1. Articles from iovs.org

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    1. Prognostic value of multi-focal electroretinography and optical coherence tomography in eyes undergoing pan-retinal photocoagulation for diabetic retinopathy

      Prognostic value of multi-focal electroretinography and optical coherence tomography in eyes undergoing pan-retinal photocoagulation for diabetic retinopathy

      Purpose: To investigate the prognostic utility on visual acuity of multi-focal electroretinography (mfERG) and optical coherence tomography (OCT) in diabetic eyes receiving pan-retinal photocoagulation (PRP). Methods: Patients with severe non-proliferative diabetic retinopathy (NPDR) or early proliferative diabetic retinopathy (PDR) who needed PRP were included in this study. MfERG and OCT data were recorded before PRP, while the final best corrected visual acuity (BCVA) was recorded at 6 months following PRP. The correlation between pre-PRP data and post-PRP BCVA was analyzed using Pearson's correlation analysis and multivariate linear regression analysis. Results: Among the 42 eyes included, 31 eyes (73.8 ...

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      Mentions: Fudan University
    2. Automated volumetric analysis of interface fluid in Descemet stripping automated endothelial keratoplasty utilizing intraoperative optical coherence tomography

      Automated volumetric analysis of interface fluid in Descemet stripping automated endothelial keratoplasty utilizing intraoperative optical coherence tomography

      Purpose: To demonstrate a novel automated algorithm for segmentation of intraoperative optical coherence tomography (iOCT) imaging of fluid interface gap in Descemet stripping automated endothelial keratoplasty (DSAEK) and to evaluate the effect of intraoperative maneuvers to promote graft apposition on interface dimensions. Methods: 30 eyes of 29 patients from the anterior segment arm of the PIONEER study were included in this analysis. iOCT scans were entered into an automated algorithm which delineated the spatial extent of the fluid interface gap in three dimensions between donor and host cornea during surgery. The algorithm was validated against manual segmentation and performance was ...

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    3. Noninvasive Evaluation of Phase Retardation in Blebs after Glaucoma Surgery Using Anterior Segment Polarization-Sensitive Optical Coherence Tomography

      Noninvasive Evaluation of Phase Retardation in Blebs after Glaucoma Surgery Using Anterior Segment Polarization-Sensitive Optical Coherence Tomography

      Purpose: Evaluation of bleb morphology using anterior segment optical coherence tomography (OCT) can offer important information regarding bleb function after glaucoma surgery. However, analysis of tissue properties, such as scar fibrosis of blebs, is difficult with conventional OCT. The birefringence of the blebs as susceptible measure of fibrosis scar was evaluated using polarization-sensitive OCT (PS-OCT) and its relation with bleb function was assessed. Methods: One hundred and fifty-three blebs of 122 patients that had undergone trabeculectomy or an Ex-Press tube shunt were examined. Also, in 14 blebs of 12 patients, consecutive measurements were performed for 2 months after surgery. The ...

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    4. Simultaneous Investigation of Vascular and Retinal Pigment Epithelial Pathologies of Exudative Macular Diseases by Multi-Functional Optical Coherence Tomography

      Simultaneous Investigation of Vascular and Retinal Pigment Epithelial Pathologies of Exudative Macular Diseases by Multi-Functional Optical Coherence Tomography

      Purpose: To investigate exudative macular disease, multi-functional optical coherence tomography (MF-OCT) using a 1-μm probe band was developed. The clinical utility of MF-OCT was examined in a descriptive case series. Methods: Ten eyes of nine subjects with exudative macular disease, including one eye with age-related macular degeneration (AMD), one eye with idiopathic neovascular maculopathy, and eight eyes with polypoidal choroidal vasculopathy (PCV), were investigated. Areas of 6 × 6 mm 2 around the pathologic region were scanned with 512 × 1024 depth scans in 6.6 seconds. Structural OCT, Doppler optical coherence angiography (OCA) and cumulative phase retardation images were obtained ...

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    5. Measurement of Subfoveal Choroidal Thickness after Cataract Surgery in Enhanced Depth Imaging Optical Coherence Tomography

      Measurement of Subfoveal Choroidal Thickness after Cataract Surgery in Enhanced Depth Imaging Optical Coherence Tomography

      Purpose:To compare Subfoveal Choroidal Thickness (SFCT) before and after unenventful cataract surgery using Enhanced Depth Imaging Optical Coherence Tomography (EDI OCT). Methods:A prospective study was conducted on 115 eyes of 95 patients who had phacoemulsification. Measurements of SFCT were performed preoperatively and one day (D1), seven days (D7), one month (M1) and three months (M3) after surgery using the EDI OCT technique. Central Retinal Thickness (CRT) was measured before surgery and at M1 and M3. Results:The 95 patients had a mean age of 76±8.3 years. The mean SFCT at baseline was 224±75μm. It ...

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    6. Age-Related Changes in Human Corneal Epithelial Thickness Measured with Anterior Segment Optical Coherence Tomography

      Age-Related Changes in Human Corneal Epithelial Thickness Measured with Anterior Segment Optical Coherence Tomography

      Purpose: To measure corneal and limbal epithelial thickness (ET) in normal subjects and to evaluate its variation with age by using anterior segment optical coherence tomography (AS-OCT). Methods: 180 normal subjects (180 healthy eyes) were enrolled and divided into four groups according to age: A (0-20 years), B (21-40 years), C (41-60 years), D (>60 years). Cornea and limbus were imaged with OCT. Corneal ET (CET) was obtained automatically by the built-in analysis software of the OCT system. Limbal ET (LET) in four quadrants was manually measured from OCT images. Results: CET of central 2-mm diameter zone in groups A ...

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    7. Vitamin D and macular thickness in the elderly: an Optical Coherence Tomography study

      Vitamin D and macular thickness in the elderly: an Optical Coherence Tomography study

      Purpose. Vitamin D insufficiency is associated with age-related macular degeneration. Our objective was to determine whether low serum 25-hydroxyvitamin D (25OHD) concentration was associated with macular thickness among older adults with no signs of macular dysfunction. Methods. Sixty-two French older community-dwellers with no patent macular dysfunction (mean±standard deviation, 71.2±5.0years; 45.2% female) included in the GAIT study (ClinicalTrials.gov number, NCT01315717) were separated into 2 groups according to serum 25OHD level (i.e., insufficient<50nmol/L or sufficient≥50nmol/L). The macular thickness was measured on 1000µm central macula with optical coherence tomography, and further ...

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    8. Relationship between Visual Acuity and Retinal Structures Measured by Spectral Domain Optical Coherence Tomography in Patients with Open Angle Glaucoma

      Relationship between Visual Acuity and Retinal Structures Measured by Spectral Domain Optical Coherence Tomography in Patients with Open Angle Glaucoma

      Purpose: To assess the relationship between retinal structures measured by spectral-domain optical coherence tomography (OCT) and visual acuity in open-angle glaucoma (OAG) patients. Methods: In this cross-sectional observational study, 186 eyes from 186 OAG patients were included. The participants underwent RTVue OCT for measurement of circumpapillary retinal nerve fiber layer (cpRNFL) thickness and macular ganglion cell complex (mGCC) thickness. The correlations between best-corrected visual acuity (BCVA) and OCT parameters were evaluated using Pearson's partial correlation test and regression analysis. Receiver operating characteristic (ROC) curve analysis was performed to obtain a cutoff value for OCT parameters in detecting decreased visual ...

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    9. Retinal Topography of Myopic Eyes: A Spectral-Domain Optical Coherence Tomography Study

      Retinal Topography of Myopic Eyes: A Spectral-Domain Optical Coherence Tomography Study

      Purpose. The purpose of this study was to investigate topographic characteristics of the retina in myopic eyes. Methods. We reviewed spectral-domain optical coherence tomography (SD-OCT) images of patients with myopia retrospectively. Retinal topography (RT) was defined as the topography of the retinal pigment epithelium layers. Retinal topographies were classified into several types, and the distribution and characteristics of each type were assessed in eyes with varying degrees of axial length (AL). Results. A total of 167 subjects with myopia were included in this study. Seventy eyes (41.9%) were classified as regular (R) type, 48 (28.7%) were wave (W ...

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      Mentions: Korea University
    10. The detection of macular analysis by SD-OCT for optic chiasmal compression neuropathy and nasotemporal overlap

      The detection of macular analysis by SD-OCT for optic chiasmal compression neuropathy and nasotemporal overlap

      Purposes: To assess the diagnostic performance of the macular parameters detected by spectral domain-optical coherence tomography (SD-OCT) in band atrophy (BA) eyes. Methods: Forty-nine BA eyes with permanent temporal hemianopia and 89 normal eyes were enrolled. Any patients who had nasal visual field loss were excluded. Each participant was imaged by 3D OCT-2000, and 10×10 grids in the macula were automatically allocated. The thickness of the macular retinal nerve fiber layer (mRNFL), ganglion cell layer (GCL)+ (GCL+inner plexiform layer (IPL)), and GCL++ thickness (RNFL+GCL+IPL) in both nasal and temporal hemiretina were calculated and compared between the ...

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    11. Spectral-Domain Optical Coherence Tomography Study on Dynamic Changes of Human Tears after Instillation of Artificial Tears

      Spectral-Domain Optical Coherence Tomography Study on Dynamic Changes of Human Tears after Instillation of Artificial Tears

      Purpose: To analyze in vivo the dynamic changes induced by different artificial tears (ATs) in the precorneal tear film (PCTF) and lower tear meniscus (LTM) by using a Spectral-domain anterior segment optical coherence tomography (SD-OCT). Methods: We prospectively examined forty-two normal human eyes by using SD-OCT imaging. On the day before OCT imaging, all enrolled subjects were evaluated for abnormalities of ocular surface. All tear film images were obtained before and after instillation of three different types of ATs (mucomimetic, lipid-based and saline) in five serial scans: immediately (within 30 seconds), at the 1st, at the 5th, at the 10th ...

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    12. Choroidal Structure in Normal Eyes and After Photodynamic Therapy Determined by Binarization of Optical Coherence Tomographic Images

      Choroidal Structure in Normal Eyes and After Photodynamic Therapy Determined by Binarization of Optical Coherence Tomographic Images

      Purpose. To determine changes in choroidal structure by binarization of optical coherence tomographic (OCT) images. Methods. Choroidal images were recorded by enhanced depth imaging OCT. The subfoveal choroidal images were analyzed, and the luminal and interstitial areas were converted to binary images by the Niblack method. The interrater, intrarater, and intersession agreements of the binary images were determined for healthy eyes. In eyes with age-related macular degeneration (AMD), the binary images of the choroid before photodynamic therapy (PDT) were compared to those after PDT. The untreated fellow eyes were studied as controls. Results. In healthy eyes, the average ratio of ...

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      Mentions: Taiji Sakamoto
    13. Retinal topography of myopic eyes: A spectral domain optical coherence tomography study

      Retinal topography of myopic eyes: A spectral domain optical coherence tomography study

      Purpose:The purpose of this study was to investigate topographic characteristics of the retina in myopic eyes. Methods:We reviewed spectral domain optical coherence tomography (SD-OCT) images of patients with myopia retrospectively. Retinal topography (RT) was defined as the topography of the retinal pigment epithelium layers. RTs were classified into several types, and the distribution and characteristics of each type were assessed in eyes with varying degrees of axial length (AL). Results:A total of 167 subjects with myopia were included in this study. Seventy eyes (41.9%) were classified as regular (R) type, 48 (28.7%) were wave (W ...

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      Mentions: Korea University
    14. Reproducibility of anterior chamber angle analyses with the Swept Source Optical Coherence Tomography in young, healthy Caucasians

      Reproducibility of anterior chamber angle analyses with the Swept Source Optical Coherence Tomography in young, healthy Caucasians

      Purpose: To assess the reproducibility of iridocorneal angle (ICA) analysis in young, healthy Caucasian subjects using swept-source optical coherence tomography (SS-OCT) by determining variability and inter-observer agreement between expert and non-expert observers. Methods: Thirty-one healthy volunteers (non-experts) acquired 3 consecutive SS-OCT images of the right eyes of their peer non-experts. Images were analyzed by 31 non-experts and additionally by 3 experts, whereby the angle opening distance (AOD) and the trabecular iris space area (TISA) at 500µm and 750µm were calculated. A random intercept model was used to determine the amount of variation between observers. In addition, the intra-observer ...

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    15. Microcysts in the Inner Nuclear Layer, a Nonspecific SD-OCT Sign of Cystoid Macular Edema

      Microcysts in the Inner Nuclear Layer, a Nonspecific SD-OCT Sign of Cystoid Macular Edema

      Recently, many authors have propagated the notion that a specific form of “microcystic macular edema” occurs in patients with optic neuritis and optic atrophy of various etiology and is due to retrograde synaptic degeneration. The finding is isolated to the inner nuclear layer on spectral-domain optical coherence tomography in most cases, and is present in a parafoveal, circumferential, and central macular distribution. This perspective critically reviews the evidence and suggests that inner nuclear layer cystoid changes are an early and nonspecific indicator of typical cystoid macular edema of any cause, and that the finding is likely not a distinct entity.

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    16. Macular choroidal thickness profile in a healthy population measured by Swept-Source Optical Coherence Tomography

      Macular choroidal thickness profile in a healthy population measured by Swept-Source Optical Coherence Tomography

      Purpose: To determine choroidal thickness (CT) profile in a healthy population using swept-source optical coherence tomography (SS-OCT). Methods: Cross-sectional, non-interventional study. 276 eyes (spherical equivalent ±3D) were scanned with SS-OCT (Topcon Corporation, Japan). Horizontal CT profile of the macula was created measuring subfoveal CT (SFCT) from the posterior edge of retinal pigment epithelium (RPE) to the choroid/sclera junction. Three determinations were performed at successive points 1000 μm nasal and five more temporal to the fovea. Subjects were divided into five age groups. Results: The mean SFCT was 301.89±80.53 μm (95% confidence interval: 292.34 to 311 ...

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    17. Influence of Correction of Ocular Magnification on Spectral-Domain OCT Retinal Nerve Fiber Layer Measurement Variability and Performance

      Influence of Correction of Ocular Magnification on Spectral-Domain OCT Retinal Nerve Fiber Layer Measurement Variability and Performance

      Purpose: To analyze the influence of ocular magnification on the peripapillary retinal nerve fiber layer (RNFL) thickness measurement and its performance as acquired with spectral-domain optical coherence tomography (SD-OCT). Methods: SD-OCT measurements from 108 normal eyes (59 subjects) and 72 glaucoma eyes (58 patients) were exported and custom software was used to correct RNFL measurements for ocular magnification. RNFL prediction limits in normal subjects, structure-function relationships, and RNFL performance for detection of glaucoma were compared before and after correction for ocular magnification (Bennett's formula). Association of disc area with cross-sectional RNFL area was explored. Results: The median (interquartile range ...

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    18. Acute Retinal Pigment Epitheliitis: Spectral Domain Optical Coherence Tomography Findings in 18 case

      Acute Retinal Pigment Epitheliitis: Spectral Domain Optical Coherence Tomography Findings in 18 case

      Purpose: To describe the imaging characteristics and to investigate the prognostic factors of acute retinal pigment epitheliitis. Methods: In this retrospective observational case series, a total of 18 patients (18 eyes) with acute retinal pigment epitheliitis were included. The features of acute retinal pigment epitheliitis were analyzed by spectral-domain optical coherence tomography (SD-OCT). Results: SD-OCT images obtained at baseline revealed abnormal reflectivity in the retinal pigment epithelium (RPE) inner layer in every case (18 eyes, 100%). The line corresponding to the RPE inner layer, the inner segment ellipsoid (ISe), showed abnormal reflectivity in 16 cases (89%). Among patients with ISe ...

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    19. A Comparative Effectiveness Analysis of Visual Field Outcomes after Projected Glaucoma Screening Using SD-OCT in African American Communities

      A Comparative Effectiveness Analysis of Visual Field Outcomes after Projected Glaucoma Screening Using SD-OCT in African American Communities

      To estimate the potential outcomes of spectral domain optical coherence tomography (SD-OCT) screening among African American patients in the US, a decision analysis model was used to synthesize the current evidence and to project visual function outcomes over a 10 year time horizon. The secondary intent of this study was to assess the cost of the screening implementation. Methods: Using a Monte Carlo micro-simulation model with a 10 year time horizon, we evaluated the impact of SD-OCT screening among African American patients on visual field loss and evaluated the associated costs of screening and treatment. Results: Based upon the model ...

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    20. Evaluation of Inner Retinal Layers in Eyes with Temporal Hemianopic Visual Loss from Chiasmal Compression using Optical Coherence Tomography

      Evaluation of Inner Retinal Layers in Eyes with Temporal Hemianopic Visual Loss from Chiasmal Compression using Optical Coherence Tomography

      PURPOSE: To measure macular inner retinal layer thicknesses using frequency-domain optical coherence tomography (fd-OCT) and to correlate these measures with visual field (VF) in eyes with temporal hemianopia from chiasmal compression and band atrophy (BA) of the optic nerve. METHODS: Macular fd-OCT scans and VFs were obtained from 33 eyes of 33 patients with temporal hemianopia and 36 control eyes. The macular retinal nerve fiber layer (mRNFL), the combined retinal ganglion cell and inner plexiform layers (RGCL+), and the inner nuclear layer (INL) were segmented. Measurements were averaged for each macula quadrant. Scans were qualitatively assessed for microcysts in the ...

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    21. A Novel OCT technique to Measure in vivo the Corneal Adhesiveness for Sodium Carboxymethylcellulose in Humans and its validity in the Diagnosis of Dry Eye

      A Novel OCT technique to Measure in vivo the Corneal Adhesiveness for Sodium Carboxymethylcellulose in Humans and its validity in the Diagnosis of Dry Eye

      Purpose: The purpose of this work was to gather preliminary data on tear film stability and the adhesive properties of the corneal surface in dry eye patients and control-group subjects, using a new, minimally invasive OCT imaging method. Methods: Eighty-five human subjects were screened for dry eye and classified in two groups, as dry eye or normal patients. Sodium carboxymethylcellulose (NaCMC) adhesiveness over the central cornea was measured using Fourier Domain anterior segment optical coherence tomography (OCT). The corneal adhesiveness for NaCMC was compared between the two groups, correlated with classical tests, and analyzed for diagnostic validity and repeatability. Results ...

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    22. Preservation of the Photoreceptor Layer following Subthreshold Laser Treatment for Diabetic Macular Edema as Demonstrated by SD-OCT

      Preservation of the Photoreceptor Layer following Subthreshold Laser Treatment for Diabetic Macular Edema as Demonstrated by SD-OCT

      Purpose: Subthreshold laser treatment of diabetic macular edema (DME) may have less deleterious effects on the photoreceptors than regular continuous wave laser. This study aimed to assess whether subthreshold laser causes a long-term damage to the retinal structures, as demonstrated by spectral-domain optical coherence tomography (SD-OCT), and to evaluate the change in the axial diameter of retinal diabetic microaneurysms following treatment. Methods: A retrospective study of eyes that were diagnosed with non-foveal involving DME and underwent subthreshold laser treatment with the Lumenis Novus SRT system. SD-OCT scans of treated retinal areas, performed prior to treatment and approximately 4 months following ...

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    23. Potential new diagnostic tool for Alzheimer's disease using a linear discriminant function for Fourier domain optical coherence tomography

      Potential new diagnostic tool for Alzheimer's disease using a linear discriminant function for Fourier domain optical coherence tomography

      Purpose: To calculate and validate a linear discriminant function (LDF) for Fourier domain optical coherence tomography (OCT) to improve the diagnostic ability of retinal and retinal nerve fiber layer (RNFL) thickness parameters in the detection of Alzheimer's disease (AD). Method: AD patients (n=151) and age-matched, healthy subjects (n=61) were enrolled. The Cirrus and Spectralis OCT systems were used to obtain retinal measurements and circumpapillary RNFL thickness for each participant. A LDF was calculated using all retinal and RNFL OCT measurements. Receiver operating characteristic (ROC) curves were plotted and compared among the LDF and the standard parameters provided ...

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