The potential of optical coherence tomography for diagnosing meniscal pathology

Abstract. An ideal diagnostic system for the tumor tissues should be able to detect and define the location of tumor tissues and the early development of malignant diseases. There is great need for enhancement of imaging ability to tumor tissues. Optical coherence tomography (OCT) is used in detection and location of varied tumor tissues. In order to improve the sensitivity and specificity of an OCT image, hematoporphyrin as a new type of contrast agent was used in this study. The orthotopic graft model of gastric cancer in nude mice was used. The image formations of the tumor tissues without and ...
Abstract. We present a theoretical model for analyzing the speckle contrast of optical coherence tomography (OCT). This model is based on the addition of noise and an OCT signal in the logarithmic scale. The theoretical model reveals that, for the superficial layer of homogenous tissue, the contrast ratio is a linear function of the location of the coherence gate in the sample and the slope of this linear dependence is proportional to the scattering coefficient. The theoretical model is consistent with the experimental results, suggesting that the slope can be useful to characterize the scattering coefficient of the homogenous samples.