1. Articles from iovs.org

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    1. Vitamin D and macular thickness in the elderly: an Optical Coherence Tomography study

      Vitamin D and macular thickness in the elderly: an Optical Coherence Tomography study

      Purpose. Vitamin D insufficiency is associated with age-related macular degeneration. Our objective was to determine whether low serum 25-hydroxyvitamin D (25OHD) concentration was associated with macular thickness among older adults with no signs of macular dysfunction. Methods. Sixty-two French older community-dwellers with no patent macular dysfunction (mean±standard deviation, 71.2±5.0years; 45.2% female) included in the GAIT study (ClinicalTrials.gov number, NCT01315717) were separated into 2 groups according to serum 25OHD level (i.e., insufficient<50nmol/L or sufficient≥50nmol/L). The macular thickness was measured on 1000µm central macula with optical coherence tomography, and further ...

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    2. Relationship between Visual Acuity and Retinal Structures Measured by Spectral Domain Optical Coherence Tomography in Patients with Open Angle Glaucoma

      Relationship between Visual Acuity and Retinal Structures Measured by Spectral Domain Optical Coherence Tomography in Patients with Open Angle Glaucoma

      Purpose: To assess the relationship between retinal structures measured by spectral-domain optical coherence tomography (OCT) and visual acuity in open-angle glaucoma (OAG) patients. Methods: In this cross-sectional observational study, 186 eyes from 186 OAG patients were included. The participants underwent RTVue OCT for measurement of circumpapillary retinal nerve fiber layer (cpRNFL) thickness and macular ganglion cell complex (mGCC) thickness. The correlations between best-corrected visual acuity (BCVA) and OCT parameters were evaluated using Pearson's partial correlation test and regression analysis. Receiver operating characteristic (ROC) curve analysis was performed to obtain a cutoff value for OCT parameters in detecting decreased visual ...

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    3. The detection of macular analysis by SD-OCT for optic chiasmal compression neuropathy and nasotemporal overlap

      The detection of macular analysis by SD-OCT for optic chiasmal compression neuropathy and nasotemporal overlap

      Purposes: To assess the diagnostic performance of the macular parameters detected by spectral domain-optical coherence tomography (SD-OCT) in band atrophy (BA) eyes. Methods: Forty-nine BA eyes with permanent temporal hemianopia and 89 normal eyes were enrolled. Any patients who had nasal visual field loss were excluded. Each participant was imaged by 3D OCT-2000, and 10×10 grids in the macula were automatically allocated. The thickness of the macular retinal nerve fiber layer (mRNFL), ganglion cell layer (GCL)+ (GCL+inner plexiform layer (IPL)), and GCL++ thickness (RNFL+GCL+IPL) in both nasal and temporal hemiretina were calculated and compared between the ...

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    4. Spectral-Domain Optical Coherence Tomography Study on Dynamic Changes of Human Tears after Instillation of Artificial Tears

      Spectral-Domain Optical Coherence Tomography Study on Dynamic Changes of Human Tears after Instillation of Artificial Tears

      Purpose: To analyze in vivo the dynamic changes induced by different artificial tears (ATs) in the precorneal tear film (PCTF) and lower tear meniscus (LTM) by using a Spectral-domain anterior segment optical coherence tomography (SD-OCT). Methods: We prospectively examined forty-two normal human eyes by using SD-OCT imaging. On the day before OCT imaging, all enrolled subjects were evaluated for abnormalities of ocular surface. All tear film images were obtained before and after instillation of three different types of ATs (mucomimetic, lipid-based and saline) in five serial scans: immediately (within 30 seconds), at the 1st, at the 5th, at the 10th ...

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    5. Choroidal Structure in Normal Eyes and After Photodynamic Therapy Determined by Binarization of Optical Coherence Tomographic Images

      Choroidal Structure in Normal Eyes and After Photodynamic Therapy Determined by Binarization of Optical Coherence Tomographic Images

      Purpose. To determine changes in choroidal structure by binarization of optical coherence tomographic (OCT) images. Methods. Choroidal images were recorded by enhanced depth imaging OCT. The subfoveal choroidal images were analyzed, and the luminal and interstitial areas were converted to binary images by the Niblack method. The interrater, intrarater, and intersession agreements of the binary images were determined for healthy eyes. In eyes with age-related macular degeneration (AMD), the binary images of the choroid before photodynamic therapy (PDT) were compared to those after PDT. The untreated fellow eyes were studied as controls. Results. In healthy eyes, the average ratio of ...

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      Mentions: Taiji Sakamoto
    6. Retinal topography of myopic eyes: A spectral domain optical coherence tomography study

      Retinal topography of myopic eyes: A spectral domain optical coherence tomography study

      Purpose:The purpose of this study was to investigate topographic characteristics of the retina in myopic eyes. Methods:We reviewed spectral domain optical coherence tomography (SD-OCT) images of patients with myopia retrospectively. Retinal topography (RT) was defined as the topography of the retinal pigment epithelium layers. RTs were classified into several types, and the distribution and characteristics of each type were assessed in eyes with varying degrees of axial length (AL). Results:A total of 167 subjects with myopia were included in this study. Seventy eyes (41.9%) were classified as regular (R) type, 48 (28.7%) were wave (W ...

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      Mentions: Korea University
    7. Reproducibility of anterior chamber angle analyses with the Swept Source Optical Coherence Tomography in young, healthy Caucasians

      Reproducibility of anterior chamber angle analyses with the Swept Source Optical Coherence Tomography in young, healthy Caucasians

      Purpose: To assess the reproducibility of iridocorneal angle (ICA) analysis in young, healthy Caucasian subjects using swept-source optical coherence tomography (SS-OCT) by determining variability and inter-observer agreement between expert and non-expert observers. Methods: Thirty-one healthy volunteers (non-experts) acquired 3 consecutive SS-OCT images of the right eyes of their peer non-experts. Images were analyzed by 31 non-experts and additionally by 3 experts, whereby the angle opening distance (AOD) and the trabecular iris space area (TISA) at 500µm and 750µm were calculated. A random intercept model was used to determine the amount of variation between observers. In addition, the intra-observer ...

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    8. Microcysts in the Inner Nuclear Layer, a Nonspecific SD-OCT Sign of Cystoid Macular Edema

      Microcysts in the Inner Nuclear Layer, a Nonspecific SD-OCT Sign of Cystoid Macular Edema

      Recently, many authors have propagated the notion that a specific form of “microcystic macular edema” occurs in patients with optic neuritis and optic atrophy of various etiology and is due to retrograde synaptic degeneration. The finding is isolated to the inner nuclear layer on spectral-domain optical coherence tomography in most cases, and is present in a parafoveal, circumferential, and central macular distribution. This perspective critically reviews the evidence and suggests that inner nuclear layer cystoid changes are an early and nonspecific indicator of typical cystoid macular edema of any cause, and that the finding is likely not a distinct entity.

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    9. Macular choroidal thickness profile in a healthy population measured by Swept-Source Optical Coherence Tomography

      Macular choroidal thickness profile in a healthy population measured by Swept-Source Optical Coherence Tomography

      Purpose: To determine choroidal thickness (CT) profile in a healthy population using swept-source optical coherence tomography (SS-OCT). Methods: Cross-sectional, non-interventional study. 276 eyes (spherical equivalent ±3D) were scanned with SS-OCT (Topcon Corporation, Japan). Horizontal CT profile of the macula was created measuring subfoveal CT (SFCT) from the posterior edge of retinal pigment epithelium (RPE) to the choroid/sclera junction. Three determinations were performed at successive points 1000 μm nasal and five more temporal to the fovea. Subjects were divided into five age groups. Results: The mean SFCT was 301.89±80.53 μm (95% confidence interval: 292.34 to 311 ...

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    10. Influence of Correction of Ocular Magnification on Spectral-Domain OCT Retinal Nerve Fiber Layer Measurement Variability and Performance

      Influence of Correction of Ocular Magnification on Spectral-Domain OCT Retinal Nerve Fiber Layer Measurement Variability and Performance

      Purpose: To analyze the influence of ocular magnification on the peripapillary retinal nerve fiber layer (RNFL) thickness measurement and its performance as acquired with spectral-domain optical coherence tomography (SD-OCT). Methods: SD-OCT measurements from 108 normal eyes (59 subjects) and 72 glaucoma eyes (58 patients) were exported and custom software was used to correct RNFL measurements for ocular magnification. RNFL prediction limits in normal subjects, structure-function relationships, and RNFL performance for detection of glaucoma were compared before and after correction for ocular magnification (Bennett's formula). Association of disc area with cross-sectional RNFL area was explored. Results: The median (interquartile range ...

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    11. Acute Retinal Pigment Epitheliitis: Spectral Domain Optical Coherence Tomography Findings in 18 case

      Acute Retinal Pigment Epitheliitis: Spectral Domain Optical Coherence Tomography Findings in 18 case

      Purpose: To describe the imaging characteristics and to investigate the prognostic factors of acute retinal pigment epitheliitis. Methods: In this retrospective observational case series, a total of 18 patients (18 eyes) with acute retinal pigment epitheliitis were included. The features of acute retinal pigment epitheliitis were analyzed by spectral-domain optical coherence tomography (SD-OCT). Results: SD-OCT images obtained at baseline revealed abnormal reflectivity in the retinal pigment epithelium (RPE) inner layer in every case (18 eyes, 100%). The line corresponding to the RPE inner layer, the inner segment ellipsoid (ISe), showed abnormal reflectivity in 16 cases (89%). Among patients with ISe ...

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    12. A Comparative Effectiveness Analysis of Visual Field Outcomes after Projected Glaucoma Screening Using SD-OCT in African American Communities

      A Comparative Effectiveness Analysis of Visual Field Outcomes after Projected Glaucoma Screening Using SD-OCT in African American Communities

      To estimate the potential outcomes of spectral domain optical coherence tomography (SD-OCT) screening among African American patients in the US, a decision analysis model was used to synthesize the current evidence and to project visual function outcomes over a 10 year time horizon. The secondary intent of this study was to assess the cost of the screening implementation. Methods: Using a Monte Carlo micro-simulation model with a 10 year time horizon, we evaluated the impact of SD-OCT screening among African American patients on visual field loss and evaluated the associated costs of screening and treatment. Results: Based upon the model ...

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    13. Evaluation of Inner Retinal Layers in Eyes with Temporal Hemianopic Visual Loss from Chiasmal Compression using Optical Coherence Tomography

      Evaluation of Inner Retinal Layers in Eyes with Temporal Hemianopic Visual Loss from Chiasmal Compression using Optical Coherence Tomography

      PURPOSE: To measure macular inner retinal layer thicknesses using frequency-domain optical coherence tomography (fd-OCT) and to correlate these measures with visual field (VF) in eyes with temporal hemianopia from chiasmal compression and band atrophy (BA) of the optic nerve. METHODS: Macular fd-OCT scans and VFs were obtained from 33 eyes of 33 patients with temporal hemianopia and 36 control eyes. The macular retinal nerve fiber layer (mRNFL), the combined retinal ganglion cell and inner plexiform layers (RGCL+), and the inner nuclear layer (INL) were segmented. Measurements were averaged for each macula quadrant. Scans were qualitatively assessed for microcysts in the ...

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    14. A Novel OCT technique to Measure in vivo the Corneal Adhesiveness for Sodium Carboxymethylcellulose in Humans and its validity in the Diagnosis of Dry Eye

      A Novel OCT technique to Measure in vivo the Corneal Adhesiveness for Sodium Carboxymethylcellulose in Humans and its validity in the Diagnosis of Dry Eye

      Purpose: The purpose of this work was to gather preliminary data on tear film stability and the adhesive properties of the corneal surface in dry eye patients and control-group subjects, using a new, minimally invasive OCT imaging method. Methods: Eighty-five human subjects were screened for dry eye and classified in two groups, as dry eye or normal patients. Sodium carboxymethylcellulose (NaCMC) adhesiveness over the central cornea was measured using Fourier Domain anterior segment optical coherence tomography (OCT). The corneal adhesiveness for NaCMC was compared between the two groups, correlated with classical tests, and analyzed for diagnostic validity and repeatability. Results ...

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    15. Preservation of the Photoreceptor Layer following Subthreshold Laser Treatment for Diabetic Macular Edema as Demonstrated by SD-OCT

      Preservation of the Photoreceptor Layer following Subthreshold Laser Treatment for Diabetic Macular Edema as Demonstrated by SD-OCT

      Purpose: Subthreshold laser treatment of diabetic macular edema (DME) may have less deleterious effects on the photoreceptors than regular continuous wave laser. This study aimed to assess whether subthreshold laser causes a long-term damage to the retinal structures, as demonstrated by spectral-domain optical coherence tomography (SD-OCT), and to evaluate the change in the axial diameter of retinal diabetic microaneurysms following treatment. Methods: A retrospective study of eyes that were diagnosed with non-foveal involving DME and underwent subthreshold laser treatment with the Lumenis Novus SRT system. SD-OCT scans of treated retinal areas, performed prior to treatment and approximately 4 months following ...

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    16. Potential new diagnostic tool for Alzheimer's disease using a linear discriminant function for Fourier domain optical coherence tomography

      Potential new diagnostic tool for Alzheimer's disease using a linear discriminant function for Fourier domain optical coherence tomography

      Purpose: To calculate and validate a linear discriminant function (LDF) for Fourier domain optical coherence tomography (OCT) to improve the diagnostic ability of retinal and retinal nerve fiber layer (RNFL) thickness parameters in the detection of Alzheimer's disease (AD). Method: AD patients (n=151) and age-matched, healthy subjects (n=61) were enrolled. The Cirrus and Spectralis OCT systems were used to obtain retinal measurements and circumpapillary RNFL thickness for each participant. A LDF was calculated using all retinal and RNFL OCT measurements. Receiver operating characteristic (ROC) curves were plotted and compared among the LDF and the standard parameters provided ...

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    17. Advancing OCT Algorithmic Standardization

      Advancing OCT Algorithmic Standardization

      Neovascular exudative AMD (wet AMD) continues to rank as a top reason to visit eye care specialists, and the early identification of this disease has important prognostic implications for patients. 1 Advancements in optical coherence tomography (OCT) imaging have surpassed other modalities in the ability to detect the earliest development of wet AMD and prompt treatment initiation, in spite of lack of inter- and intradevice standardization. 2 , 3 Zhang et al. 4 present a novel, automated way to detect changes at the border where choroidal neovascularization (CNV) first affects the retina. They use a technique that presents an automated method ...

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    18. Structure-Function Correlations in Glaucoma Using Matrix and Standard Automated Perimetry Versus Time Domain and Spectral Domain OCT devices

      Structure-Function Correlations in Glaucoma Using Matrix and Standard Automated Perimetry Versus Time Domain and Spectral Domain OCT devices

      Purpose: To examine the structure-function relationship between two perimetric tests, the Frequency-Doubling Technology (FDT) Matrix and Standard Automated Perimetry (SAP), and two Optical Coherence Tomography (OCT) devices (Time-Domain and Spectral-Domain). Methods: This cross-sectional study included 97 eyes from 29 healthy individuals and 68 individuals with early, moderate, or advanced primary open-angle glaucoma. The correlations between overall and sectorial parameters of retinal nerve fiber layer thickness (RNFL) measured with Stratus and Spectralis OCT and the visual field sensitivity obtained with FDT Matrix and SAP were assessed. The relationship was also evaluated using a previously described linear model. Results: The correlation coefficients ...

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    19. Correlation between Spectral-Domain OCT findings and Visual Acuity in X-linked Retinoschisis

      Correlation between Spectral-Domain OCT findings and Visual Acuity in X-linked Retinoschisis

      PURPOSE: To investigate the tomographic characteristics of the outer retina and choroid and their relationship with visual auity in X-linked juvenile retinoschisis (XLRS) patients using spectral-domain optical coherence tomography (SD-OCT). METHODS: In this retrospective, observational, case-control study, we analyzed 20 eyes of 10 patients with XLRS using SD-OCT. The clinical and tomographic features of the outer retina, including the external limiting membrane (ELM), inner segment/outer segment (IS/OS) junction, cone cell outer segment tips (COST) line, photoreceptor outer segment (PROS) length, and choroid, were evaluated. As controls, 40 age-, sex-, and refraction-matched healthy eyes (1:2 matched) were randomly ...

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    20. Structure-function relationships with spectral-domain optical coherence tomography retinal nerve fiber layer and optic nerve head measurements

      Structure-function relationships with spectral-domain optical coherence tomography retinal nerve fiber layer and optic nerve head measurements

      Purpose: To evaluate the regional structure-function relationship between visual field sensitivity and retinal nerve fiber layer (RNFL) thickness and optic nerve head (ONH) measurements using spectral-domain optical coherence tomography (SD-OCT). Methods: Prospective cross-sectional study conducted on patients with glaucoma, suspected glaucoma and healthy subjects. Eyes were tested on Cirrus OCT and standard achromatic perimetry. RNFL thickness of 12 peripapillary 30° sectors, neuroretinal rim thickness extracted from 36 neuroretinal rim scans, and Bruch membrane opening minimum rim width (BMO-MRW) - a recently defined parameter - extracted from 36 neuroretinal rim scans were obtained. Correlations between peripapillary RNFL thickness, neuroretinal rim thickness, all six ...

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    21. Choroidal thickness in patients with reticular pseudodrusen using 3D-1060nm OCT maps

      Choroidal thickness in patients with reticular pseudodrusen using 3D-1060nm OCT maps

      Purpose: To map and analyze choroidal thickness (ChT) in age-related macular degeneration patients with reticular pseudodrusen (RPD) using 3-dimensional (3D) 1060nm optical coherence tomography (OCT). Methods: Fifty eyes from twenty-five patients with RPD were grouped according to the severity of age-related macular degeneration (AMD) and the presence of RPD. All patients were imaged by high speed (60.000 A-scans/s) 3D-1060nm OCT over a 36x36° field of view. ChT-maps were automatically generated and compared to RPD areas visualized by fundus autofluorescence and infra-red imaging. Retinal thickness maps, ChT maps, Haller's and Sattler's layer thickness were statistically analyzed between ...

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    22. Posterior Precortical Vitreous Pockets and Connecting Channels in Children on Swept-Source Optical Coherence Tomography

      Posterior Precortical Vitreous Pockets and Connecting Channels in Children on Swept-Source Optical Coherence Tomography

      PURPOSE. To observe the posterior vitreous in children using swept-source optical coherence tomography (SS-OCT). METHODS. The normal right eyes of 73 children (ages, 3-11) years were studied using SS-OCT with 12-mm horizontal and vertical scans in the posterior fundus. RESULTS. Posterior precortical vitreous pockets (PPVPs), narrow liquefied spaces along the vitreoretinal interface in the macula (mean, 165.4±35.2 µm (depth) x 3,327±615.7 µm (width), were observed at age 3 in horizontal scans. The PPVPs enlarged to 382.9±51.8 x 4,486.5±342.3 from ages 4 to 6 (P<0.01) and ...

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      Mentions: Gunma University
    23. Pilocarpine-induced dilation of Schlemm's canal and prevention of lumen collapse at elevated intraocular pressures in living mice visualized by OCT

      Pilocarpine-induced dilation of Schlemm's canal and prevention of lumen collapse at elevated intraocular pressures in living mice visualized by OCT

      Purpose:The goal was to assess effects of intraocular pressure (IOP) and pilocarpine-induced ciliary muscle contraction on conventional outflow pathway tissues in living anesthetized mice. Methods:IOP was controlled by intracameral cannulation of mouse eyes while imaging using spectral domain optical coherence tomography (SD-OCT). Time-lapse sagittal SD-OCT sections through Schlemm's canal (SC) were acquired while changing IOP stepwise between 10 and 45 mmHg. After topical application of 1% pilocarpine, the series of IOP steps and imaging were repeated. Effects of pilocarpine on IOP and outflow facility in living mice were verified by rebound tonometry and flow measurements at 3 ...

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    1-24 of 547 1 2 3 4 ... 21 22 23 »
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