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    1. The application of optical coherence tomography angiography in Alzheimer's disease: A systematic review

      The application of optical coherence tomography angiography in Alzheimer's disease: A systematic review

      Introduction Discovering non‐invasive and easily acquired biomarkers that are conducive to the accurate diagnosis of dementia is an urgent area of ongoing clinical research. One promising approach is retinal imaging, as there is homology between retinal and cerebral vasculature. Recently, optical coherence tomography angiography (OCT‐A) has emerged as a promising new technology for imaging the microvasculature of the retina. Methods A systematic review and meta‐analysis was conducted to examine the application of OCT‐A in dementia. Results Fourteen studies assessing OCT‐A in preclinical Alzheimer's disease (AD), mild cognitive impairment, or AD were included. Exploratory meta ...

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    2. A recommended "minimum data set" framework for SD-OCT retinal image acquisition and analysis from the Atlas of Retinal Imaging in Alzheimer's Study (ARIAS)

      A recommended "minimum data set" framework for SD-OCT retinal image acquisition and analysis from the Atlas of Retinal Imaging in Alzheimer's Study (ARIAS)

      Introduction: We propose a minimum data set framework for the acquisition and analysis of retinal images for the development of retinal Alzheimer's disease (AD) biomarkers. Our goal is to describe methodology that will increase concordance across laboratories, so that the broader research community is able to cross-validate findings in parallel, accumulate large databases with normative data across the cognitive aging spectrum, and progress the application of this technology from the discovery stage to the validation stage in the search for sensitive and specific retinal biomarkers in AD. Methods: The proposed minimum data set framework is based on the Atlas ...

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