Articles from iovs.org

1. High Resolution Fourier-Domain Optical Coherence Tomography of Choroidal Neovascular Membranes Associated with Age-Related Macular Degeneration

   Explore Article iovs.org (17 hours, 10 min ago) Ophthalmology

   Purpose: To investigate to use of high resolution Fourier-domain optical coherence tomography (Fd-OCT) to image choroidal neovascular membranes (CNVM) associated with exudative age-related macular degeneration (eAMD). Methods: An Fd-OCT instrument with axial resolution of 4 to 4.5 µm and transverse resolution of 10 to 15 µm was used to image 21 eyes (19 subjects) with newly-diagnosed eAMD. A raster series of 100 B-scans separated by 60 µm was used study the growth pattern of CNVM and associated morphologic changes. CNVM size was determined using 250 to 300 serial virtual C-scans of reconstructed 3-dimensional macular volume. Results: A highly reflective subretinal ... (Read Full Article)
   

   Comment on Article Mentions:   UC Davis   Robert J. Zawadzki   Susanna S. Park

2. Macular and Peripapillary Retinal Nerve Fiber Layer Measurements by Spectral Domain Optical Coherence Tomography in Normal-Tension Glaucoma

   Explore Article iovs.org (Feb 26 2010) Ophthalmology

   Purpose. To evaluate and compare the glaucoma discrimination ability of macular inner retinal layer (MIRL) thickness with that of peripapillary retinal nerve fiber layer (pRNFL) thickness measured by spectral-domain optical coherence tomography (RTVue-100; Optovue Inc, Fremont, CA) in patients with normal-tension glaucoma (NTG). Methods. Sixty-five healthy subjects and 102 with NTG were enrolled. MIRL thickness provided by a ganglion cell complex (GCC) scan and two RNFL thicknesses measured by the NHM4 (RNFL1) and RNFL 3.45 (RNFL2) modes of the RTVue-100 system were analyzed. The areas under the receiver operating characteristic curves (AUCs) of MIRL and pRNFL thicknesses for discriminating patients ... (Read Full Article)
   

   Comment on Article Mentions:   Optovue   University of Ulsan   Optovue RTVue-100

3. Effects on Choroidal Neovascularization after Anti-VEGF Upload Using Intravitreal Ranibizumab, as Determined by Spectral Domain-Optical Coherence Tomography

   Explore Article iovs.org (Feb 26 2010) Ophthalmology

   Purpose. It is unclear whether anti-VEGF monotherapy in age-related macular degeneration (AMD) achieves morphologic CNV regression or only stops further CNV growth. In this study, spectral domain-optical coherence tomography (SD-OCT) was used to image CNV structure before and after anti-VEGF treatment. Methods. Out of 107 consecutive patients, a prospective CNV evaluation was possible in 78 of them. Newly diagnosed CNV (classic CNV: n = 16; occult CNV: n = 54; minimal classic CNV: n = 8) due to AMD was imaged before and 4 weeks after anti-VEGF upload in three intravitreal injections of ranibizumab. Qualitative (structural changes) and quantitative measurements ... (Read Full Article)
   

   Comment on Article Mentions:   Reginald Birngruber   University of Lübeck

4. Clinical Assessment of Mirror Artifacts in Spectral Domain Optical Coherence Tomography

   Explore Article iovs.org (Feb 26 2010) Ophthalmology

   Purpose: To investigate the characteristics of a spectral domain Optical Coherence Tomography (SD OCT) image artifact known as the "mirror artifact", calculate its prevalence, analyze potential risk factors, measure severity, and correlate it to spherical equivalent and central visual acuity (VA). Methods: Cirrus HD-OCT Macular Cube 512x128 scans taken between January 2008 and February 2009 at the New England Eye Center were analyzed for the presence of mirror artifacts. Artifact severity was analyzed by the degree of segmentation breakdown that it causes on the macular map. A retrospective medical records review was conducted for patients with artifacts and for a ... (Read Full Article)
   

   Comment on Article Mentions:   University of Pittsburgh   Massachusetts Institute of Technology   James G. Fujimoto

5. Morphologic Photoreceptor Abnormality in Occult Macular Dystrophy on Spectral-Domain Optical Coherence Tomography

   Explore Article iovs.org (Feb 19 2010) Ophthalmology

   Purpose: To investigate morphologic photoreceptor layer abnormalities and its correlation with visual function in occult macular dystrophy (OMD) using spectral-domain optical coherence tomography (SD-OCT). Methods: This was an observational case series including eighteen eyes of nine patients with OMD. All patients underwent an ophthalmologic evaluation, which included a fundus examination, fluorescein angiography, full-field electroretinography (ERG), multifocal ERG, time-domain optical coherence tomography (TD-OCT), and visual field testing. Morphologic photoreceptor layer abnormalities of the retinal layers were investigated with SD-OCT. The structure-function relationship was investigated regarding visual acuity, symptom duration, and multifocal ERG results. Results: Best corrected visual acuities ranged from 20/200 ... (Read Full Article)
   

   Comment on Article Mentions:   Seoul National University

6. Simultaneous measurement of tear film dynamics using wavefront sensor and optical coherence tomography

   Explore Article iovs.org (Feb 19 2010) Ophthalmology

   PURPOSE: To investigate tear film dynamics using simultaneous measurements of ocular aberrations and lower tear meniscus. METHODS: Simultaneous measurements of wavefront aberration and lower tear meniscus were performed for 11 normal eyes and 7 eyes with short tear film break-up time dry eye (SBUT dry eye), which have tear film break-up time shorter than 5 seconds, using a wavefront sensor and an anterior segment optical coherence tomography (OCT). During the measurement, the subjects were instructed to blink every 6 seconds for a total of 30 seconds. From the measured aberration, root mean square (RMS) wavefront error and volume modulation transfer ... (Read Full Article)
   

   Comment on Article Mentions:   University of Rochester

7. Biometry of the Cornea and Anterior Chamber in Chinese Eyes: an Anterior Segment Optical Coherence Tomography Study

   Explore Article iovs.org (Feb 5 2010) Ophthalmology

   Purpose: To investigate the normative data of corneal and anterior segment biometric parameters in Chinese adults and their associations for use in preoperative assessment for corneal and anterior segment surgery. Methods: This cross-sectional, population based study included 750 subjects aged 50 years. The subjects underwent an ophthalmic examination including imaging using anterior segment optical coherence tomography (AS-OCT). Dimensions were subsequently measured with the Zhongshan Assessment Program (ZAP). We also include posterior corneal arc length (PCAL), a novel parameter defined as the arc distance between scleral spurs on the posterior border of the cornea. Correlations with age, gender, height, weight, body ... (Read Full Article)
   

   Comment on Article Mentions:   Singapore Eye Research Institute   Sun Yat-Sen University

8. Cross-sectional Anatomic Configurations of Peripapillary Atrophy Evaluated with Spectral Domain-Optical Coherence Tomography

   Explore Article iovs.org (Jan 19 2010) Ophthalmology

   Purpose. To evaluate the cross-sectional configurations of peripapillary atrophy (PPA)- and -β in ophthalmologically normal subjects using spectral domain-optical coherence tomography (SD-OCT). Methods. One hundred twenty normal subjects had a complete ophthalmic examination including axial length measurement, standard automated perimetry, fundus imaging with photography, and SD-OCT (3D OCT-1000; Topcon Inc., Tokyo, Japan). PPA- and -β were identified in color photographs of the optic disc. Cross-sectional B-mode images of the peripapillary retina and sclera, including PPA- and -β obtained with SD-OCT, were analyzed. Results. Of 120 normal eyes, 120 (100%) had PPA- and 90 (75%) had PPA-β. In OCT images of ... (Read Full Article)
   

   Comment on Article Mentions:   University of Tokyo   Topcon Medical Systems   Topcon 3D OCT-1000

9. Fourier Domain Optical Coherence Tomography as a Noninvasive Means for In Vivo Detection of Retinal Degeneration in Xenopus laevis Tadpoles

   Explore Article iovs.org (Jan 19 2010) Developmental Biology , Ophthalmology

   ose. To determine the efficacy of Fourier domain optical coherence tomography (FD-OCT) as a noninvasive, nonlethal method for detecting in vivo, pathologic signs of retinal degeneration in Xenopus laevis larvae. Methods. A prototype OCT system using FD detection customized for tadpole imaging was used to noninvasively obtain retinal scans in two different transgenic X. laevis models of retinal degeneration. FD-OCT retinal scans were compared with laser scanning confocal micrographs of histologic sections of the same eye. Retinal thickness was measured in the histologic micrographs and compared with in vivo measurements acquired with FD-OCT. Results. In vivo retinal images of X. ... (Read Full Article)
   

   Comment on Article Mentions:   University of British Columbia   Marinko V. Sarunic   Simon Fraser University

10. Optimizing Hand-Held Spectral Domain Optical Coherence Tomography Imaging for Neonates, Infants and Children.

    Explore Article iovs.org (Jan 15 2010) Ophthalmology

    Purpose. To describe age-related considerations and methods to improve hand-held spectral domain optical coherence tomography (HH-SD OCT) imaging of eyes of neonates, infants and children. Methods. Based on calculated optical parameters for neonatal and infant eyes, individualized SD OCT scan parameters were developed for improved imaging in pediatric eyes. Forty-two subjects from 31 weeks post-menstrual age to 1.5 years were imaged with a portable HH-SD OCT system. Images were analyzed for quality, field of scan, magnification and potential clinical utility. Results. The axial length of the premature infant eye increases rapidly in a linear pattern during the neonatal period and ... (Read Full Article)
    

    Comment on Article Mentions:   Joseph A. Izatt   Duke University   Sharon F. Freedman

11. Evaluation of Retinal Nerve Fiber Layer Progression in Glaucoma: A Study on Optical Coherence Tomography Guided Progression Analysis

    Explore Article iovs.org (Jan 5 2010) Ophthalmology

    ose. To evaluate optical coherence tomography (OCT) retinal nerve fiber layer thickness (RNFLT) measurement for glaucoma progression analysis. Methods. One hundred sixteen eyes of 64 patients with glaucoma who were observed within a period of 5 years were included. All eyes had at least four serial RNFL measurements obtained with the Stratus OCT (Carl Zeiss Meditec, Dublin, CA) and with the first and last measurements separated by at least 3 years. Visual field (VF) testing was performed on the same day as RNFL imaging. Serial average RNFLTs were evaluated with guided progression analysis (GPA). VF progression was assessed with trend ... (Read Full Article)
    

    Comment on Article Mentions:   Carl Zeiss Meditec   Chris K. S. Leung   UCSD

12. Blood-retinal-barrier glycerol permeability in diabetic macular oedema and healthy. Estimations from macular volume changes after peroral glycerol.

    Explore Article iovs.org (Jan 4 2010) Ophthalmology

    Purpose: To compare the changes in macular volume (MV) between healthy subjects and patients with diabetic macular oedema (DMO) after an osmotic load and to determine the glycerol permeability (P) of the blood-retinal-barrier (BRB). Methods: Unmasked study. Thirteen patients with DMO and five healthy controls ingested a glycerol solution (0.57 g/mL) of 3 mL/kg body weight (maximum 250 mL). Subsequently, MV of the retinal maps of the Stratus OCT fast retinal thickness protocol, were monitored at 12 time points for 180 min. A mathematical model of glycerol and osmotic water movements across the BRB was constructed to estimate P. Results: ... (Read Full Article)
    

    Comment on Article Mentions:   University of Copenhagen   Zeiss Stratus OCT

13. Correlation of Optical Coherence Tomography and Multifocal Visual-Evoked Potential After Optic Neuritis

    Explore Article iovs.org (Jan 4 2010) Ophthalmology

    Purpose. Acute optic neuritis (ON) is often followed by recovery of visual function. While this recovery is mainly attributed to resolution of acute inflammation, the redistribution of ion channels along the demyelinated membrane and subsequent remyelination, part of this recovery may result from neural plasticity. In the current study we examined the interrelationship between structural (Retinal Nerve Fiber Layer (RNFL) thickness) and functional (amplitude of Multifocal Visual Evoked Potentials (mfVEP)) measures of the integrity of the visual pathway in the post-acute stage of ON with an aim to determine if there was any evidence for an ongoing neural reorganization. Method. ... (Read Full Article)
    

    Comment on Article Mentions:   University of Sydney

14. Comparison of retinal thickness in normal eyes using Stratus and Spectralis Optical Coherence Tomography

    Explore Article iovs.org (Dec 12 2009) Ophthalmology

    Purpose: Spectral-domain OCT (SD-OCT) is an advancement over time-domain OCT (TD-OCT) in the imaging of retinal disorders. The retinal thickness, as measured by SD-OCT (Spectralis) differs from that by TD-OCT (Stratus) as the delineation of outer boundary of the retina differs in the two instruments. The present study aims to evaluate this difference by comparing the macular thickness, as obtained by Stratus and Spectralis OCT in subjects without any known retinal disease. Methods: Thirty-six subjects with no history of any prior retinal disease, normal vision and intraocular pressure were enrolled in the study. Both Stratus and Spectralis OCT scanning were ... (Read Full Article)
    

    Comment on Article Mentions:   Heidelberg Engineering   University of Florida   Carl Zeiss Meditec

15. Multimodal Imaging Including Spectral Domain OCT and Confocal Near Infrared Reflectance for Characterization of Outer Retinal Pathology in Pseudoxanthoma Elasticum

    Explore Article iovs.org (Dec 3 2009) Ophthalmology

    Purpose. To investigate the value of multimodal confocal scanning laser ophthalmoscopy (cSLO) for phenotyping fundus lesions in patients with pseudoxanthoma elasticum (PXE) and to correlate these findings with morphologic alterations detected by spectral domain optical coherence tomography (SD-OCT). Methods. Imaging was performed with a combined SD-OCT-cSLO system (Spectralis HRA-OCT; Heidelberg Engineering, Heidelberg, Germany). OCT scans were placed at locations of interest on near-infrared (NIR) reflectance, fundus autofluorescence (FAF), and fluorescein angiography (FA) images. The instrument allowed for exact topographic correlation of findings on OCT and cSLO images. Results. NIR reflectance imaging showed the highest sensitivity to detect angioid streaks and ... (Read Full Article)
    

    Comment on Article Mentions:   Frank G. Holz   Hendrik P. N. Scholl   Heidelberg Spectralis

16. Detection of Glaucoma Progression with Stratus OCT Retinal Nerve Fiber Layer, Optic Nerve Head, and Macular Thickness Measurements

    Explore Article iovs.org (Dec 3 2009) Ophthalmology

    Purpose. To evaluate and compare the ability of optical coherence tomography (OCT) retinal nerve fiber layer (RNFL), optic nerve head, and macular thickness parameters to detect progressive structural damage in glaucoma. Methods. This observational cohort study included 253 eyes of 253 patients. Images were obtained annually with the Stratus OCT (Carl Zeiss Meditec, Inc., Dublin, CA) along with optic disc stereophotographs and standard automated perimetry (SAP) visual fields. The median follow-up time was 4.01 years. Progression was determined by the Guided Progression Analysis software for SAP (Carl Zeiss Meditec, Inc.) and by masked assessment of optic disc stereophotographs performed by ... (Read Full Article)
    

    Comment on Article Mentions:   UCSD   Robert N. Weinreb   Christopher Bowd

17. Ultra-high Resolution Measurement by Optical Coherence Tomography of Dynamic Tear Film Changes on Contact Lenses

    Explore Article iovs.org (Nov 21 2009) Ophthalmology

    Purpose: To determine the dynamic pre- (PLTF) and post-lens (PoLTF) tear film thicknesses using optical coherence tomography (OCT). Methods: Ultra-high resolution OCT was used to image the tear film of 22 subjects before and after contact lens wear. A soft lens with one drop of artificial tears on its concave surface was inserted onto one randomly selected eye. OCT images were taken before insertion, immediately afterwards, and every 2 minutes for 10 minutes. For the contralateral eye, the lens inserted was not pre-wetted on the concave surface. OCT images were taken before insertion, immediately afterwards, and at 3 minutes. Then ... (Read Full Article)
    

    Comment on Article Mentions:   Shuliang Jiao   Jianhua Wang   Wenzhou Medical College

18. Effects on Choroidal Neovascularizations after Anti-VEGF Upload Using Intravitreal Ranibizumab as Determined by Spectral Domain Optical Coherence Tomography

    Explore Article iovs.org (Oct 31 2009) Ophthalmology

    Purpose: To image CNV structure before and after anti-VEGF treatment using spectral domain optical coherence tomography (SD-OCT). Material and methods: In 78 patients newly diagnosed CNVs (classic CNV: n=16; occult CNV: n=54; minimal classic CNV: n=8) due to AMD were imaged before and 4 weeks after anti-VEGF upload with 3 intravitreal injections of Ranibizumab. Qualitative (structural changes) and quantitative measurements (diameter and thickness) of the CNVs were obtained from the OCT images using the Heidelberg Eye Explorer software. Results: Classic CNV components were observed above the RPE/photoreceptor complex, whereas occult CNVs stayed below. Qualitatively, overall CNV architecture appeared to be ... (Read Full Article)
    

    Comment on Article Mentions:   Reginald Birngruber   University of Lübeck

19. A Comparison of Optic Nerve Head Morphology Viewed by Spectral Domain Optical Coherence Tomography and By Serial Histology

    Explore Article iovs.org (Oct 31 2009) Ophthalmology

    PURPOSE: To compare serial optic nerve head (ONH) histology with interpolated B-scans generated from a three-dimensional (3D) spectral domain OCT (SD-OCT) ONH volume acquired in vivo from the same normal monkey eye. METHODS: A 15°, ONH SD-OCT volume was acquired in a normal monkey eye, with IOP manometrically controlled at 10 mmHg, using the Heidelberg Spectralis. Following perfusion fixation at 10 mmHg, the ONH was trephined, embedded in a paraffin block and serial sagittal sections were cut at 4 µm intervals. The location of each histologic section was identified within the optic disc photograph by matching the position of the ... (Read Full Article)
    

    Comment on Article Mentions:   Devers Eye Institute   Heidelberg Spectralis

20. Photoreceptor inner/outer segment defect imaging by spectral domain OCT and visual prognosis after macular hole surgery

    Explore Article iovs.org (Oct 23 2009) Ophthalmology

    Purpose: To evaluate photoreceptor inner/outer segment (IS/OS) defect parameters using spectral domain optical coherence tomography (SD-OCT) for correlation with visual outcomes in macular hole surgery (MHS). Design: Interventional, retrospective case series. Methods: Twenty-three eyes (23 patients) were examined by SD-OCT before and after (median 2.3 months) anatomically successful MHS. Two formats of OCT were analyzed: linear (raster) and composite (partial fundus image). Factors that might have confounded IS/OS measurements were controlled using weighting and normalization of data. Main outcome measures: Diameter and area of the IS/OS defect, weighted IS/OS area defect, macular density ratio (MDR) healing pattern of macular hole, ... (Read Full Article)
    

    Comment on Article Mentions:   Giovanni Gregori   University of Miami   Korea University

21. Cross-sectional Anatomic Configurations of Peripapillary Atrophy Evaluated with A Spectral-Domain Optical Coherence Tomography

    Explore Article iovs.org (Oct 23 2009) Ophthalmology

    Purpose: To evaluate the cross-sectional configurations of peripapillary atrophy (PPA) and β in ophthalmologically normal subjects using a spectral-domain optical coherence tomography (SD-OCT). Methods: 120 normal subjects had complete ophthalmic examination including axial length measurement, standard automated perimetry, fundus imaging with photography and SD-OCT (3D-OCT1000, Topcon Inc.). PPA- and β were identified from disc color photographs. Cross-sectional B-mode images of the peripapillary retina and sclera, including PPA- and β.obtained with SD-OCT were analyzed. Results: Of 120 normal eyes, 120 (100%) had PPA- and 90 (75%) had PPA-β. In OCT images of the peripapillary retina, the ganglion cell, inner and outer ... (Read Full Article)
    

    Comment on Article Mentions:   Topcon Medical Systems   University of Tokyo   Topcon 3D OCT-1000

22. Diagnostic Comparison between Macular and Peripapillary Retinal Nerve Fiber Layer Measurements by Spectral Domain Optical Coherence Tomography in Normal-Tension Glaucoma

    Explore Article iovs.org (Oct 16 2009) Ophthalmology

    Purpose: To evaluate and compare the glaucoma discrimination ability of macular inner retinal layer (MIRL) thickness with that of peripapillary retinal nerve fiber layer (pRNFL) thickness measured by spectral-domain optical coherence tomography (RTVue-100) in normal-tension glaucoma (NTG) patients. Methods: Sixty-five healthy and 102 NTG subjects were enrolled. MIRL thickness provided by Ganglion Cell Complex (GCC) scan and two RNFL thickness measured by the NHM4 (RNFL1) and RNFL 3.45 (RNFL2) modes were analyzed. The areas under the receiver operating characteristic curves (AUCs) of MIRL and pRNFL thicknesses, for discriminating NTG patients from controls, were determined. The AUCs were compared between patients ... (Read Full Article)
    

    Comment on Article Mentions:   University of Ulsan   Optovue RTVue-100   Sung Yong Kang

23. Detection of Glaucoma Progression using Stratus OCT Retinal Nerve Fiber Layer, Optic Nerve Head and Macular Thickness Measurements

    Explore Article iovs.org (Oct 11 2009) Ophthalmology

    Purpose: To evaluate and compare the ability of optical coherence tomography (OCT) retinal nerve fiber layer (RNFL), optic nerve head and macular thickness parameters to detect progressive structural damage in glaucoma. Methods: This was an observational cohort study that included 253 eyes of 253 patients. Images were obtained annually with the Stratus OCT, along with optic disc stereophotographs and standard automated perimetry (SAP) visual fields. The median follow-up time was 4.01 years. Progression was determined by the Guided Progression Analysis software for SAP and by masked assessment of optic disc stereophotographs performed by expert graders. Random coefficient models and receiver ... (Read Full Article)
    

    Comment on Article Mentions:   UCSD   Robert N. Weinreb   Christopher Bowd

24. Imaging of the retinal pigment epithelium in age-related macular degeneration using polarization sensitive optical coherence tomography

    Explore Article iovs.org (Oct 3 2009) Ophthalmology

    Purpose: Spectral-domain optical coherence tomography (SD-OCT) provided new insights into the understanding of age-related macular degeneration (AMD) but provides limited information on the nature of hyperreflective tissue at the level of the retinal pigment epithelium (RPE). Therefore, a polarization-sensitive SD-OCT (PS-SD-OCT) was used to identify and characterize typical RPE-findings in AMD. Methods: 44 eyes of 44 AMD-patients were included into this prospective case series representing the entire AMD-spectrum from drusen (n=11), geographic atrophy (GA, n=11), neovascular AMD (nAMD, n=11) to fibrotic scars (n=11). Cirrus (Carl-Zeiss-Meditec), Spectralis (Heidelberg) and 3D-OCT-1000 (Topcon) were used for comparative imaging. A PS-SD-OCT instrument was developed ... (Read Full Article)
    

    Comment on Article Mentions:   Christoph K. Hitzenberger   Michael Pircher   Medical University of Vienna

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