1. Articles from iovs.org

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    1. Repeatability of peripapillary retinal nerve fiber layer and inner retinal thickness among 2 spectral domain optical coherence tomography devices

      Repeatability of peripapillary retinal nerve fiber layer and inner retinal thickness among 2 spectral domain optical coherence tomography devices

      PURPOSE. To compare measurement of macular inner retina and peripapillary retinal nerve fiber layer (pRNFL) thickness using 2 spectral-domain optical coherence tomography (OCT) devices in glaucoma patients, patients with ocular hypertension, idiopathic and atypical Parkinson's disease and healthy controls. METHODS. One-hundred seventy-one eyes of 146 participants underwent successful pRNFL and macular scanning and automated measurement of ganglion cell layer + inner plexiform layer (GCL-IPL) using Cirrus® HD-OCT or retinal nerve fiber layer + ganglion cell layer + inner plexiform layer (RNFL-GCL-IPL) using RTVue-100®. Macular RNFL was added to the GCL-IPL thickness measured by Cirrus and was compared to the RNFL-GCL-IPL thickness of ...

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    2. In Vivo Three-Dimensional Characterization of the Healthy Human Lamina Cribrosa with Adaptive Optics Spectral-Domain Optical Coherence Tomography

      In Vivo Three-Dimensional Characterization of the Healthy Human Lamina Cribrosa with Adaptive Optics Spectral-Domain Optical Coherence Tomography

      Purpose: To characterize the in vivo 3D lamina cribrosa (LC) microarchitecture of healthy eyes using adaptive optics spectral-domain optical coherence tomography (AO-SDOCT). Methods: One randomly selected eye from each of 18 healthy subjects was scanned with Cirrus HD-OCT and AO-SDOCT centered on the optic nerve head. LC microarchitecture, imaged by the later device, was semi-automatically segmented and quantified for connective tissue volume fraction (CTVF), beam thickness, pore diameter, pore area and pore aspect ratio. The LC was assessed in central and peripheral regions of equal areas, quadrants and with depth. A linear mixed-effects model weighted by the fraction of visible ...

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    3. Retinal Regeneration Following OCT-guided Laser Injury in Zebrafish

      Retinal Regeneration Following OCT-guided Laser Injury in Zebrafish

      Purpose: Establish a focal injury/regeneration model in zebrafish using laser photocoagulation guided by optical coherence tomography (OCT). Methods: Adult zebrafish were imaged by OCT and confocal scanning laser ophthalmoscopy (cSLO) in room air through a contact lens. Using a beam combiner, 532nm laser photocoagulation was applied using the OCT C-scan image for targeting. Laser spots of 42-47mW were delivered to the retina. At multiple intervals post-injury, fish were imaged using both OCT and cSLO to follow the progression of each lesion. Histologic sections and TUNEL staining were performed to monitor the injury response. Results: Round lesions (26057 ± 621μm2 ...

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    4. Age-related Differences in Longitudinal Structural Change by Spectral Domain Optical Coherence Tomography in Early Experimental Glaucoma

      Age-related Differences in Longitudinal Structural Change by Spectral Domain Optical Coherence Tomography in Early Experimental Glaucoma

      Purpose. To characterize age-related differences in the magnitude of Spectral Domain Optical Coherence Tomography (SDOCT) structural change in early experimental glaucoma (EG). Methods. Both eyes from 4 young (1.4 - 2.6 yrs) and 4 old (18.6 - 21.9 yrs) rhesus monkeys were imaged at least 3 times at baseline, and then every 2 weeks following laser-induced, chronic, unilateral IOP elevation until the onset of EG (Confocal Scanning Laser Tomographic surface change confirmed twice). Two to 20 weeks after EG onset, animals were sacrificed and optic nerve axon counts for all eyes were performed. Masked operators delineated retinal and ...

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    5. Retinal Layer Measurements After Successful Macula-off Retinal Detachment Repair using OCT

      Retinal Layer Measurements After Successful Macula-off Retinal Detachment Repair using OCT

      Purpose: Optical coherence tomography (OCT) was used to analyze the thickness of various retinal layers of patients following successful macula-off retinal detachment (RD) repair. Methods: OCT scans of patients after successful macula-off RD repair were re-analyzed with a sub-segmentation algorithm to measure various retinal layers. Regression analysis was performed to correlate time after surgery with changes in layer thickness. In addition, patients were divided in two groups. Group 1 had a follow up period after surgery of up to 7 weeks (range 21 to 49 days). In group 2 the follow up was > 8 weeks (range 60 to 438 days ...

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    6. Prognostic value of multi-focal electroretinography and optical coherence tomography in eyes undergoing pan-retinal photocoagulation for diabetic retinopathy

      Prognostic value of multi-focal electroretinography and optical coherence tomography in eyes undergoing pan-retinal photocoagulation for diabetic retinopathy

      Purpose: To investigate the prognostic utility on visual acuity of multi-focal electroretinography (mfERG) and optical coherence tomography (OCT) in diabetic eyes receiving pan-retinal photocoagulation (PRP). Methods: Patients with severe non-proliferative diabetic retinopathy (NPDR) or early proliferative diabetic retinopathy (PDR) who needed PRP were included in this study. MfERG and OCT data were recorded before PRP, while the final best corrected visual acuity (BCVA) was recorded at 6 months following PRP. The correlation between pre-PRP data and post-PRP BCVA was analyzed using Pearson's correlation analysis and multivariate linear regression analysis. Results: Among the 42 eyes included, 31 eyes (73.8 ...

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      Mentions: Fudan University
    7. Automated volumetric analysis of interface fluid in Descemet stripping automated endothelial keratoplasty utilizing intraoperative optical coherence tomography

      Automated volumetric analysis of interface fluid in Descemet stripping automated endothelial keratoplasty utilizing intraoperative optical coherence tomography

      Purpose: To demonstrate a novel automated algorithm for segmentation of intraoperative optical coherence tomography (iOCT) imaging of fluid interface gap in Descemet stripping automated endothelial keratoplasty (DSAEK) and to evaluate the effect of intraoperative maneuvers to promote graft apposition on interface dimensions. Methods: 30 eyes of 29 patients from the anterior segment arm of the PIONEER study were included in this analysis. iOCT scans were entered into an automated algorithm which delineated the spatial extent of the fluid interface gap in three dimensions between donor and host cornea during surgery. The algorithm was validated against manual segmentation and performance was ...

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    8. Ganglion Cell-Inner Plexiform Layer Thickness of High Definition Optical Coherence Tomography in Perimetric and Preperimetric Glaucoma

      Ganglion Cell-Inner Plexiform Layer Thickness of High Definition Optical Coherence Tomography in Perimetric and Preperimetric Glaucoma

      Purpose. We determined the diagnostic performance of ganglion cell-inner plexiform layer (GCIPL) parameters of high definition optical coherence tomography (HD-OCT) in perimetric and preperimetric glaucoma, and compared it to optic nerve head (ONH) and peripapillary retinal nerve fiber layer (RNFL) parameters. Methods. In a cross-sectional study, 53 eyes of normal subjects and 83 eyes of glaucoma patients (62 perimetric and 21 preperimetric) from the Longitudinal Glaucoma Evaluation Study (LOGES) underwent HD-OCT imaging with Optic Disc and Macular Cube protocols. Diagnostic abilities of GCIPL, ONH, and RNFL parameters were determined using area under receiver operating characteristic curves (AUC) and likelihood ratios ...

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    9. Noninvasive Evaluation of Phase Retardation in Blebs after Glaucoma Surgery Using Anterior Segment Polarization-Sensitive Optical Coherence Tomography

      Noninvasive Evaluation of Phase Retardation in Blebs after Glaucoma Surgery Using Anterior Segment Polarization-Sensitive Optical Coherence Tomography

      Purpose: Evaluation of bleb morphology using anterior segment optical coherence tomography (OCT) can offer important information regarding bleb function after glaucoma surgery. However, analysis of tissue properties, such as scar fibrosis of blebs, is difficult with conventional OCT. The birefringence of the blebs as susceptible measure of fibrosis scar was evaluated using polarization-sensitive OCT (PS-OCT) and its relation with bleb function was assessed. Methods: One hundred and fifty-three blebs of 122 patients that had undergone trabeculectomy or an Ex-Press tube shunt were examined. Also, in 14 blebs of 12 patients, consecutive measurements were performed for 2 months after surgery. The ...

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    10. Simultaneous Investigation of Vascular and Retinal Pigment Epithelial Pathologies of Exudative Macular Diseases by Multi-Functional Optical Coherence Tomography

      Simultaneous Investigation of Vascular and Retinal Pigment Epithelial Pathologies of Exudative Macular Diseases by Multi-Functional Optical Coherence Tomography

      Purpose: To investigate exudative macular disease, multi-functional optical coherence tomography (MF-OCT) using a 1-μm probe band was developed. The clinical utility of MF-OCT was examined in a descriptive case series. Methods: Ten eyes of nine subjects with exudative macular disease, including one eye with age-related macular degeneration (AMD), one eye with idiopathic neovascular maculopathy, and eight eyes with polypoidal choroidal vasculopathy (PCV), were investigated. Areas of 6 × 6 mm 2 around the pathologic region were scanned with 512 × 1024 depth scans in 6.6 seconds. Structural OCT, Doppler optical coherence angiography (OCA) and cumulative phase retardation images were obtained ...

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    11. Measurement of Subfoveal Choroidal Thickness after Cataract Surgery in Enhanced Depth Imaging Optical Coherence Tomography

      Measurement of Subfoveal Choroidal Thickness after Cataract Surgery in Enhanced Depth Imaging Optical Coherence Tomography

      Purpose:To compare Subfoveal Choroidal Thickness (SFCT) before and after unenventful cataract surgery using Enhanced Depth Imaging Optical Coherence Tomography (EDI OCT). Methods:A prospective study was conducted on 115 eyes of 95 patients who had phacoemulsification. Measurements of SFCT were performed preoperatively and one day (D1), seven days (D7), one month (M1) and three months (M3) after surgery using the EDI OCT technique. Central Retinal Thickness (CRT) was measured before surgery and at M1 and M3. Results:The 95 patients had a mean age of 76±8.3 years. The mean SFCT at baseline was 224±75μm. It ...

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    12. Age-Related Changes in Human Corneal Epithelial Thickness Measured with Anterior Segment Optical Coherence Tomography

      Age-Related Changes in Human Corneal Epithelial Thickness Measured with Anterior Segment Optical Coherence Tomography

      Purpose: To measure corneal and limbal epithelial thickness (ET) in normal subjects and to evaluate its variation with age by using anterior segment optical coherence tomography (AS-OCT). Methods: 180 normal subjects (180 healthy eyes) were enrolled and divided into four groups according to age: A (0-20 years), B (21-40 years), C (41-60 years), D (>60 years). Cornea and limbus were imaged with OCT. Corneal ET (CET) was obtained automatically by the built-in analysis software of the OCT system. Limbal ET (LET) in four quadrants was manually measured from OCT images. Results: CET of central 2-mm diameter zone in groups A ...

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    13. Vitamin D and macular thickness in the elderly: an Optical Coherence Tomography study

      Vitamin D and macular thickness in the elderly: an Optical Coherence Tomography study

      Purpose. Vitamin D insufficiency is associated with age-related macular degeneration. Our objective was to determine whether low serum 25-hydroxyvitamin D (25OHD) concentration was associated with macular thickness among older adults with no signs of macular dysfunction. Methods. Sixty-two French older community-dwellers with no patent macular dysfunction (mean±standard deviation, 71.2±5.0years; 45.2% female) included in the GAIT study (ClinicalTrials.gov number, NCT01315717) were separated into 2 groups according to serum 25OHD level (i.e., insufficient<50nmol/L or sufficient≥50nmol/L). The macular thickness was measured on 1000µm central macula with optical coherence tomography, and further ...

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    14. Relationship between Visual Acuity and Retinal Structures Measured by Spectral Domain Optical Coherence Tomography in Patients with Open Angle Glaucoma

      Relationship between Visual Acuity and Retinal Structures Measured by Spectral Domain Optical Coherence Tomography in Patients with Open Angle Glaucoma

      Purpose: To assess the relationship between retinal structures measured by spectral-domain optical coherence tomography (OCT) and visual acuity in open-angle glaucoma (OAG) patients. Methods: In this cross-sectional observational study, 186 eyes from 186 OAG patients were included. The participants underwent RTVue OCT for measurement of circumpapillary retinal nerve fiber layer (cpRNFL) thickness and macular ganglion cell complex (mGCC) thickness. The correlations between best-corrected visual acuity (BCVA) and OCT parameters were evaluated using Pearson's partial correlation test and regression analysis. Receiver operating characteristic (ROC) curve analysis was performed to obtain a cutoff value for OCT parameters in detecting decreased visual ...

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    15. Retinal Topography of Myopic Eyes: A Spectral-Domain Optical Coherence Tomography Study

      Retinal Topography of Myopic Eyes: A Spectral-Domain Optical Coherence Tomography Study

      Purpose. The purpose of this study was to investigate topographic characteristics of the retina in myopic eyes. Methods. We reviewed spectral-domain optical coherence tomography (SD-OCT) images of patients with myopia retrospectively. Retinal topography (RT) was defined as the topography of the retinal pigment epithelium layers. Retinal topographies were classified into several types, and the distribution and characteristics of each type were assessed in eyes with varying degrees of axial length (AL). Results. A total of 167 subjects with myopia were included in this study. Seventy eyes (41.9%) were classified as regular (R) type, 48 (28.7%) were wave (W ...

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      Mentions: Korea University
    16. The detection of macular analysis by SD-OCT for optic chiasmal compression neuropathy and nasotemporal overlap

      The detection of macular analysis by SD-OCT for optic chiasmal compression neuropathy and nasotemporal overlap

      Purposes: To assess the diagnostic performance of the macular parameters detected by spectral domain-optical coherence tomography (SD-OCT) in band atrophy (BA) eyes. Methods: Forty-nine BA eyes with permanent temporal hemianopia and 89 normal eyes were enrolled. Any patients who had nasal visual field loss were excluded. Each participant was imaged by 3D OCT-2000, and 10×10 grids in the macula were automatically allocated. The thickness of the macular retinal nerve fiber layer (mRNFL), ganglion cell layer (GCL)+ (GCL+inner plexiform layer (IPL)), and GCL++ thickness (RNFL+GCL+IPL) in both nasal and temporal hemiretina were calculated and compared between the ...

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    17. Spectral-Domain Optical Coherence Tomography Study on Dynamic Changes of Human Tears after Instillation of Artificial Tears

      Spectral-Domain Optical Coherence Tomography Study on Dynamic Changes of Human Tears after Instillation of Artificial Tears

      Purpose: To analyze in vivo the dynamic changes induced by different artificial tears (ATs) in the precorneal tear film (PCTF) and lower tear meniscus (LTM) by using a Spectral-domain anterior segment optical coherence tomography (SD-OCT). Methods: We prospectively examined forty-two normal human eyes by using SD-OCT imaging. On the day before OCT imaging, all enrolled subjects were evaluated for abnormalities of ocular surface. All tear film images were obtained before and after instillation of three different types of ATs (mucomimetic, lipid-based and saline) in five serial scans: immediately (within 30 seconds), at the 1st, at the 5th, at the 10th ...

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    18. Choroidal Structure in Normal Eyes and After Photodynamic Therapy Determined by Binarization of Optical Coherence Tomographic Images

      Choroidal Structure in Normal Eyes and After Photodynamic Therapy Determined by Binarization of Optical Coherence Tomographic Images

      Purpose. To determine changes in choroidal structure by binarization of optical coherence tomographic (OCT) images. Methods. Choroidal images were recorded by enhanced depth imaging OCT. The subfoveal choroidal images were analyzed, and the luminal and interstitial areas were converted to binary images by the Niblack method. The interrater, intrarater, and intersession agreements of the binary images were determined for healthy eyes. In eyes with age-related macular degeneration (AMD), the binary images of the choroid before photodynamic therapy (PDT) were compared to those after PDT. The untreated fellow eyes were studied as controls. Results. In healthy eyes, the average ratio of ...

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      Mentions: Taiji Sakamoto
    19. Retinal topography of myopic eyes: A spectral domain optical coherence tomography study

      Retinal topography of myopic eyes: A spectral domain optical coherence tomography study

      Purpose:The purpose of this study was to investigate topographic characteristics of the retina in myopic eyes. Methods:We reviewed spectral domain optical coherence tomography (SD-OCT) images of patients with myopia retrospectively. Retinal topography (RT) was defined as the topography of the retinal pigment epithelium layers. RTs were classified into several types, and the distribution and characteristics of each type were assessed in eyes with varying degrees of axial length (AL). Results:A total of 167 subjects with myopia were included in this study. Seventy eyes (41.9%) were classified as regular (R) type, 48 (28.7%) were wave (W ...

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      Mentions: Korea University
    20. Reproducibility of anterior chamber angle analyses with the Swept Source Optical Coherence Tomography in young, healthy Caucasians

      Reproducibility of anterior chamber angle analyses with the Swept Source Optical Coherence Tomography in young, healthy Caucasians

      Purpose: To assess the reproducibility of iridocorneal angle (ICA) analysis in young, healthy Caucasian subjects using swept-source optical coherence tomography (SS-OCT) by determining variability and inter-observer agreement between expert and non-expert observers. Methods: Thirty-one healthy volunteers (non-experts) acquired 3 consecutive SS-OCT images of the right eyes of their peer non-experts. Images were analyzed by 31 non-experts and additionally by 3 experts, whereby the angle opening distance (AOD) and the trabecular iris space area (TISA) at 500µm and 750µm were calculated. A random intercept model was used to determine the amount of variation between observers. In addition, the intra-observer ...

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    21. Microcysts in the Inner Nuclear Layer, a Nonspecific SD-OCT Sign of Cystoid Macular Edema

      Microcysts in the Inner Nuclear Layer, a Nonspecific SD-OCT Sign of Cystoid Macular Edema

      Recently, many authors have propagated the notion that a specific form of “microcystic macular edema” occurs in patients with optic neuritis and optic atrophy of various etiology and is due to retrograde synaptic degeneration. The finding is isolated to the inner nuclear layer on spectral-domain optical coherence tomography in most cases, and is present in a parafoveal, circumferential, and central macular distribution. This perspective critically reviews the evidence and suggests that inner nuclear layer cystoid changes are an early and nonspecific indicator of typical cystoid macular edema of any cause, and that the finding is likely not a distinct entity.

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    22. Macular choroidal thickness profile in a healthy population measured by Swept-Source Optical Coherence Tomography

      Macular choroidal thickness profile in a healthy population measured by Swept-Source Optical Coherence Tomography

      Purpose: To determine choroidal thickness (CT) profile in a healthy population using swept-source optical coherence tomography (SS-OCT). Methods: Cross-sectional, non-interventional study. 276 eyes (spherical equivalent ±3D) were scanned with SS-OCT (Topcon Corporation, Japan). Horizontal CT profile of the macula was created measuring subfoveal CT (SFCT) from the posterior edge of retinal pigment epithelium (RPE) to the choroid/sclera junction. Three determinations were performed at successive points 1000 μm nasal and five more temporal to the fovea. Subjects were divided into five age groups. Results: The mean SFCT was 301.89±80.53 μm (95% confidence interval: 292.34 to 311 ...

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    1-24 of 562 1 2 3 4 ... 22 23 24 »
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