1. Articles from journals.healio.com

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    1. Optical Coherence Tomography of a Traumatic Neodymium:YAG Laser-Induced Macular Hole

      Optical Coherence Tomography of a Traumatic Neodymium:YAG Laser-Induced Macular Hole

      Abstract A 34-year-old electronics technician with a macular hole caused by a Neodymium (Nd):YAG laser injury underwent follow up with optical coherence tomography for 1 year. Optical coherence tomography showed a defect in all retinal layers at the macula center, with rectified and perpendicularly orientated borders to the retinal pigment epithelium. One year postinjury, the hole dimensions increased, and optical coherence tomography disclosed less evident rectified borders. After 1 year of follow up, the optical coherence tomography characteristics of a traumatic Nd:YAG laser macular hole can change, looking similar to a senile idiopathic hole.

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    2. Optical Coherence Tomography Features of Ocular Cysticercosis: A Review of Literature With Observer Variation

      Optical Coherence Tomography Features of Ocular Cysticercosis: A Review of Literature With Observer Variation

      Ocular cysticercosis is a sparsely reported condition, requiring urgent management. The gold standard for diagnosis is an in toto extraction of the cyst with subsequent histopathology. The procedure can be demanding in contrast to the frequently adopted practice of in vivo cyst lysis. The latter, however, obviates a conventional biopsy. We reviewed published optical coherence tomography (OCT) images of ocular cysticercosis for their suitability to surrogate a conventional biopsy and identified commonly reported features. We also used triple masking and ascertained the observer agreement on identification of these features. We found that the features of the parasite are much more ...

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    3. Detection of Corneal Ectasia Using OCT Maps of Pachymetry and Posterior Surface Mean Curvature

      Detection of Corneal Ectasia Using OCT Maps of Pachymetry and Posterior Surface Mean Curvature

      Purpose: To quantify the abnormal corneal thinning and posterior surface steepening that is observed in keratoconus with an Ectasia Index. Methods: Optical coherence tomography (OCT) was used to image the corneas of normal individuals and patients with varying stages of keratoconus (manifest, subclinical, and forme fruste). Maps of corneal pachymetry and posterior surface mean curvature were generated, and an Ectasia Index was calculated by multiplying Gaussian fits obtained from the two types of maps. Repeated five-fold cross-validation was used to evaluate the ability of the Ectasia Index to differentiate between normal and keratoconic eyes. The classification performance of the Ectasia ...

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    4. Intracorneal Ring Segment Implantation Results in Corneal Mechanical Strengthening Visualized With Optical Coherence Elastography

      Intracorneal Ring Segment Implantation Results in Corneal Mechanical Strengthening Visualized With Optical Coherence Elastography

      PURPOSE: To quantify the mechanical impact of intracorneal ring segment (ICRS) implantation of different dimensions in an ex vivo eye model. METHODS: A total of 30 enucleated porcine eyes were assigned to ICRS implantation (thickness: 300 µm, angle: 120°, 210°, or 325°), tunnel creation only, or virgin control groups. For mechanical evaluation, each globe was mounted on a customized holder and intraocular pressure (IOP) was increased in steps of 0.5 mm Hg from 15 to 17 mm Hg, simulating physiologic diurnal IOP fluctuations. At each step, an optical coherence tomography volume scan was recorded. Deformations between subsequent scans and ...

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    5. Findings on Optical Coherence Tomography in Malignant Infantile Osteopetrosis

      Findings on Optical Coherence Tomography in Malignant Infantile Osteopetrosis

      Malignant infantile osteopetrosis is a rare inherited disorder with neurological complications and a shortened life expectancy. Vision loss is typically attributed to osseous compression of the optic nerves at the level of the optic canal. Fundus imaging is reported, as well as the first optical coherence tomography and optical coherence tomography angiography in this rare condition. Imaging revealed optic nerve pallor, subfoveal ellipsoid zone disruption, and an enlarged foveal avascular zone. These results provide insight regarding other potential mechanisms of vision loss in these patients.

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    6. Retinal Nerve Fiber Layer Analysis in Children With Migraine With and Without Aura Using Optical Coherence Tomography: A Case-Control Study

      Retinal Nerve Fiber Layer Analysis in Children With Migraine With and Without Aura Using Optical Coherence Tomography: A Case-Control Study

      Purpose: To evaluate retinal nerve fiber layer (RNFL) thickness in children with migraine, with and without aura, compared to healthy controls using optical coherence tomography (OCT). Methods: In this cross-sectional case-control study, patients with a diagnosis of migraine with aura (MwA) or without aura (MwoA) were considered and healthy children were included as controls. Age, sex, duration of migraine, number of episodes per month, duration of episodes, and use of prophylactic treatment with magnesium were recorded. All patients underwent complete ophthalmologic, neurologic, and pediatric examination. Optic nerve OCT images were obtained using Heidelberg Spectralis OCT (Heidelberg Engineering) and mean global ...

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    7. Combining Spectral-Domain OCT and Air-Puff Tonometry Analysis to Diagnose Keratoconus

      Combining Spectral-Domain OCT and Air-Puff Tonometry Analysis to Diagnose Keratoconus

      Purpose: To investigate the diagnostic capacity of spectral-domain optical coherence tomography (SD-OCT) combined with air-puff tonometry using artificial intelligence (AI) in differentiating between normal and keratoconic eyes. Methods: Patients who had either undergone uneventful laser vision correction with at least 3 years of stable follow-up or those who had forme fruste keratoconus (FFKC), early keratoconus (EKC), or advanced keratoconus (AKC) were included. SD-OCT and biomechanical information from air-puff tonometry was divided into training and validation sets. AI models based on random forest or neural networks were trained to distinguish eyes with FFKC from normal eyes. Model accuracy was independently tested ...

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    8. Repeatability and Comparison of Corneal Tomography in Mild to Severe Keratoconus Between the Anterior Segment OCT MS-39 and Pentacam HR

      Repeatability and Comparison of Corneal Tomography in Mild to Severe Keratoconus Between the Anterior Segment OCT MS-39 and Pentacam HR

      Purpose: To detect keratoconus progression, accuracy of tomographic measurements is crucial. The impoved axial resolution of optical coherence tomography (OCT) compared to Scheimpflug photography serves as the motivation to investigate and compare the repeatability of the anterior segment OCT MS-39 (CSO) to Pentacam HR (Oculus Optikgeräte GmbH) in patients with keratoconus. Methods: One hundred twenty-three eyes of 123 patients with keratoconus were enrolled and subdivided in four groups by maximum keratometry (Kmax): Kmax < 48.00 diopters (D), Kmax of 48.00 to 53.01 D, Kmax of 53.00 to 58.00 D, and Kmax > 58.00 D. Three ...

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    9. Proof-of-Concept Analysis of a Deep Learning Model to Conduct Automated Segmentation of OCT Images for Macular Hole Volume

      Proof-of-Concept Analysis of a Deep Learning Model to Conduct Automated Segmentation of OCT Images for Macular Hole Volume

      Background and objective: To determine whether an automated artificial intelligence (AI) model could assess macular hole (MH) volume on swept-source optical coherence tomography (OCT) images. Patients and methods: This was a proof-of-concept consecutive case series. Patients with an idiopathic full-thickness MH undergoing pars plana vitrectomy surgery with 1 year of follow-up were considered for inclusion. MHs were manually graded by a vitreoretinal surgeon from preoperative OCT images to delineate MH volume. This information was used to train a fully three-dimensional convolutional neural network for automatic segmentation. The main outcome was the correlation of manual MH volume to automated volume segmentation ...

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      Mentions: Voxeleron
    10. Functional and Structural Findings in Infants Treated for Retinopathy of Prematurity Using Optical Coherence Tomography Angiography

      Functional and Structural Findings in Infants Treated for Retinopathy of Prematurity Using Optical Coherence Tomography Angiography

      Background and objective: To assess the foveal microvascular structure of children with retinopathy of prematurity (ROP) treated with diode laser photocoagulation using optical coherence tomography angiography (OCTA). Patients and methods: OCTA was performed at a tertiary medical center in 17 children (27 eyes) aged 4 to 16 years with a history of diode laser photocoagulation treated ROP. OCTA parameters were compared with those of 12 healthy age-matched controls (23 eyes) attending the orthoptics clinic and correlated with clinical factors. Results: Compared with controls, the ROP group had a smaller foveal avascular zone area ( P < .001), lower deep vascular plexus density ...

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    11. Utility of Anterior Segment Optical Coherence Tomography in Muscle Aplasia

      Utility of Anterior Segment Optical Coherence Tomography in Muscle Aplasia

      Congenital absence of the extraocular muscles is a relatively rare entity that is diagnosed by magnetic resonance imaging and is usually associated with craniofacial syndromes, microcornea, microphthalmos, and coloboma. The authors describe anterior segment optical coherence tomography as a quick and valuable modality in this setting before subjecting the patient to magnetic resonance imaging or computed tomography.

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    12. Medial Rectus Muscle Resection Versus Plication: A Comparison of Conjunctival-Scleral Thickness Measured by AS-OCT

      Medial Rectus Muscle Resection Versus Plication: A Comparison of Conjunctival-Scleral Thickness Measured by AS-OCT

      Purpose: To compare conjunctival-scleral thickness measured with anterior segment optical coherence tomography before and after medial rectus muscle resection and plication for exotropia. Methods: In this prospective observational study, patients with exotropia aged 5 years and older who underwent medial rectus muscle resection or plication through limbal incision of the conjunctiva between April 2016 and June 2018 were enrolled. Conjunctivalscleral thickness was measured with anterior segment optical coherence tomography before and 3 and 6 months after surgery at 1.5 mm (limbus), 4 mm (insertion), and 5.5 mm (tendon) posterior to the scleral spur. One examiner made measurements twice ...

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    13. Differentiating Between Contact Lens Warpage and Keratoconus Using OCT Maps of Corneal Mean Curvature and Epithelial Thickness

      Differentiating Between Contact Lens Warpage and Keratoconus Using OCT Maps of Corneal Mean Curvature and Epithelial Thickness

      Purpose: To formulate an Epithelial Modulation index to differentiate between eyes with contact lens warpage and keratoconus. Methods: Normal eyes and eyes with either contact lens warpage or keratoconus were scanned by a Fourier-domain optical coherence tomography (OCT) system. Maps of epithelial thickness and anterior surface mean curvature were generated and converted to deviation maps by subtracting the average maps from a healthy population. The Epithelial Modulation index was defined as the covariance between the two types of deviation maps. A logistic regression model was used to classify eyes as non-keratoconus (normal or warp-age) or keratoconus (manifest, subclinical, or forme ...

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    14. Risk Classification for Progression to Subfoveal Geographic Atrophy in Dry Age-Related Macular Degeneration Using Machine Learning–Enabled Outer Retinal Feature Extraction

      Risk Classification for Progression to Subfoveal Geographic Atrophy in Dry Age-Related Macular Degeneration Using Machine Learning–Enabled Outer Retinal Feature Extraction

      Background and objective: To evaluate the utility of spectral-domain optical coherence tomography biomarkers to predict the development of subfoveal geographic atrophy (sfGA). Patients and methods: This was a retrospective cohort analysis including 137 individuals with dry age-related macular degeneration without sfGA with 5 years of follow-up. Multiple spectral-domain optical coherence tomography quantitative metrics were generated, including ellipsoid zone (EZ) integrity and subretinal pigment epithelium (sub-RPE) compartment features. Results: Reduced mean EZ-RPE central subfield thickness and increased sub-RPE compartment thickness were significantly different between sfGA convertors and nonconvertors at baseline in both 2-year and 5-year sfGA risk assessment. Longitudinal change assessment ...

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      Mentions: Cleveland Clinic
    15. Accuracy of IOL Power Calculation Formulas for Quadrifocal Acrysof IQ PanOptix TFNT Implantation in Patients With Previous Corneal Refractive Surgery: Comparison of SS-OCT-Based Biometers

      Accuracy of IOL Power Calculation Formulas for Quadrifocal Acrysof IQ PanOptix TFNT Implantation in Patients With Previous Corneal Refractive Surgery: Comparison of SS-OCT-Based Biometers

      Purpose: To evaluate the accuracy of intraocular lens (IOL) power calculation formulas from two biometers using swept-source optical coherence tomography for quadrifocal Acrysof IQ Panoptix TFNT IOL (Alcon Laboratories, Inc) implantation in patients with visually significant cataract with previous corneal refractive surgery. Methods: This retrospective study comprised 50 eyes from 50 patients with a history of corneal refractive surgery and TFNT IOL implantation. Candidate formulas were Shammas-PL and Barrett True-K in the Argos (Movu, Inc), Barret True-K and Haigis-L in the IOLMaster 700 (Carl Zeiss Meditec AG), and Haigis using the total keratometry (TK) mode in the IOLMaster 700. The ...

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    16. Comparison Between Different Segmentation Strategies for the Choriocapillaris Using Optical Coherence Tomography Angiography

      Comparison Between Different Segmentation Strategies for the Choriocapillaris Using Optical Coherence Tomography Angiography

      Background and objective: To assess the relationship between retinal pigment epithelium (RPE) and RPE fit-based segmentations of the choriocapillaris (CC) and its expected anatomic location. Patients and methods: Consecutive healthy participants' eyes were imaged with optical coherence tomography angiography (PLEX Elite) with 3 × 3-mm and 6 × 6-mm scan. Ground-truth images were generated using 16-μm-thick slabs starting from 4 μm below the automatically segmented Bruch's membrane (BM) band. A series of slabs positioned below the RPE band and RPE fit were also generated, and CC flow deficit percentage was compared with the ground-truth segmentation. Results: Twenty-six eyes of 26 ...

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      Mentions: UCLA
    17. Vitreomacular Traction Surgery from the DISCOVER Study: Intraoperative OCT Utility, Ellipsoid Zone Dynamics, and Outcomes

      Vitreomacular Traction Surgery from the DISCOVER Study: Intraoperative OCT Utility, Ellipsoid Zone Dynamics, and Outcomes

      BACKGROUND AND OBJECTIVES: To characterize the clinical and ellipsoid zone (EZ) integrity outcomes in surgical intervention for symptomatic vitreomacular traction (VMT), and to evaluate the utility of intraoperative optical coherence tomography (OCT) during VMT surgery. PATIENTS AND METHODS: This was a post-hoc analysis of eyes in the DISCOVER study undergoing pars plana vitrectomy (PPV) with intraoperative OCT for VMT-related macular disease. Data were collected prospectively on feasibility and utility of intraoperative OCT, with follow-up lasting 12 months. RESULTS: Forty-three eyes of 41 patients were included and mean visual acuity improved from 20/96 to 20/45 ( P < .001). Intraoperative OCT ...

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      Mentions: Cleveland Clinic
    18. Accuracy of Total Corneal Power Calculation for Multifocal Toric Intraocular Lens Implantation: Swept-Source OCT-Based Biometer vs Scheimpflug Tomographer

      Accuracy of Total Corneal Power Calculation for Multifocal Toric Intraocular Lens Implantation: Swept-Source OCT-Based Biometer vs Scheimpflug Tomographer

      Purpose: To evaluate the accuracy of total corneal power calculation from a swept-source optical coherence tomography-based biometer and a rotating Scheimpflug tomographer for the Acrysof IQ Panoptix toric TFNT intraocular lens (IOL) (Alcon Labroatories, Inc). Methods: A retrospective study was undertaken on 145 eyes implanted with the TFNT IOL. The accuracy of total corneal power calculation from a SS-OCT-based biometer (IOLMaster 700; Carl Zeiss Meditec AG; total keratometry [TK]) and a rotating Scheimpflug tomographer (Oculus Optikgeräte GmbH; total corneal refractive power at 3 mm [TCRP3] and at 4 mm [TCRP4]) were compared. The surgically induced astigmatism vector, difference vector ...

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    19. The Precision of a New Anterior Segment Optical Coherence Tomographer and Its Comparison With a Swept-Source OCT-Based Optical Biometer in Patients With Cataract

      The Precision of a New Anterior Segment Optical Coherence Tomographer and Its Comparison With a Swept-Source OCT-Based Optical Biometer in Patients With Cataract

      PURPOSE: To assess the precision of a new spectral-domain optical coherence tomographer (SD-OCT)/Placido topographer (MS-39; CSO) and its comparison with a swept-source OCT (SS-OCT) biometer (Argos; Movu, Inc) in patients with cataract. METHODS: Fifty-three right eyes from 53 patients were examined by two experienced operators three times using both devices randomly. Employing the within-subject standard deviation (S w ), test–retest variability, coefficient of variation, and intraclass correlation coefficient to evaluate intraoperator repeatability and interoperator reproducibility; the double-angle plots to analyze astigmatism; and Bland-Altman plots and 95% limits of agreement to verify the agreement between devices. RESULTS: The SD-OCT/Placido ...

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      Mentions: Movu CSO
    20. Refractive Outcomes of Phacovitrectomy in Retinal Detachment Compared to Phacoemulsification Alone Using Swept-Source OCT Biometry

      Refractive Outcomes of Phacovitrectomy in Retinal Detachment Compared to Phacoemulsification Alone Using Swept-Source OCT Biometry

      Background and objective: To assess the refractive outcomes in patients who underwent combined phacovitrectomy for retinal detachment compared to phacoemulsification and intraocular lens (IOL) implant utilizing newer swept-source optical-coherence-tomography (SS-OCT) biometry and determine the requirement of an adjustment factor for superior predicted refractive outcomes. Patients and methods: Retrospective study of 95 eyes: 52 eyes that underwent phacovitrectomy and 43 eyes with phacoemulsification only that served as the control group. Mean refractive error (ME) and mean absolute error (MAE) were used to compare the groups. Results: No statistically significant postoperative refractive shift was found between phacoemulsification and phacovitrectomy eyes for (1 ...

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    21. Clinical Significance of Macula-Off Rhegmatogenous Retinal Detachment Preoperative Features on Optical Coherence Tomography

      Clinical Significance of Macula-Off Rhegmatogenous Retinal Detachment Preoperative Features on Optical Coherence Tomography

      Background and objective: To evaluate the clinical significance of preoperative spectral-domain optical coherence tomography (OCT) features and their association with postoperative outcomes in eyes with primary macula-off rhegmatogenous retinal detachment (RRD). Patients and methods: This is a retrospective case series of all consecutive cases undergoing repair of primary macula-off RRD at two tertiary care academic centers between January 2018 to January 2021. Results: Among 406 eyes, baseline visual acuity (β = 0.184, P = .001) and time to surgery (β = 0.009, P = .033) were predictive of postoperative visual acuity at 1-year follow-up after adjusting for age, sex and lens status, as well ...

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    22. OCTA and Functional Signs of Preclinical Retinopathy in Type 1 Diabetes Mellitus

      OCTA and Functional Signs of Preclinical Retinopathy in Type 1 Diabetes Mellitus

      BACKGROUND AND OBJECTIVE: There is an emerging role for optical coherence tomography angiography (OCTA) in detecting microvasculature changes in diabetic retinopathy (DR). This study aimed to investigate visual functions and OCTA parameters of retinal and choriocapillaris (CC) flow in patients with type 1 diabetes mellitus (T1DM) without apparent DR. PATIENTS AND METHODS: Patients and age-matched healthy volunteers were enrolled. All participants underwent low-luminance visual acuity assessment, OCT, and OCTA. Assessed OCTA parameters included foveal avascular zone area, acircularity index, vessel density (VD), skeletonized density, and CC flow deficits. RESULTS: Low-luminance deficit (LLD) was significantly higher in patients with diabetes mellitus ...

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    23. Swept-Source OCT En Face Imaging of Paravascular Inner Retinal Defects

      Swept-Source OCT En Face Imaging of Paravascular Inner Retinal Defects

      Widefield swept-source optical coherence tomography angiography (SS-OCTA) was performed on eyes with paravascular inner retinal defects (PIRDs) and the morphological alterations of PIRDs were described. Patients with PIRDs were imaged using 12 mm × 12 mm SS-OCTA scans. En face structural and angiographic images of the superficial retinal layers were reviewed along with retinal thickness maps. SS-OCTA en face structural images identified dark, scalloped regions along major retinal veins that corresponded to PIRDs on B-scans. The authors concluded that imaging with both structural and angiographic en face OCT was useful for the diagnosis and monitoring of patients with PIRDs.

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    24. Intraoperative Swept-Source OCT-Based Corneal Topography for Measurement and Analysis of Stromal Surface After Epithelial Removal

      Intraoperative Swept-Source OCT-Based Corneal Topography for Measurement and Analysis of Stromal Surface After Epithelial Removal

      Purpose: To assess intraoperative stromal topography measurements using swept-source optical coherence tomography (OCT)-based topography/tomography after epithelial removal and to analyze the epithelial contribution to the corneal topography and optics. Methods: This was a prospective series of 22 eyes of 19 patients referred to receive phototherapeutic keratotomy (PTK) for treatment of recurrent corneal erosion and a control group of 22 virgin eyes. Swept-source OCT corneal topography/tomography was obtained immediately before and immediately after mechanical deepithelialization before PTK. Epithelial thickness maps were obtained before the surgery using spectral-domain OCT in the control group and as a reference in the ...

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    1-24 of 34 1 2 »
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