, structure, and thickness using high-speed, high axial resolution, swept-source optical coherence tomography (SS-OCT) at 1060 nm, demonstrating enhanced penetration through all choroidal layers. Methods. An ophthalmic SS-OCT system was developed operating at 57,000 A-lines/s with 5.9 μm axial resolution and was used to collect 3D images with scanning angles up to ~70° x 35°. The similar features were observed in the choroidal layers by imaging three healthy volunteers. En face images, extracted at different depths, capture features of the retinal and choroidal vasculature networks and substructure. Retinal and ...

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    19. Comparison of Retinal Nerve Fiber Layer Thickness Measurement Bias and Imprecision Across Three Spectral-Domain Optical Coherence Tomography Devices

      Comparison of Retinal Nerve Fiber Layer Thickness Measurement Bias and Imprecision Across Three Spectral-Domain Optical Coherence Tomography Devices

      Purpose: To compare retinal nerve fiber layer (RNFL) bias and imprecision amongst three spectral-domain optical coherence tomographs (SD-OCT). Methods: 152 eyes of 83 subjects (96 healthy and 56 glaucomatous eyes) underwent peripapillary RNFL imaging using at least 2 of the following 3 SD-OCT devices on the same day: Cirrus HD-OCT (optic nerve head (ONH) cube 200x200 protocol), RTVue-100 (ONH protocol (12 radial lines and 13 concentric circles), and 3D OCT-1000 (3D Scan 256x256 protocol). Calibration equations, bias and imprecision of RNFL measurements were calculated using structural equation models. Results: The calibration equations for healthy and glaucoma RNFL thickness measurements among ...

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    20. Assessment of Macular Function for Idiopathic Epiretinal Membranes Classified by Spectral Domain Optical Coherence Tomography

      Assessment of Macular Function for Idiopathic Epiretinal Membranes Classified by Spectral Domain Optical Coherence Tomography

      Purpose: To evaluate the functional changes in various morphologic types of idiopathic epiretinal membrane (ERM) by multifocal electroretinography (mfERG) and spectral domain optical coherence tomography (SD-OCT). Methods: All patients (n=71) with unilateral idiopathic ERM underwent complete ophthalmological examination, including measurements of best-corrected visual acuity (BCVA), SD-OCT, and mfERG for both eyes. To classify idiopathic ERM by subtype, the morphologic characteristics of the foveal area on representative scanned images were assessed. The 5 subtypes by foveal SD-OCT morphology included fovea-attached ERM with outer retinal thickening and minimal inner retinal change (Group 1A), outer retinal inward projection and inner retinal thickening ...

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    21. Agreement of retinal nerve fiber layer color codes between Stratus and Cirrus OCT according to glaucoma severity

      Agreement of retinal nerve fiber layer color codes between Stratus and Cirrus OCT according to glaucoma severity

      Purpose: To assess the agreement of retinal nerve fiber layer (RNFL) color codes between Stratus and Cirrus optical coherence tomography (OCT) according to the glaucoma severity. Methods: A total of 184 eyes from 144 subjects with glaucoma and 40 normal subjects were analyzed. Glaucoma was categorized into three subgroups according to mean deviation of visual field. The agreement of RNFL color code according to the glaucoma severity was assessed using Cohen's kappa value. Red or yellow color codes were defined as abnormal results while green or white were defined as normal. Disagreement frequency of abnormal color code displayed by ...

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    22. Morphometric Analysis of Aqueous Humor Outflow Structures with Spectral Domain Optical Coherence Tomography

      Morphometric Analysis of Aqueous Humor Outflow Structures with Spectral Domain Optical Coherence Tomography

      Purpose: To describe morphometric details of the human aqueous humor (AH) outflow microvasculature visualized with 360 degree virtual castings during active AH outflow in cadaver eyes and comparing these structures with corrosion casting studies. Methods: The conventional AH outflow pathways of donor eyes (N=7) and eyes in vivo (N=3) were imaged with spectral-domain optical coherence tomography (SD-OCT) and wide-bandwidth super luminescent diode array during active AH outflow. Digital image contrast was adjusted to isolate AH microvasculature and images were viewed in a 3D viewer. Additional eyes (N=3) were perfused with mock AH containing fluorescent tracer microspheres to ...

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    23. Factors associated with anterior chamber narrowing with age: an optical coherence tomography study

      Factors associated with anterior chamber narrowing with age: an optical coherence tomography study

      Purpose: To evaluate the effect of age on various anterior segment (AS) parameters in healthy eyes using AS optical coherence tomography (OCT), and to examine their relationship to anterior chamber angle (ACA) narrowing with age. Methods: Three hundred-and-eighty-eight consecutive Korean subjects aged 30 to 89 years were imaged by AS OCT (Visante, version 2.0; Carl Zeiss Meditec, Dublin, CA). Anterior chamber depth (ACD), iris cross-sectional area (IA), iris thickness at 750 and 1,500 microns from the scleral spur (IT750, 1500), iris curvature (IC), lens vault (LV), and anterior chamber area (AA) were determined using Image J software (version ...

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    24. Relationship among visual field, blood flow, and neural structure measurements in glaucoma

      Relationship among visual field, blood flow, and neural structure measurements in glaucoma

      Purpose:To determine the relationship among visual field, neural structural, and blood flow measurements in glaucoma. Methods:Case-control study. Forty-seven eyes of 42 patients with perimetric glaucoma were age-matched with 27 normal eyes of 27 patients. All patients underwent Doppler Fourier-domain optical coherence tomography to measure retinal blood flow and standard glaucoma evaluation with visual field testing and quantitative structural imaging. Linear regression analysis was performed to analyze the relationship among visual field, blood flow, and structure, after all variables were converted to logarithmic decibel scale. Results:Retinal blood flow was reduced in glaucoma eyes compared to normal eyes (p

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